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Volumn 2, Issue 7, 2007, Pages 935-947

Functional drug candidate profiling using complex human organotypic cell culture models: A promising way to reduce clinical drug failure

Author keywords

Chronic inflammation; Clinical trials; Co culture; Cytokines; Drug screening; Human; In vitro model; In vitro pharmacology; Organotypic

Indexed keywords

ANTIINFLAMMATORY AGENT; CALENDULA EXTRACT; CORTISONE; CYCLOOXYGENASE 2 INHIBITOR; DICLOFENAC; GAMMA INTERFERON; HYDROCORTISONE; IMMUNOMODULATING AGENT; IMMUNOSUPPRESSIVE AGENT; MONOCLONAL ANTIBODY CD28; NONSTEROID ANTIINFLAMMATORY AGENT; PROBIOTIC AGENT; TGN 1412; UNCLASSIFIED DRUG;

EID: 34547452132     PISSN: 17460441     EISSN: None     Source Type: Journal    
DOI: 10.1517/17460441.2.7.935     Document Type: Review
Times cited : (2)

References (69)
  • 1
    • 15944417512 scopus 로고    scopus 로고
    • Techniques: High-throughput measurement of intracellular Ca(2+) - back to basics
    • MONTEITH GR, BIRD GS: Techniques: high-throughput measurement of intracellular Ca(2+) - back to basics. Trends Pharmacol. Sci. (2005) 26(4):218-223.
    • (2005) Trends Pharmacol. Sci , vol.26 , Issue.4 , pp. 218-223
    • MONTEITH, G.R.1    BIRD, G.S.2
  • 2
    • 0037850027 scopus 로고    scopus 로고
    • Reporter gene assays and their applications to bioassays of natural products
    • NEW DC, MILLER-MARTINI DM, WONG YH: Reporter gene assays and their applications to bioassays of natural products. Phytother. Res. (2003) 17(5):439-448.
    • (2003) Phytother. Res , vol.17 , Issue.5 , pp. 439-448
    • NEW, D.C.1    MILLER-MARTINI, D.M.2    WONG, Y.H.3
  • 3
    • 33644844520 scopus 로고    scopus 로고
    • Microarray technology: Beyond transcript profiling and genotype analysis
    • HOHEISEL JD: Microarray technology: beyond transcript profiling and genotype analysis. Nat. Rev. Genet. (2006) 7(3):200-210.
    • (2006) Nat. Rev. Genet , vol.7 , Issue.3 , pp. 200-210
    • HOHEISEL, J.D.1
  • 6
    • 34247566181 scopus 로고    scopus 로고
    • Humanized mice as a model for rheumatoid arthritis
    • EMING R, VISCONTI K, HALL F et al.: Humanized mice as a model for rheumatoid arthritis. Arthritis Res. (2002) 4(Suppl. 3):S133-S140.
    • (2002) Arthritis Res , vol.4 , Issue.SUPPL. 3
    • EMING, R.1    VISCONTI, K.2    HALL, F.3
  • 7
    • 0030799599 scopus 로고    scopus 로고
    • Incomplete rescue of cystic fibrosis transmembrane conductance regulator deficient mice by the human CFTR cDNA
    • ROZMAHEL R, GYOMOREY K, PLYTE S et al.: Incomplete rescue of cystic fibrosis transmembrane conductance regulator deficient mice by the human CFTR cDNA. Hum. Mol. Genet. (1997) 6(7):1153-1162.
    • (1997) Hum. Mol. Genet , vol.6 , Issue.7 , pp. 1153-1162
    • ROZMAHEL, R.1    GYOMOREY, K.2    PLYTE, S.3
  • 8
    • 1342303482 scopus 로고    scopus 로고
    • Of mice and not men: Differences between mouse and human immunology
    • MESTAS J, HUGHES CCW: Of mice and not men: differences between mouse and human immunology. J. Immunol. (2004) 172:2731-2738.
    • (2004) J. Immunol , vol.172 , pp. 2731-2738
    • MESTAS, J.1    HUGHES, C.C.W.2
  • 9
    • 0001929693 scopus 로고    scopus 로고
    • Cytokines in acute and chronic inflammation
    • FEGHALI CA, WRIGHT TM: Cytokines in acute and chronic inflammation. Front. Biosci. (1997) 2:2-26.
