Intrathecal substance P (1-7) prevents morphine-evoked spontaneous pain behavior via spinal NMDA-NO cascade

Biochemical Pharmacology

Volumn 74, Issue 5, 2007, Pages 758-767

  Sakurada, Tsukasa ^a   Komatsu, Takaaki ^a   Kuwahata, Hikari ^a   Watanabe, Chizuko ^b   Orito, Toru ^b   Sakurada, Chikai ^c   Tsuzuki, Minoru ^c   Sakurada, Shinobu ^b  

^a DAIICHI UNIVERSITY OF PHARMACY   (Japan)

^b TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^c NIHON PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Glutamate; High dose morphine; Intrathecal injection; Nitric oxide; Spinal microdialysis; Substance P (1 7); Vocalization and agitation

Indexed keywords

GLUTAMIC ACID; MORPHINE; N METHYL DEXTRO ASPARTIC ACID; NITRIC OXIDE; SUBSTANCE P [1-7]; SUBSTANCE P ANTAGONIST;

AGITATION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG RESPONSE; MALE; MICRODIALYSIS; NONHUMAN; PAIN ASSESSMENT; PAIN THRESHOLD; PRIORITY JOURNAL; RAT; SPINAL CORD; VOCALIZATION;

ANALGESICS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTAMIC ACID; MALE; MORPHINE; N-METHYLASPARTATE; NITRATES; NITRIC OXIDE; NITRITES; PAIN; PEPTIDE FRAGMENTS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; SUBSTANCE P; TIME FACTORS;

EID: 34447622885     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.05.025     Document Type: Article

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