RANKL coordinates cell cycle withdrawal and differentiation in osteoclasts through the cyclin-dependent kinase inhibitors p27KIP1 and p21 CIP1

Journal of Bone and Mineral Research

Volumn 19, Issue 8, 2004, Pages 1339-1348

  Sankar, Uma ^a,b,c   Patel, Krupen ^a,b   Rosol, Thomas J ^a,b   Ostrowski, Michael C ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Cyclin dependent kinase inhibitors; Modeling and remodeling; Osteopetrosis; RANKL

Indexed keywords

CATHEPSIN K; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACID PHOSPHATASE; ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; ALKALINE PHOSPHATASE; CARRIER PROTEIN; CATHEPSIN; CDK2 PROTEIN, MOUSE; CDKN1A PROTEIN, MOUSE; CDKN1B PROTEIN, MOUSE; CDKN2C PROTEIN, MOUSE; CDKN2D PROTEIN, MOUSE; CELL CYCLE PROTEIN; CHROMONE DERIVATIVE; COLONY STIMULATING FACTOR 1; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN DEPENDENT KINASE INHIBITOR 2C; CYCLIN DEPENDENT KINASE INHIBITOR 2D; ENZYME INHIBITOR; FLAVONOID; IMIDAZOLE DERIVATIVE; ISOENZYME; MEMBRANE PROTEIN; MORPHOLINE DERIVATIVE; OSTEOCLAST DIFFERENTIATION FACTOR; PYRIDINE DERIVATIVE; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; TARTRATE-RESISTANT ACID PHOSPHATASE; TNFRSF11A PROTEIN, MOUSE; TNFSF11 PROTEIN, MOUSE; TUMOR SUPPRESSOR PROTEIN;

ALBERS SCHOENBERG DISEASE; ANIMAL CELL; ARTICLE; CELL CYCLE; CELL DIFFERENTIATION; CELL STRUCTURE; CONTROLLED STUDY; GENE EXPRESSION; GENE MUTATION; LONG BONE; MOUSE; NONHUMAN; OSTEOCLAST; PROTEIN EXPRESSION; PROTEIN FUNCTION; ANIMAL; BONE MARROW CELL; C57BL MOUSE; CELL CULTURE; CELL PROLIFERATION; DRUG EFFECT; ENZYMOLOGY; FEMUR; GENETICS; MACROPHAGE; METABOLISM; MOUSE MUTANT; PATHOLOGY; RADIOGRAPHY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ACID PHOSPHATASE; ALKALINE PHOSPHATASE; ANIMALS; BLOTTING, WESTERN; BONE MARROW CELLS; CARRIER PROTEINS; CATHEPSINS; CDC2-CDC28 KINASES; CELL CYCLE; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CHROMONES; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P18; CYCLIN-DEPENDENT KINASE INHIBITOR P19; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; ENZYME INHIBITORS; FEMUR; FLAVONOIDS; GENE EXPRESSION; IMIDAZOLES; ISOENZYMES; MACROPHAGE COLONY-STIMULATING FACTOR; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MORPHOLINES; OSTEOCLASTS; OSTEOPETROSIS; PYRIDINES; RANK LIGAND; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR PROTEINS;

EID: 16644392773     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/JBMR.040321     Document Type: Article

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