A single-nucleotide polymorphism in human angiotensinogen gene is associated with essential hypertension and affects glucocorticoid induced promoter activity

Journal of Molecular Medicine

Volumn 83, Issue 2, 2005, Pages 121-131

  Jain, Sudhir ^a   Li, Yanna ^a   Patil, Sai ^a   Kumar, Ashok ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

African Americans; Angiotensinogen gene; Glucocorticoids; Hypertension; Single nucleotide polymorphism

Indexed keywords

ACUTE PHASE PROTEIN; ANGIOTENSINOGEN; CCAAT ENHANCER BINDING PROTEIN BETA; CCAAT ENHANCER BINDING PROTEIN DELTA; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; INTERLEUKIN 6; NUCLEOSIDE; RECOMBINANT RECEPTOR;

ALLELE; ARTICLE; CONTROLLED STUDY; EMBRYO; ESSENTIAL HYPERTENSION; GENE ACTIVITY; GENE CONSTRUCT; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PROMOTER REGION; RECEPTOR BINDING; SINGLE NUCLEOTIDE POLYMORPHISM;

ANGIOTENSINOGEN; CARCINOMA, HEPATOCELLULAR; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CCAAT-ENHANCER-BINDING PROTEIN-DELTA; CCAAT-ENHANCER-BINDING PROTEINS; CELLS, CULTURED; DEXAMETHASONE; DNA PRIMERS; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; HUMANS; HYPERTENSION; INTERLEUKIN-6; KIDNEY; LIVER NEOPLASMS; MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); RECEPTORS, GLUCOCORTICOID; RECOMBINANT PROTEINS; REGULATORY SEQUENCES, NUCLEIC ACID; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 15044365863     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-004-0621-5     Document Type: Article

References (39)