    • (1997) Front. Biosci , vol.2 , pp. 2-26
    • FEGHALI, C.A.1    WRIGHT, T.M.2
  • 10
    • 33748416499 scopus 로고    scopus 로고
    • Cytokine storm in a Phase I trial of the anti-CD28 monoclonal antibody TGN1412
    • SUNTHARALINGAM G, PERRY MR, WARD S et al.: Cytokine storm in a Phase I trial of the anti-CD28 monoclonal antibody TGN1412. N. Engl. J. Med. (2006) 355(10):1018-1028.
    • (2006) N. Engl. J. Med , vol.355 , Issue.10 , pp. 1018-1028
    • SUNTHARALINGAM, G.1    PERRY, M.R.2    WARD, S.3
  • 11
    • 0038724906 scopus 로고    scopus 로고
    • Microarray profiling of human skeletal muscle reveals that insulin regulates approximately 800 genes during a hyperinsulinemic clamp
    • ROME S, CLEMENT K, RABASA-LHORET R et al.: Microarray profiling of human skeletal muscle reveals that insulin regulates approximately 800 genes during a hyperinsulinemic clamp. J. Biol. Chem. (2003) 278(20):18063-18068.
    • (2003) J. Biol. Chem , vol.278 , Issue.20 , pp. 18063-18068
    • ROME, S.1    CLEMENT, K.2    RABASA-LHORET, R.3
  • 12
    • 33745463739 scopus 로고    scopus 로고
    • A comprehensive map of the toll-like receptor signaling network
    • Epub ahead of print
    • ODA K, KITANO H: A comprehensive map of the toll-like receptor signaling network. Mol. Syst. Biol. (2006) [Epub ahead of print].
    • (2006) Mol. Syst. Biol
    • ODA, K.1    KITANO, H.2
  • 13
    • 33748135662 scopus 로고    scopus 로고
    • Molecular signatures induced by interleukin-2 on peripheral blood mononuclear cells and T cell subsets
    • Epub ahead of print
    • PING J, WANG E, PROVENZANO M et al.: Molecular signatures induced by interleukin-2 on peripheral blood mononuclear cells and T cell subsets. J. Transl. Med. (2006) [Epub ahead of print].
    • (2006) J. Transl. Med
    • PING, J.1    WANG, E.2    PROVENZANO, M.3
  • 14
    • 0037370311 scopus 로고    scopus 로고
    • Natural variation in human gene expression assessed in lymphoblastoid cells
    • CHEUNG VG, CONLIN LK, WEBER TM et al.: Natural variation in human gene expression assessed in lymphoblastoid cells. Nat. Genet. (2003) 33(3):422-425.
    • (2003) Nat. Genet , vol.33 , Issue.3 , pp. 422-425
    • CHEUNG, V.G.1    CONLIN, L.K.2    WEBER, T.M.3
  • 15
    • 0142216213 scopus 로고    scopus 로고
    • Methylation and demethylation in the resolution of genes, cell and responses in the immune system
    • FITZPATRICK DR, WILSON CB: Methylation and demethylation in the resolution of genes, cell and responses in the immune system. Clin. Immunol. (2003) 109:37-45.
    • (2003) Clin. Immunol , vol.109 , pp. 37-45
    • FITZPATRICK, D.R.1    WILSON, C.B.2
  • 16
    • 34547448184 scopus 로고    scopus 로고
    • FAN J, HELLER NM, GOROSPE M et al.: The role of post-transcriptional regulation in chemokine gene expression in inflammation and allergy. In: Series Signalling and Transcriptional Regulation in Inflammatory and Immune Cells: Importance in Lung Biology and Disease'. Chung KF, Adcock IM (FAs), No. 1 in this Series.
    • FAN J, HELLER NM, GOROSPE M et al.: The role of post-transcriptional regulation in chemokine gene expression in inflammation and allergy. In: Series "Signalling and Transcriptional Regulation in Inflammatory and Immune Cells: Importance in Lung Biology and Disease'. Chung KF, Adcock IM (FAs), No. 1 in this Series.
  • 17
    • 0035174962 scopus 로고    scopus 로고
    • The regulation of interlekin-8 by hypoxia in human macrophages - a potential role in the pathogenesis of the acute respiratory distress syndrome (ARDS)
    • HIRANI V, ANTONICELLI F, STRIETER RM et al.: The regulation of interlekin-8 by hypoxia in human macrophages - a potential role in the pathogenesis of the acute respiratory distress syndrome (ARDS). Mol. Med. (2001) 7(10):685-697.
