Identification and characterisation of the angiotensin converting enzyme-3 (ACE3) gene: A novel mammalian homologue of ACE

BMC Genomics

Volumn 8, Issue , 2007, Pages

  Rella, Monika ^a   Elliot, Joann L ^a,b   Revett, Timothy J ^a,b   Lanfear, Jerry ^c   Phelan, Anne ^c   Jackson, Richard M ^a   Turner, Anthony J ^a   Hooper, Nigel M ^a,b  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME 3; DIPEPTIDYL CARBOXYPEPTIDASE; GLUTAMIC ACID; GLUTAMINE; METALLOPROTEINASE; UNCLASSIFIED DRUG; ZINC; ACE3 PROTEIN, HUMAN; ACE3 PROTEIN, MOUSE;

ANIMAL TISSUE; ARTICLE; CATALYSIS; CHROMOSOME; CONTROLLED STUDY; COW; DOG; EXPRESSED SEQUENCE TAG; GENE DELETION; GENE EXPRESSION; GENE IDENTIFICATION; GENE INSERTION; GENE LOCATION; GENE MUTATION; GENOME; HUMAN; MAMMAL; MOLECULAR MODEL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PREDICTION; PROTEIN BINDING; PROTEIN MOTIF; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; AMINO ACID SEQUENCE; ANIMAL; CATTLE; CHEMISTRY; GENE EXPRESSION PROFILING; GENETICS; GENOMICS; METHODOLOGY; MOLECULAR GENETICS; SEQUENCE HOMOLOGY; SPECIES DIFFERENCE;

CANIS FAMILIARIS; MAMMALIA; RATTUS;

AMINO ACID SEQUENCE; ANIMALS; CATTLE; DOGS; EXPRESSED SEQUENCE TAGS; GENE EXPRESSION PROFILING; GENOMICS; HUMANS; METALLOPROTEASES; MICE; MOLECULAR SEQUENCE DATA; PEPTIDYL-DIPEPTIDASE A; RATS; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY;

EID: 34447644270     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-8-194     Document Type: Article

References (44)

