Alpha 2-adrenergic receptors decrease DNA replication and cell proliferation and induce neurite outgrowth in transfected rat pheochromocytoma cells

Annals of the New York Academy of Sciences

Volumn 1088, Issue , 2006, Pages 335-345

  Karkoulias, G ^a   Mastrogianni, O ^a   Ilias, I ^a   Lymperopoulos, A ^b   Taraviras, S ^a   Tsopanoglou, N ^a   Sitaras, N ^c   Flordellis, C S ^a  

^a UNIVERSITY OF PATRAS   (Greece)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Neurite outgrowth; Neuronal differentiation; PC12 cells; 2 adrenergic receptor

Indexed keywords

ADRENALIN; ALPHA 2 ADRENERGIC RECEPTOR; NEUROTROPHIC FACTOR; NORADRENALIN; RADIOISOTOPE; THYMIDINE H 3; UNCLASSIFIED DRUG; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT;

ANIMAL CELL; CELL PROLIFERATION; CONFERENCE PAPER; CONTROLLED STUDY; DNA REPLICATION; IMMUNOCYTOCHEMISTRY; NERVE CELL; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PHEOCHROMOCYTOMA CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; RAT; WESTERN BLOTTING; ANIMAL; ARTICLE; CELL DIFFERENTIATION; CELL DIVISION; CELL STRAIN; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; NEURITE; PHYSIOLOGY; ULTRASTRUCTURE;

RATTUS;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; CELL DIFFERENTIATION; CELL DIVISION; DNA REPLICATION; EPINEPHRINE; HUMANS; NEURITES; NEURONS; PC12 CELLS; RATS; RECEPTORS, ADRENERGIC, ALPHA-2; TRANSFECTION;

EID: 34447621574     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1366.017     Document Type: Conference Paper

References (39)

