The ingestion of inorganic nitrate increases gastric S-nitrosothiol levels and inhibits platelet function in humans

Nitric Oxide - Biology and Chemistry

Volumn 7, Issue 1, 2002, Pages 24-29

  Richardson, G ^a   Hicks, S L ^a   O'Byrne, S ^a   Frost, M T ^b   Moore, K ^c   Benjamin, N ^a   McKnight, G M ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

Gastric; Inorganic nitrate; Nitric oxide; Platelets; S nitrosothiols

Indexed keywords

3 NITROTYROSINE; COLLAGEN; CYCLIC GMP; NITRATE; POTASSIUM NITRATE; S NITROSOTHIOL; THIOL DERIVATIVE; UNCLASSIFIED DRUG; 3-NITROTYROSINE; DRUG DERIVATIVE; TYROSINE;

ADULT; ARTICLE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; INGESTION; NORMAL HUMAN; PRIORITY JOURNAL; STOMACH JUICE; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE FUNCTION; ADOLESCENT; BLOOD CLOTTING PARAMETERS; CHEMISTRY; DRUG EFFECT; FEMALE; KINETICS; MALE; METABOLISM; ORAL DRUG ADMINISTRATION; VEGETARIAN DIET;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; COLLAGEN; CYCLIC GMP; DIET, VEGETARIAN; FEMALE; GASTRIC JUICE; HUMANS; KINETICS; MALE; NITRATES; PLATELET AGGREGATION; PLATELET FUNCTION TESTS; S-NITROSOTHIOLS; TYROSINE;

EID: 0036036981     PISSN: 10898603     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1089-8603(02)00010-1     Document Type: Article

References (33)

1. Platelets, thrombosis and atherosclerosis
2. Platelet activation in unstable coronary disease
3. Fish consumption omega-3 fatty acids and the Mediterranean diet
4. Diet lifestyle and the etiology of coronary artery disease: The Cornell China study
5. Serial coronary angiographic evidence that antioxidant vitamin intake reduces progression of coronary artery atherosclerosis
6. Hyperhomocyst(e)inemia is a risk factor for arterial endothelial dysfunction in humans
7. Nitrate and nitrite content of some fresh and processed market vegetables
8. Estimation of dietary intake of nitrate and nitrite in Great Britain
9. The effect of nitrate intake on nitrite formation in human saliva
10. Chemical generation of nitric oxide in the mouth from the enterosalivary circulation of dietary nitrate
11. Chemical synthesis of nitric oxide in the stomach from dietary nitrate in humans
12. The biological and pharmacological role of nitric oxide in platelet function
13. cGMP mediates the vascular and platelet actions of nitric oxide: Confirmation using an inhibitor of the soluble guanylyl cyclase
14. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
15. Superoxide reacts with nitric oxide to nitrate tyrosine at physiological pH via peroxynitrite
16. Peroxynitrite-induced tyrosine nitration and phosphorylation in human platelets
17. High concentrations of glutathione in glandular stomach: Possible implications for carcinogenesis
18. Regional variations in total and nonprotein sulfhydryl compounds in the human gastric mucosa and effects of ethanol
19. S-nitrosylation of proteins with nitric oxide: Synthesis and characterization of biologically active compounds
20. Kinetics and mechanisms of nitrosation of alcohols carbohydrates and a thiol
21. S-nitrosoglutathione inhibits platelet activation in vitro and in vivo
22. NO+ NO and NO- donation by S-nitrosothiols: Implications for regulation of physiological functions by S-nitrosylation and acceleration of disulfide formation
23. Evidence for a cyclic GMP-independent mechanism in the anti-platelet action of S-nitrosoglutathione
24. Inhibition of platelet aggregation by S-nitroso-cysteine via cGMP-independent mechanisms: Evidence of inhibition of thromboxane A2 synthesis in human blood platelets
25. The aggregation of blood platelets
26. Analysis of free and protein-bound nitrotyrosine in human plasma by a gas chromatography/mass spectrometry method that avoids nitration artifacts
27. A chemiluminescence-based assay for S-nitrosoalbumin and other plasma S-nitrosothiols
28. Diffusion of peroxynitrite into the human platelet inhibits cyclooxygenase via nitration of tyrosine residues
29. Antithrombotic effects of peroxynitrite: Inhibition and reversal of aggregation in human platelets
30. Cell-mediated biotransformation of S-nitrosoglutathione
31. Dose-related kinetics of aspirin Presystemic acetylation of platelet cyclooxygenase
32. Generation of nitric oxide by a nitrite reductase activity of xanthine oxidase: A potential pathway for nitric oxide formation in the absence of nitric oxide synthase activity
33. Inhibition of platelet aggregation with glyceryl trinitrate and xanthine oxidoreductase