Sodium fusidate-poly(D,L-lactide-co-glycolide) microspheres: Preparation, characterisation and in vivo evaluation of their effectiveness in the treatment of chronic osteomyelitis

Journal of Microencapsulation

Volumn 24, Issue 6, 2007, Pages 577-595

  Cevher, Erdal ^a,b   Orhan, Zafer ^c   Şensoy, Demet ^a   Ahiskali, Rengin ^d   Kan, Pei Lee ^b   Saǧirli, Olcay ^a   Mülazimoǧlu, Lüfiye ^d  

^a ISTANBUL UNIVERSITY   (Turkey)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c ABANT IZZET BAYSAL UNIVERSITY   (Turkey)

^d MARMARA UNIVERSITY   (Turkey)

Author keywords

Chronic osteomyelitis; Emulsion solvent evaporation method; Methicillin resistant Staphylococcus aureus; Poly(D,L lactide co glycolide) microspheres; Sodium fusidate

Indexed keywords

FUSIDATE SODIUM; METICILLIN; MICROSPHERE; POLYGLACTIN; POLYMER; SOLVENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC RESISTANCE; ARTICLE; CHRONIC OSTEOMYELITIS; CLINICAL EFFECTIVENESS; COLONY FORMING UNIT; CONTROLLED STUDY; DRUG EFFICACY; DRUG RELEASE; EMULSION; ENCAPSULATION; EVAPORATION; HEAT SENSITIVITY; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIOLOGICAL EXAMINATION; NONHUMAN; OUTCOME ASSESSMENT; PARTICLE SIZE; RAT; TEMPERATURE MEASUREMENT; TREATMENT DURATION;

ANIMALS; CALORIMETRY, DIFFERENTIAL SCANNING; CHRONIC DISEASE; DRUG CARRIERS; FUSIDIC ACID; LACTIC ACID; MALE; METHICILLIN RESISTANCE; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; OSTEOGENESIS; OSTEOMYELITIS; POLYGLYCOLIC ACID; POLYMERS; POLYVINYL ALCOHOL; RATS; RATS, WISTAR; STAPHYLOCOCCUS AUREUS;

EID: 34547507176     PISSN: 02652048     EISSN: 14645246     Source Type: Journal    
DOI: 10.1080/02652040701472584     Document Type: Article

References (42)

