Fusidic acid pharmacology, pharmacokinetics and pharmacodynamics

International Journal of Antimicrobial Agents

Volumn 12, Issue SUPPL. 2, 1999, Pages

  Turnidge, John ^a  

^a WOMEN S AND CHILDREN S HOSPITAL   (Australia)

Author keywords

Antimicrobial agent; Fusidic acid; Pharmacodynamics; Pharmacokinetics

Indexed keywords

FUSIDIC ACID;

BACTERIAL INFECTION; CHOLESTASIS; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG PENETRATION; HUMAN; HYPOALBUMINEMIA; INTRAVENOUS DRUG ADMINISTRATION; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; PRIORITY JOURNAL; REVIEW; STAPHYLOCOCCUS AUREUS; SUSPENSION; TABLET; TOPICAL DRUG ADMINISTRATION;

EID: 0032856048     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-8579(98)00071-5     Document Type: Article

References (62)

1. The Merck Index. 11th ed. Budavari S, editor. Merck and Company, Rahway, New Jersey, 1989, p. 676.
2. Carey M.C., Small D.M. Micellar properties of sodium fusidate, a steroid antibiotic structurally resembling the bile salts. J Lipid Res. 12:1971;604-612.
3. Coello A., Meijide F., Nunez E.R., Tato J.V. Aggregation behaviour of sodium fusidate in aqueous solution. J Pharmaceut Sci. 83:1994;828-832.
4. Godtfredsen W., Roholt K., Tybring L. Fucidin: a new orally active antibiotic. Lancet. 1:1962;928-931.
5. Perry M.J., Hendricks-Gittins A., Stacey L.M., Adlard M.W., Noble W.C. Fusidane antibiotics produced by dermatophytes. J Antibiot. 36:1983;1659-1663.
6. Hikal A.H., Shibl A., El-Hoofy S. Determination of sodium fusidate and fusidic acid in dosage form by high-performance liquid chromatography and a microbiological method. J Pharmaceut Sci. 71:1982;1297-1298.
7. Carlström A., Dornbusch K., Hagelberg A. Use of electrophoresis in the identification and quantification of antibiotics administered in combinations. Scand J Infect Dis. 9:1977;46-54.
8. Rhaman A., Hoffman N.E. High-performance liquid chromatographic determination of fusidic acid in plasma. J Chromatography. 433:1988;159-166.
9. Sorensen H. Liquid chromatographic determination of fusidic acid in serum. J Chromatography. 430:1988;400-405.
10. Gatti R., Gotti R., Bonazzi D., Cavrini V. A comparative evaluation of three detectors in the HPLC analysis of sodium fusidate. Il Farmaco. 51:1996;115-119.
11. Hassan S.M., Amer S.M., Amer M.M. Determination of fusidic acid and sodium fusidate in pharmaceutical dosage forms by first-derivative ultraviolet spectrophotometry. Analyst. 112:1987;1459-1461.
12. Vladimiriv S, Fiser Z, Agbaba D, Zivanov-Stakic D. Spectrophotometric determination of fusidic acid and sodium fusidate in dosage forms. J Pharmaceut Biomed Analysis 1995;13:675-678.
13. Parsons R.L., Hossack G., Paddock G. The absorption of antibiotics in adult patients with coeliac disease. J Antimicrob Chemother. 1:1975;39-50.
14. Wise R., Pippard M., Mitchard M. The disposition of sodium fusidate in man. Br J Clin Pharmacol. 4:1977;615-619.
15. MacGowan A.P., Greig M.A., Andrews J.M., Reeves D.S., Wise R. Pharmacokinetics and tolerance of a new film-coated tablet of sodium fusidate administered as a single dose to healthy volunteers. J Antimicrob Chemother. 23:1989;409-415.
16. Taburet AM, Guibert J, Kitzis MD, Sorensen H, Acar JF, Singlas E. Pharmacokinetics of sodium fusidate after single and repeated infusions and oral administration of new formulation. J Antimicrob Chemother 1990;25 Suppl B:23-31.
17. Schepky G., Busch U., Heinzel G., Jost K., Lechner U., Mielenz H., Su C.hA. Influence of enteric coating on drug delivery and absorption of fusidic acid film-coated tablets. Pharmazeutische Industrie. 53:1991;135-139.
18. Munkholm P., Hey H., Rasmussen S.N., Johansen P.B. Antibiotic activity in serum following single and repeated oral administration of sodium fusidate in volunteers. Eur J Drug Metab Pharmacokin. 19:1994;337-341.