    • (2001) Mol. Med , vol.7 , Issue.10 , pp. 685-697
    • HIRANI, V.1    ANTONICELLI, F.2    STRIETER, R.M.3
  • 18
    • 0033967258 scopus 로고    scopus 로고
    • Redox regulation of NF-κB: Therapeutic potential for attenuating inflammatory responses
    • CHRISTMAN JW, BLACKWELL TS, JUURLINK BJH: Redox regulation of NF-κB: therapeutic potential for attenuating inflammatory responses. Brain Pathol. (2000) 10:153-162.
    • (2000) Brain Pathol , vol.10 , pp. 153-162
    • CHRISTMAN, J.W.1    BLACKWELL, T.S.2    JUURLINK, B.J.H.3
  • 19
    • 0344183093 scopus 로고    scopus 로고
    • Evidence for a crucial role of neutrophil derivd serum proteases in the inactivation of interleukin-6 at sites of inflammation
    • BANK U, KÜPPER B, REINHOLD D et al.: Evidence for a crucial role of neutrophil derivd serum proteases in the inactivation of interleukin-6 at sites of inflammation. FEBS Lett. (1999) 461:235-240.
    • (1999) FEBS Lett , vol.461 , pp. 235-240
    • BANK, U.1    KÜPPER, B.2    REINHOLD, D.3
  • 20
    • 7944224566 scopus 로고    scopus 로고
    • The role of protease activation of inflammation in allergic respiratory diseases
    • REED CE, KITA H: The role of protease activation of inflammation in allergic respiratory diseases. J. Allergy Clin. Immunol. (2004) 114:997-1008.
    • (2004) J. Allergy Clin. Immunol , vol.114 , pp. 997-1008
    • REED, C.E.1    KITA, H.2
  • 21
    • 32944470765 scopus 로고    scopus 로고
    • Cryopyrin activates the inflammasome in response to toxins and ATP
    • MARIATHASAN S, WEIS DS, NEWTON K et al.: Cryopyrin activates the inflammasome in response to toxins and ATP. Nature (2006) 440(7081):228-232.
    • (2006) Nature , vol.440 , Issue.7081 , pp. 228-232
    • MARIATHASAN, S.1    WEIS, D.S.2    NEWTON, K.3
  • 22
    • 32944462834 scopus 로고    scopus 로고
    • Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3
    • KANNEGANTI TD, OZOREN N, BODY-MALAPEL M et al.: Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature (2006) 440(7081):233-236.
    • (2006) Nature , vol.440 , Issue.7081 , pp. 233-236
    • KANNEGANTI, T.D.1    OZOREN, N.2    BODY-MALAPEL, M.3
  • 23
    • 32244447306 scopus 로고    scopus 로고
    • Gastrointestinal inflammation: A central component of mucosal defense and repair
    • MARTIN GR, WALLACE JL: Gastrointestinal inflammation: a central component of mucosal defense and repair. Exp. Biol. Med. (2006) 231(2):130-137.
    • (2006) Exp. Biol. Med , vol.231 , Issue.2 , pp. 130-137
    • MARTIN, G.R.1    WALLACE, J.L.2
  • 24
    • 16844386086 scopus 로고    scopus 로고
    • Intestinal epithelial TOLLerance versus InTOLLerance of commensals
    • CARIO E, PODOLSKY DK: Intestinal epithelial TOLLerance versus InTOLLerance of commensals. Mol. Immunol. (2005) 42:883-893.
    • (2005) Mol. Immunol , vol.42 , pp. 883-893
    • CARIO, E.1    PODOLSKY, D.K.2
  • 25
    • 13244283293 scopus 로고    scopus 로고
    • Chemokines and their receptors in the pathogenesis of allergic asthma: Progress and perspective
    • BISSET LR, SCHMID-GRENDELMEIER P: Chemokines and their receptors in the pathogenesis of allergic asthma: progress and perspective. Curr. Opin. Pulm. Med. (2005) 11(1):35-42.
    • (2005) Curr. Opin. Pulm. Med , vol.11 , Issue.1 , pp. 35-42
    • BISSET, L.R.1    SCHMID-GRENDELMEIER, P.2
  • 27
    • 33646575644 scopus 로고    scopus 로고
    • Emerging drugs for the treatment of chronic obstructive pulmonary disease
    • MALHOTRA S, PAUL MAN SF, SIN DS: Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin. Emerging Drugs (2006) 11(2):275-291.
