HNF-1α plays an important role in IL-6-induced expression of the human angiotensinogen gene

American Journal of Physiology - Cell Physiology

Volumn 293, Issue 1, 2007, Pages

  Jain, Sudhir ^a   Li, Yanna ^a   Patil, Sai ^a   Kumar, Ashok ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Chromatin immunoprecipitation; Hypertension; Inflammation; STAT 3 binding sites; Transcription

Indexed keywords

ANGIOTENSINOGEN; APRE 2 PROTEIN; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; INTERLEUKIN 6; NUCLEIC ACID BINDING PROTEIN; STAT3 PROTEIN; UNCLASSIFIED DRUG; GLUCOCORTICOID RECEPTOR; SMALL INTERFERING RNA; STAT3 PROTEIN, HUMAN;

ARTICLE; BINDING SITE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GENE ACTIVITY; GENE DELETION; GENE EXPRESSION; GENE LOCATION; GENE LOCUS; HEPATOMA CELL; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN INTERACTION; SEQUENCE HOMOLOGY; CHROMATIN; DRUG EFFECT; GEL MOBILITY SHIFT ASSAY; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; LIVER TUMOR; METABOLISM; MOLECULAR GENETICS; MUTATION; PATHOLOGY; RNA INTERFERENCE; TUMOR CELL LINE;

ANGIOTENSINOGEN; BASE SEQUENCE; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; HUMANS; INTERLEUKIN-6; LIVER NEOPLASMS; MOLECULAR SEQUENCE DATA; MUTATION; PROMOTER REGIONS (GENETICS); RECEPTORS, GLUCOCORTICOID; RNA INTERFERENCE; RNA, SMALL INTERFERING; STAT3 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 34547114247     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00433.2006     Document Type: Article

References (38)

