Vancomycin encapsulation in biodegradable poly(ε-caprolactone) microparticles for bone implantation. Influence of the formulation process on size, drug loading, in vitro release and cytocompatibility

Biomaterials

Volumn 24, Issue 3, 2003, Pages 443-449

  Le Ray, A M ^a   Chiffoleau, S ^a   Iooss, P ^a   Grimandi, G ^a   Gouyette, A ^a   Daculsi, G ^a   Merle, C ^a  

^a INSERM   (France)

Author keywords

Cytocompatibility; In vitro release; Microparticles; Poly( caprolactone); Solvent evaporation process; Vancomycin

Indexed keywords

ANTIINFECTIVE AGENT; BIOMATERIAL; CAPROLACTONE; HEXANOIC ACID DERIVATIVE; LACTONE; VANCOMYCIN; POLYCAPROLACTONE;

ANIMAL; ARTICLE; BIODEGRADABLE IMPLANT; BONE PROSTHESIS; CELL LINE; CHEMISTRY; DRUG DELIVERY SYSTEM; FIBROBLAST; KINETICS; METABOLISM; MOUSE; SCANNING ELECTRON MICROSCOPY; SPECTROPHOTOMETRY; TIME; ANIMAL CELL; BIOCOMPATIBILITY; BIODEGRADABILITY; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOTOXICITY; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; EMULSION; ENCAPSULATION; IMPLANTATION; IN VITRO STUDY; NONHUMAN; ORTHOPEDIC SURGERY; PARTICLE SIZE; PRIORITY JOURNAL;

ABSORBABLE IMPLANTS; ANIMALS; ANTI-BACTERIAL AGENTS; BIOCOMPATIBLE MATERIALS; BONE SUBSTITUTES; CELL LINE; DRUG DELIVERY SYSTEMS; FIBROBLASTS; HEXANOIC ACIDS; KINETICS; LACTONES; MICE; MICROSCOPY, ELECTRON, SCANNING; SPECTROPHOTOMETRY; TIME FACTORS; VANCOMYCIN;

BIODEGRADATION; BONE; DISSOLUTION; DRUG PRODUCTS; ENCAPSULATION; SCANNING ELECTRON MICROSCOPY; TOXICITY;

EMULSION TECHNIQUE;

IMPLANTS (SURGICAL);

EID: 0037290060     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0142-9612(02)00357-5     Document Type: Article

References (43)

