XRCC1 down-regulation in human cells leads to DNA-damaging agent hypersensitivity elevated sister chromatid exchange, and reduced survival of BRCA2 mutant cells

Environmental and Molecular Mutagenesis

Volumn 48, Issue 6, 2007, Pages 491-500

  Fan, Jinshui ^a   Wilson, Paul F ^b   Wong, Heng Kuan ^a   Urbin, Salustra S ^b   Thompson, Larry H ^b   Wilson III, David M ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b LAWRENCE LIVERMORE NATIONAL LABORATORY   (United States)

Author keywords

CAPAN 1; DNA base excision repair; NHF1 hTERT; X ray repair cross complementing gene 1

Indexed keywords

5 HYDROXYMETHYLDEOXYURIDINE; CARMUSTINE; DNA; MESYLIC ACID ETHYL ESTER; MESYLIC ACID METHYL ESTER; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PROTEIN XRCC1; SCAFFOLD PROTEIN; SMALL INTERFERING RNA; THYMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL SURVIVAL; CHO CELL; CHROMOSOME ABERRATION; CONTROLLED STUDY; DNA DAMAGE; DNA POLYMORPHISM; DOWN REGULATION; EXCISION REPAIR; FIBROBLAST; GENE; HELA CELL; HUMAN; HUMAN CELL; NONHUMAN; PROTEIN EXPRESSION; RNA INTERFERENCE; SISTER CHROMATID EXCHANGE; TUMOR SUPPRESSOR GENE; XRCC1 GENE;

ANIMALS; BRCA2 PROTEIN; CELL EXTRACTS; CELL SURVIVAL; CHO CELLS; CHROMOSOMAL INSTABILITY; CRICETINAE; CRICETULUS; DNA DAMAGE; DNA-BINDING PROTEINS; DOWN-REGULATION; HELA CELLS; HUMANS; METHYL METHANESULFONATE; MICRONUCLEUS TESTS; MUTAGENS; MUTATION; NEOPLASMS; RNA, SMALL INTERFERING; SISTER CHROMATID EXCHANGE; TRANSFECTION;

RODENTIA;

EID: 34547618609     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.20312     Document Type: Article

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