CAIR-1/BAG-3 modulates cell adhesion and migration by downregulating activity of focal adhesion proteins

Experimental Cell Research

Volumn 312, Issue 15, 2006, Pages 2962-2971

  Kassis, Jareer N ^a   Guancial, Elizabeth A ^b   Doong, Howard ^a   Virador, Victoria ^a   Kohn, Elise C ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NONE

Author keywords

Collagen type IV; FAK; Paxillin; Signalosome

Indexed keywords

BAG 3 PROTEIN; CAIR 1 PROTEIN; COLLAGEN TYPE 4; FOCAL ADHESION KINASE; FOCAL ADHESION KINASE 1; PAXILLIN; PHALLOIDIN; PROLINE; PROTEIN; RHODAMINE; STEROID RECEPTOR COACTIVATOR 1; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHOSPHORYLATION; CELL ADHESION; CELL MIGRATION; CONTROLLED STUDY; DOWN REGULATION; FILOPODIUM; FOCAL ADHESION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STRESS FIBER;

EID: 33747376303     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2006.05.023     Document Type: Article

References (39)

1. Lauffenburger D.A., and Horwitz A.F. Cell migration: a physically integrated molecular process. Cell 84 (1996) 359-369
2. Liotta L.A., and Kohn E.C. The microenvironment of the tumour-host interface. Nature 411 (2001) 375-379
3. Wells A. Tumor invasion: role of growth factor-induced cell motility. Adv. Cancer Res. 78 (2000) 31-101
4. Kassis J., Lauffenburger D.A., Turner T., and Wells A. Tumor invasion as dysregulated cell motility. Semin. Cancer Biol. 11 (2001) 105-117
5. Doong H., Rizzo K., Fang S., Kulpa V., Weissman A.M., and Kohn E.C. CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteins. J. Biol. Chem. 278 (2003) 28490-28500
6. Doong H., Price J., Kim Y.S., Gasbarre C., Probst J., Liotta L.A., Blanchette J., Rizzo K., and Kohn E. CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-gamma and Hsp70/Hsc70. Oncogene 19 (2000) 4385-4395
7. Felder C.C., Ma A.L., Liotta L.A., and Kohn E.C. The antiproliferative and antimetastatic compound L651582 inhibits muscarinic acetylcholine receptor-stimulated calcium influx and arachidonic acid release. J. Pharmacol. Exp. Ther. 257 (1991) 967-971
8. Kohn E.C., Felder C.C., Jacobs W., Holmes K.A., Day A., Freer R., and Liotta L.A. Structure-function analysis of signal and growth inhibition by carboxyamido-triazole, CAI. Cancer Res. 54 (1994) 935-942
9. Doong H., Vrailas A., and Kohn E.C. What's in the 'BAG'?-A functional domain analysis of the BAG-family proteins. Cancer Lett. 188 (2002) 25-32
10. Brabek J., Constancio S.S., Siesser P.F., Shin N.Y., Pozzi A., and Hanks S.K. Crk-associated substrate tyrosine phosphorylation sites are critical for invasion and metastasis of SRC-transformed cells. Mol. Cancer Res. 3 (2005) 307-315
11. Vidal M., Gigoux V., and Garbay C. SH2 and SH3 domains as targets for anti-proliferative agents. Crit. Rev. Oncol./Hematol. 40 (2001) 175-186
12. Schlaepfer D.D., Hauck C.R., and Sieg D.J. Signaling through focal adhesion kinase. Prog. Biophys. Mol. Biol. 71 (1999) 435-478
13. Schaller M.D. Biochemical signals and biological responses elicited by the focal adhesion kinase. Biochim. Biophys. Acta 1540 (2001) 1-21
14. Parsons J.T. Focal adhesion kinase: the first ten years. J. Cell Sci. 116 (2003) 1409-1416
15. Playford M.P., and Schaller M.D. The interplay between Src and integrins in normal and tumor biology. Oncogene 23 (2004) 7928-7946
16. Hanks S.K., Ryzhova L., Shin N.Y., and Brabek J. Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility. Front. Biosci. 8 (2003) d982-d996
17. Thompson E.W., Paik S., Brunner N., Sommers C.L., Zugmaier G., Clarke R., Shima T.B., Torri J., Donahue S., Lippman M.E., Martin G.R., and Dickson R.B. Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines. J. Cell. Physiol. 150 (1992) 534-544
18. Glading A., Chang P., Lauffenburger D.A., and Wells A. Epidermal growth factor receptor activation of calpain is required for fibroblast motility and occurs via an ERK/MAP kinase signaling pathway. J. Biol. Chem. 275 (2000) 2390-2398
