Catalytic mechanism of SGAP, a double-zinc aminopeptidase from Streptomyces griseus

FEBS Journal

Volumn 274, Issue 15, 2007, Pages 3864-3876

  Hershcovitz, Yifat F ^a   Gilboa, Rotem ^b   Reiland, Vera ^b   Shoham, Gil ^b   Shoham, Yuval ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Aminopeptidase; Catalytic mechanism; Catalytic residues; Fluoride inhibition; Isotope effect

Indexed keywords

AMINOPEPTIDASE; ANILIDE; FLUORIDE; HYDROXIDE; ISOTOPE; LEUCINE 4 NITROANILIDE; SOLVENT; UNCLASSIFIED DRUG; WATER; ZINC;

ACID BASE BALANCE; ARTICLE; CATALYSIS; CONSTANTS AND COEFFICIENTS; CONTROLLED STUDY; ENERGY; ENTHALPY; ENTROPY; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; HYDROLYSIS; IONIZATION; MOLECULAR INTERACTION; MONITORING; MUTANT; NONHUMAN; PH; PKA; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTON TRANSPORT; REACTION ANALYSIS; STREPTOMYCES GRISEUS; TEMPERATURE; THERMODYNAMICS;

AMINOPEPTIDASES; BINDING SITES; CATALYSIS; DEUTERIUM; ENZYME STABILITY; FLUORINE; HYDROGEN-ION CONCENTRATION; IONS; KINETICS; MOLECULAR STRUCTURE; MUTATION; PHOSPHATES; SOLVENTS; STREPTOMYCES GRISEUS; SUBSTRATE SPECIFICITY; TEMPERATURE; THERMODYNAMICS; ZINC;

STREPTOMYCES GRISEUS;

EID: 34447618092     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2007.05912.x     Document Type: Article

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