Receptor activator of nuclear factor kappa B ligand (RANKL) modulates the expression of genes involved in apoptosis and cell cycle in human osteoclasts

Anatomical Record

Volumn 290, Issue 7, 2007, Pages 838-845

  Rimondi, Erika ^a   Zweyer, Marina ^b   Ricci, Enrico ^a   Fadda, Roberto ^a   Secchiero, Paola ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF TRIESTE   (Italy)

Author keywords

Apoptosis; Cell cycle; Gene expression; Macrophages; Osteoclasts; RANKL

Indexed keywords

APOPTOSIS REGULATORY PROTEIN; CD11B ANTIGEN; CD14 ANTIGEN; CELL CYCLE PROTEIN; COLONY STIMULATING FACTOR 1; CYTOKINE; ITGAM PROTEIN, HUMAN; MESSENGER RNA; OSTEOCLAST DIFFERENTIATION FACTOR; TNFSF11 PROTEIN, HUMAN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL CYCLE; CELL DIFFERENTIATION; COMPARATIVE STUDY; DNA MICROARRAY; DRUG EFFECT; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETICS; HUMAN; IMMUNOLOGY; MACROPHAGE; METABOLISM; MONONUCLEAR CELL; OSTEOCLAST; SIGNAL TRANSDUCTION;

ANTIGENS, CD11B; ANTIGENS, CD14; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL CYCLE; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; CYTOKINES; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; LEUKOCYTES, MONONUCLEAR; MACROPHAGE COLONY-STIMULATING FACTOR; MACROPHAGES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OSTEOCLASTS; RANK LIGAND; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 34547448131     PISSN: 19328486     EISSN: 19328494     Source Type: Journal    
DOI: 10.1002/ar.20550     Document Type: Article

References (30)