1. Turner AJ Hooper NM The angiotensin-converting enzyme gene family: genomics and pharmacology Trends Pharmacol Sci 2002 23 177-183 11931993
2. Acharya KR Sturrock ED Riordan JF Ehlers MR Ace revisited: A new target for structure-based drug design Nat Rev Drug Discov 2003 2 891-902 14668810
3. Hubert C Houot AM Corvol P Soubrier F Structure of the angiotensin I-converting enzyme gene. Two alternate promoters correspond to evolutionary steps of a duplicated gene Journal of Biological Chemistry 1991 266 15377-15383 1651327
4. Hooper NM Families of zinc metalloproteases FEBS Letters 1994 354 1-6 7957888
5. Natesh R Schwager SL Sturrock ED Acharya KR Crystal structure of the human angiotensin-converting enzyme-lisinopril complex Nature 2003 421 551-554 12540854
6. Corradi HR Schwager SL Nchinda AT Sturrock ED Acharya KR Crystal structure of the N domain of human somatic angiotensin I-converting enzyme provides a structural basis for domain-specific inhibitor design J Mol Biol 2006 357 964-974 16476442
7. Tipnis SR Hooper NM Hyde R Karran EH Christie G Turner AJ A human homolog of angiotensin converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase J Biol Chem 2000 275 33238-33243 10924499
8. Donoghue M Hsieh F Baronas E Godbout K Gosselin M Stagliano N Donovan M Woolf B Robison K Jeyaseelan R Breitbart RE Acton S A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9 Circ Res 2000 87 E1-9 10969042
9. Crackower MA Sarao R Oudit GY Yagil C Kozieradzki I Scanga SE Oliveira-dos-Santos AJ da Costa J Zhang L Pei Y Scholey J Ferrario CM Manoukian AS Chappell MC Backx PH Yagil Y Penninger JM Angiotensin-converting enzyme 2 is an essential regulator of heart function Nature 2002 417 822-828 12075344
10. Imai Y Kuba K Rao S Huan Y Guo F Guan B Yang P Sarao R Wada T Leong-Poi H Crackower MA Fukamizu A Hui CC Hein L Uhlig S Slutsky AS Jiang C Penninger JM Angiotensin-converting enzyme 2 protects from severe acute lung failure Nature 2005 436 112-116 16001071
11. Li W Moore MJ Vasilieva N Sui J Wong SK Berne MA Somasundaran M Sullivan JL Luzuriaga K Greenough TC Choe H Farzan M Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus Nature 2003 426 450-454 14647384
12. Guy JL Jackson RM Acharya KR Sturrock ED Hooper NM Turner AJ Angiotensin-Converting Enzyme-2 (ACE2): Comparative Modeling of the Active Site, Specificity Requirements, and Chloride Dependence Biochemistry 2003 42 13185-13192 14609329
13. Towler P Staker B Prasad SG Menon S Tang J Parsons T Ryan D Fisher M Williams D Dales NA Patane MA Pantoliano MW ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis J Biol Chem 2004 279 17996-18007 14754895
14. Rice GI Thomas DA Grant PJ Turner AJ Hooper NM Evaluation of angiotensin converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism Biochem J 2004 383 45-51 1134042 15283675
15. Isaac RE Lamango NS Ekbote U Taylor CA Hurst D Weaver RJ Carhan A Burnham S Shirras AD Angiotensin-converting enzyme as a target for the development of novel insect growth regulators Peptides 2007 28 153-162 17157962
16. Riviere G Michaud A Deloffre L Vandenbulcke F Levoye A Breton C Corvol P Salzet M Vieau D Characterization of the first non-insect invertebrate functional angiotensin-converting enzyme (ACE): Leech TtACE resembles the N-domain of mammalian ACE Biochem J 2004 382 565-573 1133813 15175004
17. Houard X Williams TA Michaud A Dani P Isaac RE Shirras AD Coates D Corvol P The Drosophila melanogaster-related angiotensin-I-converting enzymes Acer and Ance - distinct enzymic characteristics and alternative expression during pupal development [In Process Citation] Eur J Biochem 1998 257 599-606 9839949
18. Coates D Isaac RE Cotton J Siviter R Williams TA Shirras A Corvol P Dive V Functional conservation of the active sites of human and Drosophila angiotensin I-converting enzyme Biochemistry 2000 39 8963-8969 10913309
19. Burnham S Smith JA Lee AJ Isaac RE Shirras AD The angiotensin-converting enzyme (ACE) gene family of Anopheles gambiae BMC Genomics 2005 6 172 1325048 16329762
20. Brooks DR Appleford PJ Murray L Isaac RE An essential role in molting and morphogenesis of Caenorhabditis elegans for ACN-1, a novel member of the angiotensin-converting enzyme family that lacks a metallopeptidase active site J Biol Chem 2003 278 52340-52346 14559923