    • (2006) Expert Opin. Emerging Drugs , vol.11 , Issue.2 , pp. 275-291
    • MALHOTRA, S.1    PAUL MAN SF, S.D.2
  • 28
    • 33845208108 scopus 로고    scopus 로고
    • Life isn't flat: Taking cancer biology to the next dimension
    • SMALLEY KS, LIONI M, HERLYN M: Life isn't flat: taking cancer biology to the next dimension. In vitro Cell Dev. Biol. Anim. (2006) 42(8):242-247.
    • (2006) In vitro Cell Dev. Biol. Anim , vol.42 , Issue.8 , pp. 242-247
    • SMALLEY, K.S.1    LIONI, M.2    HERLYN, M.3
  • 29
    • 0020174498 scopus 로고
    • Lumen formation by epithelial cell lines in response to collagen overlay: A morphogenetic model in culture
    • HALL HG, FARSON DA, BISSELL MJ: Lumen formation by epithelial cell lines in response to collagen overlay: a morphogenetic model in culture. Proc. Natl. Acad. Sci. USA (1982) 79(15):4672-4676.
    • (1982) Proc. Natl. Acad. Sci. USA , vol.79 , Issue.15 , pp. 4672-4676
    • HALL, H.G.1    FARSON, D.A.2    BISSELL, M.J.3
  • 30
    • 33749992857 scopus 로고    scopus 로고
    • Tissue geometry determines sites of mammary branching morphogenesis in organotypic cultures
    • NELSON CM, VANDUIJN MM, INMAN JL, FLETCHER DA, BISSELL MJ: Tissue geometry determines sites of mammary branching morphogenesis in organotypic cultures. Science (2006) 314(5797):298-300.
    • (2006) Science , vol.314 , Issue.5797 , pp. 298-300
    • NELSON, C.M.1    VANDUIJN, M.M.2    INMAN, J.L.3    FLETCHER, D.A.4    BISSELL, M.J.5
  • 31
    • 0037449752 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mediates increased cell proliferation, migration and aggregation in esophageal keratinocytes in vitro and in vivo
    • ANDL CD, MIZUSHIMA T, NAKAGAWA H et al.: Epidermal growth factor receptor mediates increased cell proliferation, migration and aggregation in esophageal keratinocytes in vitro and in vivo. J. Biol. Chem. (2003) 278(3):1824-1830.
    • (2003) J. Biol. Chem , vol.278 , Issue.3 , pp. 1824-1830
    • ANDL, C.D.1    MIZUSHIMA, T.2    NAKAGAWA, H.3
  • 32
    • 0032831802 scopus 로고    scopus 로고
    • An in vitro coculture model of transmigrant monocytes and foam cell formation
    • TAKAICU M, WADA Y, JINNOUCHI K et al.: An in vitro coculture model of transmigrant monocytes and foam cell formation. Arterioscler. Thromb. Vasc. Biol. (1999) 19(10):2330-2339.
    • (1999) Arterioscler. Thromb. Vasc. Biol , vol.19 , Issue.10 , pp. 2330-2339
    • TAKAICU, M.1    WADA, Y.2    JINNOUCHI, K.3
  • 33
    • 0036926172 scopus 로고    scopus 로고
    • Mechanisms for monocyte activation in co-culture with autologous tumor spheroids
    • OLSNES C, HEIMDAL J-H, KROSS K, OLOFSSON J, AARSTAD HJ: Mechanisms for monocyte activation in co-culture with autologous tumor spheroids. Cell. Immunol. (2002) 219(1):11-21.
    • (2002) Cell. Immunol , vol.219 , Issue.1 , pp. 11-21
    • OLSNES, C.1    HEIMDAL, J.-H.2    KROSS, K.3    OLOFSSON, J.4    AARSTAD, H.J.5
  • 34
    • 0036327970 scopus 로고    scopus 로고
    • Impairment of insulin signaling in human skeletal muscle cells by co-culture with human adipocytes
    • DIETZE D, KOENEN M, ROHRIG K, HORIKOSHI H, HAUNER H, ECKEL J: Impairment of insulin signaling in human skeletal muscle cells by co-culture with human adipocytes. Diabetes (2002) 51(8):2369-2376.
