Articular cartilage and changes in arthritis noncollagenous proteins and proteoglycans in the extracellular matrix of cartilage

Arthritis Research

Volumn 3, Issue 6, 2001, Pages 342-347

  Roughley, P J ^a  

^a SHRINERS HOSPITAL FOR CHILDREN   (Canada)

Author keywords

Cartilage; Extracellular matrix; Protein; Proteoglycan

Indexed keywords

ARGININE; CHONDROCALCIN; COLLAGEN TYPE 2; LYSOZYME; PHOSPHOLIPASE A2; PROLINE; PROTEINASE; PROTEINASE INHIBITOR; PROTEOGLYCAN; REGULATOR PROTEIN; STRUCTURAL PROTEIN; UNCLASSIFIED DRUG;

ABSORPTION; ARTHRITIS; ARTICULAR CARTILAGE; CARTILAGE CELL; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENETIC DISORDER; HUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; REVIEW; SYNOVIAL FLUID;

ARTHRITIS; CARTILAGE, ARTICULAR; EXTRACELLULAR MATRIX PROTEINS; HUMANS; PROTEOGLYCANS;

EID: 0035174309     PISSN: 14659905     EISSN: None     Source Type: Journal    
DOI: 10.1186/ar326     Document Type: Review

References (45)

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3. The ins and outs of aggrecan
4. A human-specific polymorphism in the coding region of the aggrecan gene. Variable number of tandem repeats produce a range of core protein sizes in the general population
5. Aggrecan turnover in human articular cartilage: Use of aspartic acid racemization as a marker of molecular age
6. Mechanisms involved in cartilage proteoglycan catabolism
7. The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis
8. Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent
9. Progressive polyarthritis induced in BALB/c mice by aggrecan from normal and osteoarthritic human cartilage
10. Link protein as a monitor in situ of endogenous proteolysis in adult human articular cartilage
11. Monoclonal antibodies recognizing protease-generated neoepitopes from cartilage proteoglycan degradation. Application to studies of human link protein cleavage by stromelysin
12. Resistance of small leucine-rich repeat proteoglycans to proteolytic degradation during interleukin-1-stimulated cartilage catabolism
13. Mice lacking link protein develop dwarfism and craniofacial abnormalities
14. Non-proteoglycan forms of biglycan increase with age in human articular cartilage
15. Presence of pro-forms of decorin and biglycan in human articular cartilage
16. Changes with age in the structure of fibromodulin in human articular cartilage
17. The human lumican gene. Organization, chromosomal location, and expression in articular cartilage
18. Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility
19. Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice
20. Fibromodulin-null mice have abnormal collagen fibrils, tissue organization, and altered lumican deposition in tendon
21. Lumican regulates collagen fibril assembly: Skin fragility and corneal opacity in the absence of lumican
22. The biology of perlecan: The multifaceted heparan sulphate proteoglycan of basement membranes and pericellular matrices
23. Perlecan maintains the integrity of cartilage and some basement membranes
24. Perlecan, the major proteoglycan of basement membranes, is altered in patients with Schwartz-Jampel syndrome (chondrodystrophic myotonia)
25. Articular cartilage superficial zone protein (SZP) is homologous to megakaryocyte stimulating factor precursor and is a multifunctional proteoglycan with potential growth-promoting, cytoprotective, and in cartilage metabolism
26. CACP, encoding a secreted proteoglycan, is mutated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome
27. Noncollagenous, nonproteoglycan macromolecules of cartilage
28. Thrombospondins
29. Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene
30. Release of cartilage oligomeric matrix protein (COMP) into joint fluid after knee injury and in osteoarthritis
31. Structure and chromosomal location of the human gene encoding cartilage matrix protein
32. Normal skeletal development of mice lacking matrilin 1: Redundant function of matrilins in cartilage?
33. Enhancement of cartilage matrix protein synthesis in arthritic cartilage
34. A novel cartilage protein (CILP) present in the mid-zone of human articular cartilage increases with age
35. Cloning and deduced amino acid sequence of a novel cartilage protein (CILP) identifies a proform including a nucleotide pyrophosphohydrolase
36. Fibronectin
37. Expression of the (V+C)-fibronectin isoform is tightly linked to the presence of a cartilaginous matrix
38. The synthesis and accumulation of fibronectin by human articular cartilage
39. Cartilage chondrolysis by fibronectin fragments causes cleavage of aggrecan at the same site as found in osteoarthritic cartilage
40. The gene organization, chromosome location, and expression of a 55-kDa matrix protein (PRELP) of human articular cartilage
41. The amino-terminal part of PRELP binds to heparin and heparan sulfate
42. The structure and chromosome location of the human chondroadherin gene (CHAD)
43. Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family
44. Purification, characterization, and biosynthesis of bovine cartilage lysozyme isoforms
45. Phospholipase A2 is a major component of the salt-extractable pool of matrix proteins in adult human articular cartilage