1. Jarcho M. Calcium phosphate ceramics as hard tissue prosthetics. Clin Orthop Relat Res. 157:1981;259-278.
2. Suchanek W., Yoshimura M. Processing and properties of hydroxyapatite-based biomaterials for use as hard tissue replacement implants. J Mater Res. 13(1):1998;94-117.
3. LeGeros R.Z. Biological and synthetic apatites. LeGeros R.Z., Brown P.W., Constantz B. Hydroxyapatite and related materials. 1994;3-28 CRC Press, Boca Raton, FL.
4. LeGeros R.Z. Biodegradation and bioresorption of calcium phosphate ceramics. Clin Mater. 14:1993;65-88.
5. Fernandez E., Gil F.J., Ginebra M.P., Driessens F.C.M., Planell J.A., Best S.M. Calcium phosphate bone cements for clinical applications. Part I: solution chemistry. J Mater Sci: Mater Med. 10:1999;169-176.
6. Bouler J.M., Trécant M., Delécrin J., Royer J., Passuti N., Daculsi G. Macroporous biphasic calcium phosphate ceramics. influence of five synthetic parameters on compressive strength J Biomed Mater Res. 32:1996;603-609.
7. Pasquier G., Flautre B., Blary M.C., Anselme K., Hardouin P. Injectable percutaneous bone biomaterials. an experimental study in a rabbit model J Mater Sci: Mater Med. 7:1996;683-690.
8. Daculsi G. Biphasic calcium phosphate concept applied to artificial bone, implant coating and injectable bone substitute. Biomaterials. 19:1998;1473-1478.
9. Dupraz A., Nguyen T.P., Richard M., Delecrin J., Daculsi G. Microcharacterization of a new injectable polymer/ceramic composite as bone substitute in spine surgery. J Mater Sci: Mater Med. 7:1996;52-55.
10. Gautier H., Guicheux J., Grimandi G., Faivre-Chauvet A., Daculsi G., Merle C. In vitro influence of apatite-granule-specific area on human growth hormone loading and release. J Biomed Mater Res. 40:1998;606-613.
11. Gautier H., Merle C., Auget J.L., Daculsi G. Isostatic compression, a new process for incorporating vancomycin into biphasic calcium phosphate. comparison with a classical method Biomaterials. 21(3):2000;243-249.
12. Trécant M., Guicheux J., Grimandi G., Leroy M., Daculsi G. Dynamic compaction. a new process to compact therapeutic agent-loaded calcium phosphates Biomaterials. 18:1997;141-145.
13. Guicheux J., Grimandi G., Trécant M., Faivre A., Takahashi S., Daculsi G. Apatite as carrier for growth hormone. in vitro characterization of loading and release J Biomed Mater Res. 34:1997;165-170.
14. Downes S., Clifford C.J., Scotchford C., Klein C. Comparison of the release of growth hormone from hydroxyapatite, heat-treated hydroxyapatite, and fluoroapatite coatings on titanium. J Biomed Mater Res. 29:1995;1053-1060.
15. Itokazu M., Matsunaga T., Humazawa S., Yang W. A novel drug delivery system for osteomyelitis using porous hydroxyapatite blocks loaded by centrifugation. J Appl Biomater. 6:1995;167-169.
16. Benoit M.A., Mousset B., Delloye C., Bouillet R., Gillard J. Antibiotic-loaded plaster of Paris implants coated with poly lactic-co-glycolide as a controlled release delivery system for the treatment of bone infections. Int Orthop. 21:1997;403-408.
17. Itokazu M., Yang W., Aoki T., Ohara A., Kato N. Synthesis of antibiotic-loaded interporous hydroxyapatite blocks by vacuum method and in vitro drug release testing. Biomaterials. 19:1998;817-819.
18. Radin S., Campbell J.T., Ducheyne P., Cuckler J.M. Calcium phosphate ceramic coatings as carriers of vancomycin. Biomaterials. 18:1997;777-782.
19. Mousset B., Benoit M.A., Delloye C., Bouillet R., Gillard J. Biodegradable implants for potential use in bone infection. An in vitro study of antibiotic-loaded calcium sulphate. Int Orthop. 19:1995;157-161.
20. Iooss P., Le Ray A.M., Grimandi G., Daculsi G., Merle C. A new injectable bone substitute combining poly(ε-caprolactone) microparticles with biphasic calcium phosphate granules. Biomaterials. 22:2001;2785-2794.
21. Jameela S.R., Suma N., Jayakrishnan A. Protein release from poly(ε-caprolactone) microspheres prepared by melt encapsulation and solvent evaporation techniques. a comparative study J Biomater Sci. 8(6):1997;457-466.
22. Guzman M., Molpeceres J., Garcia F., Aberturas M.R. Preparation, characterization and in vitro drug release of poly ε-caprolactone and hydroxypropyl methylcellulose phthalate ketoprophen loaded microspheres. J Microencapsulation. 13(1):1996;25-39.
