Androgen regulates the level and subcellular distribution of the AU-rich ribonucleic acid-binding protein HuR both in vitro and in vivo

Endocrinology

Volumn 142, Issue 6, 2001, Pages 2361-2368

  Sheflin, Lowell G ^a   Zhang, Wan ^c   Spaulding, Stephen W ^a,b  

^a UNIVERSITY AT BUFFALO   (United States)

^b Ctr Positron Emission Tomography   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROSTANOLONE; HUR PROTEIN; RNA BINDING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FEMALE; HORMONAL REGULATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; ORCHIECTOMY; POLYSOME; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RNA METABOLISM; SPLEEN; SUBMANDIBULAR GLAND; THYROID GLAND; TRANSCRIPTION REGULATION;

EID: 0035015880     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.142.6.8164     Document Type: Article

References (42)

1. 1. Lafon I, Carballes F, Brewer G, Poiret M, Morello D 1998 Developmental expression of AUF1 and HuR, two c-myc mRNA binding proteins. Oncogene 16:3413-3421
2. 2. Blaxall BC, Dwyer-Nield LD, Bauer AK, Bohlmeyer TJ, Malkinson AM, Port JD 2000 Differential expression and localization of the mRNA binding proteins, AU-rich element mRNA binding protein (AUF1) and Hu antigen R (HuR) in neoplastic lung tissue. Mol Cartinog 28:76-83
3. 3. Mitchell P, Tollervey D 2000 mRNA stability in eukaryotes. Curr Opin Genet 10:193-198
4. 4. Gallouzi IE, Brennan CM, Stenberg MG, Swanson MS, Eversole A, Maizels N, Steitz JA 2000 HuR binding to cytoplasmic mRNA is perturbed by heat shock. Proc Natl Acad Sci USA 97:3073-3078
5. 5. DeMaria CT, Brewer G 1996 AUF1 binding affinity to A+U-rich elements correlates with rapid mRNA degradation. J Biol Chem 271:12179-12184
6. 6. Wagner BJ, DeMaria CT, Sun Y, Wison GM, Brewer G 1998 Structure and genomic organization of the human AUF1 gene: alternative pre-mRNA splicing generates four protein isoforms. Genomics 48:195-202
7. 7. Ma W-J, Cheng S, Campbell C, Wright A, Fumeaux H 1996 Cloning and characterization of HuR, a ubiquitiously expressed Elav-like protein. J Biol Chem 271:8144-8151
8. 8. Krecic AM, Swanson MS 2000 hnRNP complexes: composition, structure, and function. Curr Opin Cell Biol 11:363-371
9. 9. Sokolowski M, Furneaux H, Schwartz S 1999 The inhibitory activity of the AU-rich RNA element in the human papillomavirus type 1 late 3′ untranslated region correlates with its affinity for the elav-like HuR protein. J Virol 73:1080-1091
10. 10. Carlsson A, Schwartz S 2000 Inhibitory activity of the human papillomavirus type 1 AU-rkh element correlates inversely with the levels of the elav-like HuR protein in the cell cytoplasm. Arch Virol 145:491-503
11. 11. Maurer F, Tiemey M, Medcalf RL 1999 An AU-rich sequence in the 3′-UTR of plasminogen activator inhibitor type 2 (PAI-2) mRNA promotes PAI-2 mRNA decay and provides a binding site for nuclear HuR. Nucleic Acids Res 27:1664-1673
12. 12. Blaxall BC, Pellett AC, Wu SC, Pende A, Port JD 2000 Purification and characterization of β-adrenergic receptor mRNA-binding proteins. J Biol Chem 274:4290-4297
13. 13. Ford LF, Watson J, Keene JD, Wilusz, J 1999 ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system. Genes Dev 13:188-201
14. 14. Zhao Z, Chang F-C, Furneaux HM 2000 The identification of an endonuclease that cleaves within an HuR binding site in mRNA. Nucleic Acids Res 28:2695-2701
15. 15. Keene JD 1999 Why is Hu where? Shuttling of early-response-gene messenger RNA subsets. Proc Natl Acad Sci USA 96:5-7
16. 16. Good PJ 1995 A conserved family of elav-like genes in vertebrates, Proc Natl Acad Sci USA 92:4557-4561
17. 17. Atasoy U, Watson J, Patel D, Keene JD 1998 ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T-cell activation. J Cell Sci 111:3145-3156
18. 18. Fan XC, Steitz JA 1998 HNS, a nuclear-cytoplasmic shuttling sequence in HuR. Proc Natl Acad Sci USA 95:1593-1598
19. 19. Izaurralde E, Jarmolowski A, Beisel C, Mattaj IW, Dreyfuss G, Fischer U 1997 A role for the M9 transport signal of hnRNP A1 in mRNA nuclear export. J Cell Biol 137:27-35
20. 20. Peng SS-Y, Chen C-YA, Xu N, Shyu A-B 1998 RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein. EMBO J 17:3461-3470
