Gal knockout pigs: Any more carbohydrates?

Transplantation

Volumn 84, Issue 1, 2007, Pages 8-9

  Sandrin, Mauro S ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1,3 GALACTOSYLTRANSFERASE; CARBOHYDRATE;

ACUTE GRAFT REJECTION; ANTIGEN BINDING; DNA MODIFICATION; ENZYME SYNTHESIS; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KNOCKOUT GENE; NATURAL KILLER CELL; NOTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECIPIENT; THROMBOTIC THROMBOCYTOPENIC PURPURA; TRANSGENIC ANIMAL; XENOTRANSPLANTATION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIGENS, HETEROPHILE; CARBOHYDRATES; GALACTOSYLTRANSFERASES; GENE DELETION; GENE TARGETING; GRAFT REJECTION; ORGAN TRANSPLANTATION; SWINE; THROMBOSIS; TRANSPLANTATION, HETEROLOGOUS;

EID: 34447621251     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.tp.0000269728.11879.f6     Document Type: Note

References (17)

1. Kuwaki K, Knosalla C, Dor FJ, et al. Suppression of natural and elicited antibodies in pig-to-baboon heart transplantation using a human antihuman CD154 mAb-based regimen. Am J Transplant 2004; 4: 363.
2. Bhatti FN, Schmoeckel M, Zaidi A, et al. Three-month survival of HDAFF transgenic pig hearts transplanted into primates. Transplant Proc 1999; 31: 958.
3. Loveland BE, Milland J, Kyriakou P, et al. Characterization of a CD46 transgenic pig and protection of transgenic kidneys against hyperacute rejection in non-immunosuppressed baboons. Xenotransplantation 2004; 11: 171.
4. Dai Y, Vaught TD, Boone J, et al. Targeted disruption of the alpha1,3-galactosyltransferase gene in cloned pigs. Nat Biotechnol 2002; 20: 251.
5. Lai L, Kolber-Simonds D, Park KW, et al. Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning. Science 2002; 295: 1089.
6. Phelps CJ, Koike C, Vaught TD, et al. Production of alpha 1,3-galactosyltransferase-deficient pigs. Science 2003; 299: 411.
7. Chen G, Qian H, Starzl T, et al. Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys. Nat Med 2005; 11: 1295.
8. Yamada K, Yazawa K, Shimizu A, et al. Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3- galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue. Nat Med 2005; 11: 32.
9. Kuwaki K, Tseng YL, Dor FJ, et al. Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat Med 2005; 11: 29.
10. Cooper DK, Dorling A, Pierson RN, et al. α1,3galactosyltransferase gene-knockout pigs for xenotransplantation: Where do we go from here? Transplantation 2007; 84: 1.
11. Sandrin MS, Milland J, Christiansen D. The impact of the α1,3galactosyltransferase gene knockout pig on xenotransplantation. Curr Opin Organ Transplant 2007; 12: 154.
12. Keusch JJ, Manzella SM, Nyame KA, et al. Expression cloning of a new member of the ABO blood group glycosyltransferases, iGb3 synthase, that directs the synthesis of isoglobo-glycosphingolipids. J Biol Chem 2000; 275: 25308.
13. Milland J, Christiansen D, Lazarus BD, et al. The molecular basis for galalpha(1,3)gal expression in animals with a deletion of the alpha1,3galactosyltransferase gene. J Immunol 2006; 176: 2448.
14. Sharma A, Naziruddin B, Cui C, et al. Pig cells that lack the gene for alpha1-3 galactosyltransferase express low levels of the gal antigen. Transplantation 2003; 75: 430.
15. Zhou D, Mattner J, Cantu C, 3rd, et al. Lysosomal glycosphingolipid recognition by NKT cells. Science 2004; 306: 1786.
16. Milland J, Christiansen D, Sandrin MS. Alpha1,3-galactosyltransferase knockout pigs are available for xenotransplantation: Are glycosyltransferases still relevant. Immunol Cell Biol 2005; 83: 687.
17. Christiansen D, Mouhtouris E, Milland J, et al. Recognition of a carbohydrate xenoepitope by human NKRP1A (CD161). Xenotransplantation 2006; 13: 440.