21. Chou CF Loh CB Foo YK Shen S Fielding BC Tan TH Khan S Wang Y Lim SG Hong W Tan YJ Fu J ACE2 orthologues in non-mammalian vertebrates (Danio, Gallus, Fugu, Tetraodon and Xenopus) Gene 2006 377 46-55 16781089
22. Fernandez M Liu X Wouters MA Heyberger S Husain A Angiotensin I-converting enzyme transition-state stabilization by His1089: Evidence for a catalytic mechanism distinct from other gluzincin metalloproteinases J Biol Chem 2001 276 4998-5004 11067854
23. Guy JL Jackson RM Jensen HA Hooper NM Turner AJ Identification of critical active-site residues in angiotensin-converting enzyme-2 (ACE2) by site-directed mutagenesis Febs J 2005 272 3512-3520 16008552
24. Barrett AJ Rawlings ND Woessner JF Handbook of Proteolytic Enzymes Amsterdam, Elsevier Academic Press second 2004 1 1047
25. Cummins PM Pabon A Margulies EH Glucksman MJ Zinc coordination and substrate catalysis within the neuropeptide processing enzyme endopeptidase EC 3.4.24.15. Identification of active site histidine and glutamate residues J Biol Chem 1999 274 16003-16009 10347149
26. Williams TA Corvol P Soubrier F Identification of two active site residues in human angiotensin I-converting enzyme Journal of Biological Chemistry 1994 269 29430-29434 7961923
27. Le Moual H Dion N Roques BP Crine P Boileau G Asp650 is crucial for catalytic activity of neutral endopeptidase 24.11 European Journal of Biochemistry 1994 221 475-480 8168535
28. Stein KK Go JC Lane WS Primakoff P Myles DG Proteomic analysis of sperm regions that mediate sperm-egg interactions Proteomics 2006 6 3533-3543 16758446
29. Cho C Mammalian ADAMs with testis-specific or -predominant expression The ADAM family of proteases Dordrecht, Springer Hooper NM and Lendeckel U 2005 239-259
30. Zhang Z Gerstein M Large-scale analysis of pseudogenes in the human genome Curr Opin Genet Dev 2004 14 328-335 15261647
31. Puente XS Sanchez LM Overall CM Lopez-Otin C Human and mouse proteases: a comparative genomic approach Nat Rev Genet 2003 4 544-558 12838346
32. Hirotsune S Yoshida N Chen A Garrett L Sugiyama F Takahashi S Yagami K Wynshaw-Boris A Yoshiki A An expressed pseudogene regulates the messenger-RNA stability of its homologous coding gene Nature 2003 423 91-96 12721631
33. Gray TA Wilson A Fortin PJ Nicholls RD The putatively functional Mkrn1-p1 pseudogene is neither expressed nor imprinted, nor does it regulate its source gene in trans Proc Natl Acad Sci U S A 2006 103 12039-12044 1567693 16882727
34. Zheng D Gerstein MB The ambiguous boundary between genes and pseudogenes: The dead rise up, or do they? Trends Genet 2007 17382428
35. Pruitt KD Tatusova T Maglott DR NCBI Reference Sequence (RefSeq): A curated non-redundant sequence database of genomes, transcripts and proteins Nucleic Acids Res 2005 33 D501-4 539979 15608248
36. Birney E Andrews D Caccamo M Chen Y Clarke L Coates G Cox T Cunningham F Curwen V Cutts T Down T Durbin R Fernandez-Suarez XM Flicek P Graf S Hammond M Herrero J Howe K Iyer V Jekosch K Kahari A Kasprzyk A Keefe D Kokocinski F Kulesha E London D Longden I Melsopp C Meidl P Overduin B Parker A Proctor G Prlic A Rae M Rios D Redmond S Schuster M Sealy I Searle S Severin J Slater G Smedley D Smith J Stabenau A Stalker J Trevanion S Ureta-Vidal A Vogel J White S Woodwark C Hubbard TJ Ensembl 2006 Nucleic Acids Res 2006 34 D556-61 1347495 16381931
37. Rice P Longden I Bleasby A EMBOSS: The European Molecular Biology Open Software Suite Trends Genet 2000 16 276-277 10827456
38. Thompson JD Higgins DG Gibson TJ CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice Nucleic Acids Res 1994 22 4673-4680 308517 7984417
39. O'Sullivan O Suhre K Abergel C Higgins DG Notredame C 3DCoffee: combining protein sequences and structures within multiple sequence alignments J Mol Biol 2004 340 385-395 15201059
40. Kyte J Doolittle RF A simple method for displaying the hydropathic character of a protein J Mol Biol 1982 157 105-132 7108955
41. Hofmann K Stoffel W Tmbase - A database of membrane spanning protein segments Biol Chem Hoppe-Seyler 1993 374 166
42. Bendtsen JD Nielsen H von Heijne G Brunak S Improved prediction of signal peptides: SignalP 3.0 J Mol Biol 2004 340 783-795 15223320
43. Schwede T Kopp J Guex N Peitsch MC SWISS-MODEL: An automated protein homology-modeling server Nucleic Acids Res 2003 31 3381-3385 168927 12824332
44. Corvol P Williams TA Soubrier F Peptidyl dipeptidase A: Angiotensin I-converting enzyme Methods in Enzymology 1995 248 283-305 7674927