POE-PEG-POE triblock copolymeric microspheres containing protein: I. Preparation and characterization

Journal of Controlled Release

Volumn 75, Issue 1-2, 2001, Pages 115-128

  Yang, Yi Yan ^a   Wan, Jin Ping ^a   Chung, Tai Shung ^a,b   Pallathadka, Pramoda Kumari ^a   Ng, Steve ^c   Heller, Jorge ^c  

^a INSTITUTE OF MATERIALS RESEARCH AND ENGINEERING   (Singapore)

^b Department of Chemical and Environmental Engineering ^*  (Singapore)

^c Advanced Polymer Systems   (United States)

Author keywords

Microspheres; POE PEG POE triblock copolymer; Poly(ortho ester); Protein encapsulation efficiency

Indexed keywords

BOVINE SERUM ALBUMIN; COPOLYMER; M PROTEIN; MACROGOL; MICROSPHERE; POLY(ORTHO ESTER); POLYSORBATE 80; POLYVINYL ALCOHOL;

ARTICLE; CONFOCAL MICROSCOPY; DISSOLUTION; EMULSION; ENCAPSULATION; HYDROPHILICITY; MORPHOLOGY; PARTICLE SIZE; POLYMERIZATION; PRIORITY JOURNAL; ROENTGEN SPECTROSCOPY;

ALGORITHMS; CHEMISTRY, PHYSICAL; EMULSIONS; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; MOLECULAR WEIGHT; PARTICLE SIZE; POLOXAMER; POLYVINYL ALCOHOL; PROTEINS; SERUM ALBUMIN, BOVINE; SOLVENTS; VISCOSITY;

EID: 0035838327     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(01)00373-X     Document Type: Article

References (26)

1. Importance of in vitro experimental conditions on protein release kinetics, stability and polymer degradation in protein encapsulated poly(D,L-lactic acid-co-glycolic acid) microspheres
2. Visualization of pH in degrading polymer microspheres
3. Formulation strategies for the stabilization of tetanus toxoid in poly(lactide-co-glycolide) microspheres
4. Improving the delivery capacity of microparticle systems using blends of poly(DL-lactide-co-glycolide) and poly(ethylene glycol)
5. Degradation and protein release properties of microspheres prepared from biodegradable poly(lactide-co-glycolide) and ABA triblock copolymers: Influence of buffer media on polymer erosion and bovine serum albumin release
6. Optimization of preparative conditions for poly-DL-lactide-polyethylene glycol microspheres with entrapped Vibrio cholera antigens
7. Poly(ortho esters)
8. Synthesis and erosion studies of self-catalyzed poly(ortho esters)
9. Development of a poly(ortho ester) prototype with a latent acid in the polymer backbone for 5-fluorouracyl delivery
10. Use of poly(ortho esters) for the controlled release of 5-fluorouracyl and a LHRH analogue
11. Controlled release of contraceptive steroids from biodegradable and injectable gel formulations
12. Pulsatile and delayed release of lysozyme from ointment-like poly(ortho esters)
13. Poly(ortho esters) as bioerodible matrices for the controlled delivery of pyrimethamine in chemoprophylaxis of malaria
14. Studies on microencapsulation of 5-fluorouracil with poly(ortho ester) polymers
15. Effect of polymer compositions on the fabrication of poly(ortho esters) microspheres for controlled release of protein
16. POE-PEG-POE triblock copolymeric microspheres containing protein. II. Polymer erosion and protein release mechanism
17. Effect of preparation conditions on morphology and release profiles of biodegradable polymeric microspheres containing protein fabricated by double emulsion method
18. Microspheres for protein delivery prepared from amphilic multiblock copolymers 2. Modulation of release rate
19. Effect of the emulsion stability on the morphology and porosity of semicrystalline poly l-lactide microparticles prepared by w/o/w double emulsion-evaporation
20. Protein encapsulation within polyethylene glycol-coated nanospheres. I. Physicochemical characterization
21. Biodegradable microspheres as a delivery system for rismorelin porcine, a porcine-growth-hormone-releasing-hormone
22. The preparation and characterization of poly(lactide-co-glycolide) microparticles. II. The entrapment of a model protein using a (water-in-oil)-in-water emulsion solvent evaporation technique
23. A novel emulsification-solvent extraction technique for production of protein loaded biodegradable microparticles for vaccine and drug delivery