    • (2002) Diabetes , vol.51 , Issue.8 , pp. 2369-2376
    • DIETZE, D.1    KOENEN, M.2    ROHRIG, K.3    HORIKOSHI, H.4    HAUNER, H.5    ECKEL, J.6
  • 35
    • 26444582245 scopus 로고    scopus 로고
    • Human airway epithelial cell determinants of survival and functional phenotype for primary human mast cells
    • HSIEH FH, SHARMA P, GIBBONS A, GOGGANS T, ERZURUM SC, HAQUE SJ: Human airway epithelial cell determinants of survival and functional phenotype for primary human mast cells. Proc. Natl. Acad. Sci. USA (2005) 102(40):14380-14385.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , Issue.40 , pp. 14380-14385
    • HSIEH, F.H.1    SHARMA, P.2    GIBBONS, A.3    GOGGANS, T.4    ERZURUM, S.C.5    HAQUE, S.J.6
  • 36
    • 0036009467 scopus 로고    scopus 로고
    • Lung macrophage-epithelial cell interactions amplify particle-mediated cytokine release
    • TAO F, KOBZIG L: Lung macrophage-epithelial cell interactions amplify particle-mediated cytokine release. Am. J. Respir. Cell Mol. Biol. (2002) 26(4):499-505.
    • (2002) Am. J. Respir. Cell Mol. Biol , vol.26 , Issue.4 , pp. 499-505
    • TAO, F.1    KOBZIG, L.2
  • 37
    • 5444259851 scopus 로고    scopus 로고
    • The complement system in regulation of adaptive immunity
    • CARROL MC: The complement system in regulation of adaptive immunity. Nat. Immunol. (2004) 5(10):981-986.
    • (2004) Nat. Immunol , vol.5 , Issue.10 , pp. 981-986
    • CARROL, M.C.1
  • 38
    • 0036779576 scopus 로고    scopus 로고
    • Functional significance of the perforin/granzyme cell death pathway
    • TRAPANI JA, SMYTH MJ: Functional significance of the perforin/granzyme cell death pathway. Nat. Rev. Immunol. (2002) 2:735-747.
    • (2002) Nat. Rev. Immunol , vol.2 , pp. 735-747
    • TRAPANI, J.A.1    SMYTH, M.J.2
  • 39
    • 33750606896 scopus 로고    scopus 로고
    • Neutrophil superoxide anion generation during atorvastatin and fluvastatin therapy used in coronary heart disease primary prevention
    • KOWALSKI J, BARYLSKI M, BANACH M et al.: Neutrophil superoxide anion generation during atorvastatin and fluvastatin therapy used in coronary heart disease primary prevention. J. Cardiovasc. Pharmacol. (2006) 48(4):143-147.
    • (2006) J. Cardiovasc. Pharmacol , vol.48 , Issue.4 , pp. 143-147
    • KOWALSKI, J.1    BARYLSKI, M.2    BANACH, M.3
  • 40
    • 2542554553 scopus 로고    scopus 로고
    • Interaction between resident luminal bacteria and the host. Can a healthy relationship turn sour?
    • HALLER D, JOBIN C: Interaction between resident luminal bacteria and the host. Can a healthy relationship turn sour? J. Pediat. Gastroenterol. Nutr. (2004) 38:123-136.
    • (2004) J. Pediat. Gastroenterol. Nutr , vol.38 , pp. 123-136
    • HALLER, D.1    JOBIN, C.2
  • 41
    • 12744263365 scopus 로고    scopus 로고
    • Dislipidemia and inflammation - an evolutionary conserved mechanism
    • ESTEVE E, RICART W, MANUEL J et al.: Dislipidemia and inflammation - an evolutionary conserved mechanism. Clin. Nutr. (2005) 24:16-31.
    • (2005) Clin. Nutr , vol.24 , pp. 16-31
    • ESTEVE, E.1    RICART, W.2    MANUEL, J.3
  • 42
    • 0032530560 scopus 로고    scopus 로고
    • Review article: Regulation of serum amyloid A protein expression during the acute phase response
    • JENSEN LE, WHITEHEAD AS: Review article: regulation of serum amyloid A protein expression during the acute phase response. Biochem. J. (1998) 334:489-503.