1. Adams, K., Couch, L., Cierny, G., Calhoun, J. and Mader, JT (1992) In vitro and in vivo evaluation of antibiotic diffusion from antibiotic-impregnated polymethylmethacrylate beads. Clinical Orthopaedics and Related Research, 278, pp. 244-252.
2. Ambrose, CG, Clyburn, TA, Louden, K., Joseph, J., Wright, J., Gulati, P., Gogola, GR and Mikos, AG (2004) Effective treatment of osteomyelitis with biodegradable microspheres in a rabbit model. Clinical Orthopaedics and Related Research, 421, pp. 293-299.
3. Atkins, B. and Gottlieb, T. (1999) Fusidic acid in bone and joint infections. International Journal of Antimicrobial Agents, 12, pp. S79-S93.
4. Barrow, EL, Winchester, GA, Staas, JK, Quenelle, DC and Barrow, WW (1998) Use of microsphere technology for targeted delivery of rifampicin to Mycobacterium tuberculosis-infected macrophages. Antimicrobial Agents and Chemotherapy, 42, pp. 2682-2689.
5. Benita, S., Benoit, JP, Puisieux, F. and Thies, C. (1984) Characterisation of drug loaded poly (-lactide) microspheres. Journal of Pharmaceutical Sciences, 73, pp. 1721-1724.
6. Billon, A., Chabaud, L., Gouyette, A., Bouler, J-M and Merle, C. (2005) Vancomycin biodegradable poly(lactide-co-glycolide) microparticles for bone implantation. Influence of the formulation parameters on the size, morphology, drug loading and in vitro release. Journal of Microencapsulation, 22, pp. 841-852.
7. Calhoun, JH and Mader, JT (1997) Treatment of osteomyelitis with a biodegradable antibiotic implant. Clinical Orthopaedics and Related Research, 341, pp. 206-214.
8. Carek, PJ, Dickerson, LM and Sack, JL (2001) Diagnosis and management of osteomyelitis. American Family Physician, 63, pp. 2413-2420.
9. Castro, C., Evora, C., Baro, M., Soriano, I. and Sanchez, E. (2005) Two-month ciprofloxacin implants for multibacterial bone infections. European Journal of Pharmaceutics and Biopharmaceutics, 60, pp. 401-406.
10. Castro, C., Sanchez, E., Delgado, A., Soriano, I., Nunez, P., Baro, M., Perera, A. and Evora, C. (2003) Ciprofloxacin implants for bone infection. In vitro-in vivo characterization. Journal of Controlled Release, 93, pp. 341-354.
11. Cevher, E., Orhan, Z., Mülazimoǧlu, L., Sensoy, D., Alper, M., Yildiz, Y. and Özsoy, Y. (2006) Characterization of biodegradable chitosan microspheres containing vancomycin and treatment of experimental osteomyelitis caused by methicillin-resistant Staphylococcus aureus with prepared microspheres. International Journal of Pharmaceutics, 317, pp. 127-135.
12. Changez, M., Koul, V. and Dinda, AK (2005) Efficacy of antibiotics-loaded interpenetrating network (IPNs) hydrogel based on poly (acrylic acid) and gelatine for treatment of experimental osteomyelitis: In vivo study. Biomaterials, 26, pp. 2095-2104.
13. Christiansen, K. (1999) Fusidic acid adverse drug reactions. International Journal of Antimicrobial Agents, 12, pp. S3-S9.
14. Council Directive 86/609/EEC (1986) European convention for the protection of vertebrate animals used for experimental and other scientific purposes. Official Journal of the Council of the European Commission Letters, 358, pp. 1-48.
15. Cui, F., Cun, D., Tao, A., Yang, M., Shi, K., Zhao, M. and Guan, Y. (2005) Preparation and characterization of melittin-loaded poly (-lactic acid) or poly (-lactic-co-glycolic acid) microspheres made by the double emulsion method. Journal of Controlled Release, 107, pp. 310-319.
16. Robinson, DH (2004) Particle size and temperature effect on the physical stability of PLGA nanospheres and microspheres containing bodipy, 5, AAPS Pharmaceutical Science and Technology
17. Garvin, KL, Miyano, JA, Robinson, D., Giger, D., Novak, J. and Radio, S. (1994) Polylactide/polyglycolide antibiotic implants in the treatment of osteomyelitis. A canine model. Journal of Bone and Joint Surgery [American], 76, pp. 1500-1506.
18. Gitelis, S. and Brebach, GT (2002) The treatment of chronic osteomyelitis with a biodegradable antibiotic-impregnated implant. Journal of Orthopaedic Surgery, 10, pp. 53-60.
19. Gursel, I., Korkusuz, F., Turesin, F., Alaeddinoglu, NG and Hasirci, V. (2001) In vivo application of biodegradable controlled antibiotic release systems for the treatment of implant-related osteomyelitis. Biomaterials, 22, pp. 73-80.
20. Henry, SL and Galloway, KP (1995) Local antibacterial therapy for the management of orthopaedic infections. Pharmacokinetic considerations. Clinical Pharmacokinetics, 29, pp. 36-45.
21. Huneault, LM, Lussier, B., Dubreuil, P., Chouinard, L. and Desevaux, C. (2004) Prevention and treatment of experimental osteomyelitis in dogs with ciprofloxacin-loaded crosslinked high amylose starch implants. Journal of Orthopaedic Research, 22, pp. 1351-1357.
