The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionary conserved pocket

Biochemical Journal

Volumn 405, Issue 3, 2007, Pages 473-480

  Suchanek, Monika ^a   Hynynen, Riikka ^b   Wohlfahrt, Gerd ^c   Lehto, Markku ^b   Johansson, Marie ^b   Saarinen, Hannu ^b   Radzikowska, Anna ^a   Thiele, Christoph ^a   Olkkonen, Vesa M ^b  

^a MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS   (Germany)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^c ORION CORPORATION   (Finland)

Author keywords

25 hydroxycholesterol; Cholesterol; Molecular homology modelling; OSBP related protein (ORP); Oxysterol binding protein (OSBP); Photo cross linking

Indexed keywords

25-HYDROXYCHOLESTEROL; MOLECULAR HOMOLOGY MODELING; OSBP-RELATED PROTEIN (ORP); OXYSTEROL-BINDING PROTEIN (OSBP); PHOTOCROSSLINKING;

CELLS; CHOLESTEROL; CROSSLINKING; MUTAGENESIS; PH EFFECTS; YEAST;

PROTEINS;

25 HYDROXYCHOLESTEROL; ALANINE; BINDING PROTEIN; GLUTATHIONE TRANSFERASE; LYSINE; OXYSTEROL; OXYSTEROL BINDING PROTEIN; TRYPTOPHAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING ASSAY; CELL STRAIN COS7; CONTROLLED STUDY; CROSS LINKING; IN VITRO STUDY; LIGAND BINDING; LIPID ANALYSIS; MAMMAL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PURIFICATION; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING;

ANIMALS; BINDING SITES; CARRIER PROTEINS; CELL LINE; CERCOPITHECUS AETHIOPS; CONSERVED SEQUENCE; EVOLUTION, MOLECULAR; HUMANS; HYDROXYCHOLESTEROLS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; RABBITS; STEROID 12-ALPHA-HYDROXYLASE;

MAMMALIA; SACCHAROMYCES CEREVISIAE;

EID: 34547439826     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20070176     Document Type: Article

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