    • (1998) Biochem. J , vol.334 , pp. 489-503
    • JENSEN, L.E.1    WHITEHEAD, A.S.2
  • 43
    • 33845905781 scopus 로고    scopus 로고
    • T-cell regulation: With complements from innate immunity
    • KEMPER C, ATKINSON JP: T-cell regulation: with complements from innate immunity. Nat. Rev. Immunol. (2007) 7:9-18.
    • (2007) Nat. Rev. Immunol , vol.7 , pp. 9-18
    • KEMPER, C.1    ATKINSON, J.P.2
  • 44
    • 0025090039 scopus 로고
    • GMP-140 mediates adhesion of stimulated platelets to neutrophils
    • HAMBURGER SA, MCEVER RP: GMP-140 mediates adhesion of stimulated platelets to neutrophils. Blood (1990) 75(3):550-554.
    • (1990) Blood , vol.75 , Issue.3 , pp. 550-554
    • HAMBURGER, S.A.1    MCEVER, R.P.2
  • 45
    • 0842321794 scopus 로고    scopus 로고
    • Cutting edge: T-cells trigger CD40 dependent platelet activation and granular RANTES release. A novel pathway for immune response amplification
    • DANESE S, DE LA MOTTE C, REYES BMR et al.: Cutting edge: T-cells trigger CD40 dependent platelet activation and granular RANTES release. A novel pathway for immune response amplification. J. Immunol. (2004) 172:2011-2015.
    • (2004) J. Immunol , vol.172 , pp. 2011-2015
    • DANESE, S.1    DE LA MOTTE, C.2    REYES, B.M.R.3
  • 46
    • 0022340498 scopus 로고
    • 4. purification and characterization of a novel epoxide hydrolase from human erythrocytes
    • 4. purification and characterization of a novel epoxide hydrolase from human erythrocytes. J. Biol. Chem. (1985) 260(23):12832-12837.
    • (1985) J. Biol. Chem , vol.260 , Issue.23 , pp. 12832-12837
    • MCGEE, J.1    FITZPATRICK, F.2
  • 47
    • 0034658661 scopus 로고    scopus 로고
    • Chemokine receptors and their role in inflammation and infectious diseases
    • MURDOCH C, FINN A: Chemokine receptors and their role in inflammation and infectious diseases. Blood (2000) 95:3032-3043.
    • (2000) Blood , vol.95 , pp. 3032-3043
    • MURDOCH, C.1    FINN, A.2
  • 48
    • 0035874521 scopus 로고    scopus 로고
    • Red blood cells inhibit activation induced cell death and oxidative stress in human peripheral blood leukocytes
    • FONSECA F, PORTO C, UCHIDA K et al.: Red blood cells inhibit activation induced cell death and oxidative stress in human peripheral blood leukocytes. Blood (2001) 97:3152-3160.
    • (2001) Blood , vol.97 , pp. 3152-3160
    • FONSECA, F.1    PORTO, C.2    UCHIDA, K.3
  • 49
    • 0033120069 scopus 로고    scopus 로고
    • Lipopolysaccharide-coated erythrocytes activate human neutrophils via CD14 while subsequent binding is via CD11b/CD18
    • TROELSTA A, DE GRAAF-MILTENBURG C, VAN BOMMEL T et al.: Lipopolysaccharide-coated erythrocytes activate human neutrophils via CD14 while subsequent binding is via CD11b/CD18. J. Immunol. (1999) 162:4220-4225.
    • (1999) J. Immunol , vol.162 , pp. 4220-4225
    • TROELSTA, A.1    DE GRAAF-MILTENBURG, C.2    VAN BOMMEL, T.3
  • 50
    • 33746039699 scopus 로고    scopus 로고
    • Chemoattractants, extracellular proteases, and the integrated host defense response
    • ZABEL BA, ZUNIGA L, OHYAMA T et al.: Chemoattractants, extracellular proteases, and the integrated host defense response. Exp. Hematol. (2006) 34(8):1021-1032.
    • (2006) Exp. Hematol , vol.34 , Issue.8 , pp. 1021-1032
    • ZABEL, B.A.1    ZUNIGA, L.2    OHYAMA, T.3
  • 51
    • 0035112806 scopus 로고    scopus 로고
    • More than destructive - neutrophil derived serine proteases in cytokine bioactivity control
    • BANK U, ANSORGE S: More than destructive - neutrophil derived serine proteases in cytokine bioactivity control. J. Leuk. Biol. (2001) 69(2):197-206.