1. Akira S et al (1990) A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J 9:1897-1906
2. Bloem LJ et al (1997) Association of the angiotensinogen gene to serum angiotensinogen in blacks and whites. Hypertension 29:1078-1082
3. Brasier AR, Han Y, Sherman CT (1999) Transcriptional regulation of angiotensinogen gene expression. Vitam Horm 57:217-247
4. Burt VL et al (1995) Prevalence of hypertension in the US adult population. Results from the Third National Health and Nutrition Examination Survey, 1988-1991. Hypertension 25:305-313
5. Campbell DJ, Habener JF (1986) Angiotensinogen gene is expressed and differentially regulated in multiple tissues of the rat. J Clin Invest 78:31-39
6. Campbell DJ, Habener JF (1987) Cellular localization of angiotensinogen gene expression in brown adipose tissue and mesentery: quantification of messenger ribonucleic acid abundance using hybridization in situ. Endocrinology 121:1616-1626
7. Caulfield M et al (1995) Linkage of the angiotensinogen gene locus to human essential hypertension in African Caribbeans. J Clin Invest 96:687-692
8. Corvol P, Jeunemaitre X (1997) Molecular genetics of human hypertension: role of angiotensinogen. Endocr Rev 18:662-677
9. Corvol P et al (1995) Role of the renin-angiotensin system in blood pressure regulation and in human hypertension: new insights from molecular genetics. Recent Prog Horm Res 50:287-308
10. Frederich RC Jr et al (1992) Tissue-specific nutritional regulation of angiotensinogen in adipose tissue. Hypertension 19:339-344
11. Giacchetti G et al (2002) Overexpression of the renin-angiotensin system in human visceral adipose tissue in normal and overweight subjects. AmJ Hypertens 15:381-388
12. Glass CK, Rosenfeld MG (2000) The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev 14:121-141
13. Jain S et al (2002) Angiotensinogen gene polymorphism at -217 affects basal promoter activity and is associated with hypertension in African-Americans. J Biol Chem 277:36889-36896
14. Jeunemaitre X et al (1992) Molecular basis of human hypertension: role of angiotensinogen. Cell 71:169-180
15. Kalinyak JE, Perlman AJ (1987) Tissue-specific regulation of angiotensinogen mRNA accumulation by dexamethasone. J Biol Chem 262:460-464
16. Kannel WB (2000) Elevated systolic blood pressure as a cardiovascular risk factor. Am J Cardiol 85:251-255
17. Kim HS et al (1995) Genetic control of blood pressure and the angiotensinogen locus. Proc Natl Acad Sci USA 92:2735-2739
18. Kimura S et al (1992) High blood pressure in transgenic mice carrying the rat angiotensinogen gene. EMBO J 11:821-827
19. Lynch KR, Peach MJ (1991) Molecular biology of angiotensinogen. Hypertension 17:263-269
20. Masuzaki H et al (2001) A transgenic model of visceral obesity and the metabolic syndrome. Science 294:2166-2170
21. Matsuno F et al (1996) Induction of the C/EBP beta gene by dexamethasone and glucagon in primary-cultured rat hepatocytes. J Biochem (Tokyo) 119:524-532
22. Mosterd A et al (1999) Trends in the prevalence of hypertension, antihypertensive therapy, and left ventricular hypertrophy from 1950 to 1989. N Engl J Med 340:1221-1227
23. Narayanan CS, Cui Y, Kumar A (1998) DBP binds to the proximal promoter and regulates liver-specific expression of the human angiotensinogen gene. Biochem Biophys Res Commun 251:388-393
24. Narayanan CS et al (2000) cAMP increases the expression of human angiotensinogen gene through a combination of cyclic AMP responsive element binding protein and a liver specific transcription factor. Mol Cell Biochem 212 (1-2):81-90
25. Poli V (1998) The role of C/EBP isoforms in the control of inflammatory and native immunity functions. J Biol Chem 273:29279-29282
26. Rask E et al (2001) Tissue-specific dysregulation of cortisol metabolism in human obesity. J Clin Endocrinol Metab 86 [AB-3]:1418-1421
27. Rask E et al (2002) Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11beta-hydroxysteroid dehydrogenase type 1 activity. J Clin Endocrinol Metab 87:3330-3336
28. Ron D et al (1990) The permissive role of glucocorticoids on interleukin-1 stimulation of angiotensinogen gene transcription is mediated by an interaction between inducible enhancers. Mol Cell Biol 10:4389-4395
29. Ron D et al (1990) An inducible 50-kilodalton NF kappa B-like protein and a constitutive protein both bind the acute-phase response element of the angiotensinogen gene. Mol Cell Biol 10:1023-1032
30. Rotimi C et al (1994) Angiotensinogen gene in human hypertension. Lack of an association of the 235T allele among African Americans. Hypertension 24:591-594
31. Saye JA et al (1989) Angiotensinogen gene expression in 3T3-L1 cells. Am J Physiol 256:C448-C451
32. Schindler C, Darnell JE Jr (1995) Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem 64:621-651
33. Sherman CT, Brasier AR (2001) Role of signal transducers and activators of transcription 1 and -3 in inducible regulation of the human angiotensinogen gene by interleukin-6. Mol Endocrinol 15:441-457
34. Wajchenberg BL (2000) Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev 21:697-738
35. Walker WG et al (1979) Relation between blood pressure and renin, renin substrate, angiotensin II, aldosterone and urinary sodium and potassium in 574 ambulatory subjects. Hypertension 1:287-291
36. Ward R (1990) Familial aggregation and genetic epidemeology of blood pressure. In: Laragh JH, Brenner BM (eds) Hypertension: pathophysiology, diagnosis and management. Raven, New York, pp 81-100
37. Wu SJ et al (2004) Three single-nucleotide polymorphisms of the angiotensinogen gene and susceptibility to hypertension: single locus genotype vs. haplotype analysis. Physiol Genomics 17:79-86
38. Yang G et al (1994) Functional expression of the human angiotensinogen gene in transgenic mice. J Biol Chem 269:32497-32502
39. Zhang Z et al (1997) STAT3 acts as a co-activator of glucocorticoid receptor signaling. J Biol Chem 272:30607-30610