23. Youan B.B.C., Benoit M.A., Baras B., Riveau G., Gillard J. Poly (ε-caprolactone) microparticles containing muramyl dipeptide for oral controlled release of adjuvant. J Control Relat. 48:1997;339.
24. Engelberg I., Kohn J. Physico-mechanical properties of degradable polymers used in medical applications. a comparative study Biomaterials. 12(4):1991;292-304.
25. Lowry K.J., Hamson K.R., Bear L., Peng Y.B., Calaluce R., Evans M.L., Anglen J.O., Allen W.C. Polycaprolactone/glass bioabsorbable implant in a rabbit humerus fracture model. J Biomed Mater Res. 36:1997;536-541.
26. Bezwada R.S., Jamiolkowski D.D., Lee I.Y., Argawal V., Persival J., Trenka-Benthin S., Erneta M., Suryadevara J., Yang A., Liu S. Monocryl suture, a new ultra-pliable adsorbable monofilament suture. Biomaterials. 16:1996;1141-1148.
27. McDougall KE, Downes S, Corden TJ, Jones IA. Human craniofacial bone cells on poly ε-caprolactone. Proceedings of the 14th European Conference on Biomaterials, The Hague, September 1998. p. 132 [abstract].
28. Hutmacher D., Hürzeler M.B., Schliephake H. A review of material properties of biodegradable and bioresorbable polymers and devices for GTR and GBR applications. Int J Oral Maxillofac Implants. 11:1996;667-678.
29. Espuelas MS, Legrand P, Irache JM, Devissaguet JP, Ygartua P. Etude de Cytotoxicité de Nanoparticules de Poly ε-Caprolactone Associant de l'Amphotéricine B. Xèmes Journées Scientifiques du G.T.R.V., Angers, December 1995.
30. Scott D.M., Rotschafer J.C., Behrens F. Use of vancomycin and tobramycin polymethylmethacrylate impregnated beads in the management of chronic osteomyelitis. Drug Intell Clin Pharm. 22(6):1988;480-483.
31. Hamanishi C., Kitamoto K., Tanaka S., Otsuka M., Doi Y., Kitahashi T. A self-setting TTCP-DCPD apatite cement for release of vancomycin. J Biomed Mater Res. 33(3):1996;139-143.
32. Calhoun J.H., Mader J.T. Treatment of osteomyelitis with a biodegradable antibiotic implant. Clin Orthop. 341:1997;206-214.
33. Tsourvakas S., Hatzigrigoris P., Tsibinos A., Kanellakopoulou K., Giamarellou H., Dounis E. Pharmacokinetic study of fibrin clot-ciprofloxacin complex. an in vitro and in vivo experimental investigation Arch Orthop Trauma Surg. 114(5):1995;295-297.
34. Weiss P., Gauthier O., Bouler J.M., Grimandi G., Daculsi G. Injectable bone substitute using a hydrophilic polymer. Bone. 25(2 Suppl.):1999;67S-70S.
35. Grimandi G., Weiss P., Millot P., Daculsi G. In vitro evaluation of a new injectable calcium phosphate material. J Biomed Mater Res. 39:1998;660-666.
36. Malard O., Bouler J.M., Guicheux J., Heymann D., Pilet P., Coquard C., Daculsi G. Influence of biphasic calcium phosphate granulometry on bone ingrowth, ceramic resorption, and inflammatory reactions. preliminary in vitro and in vivo study J Biomed Mater Res. 46:1999;103-111.
37. Calvo P., Alonso M.J., Vila-Jato J.L., Robinson J.R. Improved ocular bioavailability of indomethacin by novel ocular drug carriers. J Pharm Pharmacol. 48:1996;1147-1152.
38. Dubernet C., Benoît J.P., Couarraze G., Duchene D. Microencapsulation of nitrofurantoin in poly ε-caprolactone. tableting and in vitro release studies Int J Pharm. 35:1987;145-156.
39. Hombreiro Perez M, Zinutti C, Hoffman M, Maincent P. Sustained release of encapsulated nifedipin and propranolol hydrochloride alone or in combination. XIIèmes Journées Scientifiques du G.T.R.V., Brussels, 1997.
40. Benoit MA, Youan BC, Gillard J, Potential of polyester microparticles for the sustained release of oral vaccine. Proceedings of the First World Meeting APGI/APV 1995. p. 431-2.
41. Masson V., Maurin F., Fessi H., Devissaguet J.P. Influence of sterilization processes on poly(ε-caprolactone) nanospheres. Biomaterials. 18:1997;327-335.
42. Technical documentation, Vancocine®, Vancomycin, Lilly France SA, Saint-Cloud, France.
43. Marchais H., Boury F., Damgé C., Proust J.E., Benoît J.P. Formulation of bovine serum albumin loaded PLGA microspheres. Influence of the process variables on the loading and in vitro release. S. T. P. Pharm Sci. 6(6):1996;417-423.