19. Singlas E, Kitzis MD, Guibert J, Taburet AM, Acar JF. Pharmacokinetics of sodium fusdiate in man after single and repeated infusions. J Pharmacie Clinique 1988;7 Suppl II:3341.
20. Bourget P, Duhamel J-F, Sorensen H, Roiron R. Pharmacokinetics of fusidic acid after a single dose of a new paediatric suspension. J Clin Pharm Ther 1993;18:171-177.
21. Saggers B.A., Harwood H.F., Day B.H. Serum levels with sodium fusidate. Br J Clin Pract. 22:1968;429-430.
22. Lautenbach E.E., Robinson R.G., Koornhof H.J. Serum and tissue concentrations of sodium fusidate in patients with chronic osteomyelitis and normal volunteers. S Afr J Surg. 13:1975;21-32.
23. Masterson J., Goldman L. Studies on the absorption and tolerance of a new fucidin preparation. Ir J Med Sci. 3:1970;115-122.
24. Peter J.D., Jehl F., Pottecher T., Dupeyron J.P., Monteil H. Pharmacokinetics of intravenous fusidic acid in patients with cholestasis. Antimicrob Agents Chemother. 37:1993;501-506.
25. Brown N.M., Reeves D.S., McMullin C.M. The pharmacokinetics and protein binding of patients with severe renal failure requiring either haemodialysis or continuous ambulatory peritoneal dialysis. J Antimicrob Chemother. 39:1997;803-809.
26. Vaillant L., Machet L., Taburet A.M., Sorensen H., Lorette G. Levels of fusidic acid in skin blister fluid and serum after repeated administration of two doses (250 and 500 mg). Br J Dermatol. 126:1992;591-595.
27. Godtfredsen W.O., Vangedal S. On the metabolism of fusidic acid in man. Acta Chem Scand. 20:1966;1599-1607.
28. Reeves D.S. The pharmacokinetics of fusidic acid. J Antimicrob Chemother. 20:1987;467-476.
29. Bergeron MG, Desaulniers D, Lessard C, Lemieux M, Després J-P, Métras J, Raymond G, Brochu G. Concentrations of fusidic acid, cloxacillin, and cefarnandole in sera and atrial appendages of patients undergoing cardiac surgery. Antimicrob Agents Chemother 1985;27:928-932.
30. Johns W.H., Bates T.R. Drug-cholestyramine interactions. II. Influence of cholestyramine on GI absorption of sodium fusidate. J Pharm Sci. 61:1972;735-739.
31. Vickers C.F. Percutaneous absorption of sodium fusidate and fusidic acid. Br J Dermatol. 81:1969;902-908.
32. Stüttgen G., Bauer E. Penetration and permeation into human skin of fusidic acid in different galenical formulation. Arzneimittelforschung. 38:1988;730-745.
33. Taylor P.B., Burd E.M., Tabbara K.F. Corneal and intraocular penetration of topical and subconjunctival fusidic acid. Br J Ophthalmol. 71:1987;598-601.
34. Hansen S. Intraocular penetration of fusidic acid with topical Fucithalmic. Eur J Drug Metab Pharmacokinet. 10:1985;329-331.
35. van Bijsterveld OP, Andriesse H, Nielsen BH. Fusidic acid in tear fluid: pharmacokinetic study with fusidic acid viscous eye drops. Eur J Metab Pharmacokinet 1987;12:215-218.
36. Raeburn J.A. A method for studying antibiotic concentrations in inflammatory exudate. J Clin Pathol. 24:1971;633-635.
37. Kraemer R., Schaad U.B., Lebek G., Rudeberg A., Rossi E. Sputum penetration of fusidic acid in patients with cystic fibrosis. Eur J Pediatr. 138:1982;172-175.
38. Saggers B.A., Lawson D. In vivo penetration of antibiotics into sputum in cystic fibrosis. Arch Dis Child. 43:1968;404-409.
39. Kendall S.W., Antrum R.M., Ramsden C.H., Kester R.C. A study of fucidin uptake in ischaemic tissues. Drugs Exp Clin Res. 14:1988;655-657.
40. Mindermann T., Zimmerli W., Rajacic Z., Gratzl O. Penetration of fusidic acid into human brain tissue and cerebrospinal fluid. Acta Neurochirurgica. 121:1993;124.
41. Chadwick A.J., Jackson B. Intraocular penetration of the antibiotic fucidin. Br J Ophthalmol. 53:1969;26-29.
42. Williamson J., Russell F., Doig W.M., Paterson R.W. Estimation of sodium fusidate levels in human serum, aqueous humour, and vitreous body. Br J Ophthalmol. 54:1970;126-130.