    • (2001) J. Leuk. Biol , vol.69 , Issue.2 , pp. 197-206
    • BANK, U.1    ANSORGE, S.2
  • 52
    • 2342495351 scopus 로고    scopus 로고
    • Interferonγ activation of polymorphonuclear neutrophil function
    • ELLIS TN, BEAMAN BL: Interferonγ activation of polymorphonuclear neutrophil function. Immunology (2004) 112:2-12.
    • (2004) Immunology , vol.112 , pp. 2-12
    • ELLIS, T.N.1    BEAMAN, B.L.2
  • 53
    • 0001023001 scopus 로고    scopus 로고
    • Interpreting the clinical significance of the differential inhibition of cyclooxygenase-1 and cyclooxygenase-2
    • BROOKS P, EMERY P, EVANS JF et al.: Interpreting the clinical significance of the differential inhibition of cyclooxygenase-1 and cyclooxygenase-2. Rheumatology (Oxford) (1999) 38(8):779-788.
    • (1999) Rheumatology (Oxford) , vol.38 , Issue.8 , pp. 779-788
    • BROOKS, P.1    EMERY, P.2    EVANS, J.F.3
  • 54
    • 0141997274 scopus 로고    scopus 로고
    • Inhibition of cytokine production by methotrexate. Studies in healthy volunteers and patients with rheumatoid arthritis
    • GERARDS AH, DE LATHOUDER S, DE GROOT ER, DIJKMANS BA, AARDEN LA: Inhibition of cytokine production by methotrexate. Studies in healthy volunteers and patients with rheumatoid arthritis. Rheumatology (Oxford) (2003) 42:1189-1196.
    • (2003) Rheumatology (Oxford) , vol.42 , pp. 1189-1196
    • GERARDS, A.H.1    DE LATHOUDER, S.2    DE GROOT, E.R.3    DIJKMANS, B.A.4    AARDEN, L.A.5
  • 55
    • 0036915135 scopus 로고    scopus 로고
    • For whom the bell tolls? - innate defense mechanisms and survival strategies of the intestinal epithelium against luminal pathogens
    • CARLO E, GERKEN E, PODOLSKY DK: "For whom the bell tolls?" - innate defense mechanisms and survival strategies of the intestinal epithelium against luminal pathogens. Z. Gastroenterol. (2002) 40:983-990.
    • (2002) Z. Gastroenterol , vol.40 , pp. 983-990
    • CARLO, E.1    GERKEN, E.2    PODOLSKY, D.K.3
  • 56
    • 0024593744 scopus 로고
    • Characterization of the human colon carcinoma cell line Caco-2 as a novel system for intestinal epithelial permeability
    • HIDALGO IJ, RAUB TJ, BORCHARDT RT: Characterization of the human colon carcinoma cell line Caco-2 as a novel system for intestinal epithelial permeability. Gastroenterology (1989) 96:736-749.
    • (1989) Gastroenterology , vol.96 , pp. 736-749
    • HIDALGO, I.J.1    RAUB, T.J.2    BORCHARDT, R.T.3
  • 57
    • 0035228290 scopus 로고    scopus 로고
    • In vitro permeabilitätsuntersuchungen als ersatz für tier-und humanstudien - welche voraussetzungen müssen erfüllt sein?
    • HALTNER E, SCHMITZ S, GUIDORF C, RUOFF J: In vitro permeabilitätsuntersuchungen als ersatz für tier-und humanstudien - welche voraussetzungen müssen erfüllt sein? ALTEX (2000) 18:81-87.
    • (2000) ALTEX , vol.18 , pp. 81-87
    • HALTNER, E.1    SCHMITZ, S.2    GUIDORF, C.3    RUOFF, J.4
  • 58
    • 33644848834 scopus 로고    scopus 로고
    • Probiotics and commensals reverse TNF-α and IFN-γ induced dysfunction in human intestinal epithelial cell lines
    • RESTA-LEHNERT S, BARRETT KE: Probiotics and commensals reverse TNF-α and IFN-γ induced dysfunction in human intestinal epithelial cell lines. Gastroenterology (2006) 130:731-746.
