The preparation of ciprofloxacin hydrochloride-loaded chitosan and pectin microspheres. Their evaluation in an animal osteomyelitis model

Journal of Bone and Joint Surgery - Series B

Volumn 88, Issue 2, 2006, Pages 270-275

  Orhan, Z ^a   Cevher, E ^b   Mulazimoglu L ^c   Gurcan D ^b   Alper, M ^a   Araman, A ^b   Ozsoy Y ^b  

^a ABANT IZZET BAYSAL UNIVERSITY   (Turkey)

^b ISTANBUL UNIVERSITY   (Turkey)

^c MARMARA UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CHITOSAN; CIPROFLOXACIN; MICROSPHERE; PECTIN; POLYMER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; OSTEOMYELITIS; PRIORITY JOURNAL; RAT; SPRAY DRYING; SUSTAINED DRUG RELEASE;

ANIMALS; ANTI-INFECTIVE AGENTS; BIOCOMPATIBLE MATERIALS; CALORIMETRY, DIFFERENTIAL SCANNING; CHITOSAN; CIPROFLOXACIN; DELAYED-ACTION PREPARATIONS; DISEASE MODELS, ANIMAL; DRUG COMPOUNDING; DRUG EVALUATION, PRECLINICAL; MALE; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; OSTEOMYELITIS; PECTINS; RATS; RATS, WISTAR; STAPHYLOCOCCAL INFECTIONS; TREATMENT OUTCOME;

EID: 33244494016     PISSN: 0301620X     EISSN: None     Source Type: Journal    
DOI: 10.1302/0301-620X.88B2.16328     Document Type: Article

References (55)