43. Sorensen B., Sejrsen P., Thomsen M. Fucidin, pro-staphlin, and penicillin concentrations in burn crusts. Acta Chir Scand. 131:1966;423-429.
44. Güttler F., Tybring L., Engberg-Pedersen H. Interaction of albumin and fusidic acid. Br J Pharmacol. 43:1971;151-160.
45. Lorezon P.P. Fusidic acid levels in synovial fluid of the knee and in bone. Zeitschrift fur Unfallmedizin und Berufskrankheiten. 72:1979;114-117.
46. Sattar M.A., Barrett S.P., Cawley M.I.D. Concentrations of some antibiotics in synovial fluid after oral administration, with special reference to antistaphylococcal activity. Annals of the Rheumatic Diseases. 42:1983;67-74.
47. Deodhar S.D., Russell F., Dick W.C., Nuki G., Buchanan W.W. Penetration of sodium fusidate (Fucidin) in the synovial cavity. Scand J Rheumatol. 1:1972;33-39.
48. Chater E.H., Flynn J., Wilson A.L. Fucidin levels in osteomyelitis. J Ir Med Assoc. 65:1972;506-508.
49. Hierholzer G., Knothe H., Rehn J., Koch F. Fusidic acid concentrations in chronically inflamed tissue: studies of chronic posttraumatic osteomyelitis. Arzneimittelforschung. 16:1966;1549-1552.
50. Hierholzer G., Knothe H., Rehn J. Penetration of fusidic acid into aseptic bone tissue. Arzneimittelforschung. 20:1970;1473-1476.
51. Sandeman JC, Percival A. Fusidic acid in the management of osteomyelitis. In: Hejzlar, Miroslav, Miroslav Semonsky, Stanislav Masak, editors. Advances in antimicrobial and antineoplastic chemotherapy: Progress in research and clinical application. Proceedings of the VIIth International Congress. Prague, Czechoslavakia Aug 23-28 1971, University Park Press: Baltimore, MD, USA. 1972:1241-1243.
52. Rolinson G.N., Sutherland R. The binding of antibiotics to serum proteins. Br J Clin Pharmacol. 25:1965;638-650.
53. Rieutord A., Bourget P., Troche G., Zazzo J.F. In vitro study of the protein binding of fusidic acid: a contribution to the comprehension of its pharmacokinetic behaviour. Int J Pharm. 119:1995;57-64.
54. Brodersen R. Fusidic acid binding to serum albumin and interaction with binding of bilirubin. Acta Paeditrica Scandinavica. 74:1985;874-880.
55. Bourget P., Quinquis-Desmaris V., Hulin A., Peter J.D., Jehl F. Study of the protein binding of fusidic acid in cholestatic individuals and comparison with in vitro findings. Int J Pharmaceutics. 128:1996;223-228.
56. Reynaud A.K., Espaze E.P., Coste-Burel M., Richet H. In vitro kinetics of the activity of fusidic acid and fluoroquinolone combinations against staphylcocci according to methicillin-resistance phenotype: implications for the treatment of osteoarticular infections. Path Biol. 40:1992;466-470.
57. Garrett E.R., Richard A.J. Kinetics and mechanisms of drug action on microorganisms XX: intergrated receptor site model rationalizing observed microbial rate dependencies on drug concentration and microbial kinetics affected by sodium fusidate. J Pharm Sci. 63:1974;884-894.
58. Drabuy Y.J., Blakemore P.H. Comparative post-antibiotic effect of five antibiotics against ten aerobic Gram-positive cocci. Drugs Exp Clin Res. 16:1990;557-563.
59. Munckhof W.J., Turnidge J.D. The postantibiotic effect of fusidic acid against Gram positive bacteria. J Antimicrob Chemother. 40:1997;433-436.
60. Drabu YJ, Blakemore PH. The post-antibiotic effect of teicopanin: monotherapy and combination studies. J Antimicrob Chemother 1991;27 Suppl B:1-7.
61. Haag R. Efficacy of penicillin G, flucloxacillin, cefazolin, fusidic acid, vancomycin, rifampicin, and fosfomycin in muscular infections in mice due to Staphylococcus aureus. Infection. 14:1986;3843.
62. Findon G., Miller T.E., Rowe L.C. Pharmacokinetics of fusidic acid in laboratory animals. Lab Anim Sci. 41:1991;462-465.