1. Akira S, Nishio Y, Tanaka T, Inoue M, Matsusaka T, Wang XJ, Wei S, Yoshida N, Kishimoto T. Transcription factors NF-IL6 and APRF involved in gp130-mediated signaling pathway. Ann NY Acad Sci 762: 15-27, 1995.
2. Baumhueter S, Courtois G, Morgan JG, Crabtree GR. The role of HNF-1 in liver-specific gene expression. Ann NY Acad Sci 557: 272-278, 1989.
3. Brasier AR, Han Y, Sherman CT. Transcriptional regulation of angiotensinogen gene expression. Vitam Horm 57: 217-247, 1999.
4. Brasier AR, Li J. Mechanisms for inducible control of angiotensinogen gene transcription. Hypertension 27: 465-475, 1996.
5. Burt VL, Whelton P, Roccella EJ, Brown C, Cutler JA, Higgins M, Horan MJ, Labarthe D. Prevalence of hypertension in the US adult population. Results from the Third National Health and Nutrition Examination Survey, 1988-1991. Hypertension 25: 305-313, 1995.
6. Campbell DJ, Habener JF. Angiotensinogen gene is expressed and differentially regulated in multiple tissues of the rat. J Clin Invest 78: 31-39, 1986.
7. Campbell DJ, Habener JF. Cellular localization of angiotensinogen gene expression in brown adipose tissue and mesentery: quantification of messenger ribonucleic acid abundance using hybridization in situ. Endocrinology 121: 1616-1626, 1987.
8. Carson P, Giles T, Higginbotham M, Hollenberg N, Kannel W, Siragy HM. Angiotensin receptor blockers: evidence for preserving target organs. Clin Cardiol 24: 183-190, 2001.
9. Cereghini S. Liver-enriched transcription factors and hepatocyte differentiation. FASEB J 10: 267-282, 1996.
10. Corvol P, Jeunemaitre X. Molecular genetics of human hypertension: role of angiotensinogen. Endocr Rev 18: 662-677, 1997.
11. Corvol P, Jeunemaitre X, Charru A, Kotelevtsev Y, Soubrier F. Role of the renin-angiotensin system in blood pressure regulation and in human hypertension: new insights from molecular genetics. Recent Prog Horm Res 50: 287-308, 1995.
12. Courtois G, Baumhueter S, Crabtree GR. Purified hepatocyte nuclear factor 1 interacts with a family of hepatocyte-specific promoters. Proc Natl Acad Sci USA 85: 7937-7941, 1988.
13. Dignam JD, Lebovitz RM, Roeder RG. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11: 1475-1489, 1983.
14. Fasola AF, Martz BL, Helmer OM. Renin activity during supine exercise in normotensives and hypertensives. J Appl Physiol 21: 1709-1712, 1966.
15. Gould AB, Green D. Kinetics of the human renin and human substrate reaction. Cardiovasc Res 5: 86-89, 1971.
16. Ihle JN, Stravapodis D, Parganas E, Thierfelder W, Feng J, Wang D, Teglund S. The roles of Jaks and Stats in cytokine signaling. Cancer J Sci Am 4, Suppl 1: S84-S91, 1998.
17. Inoue I, Nakajima T, Williams CS, Quackenbush J, Puryear R, Powers M, Cheng T, Ludwig EH, Sharma AM, Hata A, Jeunemaitre X, Lalouel JM. A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro. J Clin Invest 99: 1786-1797, 1997.
18. Jain S, Li Y, Patil S, Kumar A. A single-nucleotide polymorphism in human angiotensinogen gene is associated with essential hypertension and affects glucocorticoid induced promoter activity. J Mol Med 83: 121-131, 2005.
19. Jain S, Tang X, Narayanan CS, Agarwal Y, Peterson SM, Brown CD, Ott J, Kumar A. Angiotensinogen gene polymorphism at -217 affects basal promoter activity and is associated with hypertension in African-Americans. J Biol Chem 277: 36889-36896, 2002.
20. Jeunemaitre X, Soubrier F, Kotelevtsev YV, Lifton RP, Williams CS, Charru A, Hunt SC, Hopkins PN, Williams RR, Lalouel JM, et al. Molecular basis of human hypertension: role of angiotensinogen. Cell 71: 169-180, 1992.
21. Kannel WB. Elevated systolic blood pressure as a cardiovascular risk factor. Am J Cardiol 85: 251-255, 2000.
22. Kim HS, Krege JH, Kluckman KD, Hagaman JR, Hodgin JB, Best CF, Jennette JC, Coffman TM, Maeda N, Smithies O. Genetic control of blood pressure and the angiotensinogen locus. Proc Natl Acad Sci USA 92: 2735-2739, 1995.
23. Kimura S, Mullins JJ, Bunnemann B, Metzger R, Hilgenfeldt U, Zimmermann F, Jacob H, Fuxe K, Ganten D, Kaling M. High blood pressure in transgenic mice carrying the rat angiotensinogen gene. EMBO J 11: 821-827, 1992.
24. Leu JI, Crissey MA, Leu JP, Ciliberto G, Taub R. Interleukin-6-induced STAT3 and AP-1 amplify hepatocyte nuclear factor 1-mediated transactivation of hepatic genes, an adaptive response to liver injury. Mol Cell Biol 21: 414-424, 2001.
25. Mosterd A, D'Agostino RB, Silbershatz H, Sytkowski PA, Kannel WB, Grobbee DE, Levy D. Trends in the prevalence of hypertension, antihypertensive therapy, and left ventricular hypertrophy from 1950 to 1989. N Engl J Med 340: 1221-1227, 1999.
26. Narayanan CS, Cui Y, Kumar A. DBP binds to the proximal promoter and regulates liver-specific expression of the human angiotensinogen gene. Biochem Biophys Res Commun 251: 388-393, 1998.
27. Odom DT, Zizlsperger N, Gordon DB, Bell GW, Rinaldi NJ, Murray HL, Volkert TL, Schreiber J, Rolfe PA, Gifford DK, Fraenkel E, Bell GI, Young RA. Control of pancreas and liver gene expression by HNF transcription factors. Science 303: 1378-1381, 2004.
28. Poli V. The role of C/EBP isoforms in the control of inflammatory and native immunity functions. J Biol Chem 273: 29279-29282, 1998.
29. Poli V, Mancini FP, Cortese R. IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C/EBP. Cell 63: 643-653, 1990.
30. Ray S, Sherman CT, Lu M, Brasier AR. Angiotensinogen gene expression is dependent on signal transducer and activator of transcription 3-mediated p300/cAMP response element binding protein-binding protein coactivator recruitment and histone acetyltransferase activity. Mol Endocrinol 16: 824-836, 2002.
31. Sherman CT, Brasier AR. Role of signal transducers and activators of transcription 1 and -3 in inducible regulation of the human angiotensinogen gene by interleukin-6. Mol Endocrinol 15: 441-457, 2001.
32. Tanimoto K, Sugiyama F, Goto Y, Ishida J, Takimoto E, Yagami K, Fukamizu A, Murakami K. Angiotensinogen-deficient mice with hypotension. J Biol Chem 269: 31334-31337, 1994.
33. Tronche F, Ringeisen F, Blumenfeld M, Yaniv M, Pontoglio M. Analysis of the distribution of binding sites for a tissue- specific transcription factor in the vertebrate genome. J Mol Biol 266: 231-245, 1997.
34. Tronche F, Yaniv M. HNF1, a homeoprotein member of the hepatic transcription regulatory network. Bioessays 14: 579-587, 1992.
35. Walker WG, Whelton PK, Saito H, Russell RP, Hermann J. Relation between blood pressure and renin, renin substrate, angiotensin II, aldosterone and urinary sodium and potassium in 574 ambulatory subjects. Hypertension 1: 287-291, 1979.
36. Watt GC, Harrap SB, Foy CJ, Holton DW, Edwards HV, Davidson HR, Connor JM, Lever AF, Fraser R. Abnormalities of glucocorticoid metabolism and the renin-angiotensin system: a four-corners approach to the identification of genetic determinants of blood pressure. J Hypertens 10: 473-482, 1992.
37. Wu SJ, Chiang FT, Chen WJ, Liu PH, Hsu KL, Hwang JJ, Lai LP, Lin JL, Tseng CD, Tseng YZ. Three single-nucleotide polymorphisms of the angiotensinogen gene and susceptibility to hypertension: single locus genotype vs. haplotype analysis. Physiol Genomics 17: 79-86, 2004.
38. Zhang Z, Jones S, Hagood JS, Fuentes NL, Fuller GM. STAT3 acts as a co-activator of glucocorticoid receptor signaling. J Biol Chem 272: 30607-30610, 1997.