Differential roles of NR2A and NR2B subtypes in NMDA receptor-dependent protein synthesis in dendrites

Neuropharmacology

Volumn 53, Issue 2, 2007, Pages 252-256

  Tran, Dang Hai ^a   Gong, Ruomu ^a   Tang, Shao Jun ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

CaMKII; Dendritic protein synthesis; Hippocampal neurons; NMDA receptors; NR2A; NR2B

Indexed keywords

4 BENZYL ALPHA (4 HYDROXYPHENYL) BETA METHYL 1 PIPERIDINEPROPANOL; GREEN FLUORESCENT PROTEIN; IFENPRODIL; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NVP AAM 077; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DENDRITE; DRUG INHIBITION; DRUG MECHANISM; EMBRYO; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SYNTHESIS; UNTRANSLATED REGION;

ANIMALS; CELLS, CULTURED; DENDRITES; DRUG INTERACTIONS; EMBRYO, MAMMALIAN; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; GREEN FLUORESCENT PROTEINS; HIPPOCAMPUS; MICE; NEURONS; PROTEIN BIOSYNTHESIS; RECEPTORS, N-METHYL-D-ASPARTATE; TIME FACTORS; TRANSFECTION;

EID: 34547551485     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2007.05.005     Document Type: Article

References (30)

1. Aakalu G., Smith W.B., Nguyen N., Jiang C., and Schuman E.M. Dynamic visualization of local protein synthesis in hippocampal neurons. Neuron 30 (2001) 489-502
2. Banker G., and Goslin K. Culturing Nerve Cells. second ed. (2002), The MIT Press, Cambridge
3. Bartlett T.E., Bannister N.J., Collett V.J., Dargan S.L., Massey P.V., Bortolotto Z.A., Fitzjohn S.M., Bashir Z.I., Collingridge G.L., and Lodge D. Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus. Neuropharmacology 52 (2007) 60-70
4. Berberich S., Punnakkal P., Jensen V., Pawlak V., Seeburg P.H., Hvalby O., and Kohr G. Lack of NMDA receptor subtype selectivity for hippocampal long-term potentiation. J. Neurosci. 25 (2005) 6907-6910
5. Bradshaw K.D., Emptage N.J., and Bliss T.V.P. A role for dendritic protein synthesis in hippocampal late LTP. Eur. J. Neurosci. 18 (2003) 3150-3152
6. Cracco J.B., Serrano P., Moskowitz S.I., Bergold P.J., and Sacktor T.C. Protein synthesis-dependent LTP in isolated dendrites of CA1 pyramidal cells. Hippocampus 15 (2005) 551-556
7. Cull-Candy S., Brickely S., and Farrant M. NMDA receptor subunits: diversity, development and disease. Curr. Opin. Neurobiol. 11 (2001) 327-335
8. Erreger K., Dravid S.M., Banke T.G., Wyllie D.J.A., and Traynelis S.F. Subunit-specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles. J. Physiol. (Lond.) 563 (2005) 345-358
9. Fox C.J., Russell K.I., Wang Y.T., and Christie B.R. Contribution of NR2A and NR2B NMDA subunits to bidirectional synaptic plasticity in the hippocampus in vivo. Hippocampus 16 (2006) 907-915
10. Gong R., and Tang S.-J. Mitogen-activated protein kinase signaling is essential for activity-dependent dendritic protein synthesis. Neuroreport 17 (2006) 1575-1578
11. Gong R., Park C.S., Rezaei Abbassi N., and Tang S.-J. Roles of glutamate receptors and the mTOR signaling pathway in activity-dependent dendritic protein synthesis in hippocampal neurons. J. Biol. Chem. 281 (2006) 18802-18815
12. Huber K.M., Kayser M.S., and Bear M.F. Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression. Science 288 (2000) 1254-1257
13. Iwamoto T., Yamada Y., Hori K., Watanabe Y., Sobue K., and Inui M. Differential modulation of NR1-NR2A and NR1-NR2B subtypes of NMDA receptor by PDZ domain-containing proteins. J. Neurochem. 89 (2004) 100-108
14. Kandel E.R. The molecular biology of memory storage: a dialogue between genes and synapses. Science 294 (2001) 1030-1038
15. Kang H., and Schuman E.M. A requirement for local protein synthesis in neurotrophin-induced synaptic plasticity. Science 273 (1996) 1402-1406
16. Kelleher III R.J., Govindarajan A., and Tonegawa S. Translational regulatory mechanisms in persistent forms of synaptic plasticity. Neuron 44 (2004) 59-73
17. Kohr G., Jensen V., Koester H.J., Mihaljevic A.L.A., Utvik J.K., Kvello A., Ottersen O.P., Seeburg P.H., Sprengel R., and Hvalby O. Intracellular domains of NMDA receptor subtypes are determinants for long-term potentiation induction. J. Neurosci. 23 (2003) 10791-10799
18. Kutsuwada T., Kashiwabuchi N., Mori H., Sakimura K., Ksiya E., Araki K., Meguro H., Masaki H., Kumanishi T., Arakawa M., and Mishina M. Molecular diversity of the NMDA receptor channel. Nature 358 (1992) 36-41
19. Liu L., Wong T.P., Pozza M.F., Lingenhoehl K., Wang Y., Sheng M., Auberson Y.P., and Wang Y.T. Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity. Science 304 (2004) 1021-1024
20. Loftis J.M., and Janowsky A. The N-methyl-D-aspartate receptor subunit NR2B: localisation, functional properties, regulation and clinical implications. Pharmacol. Ther. 97 (2003) 55-85
21. Malgaroli A., and Tsien R.W. Glutamate-induced long-term potentiation of the frequency of miniature synaptic currents in cultured hippocampal neurons. Nature 357 (1992) 134-139
22. Massey P.V., Johnson B.E., Moult P.R., Auberson Y.P., Brown M.W., Molnar E., Collingridge G.L., and Bashir Z.I. Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression. J. Neurosci. 24 (2004) 7821-7828
23. Morishita W., Lu W., Smith G.B., Nicoll R.A., Bear M.F., and Malenka R.C. Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression. Neuropharmacology 52 (2007) 71-76
24. Rumbaugh G., and Vicini S. Distinct synaptic and extrasynaptic NMDA receptors in developing cerebellar granule neurons. J. Neurosci. 19 (1999) 10603-10610
25. Steward O., and Schuman E.M. Protein synthesis at synaptic sites on dendrites. Annu. Rev. Neurosci. 24 (2001) 299-325
26. Stocca G., and Vicini S. Increased contribution of NR2A subunit to synaptic NMDA receptors in developing rat cortical neurons. J. Physiol. (Lond.) 507 (1998) 13-24
27. Tang S.J., and Schuman E.M. Protein synthesis in the dendrite. Philos. Trans. Roy. Soc. (Lond.) Part B: Biol. Sci. 357 (2002) 521-529
28. Tovar K.R., and Westbrook G.L. The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro. J. Neurosci. 19 (1999) 4180-4188
29. Vanhoutte P., and Bading H. Opposing roles of synaptic and extrasynaptic NMDA receptors in neuronal calcium signalling and BDNF gene regulation. Curr. Opin. Neurobiol. 13 (2003) 366-371
30. Weitlauf C., Honse Y., Auberson Y.P., Mishina M., Lovinger D.M., and Winder D.G. Activation of NR2A-containing NMDA receptors is not obligatory for NMDA receptor-dependent long-term potentiation. J. Neurosci. 25 (2005) 8386-8390