1. Lew DP, Waldvogel FA. Osteomyelitis. Lancet 2004;364:369-79.
2. Compere EL, Metzger WI, Mitra RN. The treatment of pyogenic bone and joint infections by closed irrigation (circulation) with a non-toxic detergent and one or more antibiotics. J Bone Joint Surg [Am] 1967;49-A:614-24.
3. Finsterbush A, Weinberg H. Venous perfusion of the limb with antibiotics for osteomyelitis and other chronic infections. J Bone Joint Surg [Am] 1972;54-A: 1227-34.
4. Perry CR, Ritterbusch JK, Rice SH, Davenport K, Burdge RE. Antibiotics delivered by an implantable drug pump: a new application for treating osteomyelitis. Am J Med 1986;80:222-7.
5. Perry CR, Rice S. Ritterbusch JK, Burdge RE. Local administration of antibiotics with an implantable osmotic pump. Clin Orthop 1985;192:284-90.
6. Adams K, Couch L, Cierny C, Calhoun J, Mader JT. In vitro and in vivo evaluation of antibiotic diffusion from antibiotic-impregnated polymethylmethacrylate beads. Clin Orthop 1992;278:244-52.
7. Mousset B, Benoit MA, Delloye C, Bouillet R, Gillard J. Biodegradable implants for potential use in bone infection: an in vitro study of antibiotic-loaded calcium sulphate. Int Orthop 1995;19:157-61.
8. Solberg BD, Gutow AP, Baumgaertner MR. Efficacy of gentamycin-impregnated resorbable hydroxyapatite cement in treating osteomyelitis in a rat model. J Orthop Trauma 1999;13:102-6.
9. Rutledge B, Huyette D, Day D, Anglen J. Treatment of osteomyelitis with local antibiotics delivered via bioabsorbable polymer. Clin Orthop 2003;411:280-7.
10. Hendricks KJ, Lane D, Burd TA, et al. Elution characteristics of tobramycin from polycaprolactone in a rabbit model. Clin Orthop 2001;392:418-26.
11. Castro C, Sanchez E, Delgado A, et al. Ciprofloxacin implants for bone infection: in vitro-in vivo characterization. J Control Release 2003;93:341-54.
12. Kanellakopoulou K, Galanakis N, Giamarellos-Bourboulis EJ, et al. Treatment of experimental osteomyelitis caused by methicillin-resistant Staphylococcus aureus with a biodegradable system of lactic acid polymer releasing pefloxacin. J Antimicrob Chemother 2000;46:311-14.
13. Garvin KL, Miyano JA, Robinson D, et al. Polylactide/polyglycolide antibiotic implants in the treatment of osteomyelitis: a canine model. J Bone Joint Surg [Am] 1994;76-A:1500-6.
14. Nie L, Nicolau DP, Tessier PR, et al. Use of a bioabsorbable polymer for the delivery of ofloxacin during experimental osteomyelitis treatment. J Orthop Res 1998;16: 76-9.
15. Tsourvakas S, Hatzigrigoris F, Tsibinos A, et al. Pharmacokinetic study of fibrin clot-ciprofloxacin complex: an in vitro and in vivo experimental investigation. Arch Orthop Trauma Surg 1995;114:295-7.
16. Stemberger A, Grimm H, Bader F, Rahn HD, Ascherl R. Local treatment of bone and soft tissue infections with the collagen-gentamicin sponge. Eur J Surg Suppl 1997;578:17-26.
17. Mendel V, Simanowski HJ, Scholz HC, Heymann H. Therapy with gentamicin-PMMA beads, gentamicin-collagen sponge, and cefazolin for experimental osteomyelitis due to staphylococcus aureus in rats. Arch Orthop Trauma Surg 2005;125:363-8.
18. Johansson A, Flock JI, Svensson O. Collagen and fibronectin binding in experimental staphylococcal osteomyelitis. Clin Orthop 2001;382:241-6.
19. Kanellakopoulou K, Giamarellos-Bourboulis EJ. Carrier systems for the local delivery of antibiotics in bone infections. Drugs 2000;59:1223-32.
20. Davis R, Markham A, Balfour JA. Ciprofloxacin: an updated review of its pharmacology, therapeutic efficacy and tolerability. Drugs 1996;51:1019-74.
21. Kamath UR, Singh UV, Udupa N. Evaluation of ciprofloxacin hydrochloride ocular preparations. Indian J Pharm Sci 1993;55:148-50.
22. Özsoy Y, Tuncel T, Can A, et al. In vivo studies on nasal preparations of ciprofloxacin hydrochloride. Pharmazie 2000;55:607-9.
23. Chowdary KPR, Kumar PA. Formulation and evaluation of topical drug delivery systems of ciprofloxacin. Indian J Pharm Sci 1996;58:47-50.
24. Martinez B, Lairion F, Pena MB, Di Rocco P, Nacucchio MC. In vitro ciprofloxacin release from poly(lactide-co-glycolide) microspheres. Microencapsul 1997;14: 155-61.
25. Owusu-Ababio G, Rogers J. Formulation and release of ciprofloxacin from poly (L-lactic acid) microparticles. Eur J Pharm Biopharm 1995;42:188-92.
26. Page-Clisson ME, Pinto-Alphandary H, Ourevitch M, Andremont A, Couvreur P. Development of ciprofloxacin-loaded nanoparticles: physicochemical study of the drug carrier. J Control Release 1998;56:23-32.
27. Fawaz F, Guyot M, Lagueny AM, Devissaguet JPh. Ciprofloxacin-loaded poly-isobutylcyanoacrylate nanoparticles: preparation and characterization. Int J Pharm 1997;154:191-203.
28. Gursoy A, Senyucel B. Characterization of ciprofloxacin liposomes: derivative ultraviolet spectrophotometric determinations. J Microencapsul 1997;14:769-76.