19. Friedl P., and Brocker E.B. The biology of cell locomotion within three-dimensional extracellular matrix. Cell. Mol. Life Sci. 57 (2000) 41-64
20. Dourdin N., Bhatt A.K., Dutt P., Greer P.A., Arthur J.S., Elce J.S., and Huttenlocher A. Reduced cell migration and disruption of the actin cytoskeleton in calpain-deficient embryonic fibroblasts. J. Biol. Chem. 276 (2001) 48382-48388
21. Wehrle-Haller B., and Imhof B. The inner lives of focal adhesions. Trends Cell Biol. 12 (2002) 382-389
22. Maheshwari G., Brown G., Lauffenburger D.A., Wells A., and Griffith L.G. Cell adhesion and motility depend on nanoscale RGD clustering. J. Cell Sci. 113 Pt. 10 (2000) 1677-1686
23. Schaller M.D. Paxillin: a focal adhesion-associated adaptor protein. Oncogene 20 (2001) 6459-6472
24. Ridley A.J., Schwartz M.A., Burridge K., Firtel R.A., Ginsberg M.H., Borisy G., Parsons J.T., and Horwitz A.R. Cell migration: integrating signals from front to back. Science 302 (2003) 1704-1709
25. Sieg D.J., Hauck C.R., and Schlaepfer D.D. Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration. J. Cell Sci. 112 Pt. 16 (1999) 2677-2691
26. Polte T.R., and Hanks S.K. Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas. Proc. Natl. Acad. Sci. 92 (1995) 10678-10682
27. Schaller M.D., Hildebrand J.D., Shannon J.D., Fox J.W., Vines R.R., and Parsons J.T. Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src. Mol. Cell. Biol. 14 (1994) 1680-1688
28. Calalb M.B., Zhang X., Polte T.R., and Hanks S.K. Focal adhesion kinase tyrosine-861 is a major site of phosphorylation by Src. Biochem. Biophys. Res. Commun. 228 (1996) 662-668
29. LeBoeuf F., Houle F., and Huot J. Regulation of vascular endothelial growth factor receptor 2-mediated phosphorylation of focal adhesion kinase by heat shock protein 90 and Src kinase activities. J. Biol. Chem. 279 (2004) 39175-39185
30. Nojima Y., Morino N., Mimura T., Hamasaki K., Furuya H., Sakai R., Sato T., Tachibana K., Morimoto C., Yazaki Y., and Hirai H. Integrin-mediated cell adhesion promotes tyrosine phosphorylation of p130Cas, a Src homology 3-containing molecule having multiple Src homology 2-binding motifs. J. Biol. Chem. 270 (1995) 15398-15402
31. Thomas J.W., Ellis B., Boerner R.J., Knight W.B., White II G.C., and Schaller M.D. SH2- and SH3-mediated interactions between focal adhesion kinase and Src. J. Biol. Chem. 273 (1998) 577-583
32. Kassis J., Moellinger J., Lo H., Greenberg N.M., Kim H.G., and Wells A. A role for phospholipase C-gamma-mediated signaling in tumor cell invasion. Clin. Cancer Res. 5 (1999) 2251-2260
33. Chen P., Xie H., Sekar M.C., Gupta K., and Wells A. Epidermal growth factor receptor-mediated cell motility: phospholipase C activity is required, but mitogen-activated protein kinase activity is not sufficient for induced cell movement. J. Cell Biol. 127 (1994) 847-857
34. Kamat A., and Carpenter G. Phospholipase C-gamma1: regulation of enzyme function and role in growth factor-dependent signal transduction. Cytokine Growth Factor Rev. 8 (1997) 109-117
35. Webb D.J., Donais K., Whitmore L.A., Thomas S.M., Turner C.E., Parsons J.T., and Horwitz A.F. FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat. Cell Biol. 6 (2004) 154-161
36. Bade E.G., and Nitzgen B. Extracellular matrix (ECM) modulates the EGF-induced migration of liver epithelial cells in serum-free, hormone-supplemented medium. In Vitro Cell. Dev. Biol. 21 (1985) 245-248
37. Hood J.D., and Cheresh D.A. Role of integrins in cell invasion and migration. Nat. Rev., Cancer 2 (2002) 91-100
38. Turner C.E. Paxillin and focal adhesion signalling. Nat. Cell Biol. 2 (2000) E231-E236
39. Schlaepfer D.D., and Mitra S.K. Multiple connections link FAK to cell motility and invasion. Curr. Opin. Genet. Dev. 14 (2004) 92-101