Cyclopropylamine inactivation of cytochromes P450: Role of metabolic intermediate complexes

Archives of Biochemistry and Biophysics

Volumn 436, Issue 2, 2005, Pages 265-275

  Cerny, Matthew A ^a   Hanzlik, Robert P ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

Cytochrome P450; Flavin containing monooxygenase; Mechanism based inactivation; Metabolic intermediate complex; Suicide substrate

Indexed keywords

BENZENE DERIVATIVE; CYCLOPROPANE DERIVATIVE; CYTOCHROME P450; CYTOCHROME P450 2B1; CYTOCHROME P450 2E1; HEME DERIVATIVE; HYDROXYLAMINE; IRON;

ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION; COMPLEX FORMATION; ENZYME ACTIVATION; ENZYME MODIFICATION; HEATING; HYDROLYSIS; LIVER MICROSOME; METABOLIC ACTIVATION; OXIDATION; PRIORITY JOURNAL;

EID: 17744388983     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.abb.2005.02.020     Document Type: Article

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