22. Kanellakopoulou, K., Galanakis, N., Giamarellos-Bourboulis, EJ, Rifiotis, C., Papakostas, K., Andreopoulos, A., Dounis, E., Karagianakos, P. and Giamarellou, H. (2000) Treatment of experimental osteomyelitis caused by methicillin-resistant Staphylococcus aureus with a biodegradable system of lactic acid polymer releasing pefloxacin. Journal of Antimicrobial Chemotherapy, 46, pp. 311-314.
23. Lazarettos, J., Efstathopoulos, N., Papagelopoulos, PJ, Savvidou, OD, Kanellakopoulou, K., Giamarellou, H., Giamarellos-Bourboulis, EJ, Nikolaou, V., Kapranou, A., Papalois, A. and Papachristou, G. (2004) A bioresorbable calcium phosphate delivery system with teicoplanin for treating MRSA osteomyelitis. Clinical Orthopaedics and Related Research, 423, pp. 253-258.
24. Ray, AM Le, Chiffoleau, S., Iooss, P., Grimandi, G., Gouyette, A., Daculsi, G. and Merle, C. (2003) Vancomycin encapsulation in biodegradable poly (ε-caprolacton) microparticles for bone implantation. Influence of the formulation process on size, drug loading, in vitro release and cytocompatibility. Biomaterials, 24, pp. 443-449.
25. Mader, JT, Landon, GC and Calhoun, J. (1993) Antimicrobial treatment of osteomyelitis. Clinical Orthopaedics and Related Research, 295, pp. 87-95.
26. Mendel, V., Simanowski, HJ, Scholz, HC and Heymann, H. (2005) Therapy with gentamicin-PMMA beads, gentamicin-collagen sponge, and cefazolin for experimental osteomyelitis due to staphylococcus aureus in rats. Archives of Orthopaedic and Trauma Surgery, 125, pp. 363-368.
27. Mousset, B., Benoit, MA, Delloye, C., Bouillet, R. and Gillard, J. (1995) Biodegradable implants for potential use in bone infection. An in vitro study of antibiotic-loaded calcium sulphate. International Orthopaedics, 19, pp. 157-161.
28. Nie, L., Nicolau, DP, Tessier, PR, Kourea, HP, Browner, BD and Nightingale, CH (1998) Use of a bioabsorbable polymer for the delivery of ofloxacin during experimental osteomyelitis treatment. Journal of Orthopaedic Research, 16, pp. 76-79.
29. Norden, CW (1970) Experimental osteomyelitis. I. A description of the model. Journal of Infectious Diseases, 122, pp. 410-418.
30. O'Hara, P. and Hickey, AJ (2000) Respirable PLGA microspheres containing rifampicin for the treatment of tuberculosis: Manufacture and characterization. Pharmaceutical Research, 17, pp. 955-961.
31. O'Reilly, T. and Mader, JT (1999) Rat model of bacterial osteomyelitis of the tibia. Handbook of animal models of infection, experimental model in antimicrobial chemotherapy, pp. 560-575. Academic Press, San Diego
32. Orhan, Z., Cevher, E., Mülazimoglu, L., Gürcan, D., Alper, M., Araman, A. and Özsoy, Y. (2006) The preparation of ciprofloxacin hydrochloride-loaded chitosan and pectin microspheres. Their evaluation in an animal osteomyelitis model. Journal of Bone and Joint Surgery [British], 88, pp. 270-275.
33. Prior, S., Gamazo, C., Irache, JM, Merkle, HP and Gander, B. (2000) Gentamicin encapsulation in PLA/PLGA microspheres in view of treating Brucella infections. Journal of Controlled Release, 30, pp. 201-211.
34. Rahman, A. and Hoffman, NE (1988) High-performance liquid chromatographic determination of fusidic acid in plasma. Journal of Chromatography B, 433, pp. 159-166.
35. Rutledge, B., Huyette, D., Day, D. and Anglen, J. (2003) Treatment of osteomyelitis with local antibiotics delivered via bioabsorbable polymer. Clinical Orthopaedics and Related Research, 411, pp. 280-287.
36. Solberg, BD, Gutow, AP and Baumgaertner, MR (1999) Efficacy of gentamycin-impregnated resorbable hydroxyapatite cement in treating osteomyelitis in a rat model. Journal of Orthopaedic Trauma, 13, pp. 102-106.
37. Tsourvakas, S., Hatzigrigoris, P., Tsibinos, A., Kanellakopoulou, K., Giamarellou, H. and Dounis, E. (1995) Pharmacokinetic study of fibrin clot-ciprofloxacin complex: An in vitro and in vivo experimental investigation. Archives of Orthopaedic and Trauma Surgery, 114, pp. 295-297.
38. Turnidge, J. (1999) Fusidic acid pharmacology, pharmacokinetics and pharmacodynamics. International Journal of Antimicrobial Agents, 12, pp. S23-S34.
39. Waldvogel, FA, Medoff, G. and Swartz, MN (1970) Osteomyelitis: A review of clinical features, therapeutic considerations and unusual aspects. New England Journal of Medicine, 282, pp. 198-206.
40. Wang, J., Calhoun, JH, LeFrock, J. and Mader, JT (2003) The roles and effectiveness of adjunctive therapy in the management of musculoskeletal infections. Muskuloskeletal infections, pp. 555-585. Marcel Dekker, New York
41. Yang, YY, Wan, JP, Chung, TS, Pallathadka, PK and Heller, J. (2001) POE-PEG-POE triblock copolymeric microspheres containing protein. I. Preparation and characterization. Journal of Controlled Release, 75, pp. 115-128.
42. Zidan, AS, Sammour, OA, Hammad, MA, Megrab, NA, Hussain, MD, Khan, MA and Habib, MJ (2006) Formulation of anastrozole microparticles as biodegradable anticancer drug carriers, 7, AAPS Pharmaceutical Science and Technology