    • (2006) Gastroenterology , vol.130 , pp. 731-746
    • RESTA-LEHNERT, S.1    BARRETT, K.E.2
  • 59
    • 34547489495 scopus 로고    scopus 로고
    • A novel co-culture system consisting of differentiated human gut epithelium and human whole-blood cultures allows the combined investigation of absorption and immuno-pharmacology of test substances
    • Berlin, Germany
    • WEISS B, ZIMMERMANN K, SCHMOLZ M: A novel co-culture system consisting of differentiated human gut epithelium and human whole-blood cultures allows the combined investigation of absorption and immuno-pharmacology of test substances. Poster Presentation at the Falk Symposium: Mechanisms in Inflammatory Bowel Diseases. Berlin, Germany (2003).
    • (2003) Poster Presentation at the Falk Symposium: Mechanisms in Inflammatory Bowel Diseases
    • WEISS, B.1    ZIMMERMANN, K.2    SCHMOLZ, M.3
  • 60
    • 34547448700 scopus 로고    scopus 로고
    • Immuno-modulatory effects of intestinal samples in a novel gut epithelium/whole-blood co-culture system ("EDI-Co gut")
    • Papendal, The Netherlands
    • WEISS B, SCHMOLZ M: Immuno-modulatory effects of intestinal samples in a novel gut epithelium/whole-blood co-culture system ("EDI-Co gut"). Poster Presentation at the 4th NIZO Dairy Conference. Papendal, The Netherlands (2005).
    • (2005) Poster Presentation at the 4th NIZO Dairy Conference
    • WEISS, B.1    SCHMOLZ, M.2
  • 62
    • 0344035326 scopus 로고    scopus 로고
    • Host-pathogens cross-talk. Indigenous bacteria and probiotics also play the game
    • FREITAS M, TAVAN E, CAYUELA C, DIOP L, SAPIN C, TRUGNAN G: Host-pathogens cross-talk. Indigenous bacteria and probiotics also play the game. Biol. Cell (2003) 95(8):503-506.
    • (2003) Biol. Cell , vol.95 , Issue.8 , pp. 503-506
    • FREITAS, M.1    TAVAN, E.2    CAYUELA, C.3    DIOP, L.4    SAPIN, C.5    TRUGNAN, G.6
  • 63
    • 33846065962 scopus 로고    scopus 로고
    • Serotoninergic receptors on human airway epithelial cells
    • BAYER H, MÜLLER T, MYRTEK D et al.: Serotoninergic receptors on human airway epithelial cells. Am. J. Respir. Cell. Mol. Biol. (2007) 36:85-93.
    • (2007) Am. J. Respir. Cell. Mol. Biol , vol.36 , pp. 85-93
    • BAYER, H.1    MÜLLER, T.2    MYRTEK, D.3
  • 65
    • 33746930791 scopus 로고    scopus 로고
    • Lung epithelium as a sentinel and effector system in peumonia - molecular mechanisms of pathogen recognition and signal transduction
    • HIPPENSTIEL S, OPITZ B, SCHMECK B et al.: Lung epithelium as a sentinel and effector system in peumonia - molecular mechanisms of pathogen recognition and signal transduction. BMC Resp. Res. (2006) 7:97.
    • (2006) BMC Resp. Res , vol.7 , pp. 97
    • HIPPENSTIEL, S.1    OPITZ, B.2    SCHMECK, B.3
  • 66
    • 33845334892 scopus 로고    scopus 로고
    • Biologic immune response modifiers: Trials and tribulations - are we there yet?
    • BALLOW M: Biologic immune response modifiers: trials and tribulations - are we there yet? J. Allergy Clin. Immunol. (2006) 118:1209-1215.
    • (2006) J. Allergy Clin. Immunol , vol.118 , pp. 1209-1215
    • BALLOW, M.1
  • 68
    • 0347510684 scopus 로고    scopus 로고
    • The mucosal immune system
    • MACDONALD TT: The mucosal immune system. Parasite Immunol. (2003) 25:235-246.
    • (2003) Parasite Immunol , vol.25 , pp. 235-246
    • MACDONALD, T.T.1
  • 69
    • 21044459382 scopus 로고    scopus 로고
    • The puzzle of asthma treatment: Animal models to genetic studies
    • FRODE TS, MEDEIROS TS: The puzzle of asthma treatment: animal models to genetic studies. Curr. Pharm. Des. (2005) 11(19):2515-2524.
    • (2005) Curr. Pharm. Des , vol.11 , Issue.19 , pp. 2515-2524
    • FRODE, T.S.1    MEDEIROS, T.S.2


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