Endomorphin 1 and 2, endogenous ligands for the μ-opioid receptor, decrease cardiac output, and total peripheral resistance in the rat

Peptides

Volumn 18, Issue 9, 1997, Pages 1393-1397

  Champion, Hunter C ^a   Zadina, James E ^a,b   Kastin, Abba J ^a,b   Hackler, Laszlo ^a,b   Ge, Lin Jun ^a,b   Kadowitz, Philip J ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Cardiac output; Endomorphin 1 and 2; Systemic vascular bed; Vasodilator responses

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; ENDORPHIN; ISOPRENALINE; LIGAND; MU OPIATE RECEPTOR;

AMIDATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; BRAIN CORTEX; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; HEART OUTPUT; HEART RATE; IMMUNOREACTIVITY; INTRAVENOUS DRUG ADMINISTRATION; LIGAND BINDING; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; VASCULAR RESISTANCE; VASODILATATION;

ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; CARDIAC OUTPUT; CARDIOTONIC AGENTS; FEMALE; ISOPROTERENOL; LIGANDS; MALE; OLIGOPEPTIDES; OPIOID PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, MU; VASCULAR RESISTANCE;

EID: 0030669454     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(97)00210-6     Document Type: Article

References (6)

1. Champion H. C., Czapla M. A., Kadowitz P. J. Nociceptin, an endogenous ligand for the ORL1 receptor, decreases cardiac output, and total peripheral resistance in the rat. Peptides. 18:1997;729-732.
2. Czapla, M. A.; Champion, H. C.; Zadina, J. E.; Kastin, A. J.; Hackler, L.; Ge, L-J; Kadowitz, P. J. Endomorphin 1 and 2, the endogenous μ-opioid agonists, posses hypotensive activity in the rat. Life Sci. in press, 1997.
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6. Zadina J. E., Hackler L. ; Ge, L-J; Kastin, A. J. A potent and selective endogenous agonist for the mu-opiate receptor. Nature. 386:1997;499-502.