A-272651, a nonpeptidic blocker of large-conductance Ca 2+- activated K + channels, modulates bladder smooth muscle contractility and neuronal action potentials

British Journal of Pharmacology

Volumn 151, Issue 6, 2007, Pages 798-806

  Shieh, C C ^a   Turner, S C ^a   Zhang, X F ^a   Milicic, I ^a   Parihar, A ^a   Jinkerson, T ^a   Wilkins, J ^a   Buckner, S A ^a   Gopalakrishnan, M ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

A 272651; BK Ca; Bladder; Detrusor; Dorsal root ganglia; Large conductance Ca 2+ activated K + channel; Potassium channel; Sensory neurons; Smooth muscle

Indexed keywords

2,4 DIMETHOXY N NAPHTHALEN 2 YL BENZAMIDE; A 272651; BENZAMIDE DERIVATIVE; CALCIUM ACTIVATED POTASSIUM CHANNEL; CAPSAICIN; IBERIOTOXIN; NS 1608; POTASSIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG;

ARTICLE; BLADDER; CALCIUM CONDUCTANCE; CALCIUM CURRENT; CELL STRAIN HEK293; CONCENTRATION RESPONSE; CONTROLLED STUDY; DETRUSOR MUSCLE; ELECTRIC FIELD; ELECTROSTIMULATION; EMBRYO; HUMAN; HUMAN CELL; IC 50; MUSCLE ACTION POTENTIAL; MUSCLE CONTRACTION; MUSCLE TWITCH; NERVE CELL; NERVE CONDUCTION; NERVE POTENTIAL; NONHUMAN; PATCH CLAMP; PATHOLOGY; PHYSIOLOGY; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTILITY; SPINAL GANGLION; STATISTICAL ANALYSIS;

ACTION POTENTIALS; ANIMALS; BENZAMIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; GANGLIA, SPINAL; GUINEA PIGS; HUMANS; INHIBITORY CONCENTRATION 50; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NAPHTHALENES; NEURONS; PEPTIDES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; SWINE; URINARY BLADDER;

EID: 34447579056     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0707278     Document Type: Article

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