1. MACDONALD, E. et al. 1997. Gene targeting-homing in on alpha 2-adrenoceptor-subtype function. Trends Pharmacol. Sci. 18: 211-219.
2. HANDY, D.E. et al. 1993. Diverse tissue expression of rat alpha 2-adrenergic receptor genes. Hypertension 21: 861-865.
3. DAUNT, D.A. et al. 1997. Subtype-specific intracellular trafficking of alpha2-adrenergic receptors. Mol. Pharmacol. 51: 711-720.
4. VON ZASTROW, M. et al. 1993. Subtype-specific differences in the intracellular sorting of G protein-coupled receptors. J. Biol. Chem. 268: 763-766.
5. PHILIPP, M. et al. 2002. Physiological significance of alpha(2)-adrenergic receptor subtype diversity: one receptor is not enough. Am. J. Physiol. Regul. Integr. Comp. Physiol. 283: R287-R295.
6. MACMILLAN, L.B. et al. 1996. Central hypotensive effects of the alpha2a-adrenergic receptor subtype. Science 273: 801-803.
7. LINK, R.E. et al. 1996. Cardiovascular regulation in mice lacking alpha2-adrenergic receptor subtypes b and c. Science 273: 803-805.
8. KABLE, J.W. et al. 2000. In vivo gene modification elucidates subtype-specific functions of alpha(2)-adrenergic receptors. J. Pharmacol. Exp. Ther. 293: 1-7.
9. MAKARITSIS, K.P. et al. 1999. Role of the alpha2B-adrenergic receptor in the development of salt-induced hypertension. Hypertension 33: 14-17.
10. SALLINEN, J. et al. 1997. Genetic alteration of alpha 2C-adrenoceptor expression in mice: influence on locomotor, hypothermic, and neurochemical effects of dexmedetomidine, a subtype-nonselective alpha 2-adrenoceptor agonist. Mol. Pharmacol. 51: 36-46.
11. SALLINEN, J. et al. 1998. D-amphetamine and L-5-hydroxytryptophan-induced behaviours in mice with genetically-altered expression of the alpha2C-adrenergic receptor subtype. Neuroscience 86: 959-965.
12. BUCHELER, M.M. et al. 2002. Two alpha(2)-adrenergic receptor subtypes, alpha(2A) and alpha(2C), inhibit transmitter release in the brain of gene-targeted mice. Neuroscience 109: 819-826.
13. BREDE, M. et al. 2003. Differential control of adrenal and sympathetic catecholamine release by alpha 2-adrenoceptor subtypes. Mol. Endocrinol. 17: 1640-1646.
14. LAHDESMAKI, J. et al. 2004. Alpha2A-adrenoceptors are important modulators of the effects of D-amphetamine on startle reactivity and brain monoamines. Neuropsychopharmacology 29: 1282-1293.
15. MA, D. et al. 2005. Alpha2-adrenoceptor agonists: shedding light on neuroprotection? Br. Med. Bull. 71: 77-92.
16. TARAVIRAS, S. et al. 2002. Subtype-specific neuronal differentiation of PC12 cells transfected with alpha2-adrenergic receptors. Eur. J. Cell Biol. 81: 363-374.
17. OLLI-LAHDESMAKI, T. et al. 1999. Receptor subtype-induced targeting and subtype-specific internalization of human alpha(2)-adrenoceptors in PC12 cells. J. Neurosci. 19: 9281-9288.
18. KARKOULIAS, G. et al. 2006. alpha(2)-Adrenergic receptors activate MAPK and Akt through a pathway involving arachidonic acid metabolism by cytochrome P450-dependent epoxygenase, matrix metalloproteinase activation and subtype-specific transactivation of EGFR. Cell Signal 18: 729-739.
19. GREENE, L.A. 1984. The importance of both early and delayed responses in the biological actions of nerve growth factor. Trends Neurosci. 7: 91-94.
20. PEUNOVA, N. et al. 1995. Nitric oxide triggers a switch to growth arrest during differentiation of neuronal cells. Nature 375: 68-73.
21. WILLIAMS, N.G. et al. 1998. Differential coupling of alpha1-, alpha2-, and beta-adrenergic receptors to mitogen-activated protein kinase pathways and differentiation in transfected PC12 cells. J. Biol. Chem. 273: 24624-24632.
22. SCHEININ, M. et al. 2001. Evaluation of the alpha2C-adrenoceptor as a neuropsychiatric drug target studies in transgenic mouse models. Life Sci. 68: 2277-2285.
23. ARNSTEN, A.F. et al. 2005. Methylphenidate improves prefrontal cortical cognitive function through alpha2 adrenoceptor and dopamine D1 receptor actions: relevance to therapeutic effects in attention deficit hyperactivity disorder. Behav. Brain Funct. 1:2/doi. 10.1186/1744-9081-1-1-2
24. ARNSTEN, A.F. et al. 2005. Neurobiology of executive functions: catecholamine influences on prefrontal cortical functions. Biol. Psychiatry 57: 1377-1384.
25. KULKARNI, V.A. et al. 2002. Depletion of norepinephrine decreases the proliferation, but does not influence the survival and differentiation, of granule cell progenitors in the adult rat hippocampus. Eur. J. Neurosci. 16: 2008-2012.
26. VEYRAC, A. et al. 2005. Activation of noradrenergic transmission by alpha2-adrenoceptor antagonists counteracts deafferentation- induced neuronal death and cell proliferation in the adult mouse olfactory bulb. Exp. Neurol. 194: 444-456.
27. FUCHS, E. et al. 2004. Alterations of neuroplasticity in depression: the hippocampus and beyond. Eur. Neuropsychopharmacol. 14: S481-S490.
28. VAN PRAAG, H. et al. 2002. Functional neurogenesis in the adult hippocampus. Nature 415: 1030-1034.
29. POPOVIK, E. et al. 2000. Survival and mitogenesis of neuroepithelial cells are influenced by noradrenergic but not cholinergic innervation in cultured embryonic rat neopallium. Brain Res. 853: 227-235.
30. BAUER, S. et al. 2003. Effects of the alpha 2-adrenoreceptor antagonist dexefaroxan on neurogenesis in the olfactory bulb of the adult rat in vivo: selective protection against neuronal death. Neuroscience 117: 281-291.
31. PAYKEL, E.S. 2001. Stress and affective disorders in humans. Semin. Clin. Neuropsychiatry 6: 4-11.
32. HEINE, V.M. et al. 2004. Suppressed proliferation and apoptotic changes in the rat dentate gyrus after acute and chronic stress are reversible. Eur. J. Neurosci. 19: 131-144.
33. CAMERON, H.A. et al. 1995. Regulation of adult neurogenesis by excitatory input and NMDA receptor activation in the dentate gyrus. J. Neurosci. 15: 4687-4692.
34. RUSSO-NEUSTADT, A.A. et al. 2000. Physical activity and antidepressant treatment potentiate the expression of specific brain-derived neurotrophic factor transcripts in the rat hippocampus. Neuroscience 101: 305-312.
35. MALBERG, J.E. et al. 2000. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J. Neurosci. 20: 9104-9110.
36. MEYER, H. et al. 2000. Regulation of alpha(2A)- adrenoceptor expression by chronic stress in neurons of the brain stem. Brain Res. 880: 147-158.
37. FLUGGE, G. et al. 2003. Alpha2A and alpha2C-adrenoceptor regulation in the brain: alpha2A changes persist after chronic stress. Eur. J. Neurosci. 17: 917-928.
38. BHATNAGAR, S. et al. 1999. The paraventricular nucleus of the thalamus alters rhythms in core temperature and energy balance in a state-dependent manner. Brain Res. 851: 66-75.
39. VAN DER WERF, Y.D. et al. 2002. The intralaminar and midline nuclei of the thalamus. Anatomical and functional evidence for participation in processes of arousal and awareness. Brain Res. Brain Res. Rev. 39: 107-140.