29. Desevaux C, Dubreuil P, Lenaerts V. Characterization of crosslinked high amylose starch matrix implants: in vitro release of ciprofloxacin. J Control Release 2002;82: 83-93.
30. Ramchandani M, Robinson D. In vitro and in vivo release of ciprofloxacin from PLGA 50:50 implants. J Control Release 1998;54:167-75.
31. Giunchedi P, Conte U, Chetoni P, Saettone MF. Pectin microspheres as ophthalmic carriers for piroxicam: evaluation in vitro and in vivo in albino rabbits. Eur J Pharm Sci 1999;9:1-7.
32. Wong TW, Chan LW, Lee HY, Heng PW. Release characteristics of pectin microspheres prepared by an emulsification technique. J Microencapsul 2002;19:511-22.
33. Sinha VR, Singla AK, Wadhawan S, et al. Chiltosan microspheres as a potential carrier for drugs. Int J Pharm 2004;274:1-33.
34. Benoit JP, Marchais H, Rolland H, Velde W. Biodegradable microspheres: advances in production technology. In: Benita S, ed. Microencapsulation: methods and industrial applications. New York: Marcel Dekker, 1996;35-72.
35. Bitz C, Doelker E. Influence of the preparation method on residual solvents in biodegradable microspheres. Int J Pharm 1996;131:171-81.
36. Council Directive 86/609/EEC. European Convention for the protection of vertebrate animals used for experimental and other scientific purposes. Off J C Eur Comm L 1986;358:1-48.
37. Norden CW. Experimental osteomyelitis. I: a description of the model. J Infect Dis 1970;122:410-18.
38. O'Reilly T, Mader JT. Rat model of bacterial osteomyelitis of the tibia. In: Zak O, Sande MA, eds. Handbook of animal models of infection: experimental model in antimicrobial chemotherapy. San Diego: Academic Press, 1999;560-75.
39. Mader JT, Landon GC, Calhoun J. Antimicrobial treatment of osteomyelitis. Clin Orthop 1993;295:87-95.
40. Henry SL, Galloway KP. Local antibacterial therapy for the management of orthopaedic infections: pharmacokinetic considerations. Clin Pharmacokinet 1995;29:36-45.
41. Buchholz HW, Elson RA, Heinert K. Antibiotic-loaded acrylic cement: current concepts. Clin Orthop 1984;190:96-108.
42. Kawanabe K, Okada Y, Matsusue Y, Lida H, Nakamura T. Treatment of osteomyelitis with antibiotic-soaked porous glass ceramic. J Bone Joint Surg [Br] 1998; 80-B:527-30.
43. Korkusuz F, Uchida A, Shinto Y, et al. Experimental implant-related osteomyelitis treated by antibiotic-calcium hydroxyapatite ceramic composites. J Bone Joint Surg [Br] 1993;71-B:111-14.
44. Gürsel I, Korkusuz F, Türesin F, Alaeddinoglu NC, Hasirci V. In vivo application of biodegradable controlled antibiotic release systems for the treatment of implant-related osteomyelitis. Biomaterials 2001;22:73-80.
45. Rossi S, Azghani AO, Omri A. Antimicrobial efficacy of a new antibiotic-loaded poly (hydroxybutyric-co-hydroxyvaleric acid) controlled release system. J Antimicrob Chemother 2004;56:1013-18.
46. Lucke M, Schmidmaier G, Sadoni S, et al. Gentamisin coating of metallic implants reduces implant-related osteomyelitis in rats. Bone 2003;32:521-31.
47. Mäkinen TJ, Veiranto M, Knuuti J, et al. Efficiacy of bioabsorbable antibiotic containing bone screw in the prevention of biomaterial-related infection due to Staphylococcus aureus. Bone 2005;36:292-9.
48. Lucke M, Wildemann B, Sadoni S, et al. Systemic versus local application of gentamicin in prophylaxis of implant-related osteomyelitis in a rat model. Bone 2005;36: 770-8.
49. Koort JK, Mäkinen T, Suokas E, et al. Efficacy of ciprofloxacin-releasing bioabsorbable osteoconductive bone defect filler for treatment of experimental osteomyelitis due to Staphylococcus aureus. Antimicrob Agents Chemother 2005;49:1502-8.
50. Lazarettos J, Efstathopoulos N, Papagelopoulos PJ, et al. A bioresorbable calcium phosphate delivery system with teicoplanin for treating MRSA osteomyelitis. Clin Orthop 2004;423:253-8.
51. Huneault LH, Lussier B, Dubreuil P, Chouinard L, Desevaux C. Prevention and treatment of experimental osteomyelitis in dogs with ciprofloxacin-loaded crosslinked high amylase starch implants. J Orthop Res 2004;22:1351-7.
52. Lew DP, Valdvogel FA. Use of quinolones in osteomyelitis and infected orthopaedic prosthesis. Drugs 1999;58:85-91.
53. Owusu-Ababio G, Rogers S, Anwar H. Effectiveness of ciprofloxacin microspheres in eradicating bacterial biofilm. J Control Release 1999;57:151-9.
54. Soboh F, Khoury AE, Zamboni AC, Davidson D, Mittelman MW. Effects of ciprofloxacin and protamine sulfate combinations against catheter-associated Pseudomonas aeruginosa biofilms. Antimicrob Agents Chemother 1995;39:1281-6.
55. Wang J, Calhoun JH, LeFrock J, Mader JT. The role and effectiveness of adjunctive therapy in the management of musculoskeletal infections. In: Calhoun JH, Mader JT, eds. Musculoskeletal infections. New York: Marcel Dekker 2003:555-85.