1. Atadja P, Wong H, Veillette C, Raibowol K. 1995. Overexpression of cyclin D1 blocks proliferation of normal diploid fibroblasts. Exp Cell Res 217:205-216.
2. Bharti AC, Takada Y, Shishodia S, Aggarwal BB. 2004. Evidence that receptor activator of nuclear factor (NF)-kB ligand can suppress cell proliferation and induce apoptosis through activation of a NF-kB-independent and TRAF6-dependent mechanism. J Biol Chem 279:6065-6076.
3. Boyle WJ, Scott Simonet W, Lacey DL. 2003. Osteoclast differentiation and activation. Nature 423:337-342.
4. Campioni D, Corallini A, Zauli G, Possati L, Altavilla G, Barbanti-Brodano G. 1995. HIV type-1 extracellular Tat protein stimulates growth and protects cells from BK virus Tat transgenic mice from apoptosis. AIDS Res Hum Retroviruses 11:1039-1048.
5. Cappellen D, Luong-Nguyen NH, Bongiovanni S, Grenet O, Wanke C, Susa M. 2002. Transcriptional program of mouse osteoclast differentiation governed by the macrophage colony-stimulating factor and the ligand for the receptor activator of NF-kB. J Biol Chem 277:21971-21982.
6. Chaisson ML, Branstetter DG, Derry JM, Armstrong AP, Tometsko ME, Takeda K, Akira S, Dougall WC. 2004. Osteoclast differentiation is impaired in the absence of inhibitor of kB kinase α. J Biol Chem 279:54841-54848.
7. Da L, Li D, Yokoyama KK, Li T, Zhao M. 2006. Dual promoters control the cell-specific expression of the human cell death-inducing DFF45-like effector B gene. Biochem J 393:779-788.
8. Felix R, Hofstetter W, Wetterwald A, Cecchini MG, Fleisch H. 1994. Role of colony-stimulating factor-1 in bone metabolism. J Cell Biochem 55:340-349.
9. Kassis JN, Guancial EA, Doong H, Virador V, Kohn EC. 2006. CAIR-1/BAG-3 modulates cell adhesion and migration by downregulating activity of focal adhesion proteins. Exp Cell Res 312:2962-2971.
10. Kwak HB, Jin HM, Ha H, Kang MJ, Lee SB, Kim HH, Lee ZH. 2005. Tumor necrosis factor-alpha induces differentiation of human peripheral blood mononuclear cells into osteoclasts through the induction of p21(WAF1/ Cip1). Biochem Biophys Res Commun 330:1080-1086.
11. Hemmati PG, Guner D, Gillissen B, Wendt J, von Haefen C, Chinnadurai G, Dorken B, Daniel PT. 2006. Bak functionally complements for loss of Bax during p14ARF-induced mitochondrial apoptosis in human cancer cells. Oncogene 25:6582-6594.
12. Hsu H, Lacey DL, Dunstan CR, Solovyev I, Colombero A, Timms E, Tan HL, Elliott G, Kelley MJ, Sarosi I, Wang L, Xia XZ, Elliott R, Chiu L, Black T, Scully S, Capparelli C, Morony S, Shimamoto G, Bass MB, Boyle WJ. 1999. Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc Natl Acad Sci U S A 96:3540-3545.
13. Lacey DL, Tan HL, Lu J, Kaufman S, Van G, Qiu W, Rattan A, Scully S, Fletcher F, Juan T, Kelley M, Burgess TL, Boyle WJ, Polverino AJ. 2000. Osteoprotegerin ligand modulates murine osteoclast survival in vitro and in vivo. Am J Pathol 157:435-448.
14. Lomaga MA, Yeh W, Sarosi I, Duncan GS, Furlonger C, Ho A, Morony S, Capparelli C, Van G, Kaufman S, van der Heiden A, Itie A, Wakeham A, Khoo W, Sasaki T, Cao Z, Penninger JM, Paige CJ, Lacey DL, Dunstan CR, Boyle WJ, Goeddel DV, Mak TW. 1999. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev 13:1015-1024.
15. J3/cdk4) for mammalian D type G1 cyclins. Cell 71:323-334.
16. Milani D, Zauli G, Neri LM, Marchisio M, Previati M, Capitani S. 1993. Influence of the Human Immunodeficiency Virus-type 1 (HIV-1) Tat protein on the proliferation and differentiation of PC12 rat pheochromocytoma cells. J Gen Virol 74:2587-2594.
17. Naito A, Azuma S, Tanaka S, Miyazaki T, Takaki S, Takatsu K, Nakao K, Nakamura K, Katsuki M, Yamamoto T, Inoue J. 1999. Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice. Genes Cells 4:353-362.
18. Nishikawa M, Yamamoto M, Murakami T, Akatsu T, Kugai N, Nagata N. 1998. A third-generation bisphosphonate, YM175, inhibits osteoclast formation in murine cocultures by inhibiting proliferation of precursor cells via supporting cell-dependent mechanisms. J Bone Miner Res 13:986-995.
19. Oba Y, Lee JW, Ehrlich LA, Chung HY, Jelinek DF, Callander NS, Horuk R, Choi SJ, Roodman GD. 2005. MIP-1alpha utilizes both CCR1 and CCR5 to induce osteoclast formation and increase adhesion of myeloma cells to marrow stromal cells. Exp Hematol 33:272-278.
20. Ogasawara T, Katagiri M, Yamamoto A, Hoshi K, Takato T, Nakamura K, Tanaka S, Okayama H, Kawaguchi H. 2004. Osteoclast differentiation by RANKL requires NF-kB-mediated downregulation of cyclin-dependent kinase 6 (Cdk6). J Bone Miner Res 19:1128-1136.
21. Okahashi N, Murase Y, Koseki T, Sato T, Yamato K, Nishihara T. 2001. Osteoclast differentiation is associated with transient upregulation of cyclin-dependent kinase inhibitors p21(WAF1/CIP1) and p27(KIP1). J Cell Biochem 80:339-345.
22. Robards AW, Wilson AJ. 1993. Procedures in electron microscopy. Centre for cell and tissue research, University of York, Chicester, UK: John Wiley and Sons.
23. Sankar U, Patel K, Rosol TJ, Ostrowski MO. 2004. RANKL coordinates cell cycle withdrawal and differentiation in osteoclasts through the cyclin-dependent kinase inhibitors p27KIP1 and p21CIP1. J Bone Miner Res 19:1339-1348.
24. Secchiero P, Gonelli A, Celeghini C, Mirandola P, Guidotti L, Visani G, Capitani S, Zauli G. 2001. Activation of the nitric oxide synthase pathway represents a key component of tumor necrosis factor-related apoptosis-inducing ligand-mediated cytotoxicity on hematologic malignancies. Blood 98:2220-2228.
25. Secchiero P, Gonelli A, Mirandola P, Melloni E, Zamai L, Celeghini C, Milani D, Zauli G. 2002. Tumor necrosis factor-related apoptosis-inducing ligand induces monocytic maturation of leukemic and normal myeloid precursors through a caspase-dependent pathway. Blood 100:2421-2429.
26. Takaori-Kondo A, Hori T, Fukunaga K, Morita R, Kawamata S, Uchiyama T. 2000. Both amino- and carboxyl-terminal domains of TRAF3 negatively regulate NF-kappaB activation induced by OX40 signaling. Biochem Biophys Res Commun 272:856-863.
27. Van Eyndhoven WG, Gamper CJ, Cho E, Mackus WJ, Lederman S. 1999. TRAF-3 mRNA splice-deletion variants encode isoforms that induce NF-kappaB activation. Mol Immunol 36:647-658.
28. Wong BR, Josien R, Lee SY, Vologodskaia M, Steinman RM, Choi Y. 1998. The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor. J Biol Chem 273:28355-28359.
29. Wu X, Pan G, Mckenna MA, Zayzafoon M, Xiong WC, McDonald JM. 2005. RANKL regulates Fas expression and Fas-mediated apoptosis in osteoclasts. J Bone Miner Res 20:107-116.
30. Zauli G, Rimondi E, Nicolin V, Melloni E, Celeghini C, Secchiero P. 2004. TNF-related apoptosis inducing ligand (TRAIL) blocks osteoclastic differentiation induced by RANKL+M-CSF. Blood 104:2044-2050.