21. 21. Wang W, Furneaux H, Cheng H, Caldwell MC, Hutter D, Liu Y, Holbrook N, Gorospe M 2000 HuR regulates p21 mRNA stabilization by UV light. Mol Cell Biol 20:760-769
22. 22. Sheflin LG, Brooks EM, Spaulding SW 1996 Testosterone regulates tissue-specific changes in the binding of a 47-kilodalton protein to a highly conserved sequence in the 3′ untranslated region of epidermal growth factor messenger ribonucleic acid. Endocrinology 137:2910-2917
23. 23. Sheflin LG, Spaulding SW 2000 Testosterone and dihydrotestosterone regulate AUF1 isoforms in a tissue-specific fashion in the mouse. Am J Physiol 278:E50-E57
24. 24. Sheflin L, Keegan B, Zhang W, Spaulding SW 2000 Inhibiting proteasomes in human HepG2 and LNCaP cells increases endogenous androgen receptor levels. Biochem Biophys Res Commun 276:144-150
25. 25. Tolnay M, Barany L, Tsokos GC 2000 Heterogenous nuclear ribonucleoprotein D0 contains transactivator and DNA-binding domains. Biochem J 348:151-158
26. 26. Yeap BB, Krueger RG, Leedman PJ 1999 Differential posttranscriptional regulation of androgen receptor gene expression by androgen in prostate and breast cancer cells. Endocrinology 140:3282-3291
27. 27. Mora GR, Mahesh VB 1999 Autoregulation of the androgen receptor at the translational level: testosterone induces accumulation of androgen receptor mRNA in the rat ventral prostate polyribosomes. Steroids 64:587-591
28. 25. Berger FG, Loose D, Meisner H, Watson G 1986 Androgen induction of messenger RNA concentrations in mouse kidney is posttranscriptional. Biochemistry 25:1170-1175
29. 29. Berger FG, Watson G 1989 Androgen-regulated gene expression. Annu Rev Physiol 51:51-65
30. 30. Lagnado CA, Brown CY, Goodall GJ 1994 AUUUA is not sufficient to promote poly(A) shortening and degradation of an mRNA; the functional sequence within AU-rich elements may be UUAUUUA(U/A)(U/A). Mol Cell Biol 14:7984-7995
31. 31. Wilson GM, Sun Y, Sellers J, Lu H, Penkar N, Dillard G, Brewer G 1999 Regulation of AUF1 expression via conserved alternatively spliced elements in the 3′ untranslated region. Mol Cell Biol 19:4056-4064
32. 32. McCulloch RK, Walker CE, Chakera A, Jazayeri J, Leedman PJ 1998 Regulation of EGF-receptor expression by EGF and TGF alpha in epidermoid cancer cells is cell type-specific. Int J Biochem Cell Biol 30:1265-1278
33. 33. Brennan CM, Gallouzi IE, Steitz JA 2000 Protein ligands to HuR modulate its interaction with target mRNAs in vivo. J Cell Biol 151:1-14
34. 34. Arao Y, Kuriyama R, Kayama F, Kalo S 2000 A nuclear matrix-associated factor, SAF-B, interacts with specific isuforms of AUF1/hnRNPD. Arch Biochem Biophys 380:228-236
35. 35. Gouble A, Morrello D 2000 Synchronous and regulated expression of two AU-binding proteins, AUF1 and HuR, throughout murine development. Oncogene 19:5377-5384
36. 36. Fan XC, Steitz JA 1998 Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increase the in vivo stability of ARE-containing rnRNAs. EMBO J 17:3448-3460
37. 37. Bennett S, Joshua A, Russel P 1997 Reliable method of isolating transfected clones from the LNCaP human prostatic cell line. BioTechniques 23:66-70
38. 38. Thalman GN, Anezints PE, Chang SM, Zhau HE, Kim EE, Hopwood VL, Pathak S, von Eschenbach AC, Chung LW 1994 Androgen-independent cancer progression and bone metastasis in the LNCaP model of human prostate cancer, Cancer Res 54:2577-2581
39. 4 integrin-mediated invasive phenotype. Endocrinology 141:3172-3182
40. 40. Haeussler J, Haeusler J, Striebel AM, Assum G, Vogel W, Furneaux H, Krone W 2000 Tumor antigen HuR binds specifically to one of five protein-binding segments in the 3′-untranslated region of the neurofibromin messenger RNA. Biochem Biophys Res Commun 267:726-732
41. 41. Wang W, Caldwell MC, Lin S, Furneaux H, Gorospe M 2000 HuR regulates cyclin A, and cyclin B1 mRNA stability during cell proliferation. EMBO J 19:2340-2350
42. 42. Koffa MD, Graham SV, Takagaki Y, Manley JL, Clements JB 2000 The human papillomavirus type 16 negative regulatory RNA element interacts with three proteins that act at different posttranscriptional levels. Proc Natl Acad Sci USA 97:4677-4682