Effects of the K+ channel blockers paspalitrem-C and paxilline on mammalian smooth muscle

European Journal of Pharmacology

Volumn 314, Issue 1-2, 1996, Pages 123-128

  DeFarias, Fernando P ^a   Carvalho, Marcia F ^a   Lee, Seok H ^b   Kaczorowski, Gregory J ^b   Suarez Kurtz, Guilherme ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Ca2+ activated K+ channel; charybdotoxin; excitation contraction coupling; iberiotoxin; tremorgenic indole alkaloid

Indexed keywords

ALKALOID; ATROPINE; CARBACHOL; CHARYBDOTOXIN; INDOMETACIN; PASPALITREM C; PAXILLINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; TETRODOTOXIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; AORTA; ARTICLE; BLADDER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENTIATION; DUODENUM; EXCITATION CONTRACTION COUPLING; GUINEA PIG; ION CONDUCTANCE; MAMMAL; NONHUMAN; PORTAL VEIN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE TONE; TRACHEA; TREMOR;

ANIMALS; DRUG INTERACTIONS; GUINEA PIGS; INDOLES; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MUSCLE, SMOOTH, VASCULAR; POTASSIUM CHANNEL BLOCKERS; RATS; RATS, WISTAR;

EID: 0030600525     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00540-7     Document Type: Article

References (25)

1. + channels. Effects of channel gating, voltage and ionic strength, J. Gen. Physiol. 91, 317.
2. Bills, G.F., R.A. Giacobbe, S.H. Lee, F. Pelaez and J.S. Tkacz, 1992, Tremorgenic mycotoxins, paspalitrem A and C from a tropical Phomopsis, Mycol. Res. 96, 977.
3. + channels of canine colonic myocytes, Am. J. Physiol. 257, C470.
4. Cole, R.J. and R.H. Cox, 1981, Handbook of Toxic Fungal Metabolites (Academic Press, New York, NY) p. 355.
5. DeFarias, F.P., 1993, Estudo das ações eletrofisiológicas e miocontráteis da paxilina, M.Sc. Dissertation in Biophysics, Universidade Federal do Rio de Janeiro, Rio de Janeiro.
6. Galvez, A., G. Gimenez-Gallego, J.P. Reuben, L. Roy-Contancin, P. Feigelbaum, G.J. Kaczorowski and M.L. Garcia, 1990, Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion, Buthus tamulus, J. Biol. Chem. 265, 11083.
7. 2+ entry blockers to cardiac sarcolemmal membrane vesicles, J. Biol. Chem. 261, 8146.
8. Garcia, M.L., A. Galvez, M. Garcia-Calvo, V.F. King, J. Vazquez and G.J. Kaczorowski, 1991, Use of toxins to study potassium channels, J. Biomembr. Bioenerg. 23, 615.
9. Garcia-Calvo, M., G.J, Kaczorowski and M.L. Garcia, 1993, Molecular characterization of the charybdotoxin-sensitive, high-conductance calcium-activated potassium channel, in: Molecular and Cellular Biology of Pharmacological Targets, eds. H. Glossman and J. Striessnig (Plenum, New York, NY) Methods Pharmacol. 7, 41.
10. Giangiacomo, K.M., M.L. Garcia and O. McManus, 1992, Mechanism of the iberiotoxin block of the large conductance calcium-activated potassium channel from bovine aortic smooth muscle, Biochemistry 31, 6719.
11. Gimenez-Gallego, G., M.A. Navia, J.P. Reuben, G.M. Katz, G.J. Kaczorowski and M.L. Garcia, 1988, Purification, sequence, and model structure of charybdotoxin, a potent selective inhibitor of calcium-activated potassium channels, Proc. Natl. Acad. Sci. USA 85, 3329.
12. + channel and its functional role in smooth muscle cells of guinea pig Taenia coli, J. Gen. Physiol. 94, 833.
13. + channel blockers, Eur. J. Pharmacol. 235, 37.
14. + channel inhibitor, J. Pharmacol. Exp. Ther. 255, 697.
15. Jones, T.R., L. Charette, M.L. Garcia and G.J. Kaczorowski, 1993, Interaction of iberiotoxin with b-adrenoceptor agonists and sodium nitroprusside on guinea-pig trachea, J. Appl. Physiol, 74, 1879.
16. Klöckner, U. and G. Isenberg, 1985, Action potentials and net membrane current of isolated smooth muscle cells (urinary bladder of the guinea-pig), Pfluger's Arch. 405, 329.
17. Knaus, H.-G., O.B. McManus, S.H. Lee, W.A. Schmalhofer, M. Garcia-Calvo, L.M.H. Helms, M. Sanchez, K. Giangiacomo, J.P. Reuben, A.B. Smith III, G.J. Kaczorowski and M.L. Garcia, 1994, Tremorgenie indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels, Biochemistry 33, 5918.
18. + channels from mammalian skeletal muscle, Nature 313, 316.
19. Nelson, M.T., H. Cheng, M. Rubart, L.F. Santana, A.D. Bonev, H.J. Knot and W.J. Lederer, 1995, Relaxation of arterial smooth muscle by calcium sparks, Science 290, 633.
20. Rudy, B., 1988, Diversity and ubiquity of K channels. Neuroscience 25, 729.
21. + channels in swine tracheal smooth muscle cells, J. Pharmacol. Exp. Ther. 257, 1114.
22. Selala, M.I., G.M. Laekeman, B. Loendrs, A. Musuku, A. Herman and P. Schenfens, 1991, In vitro effects of tremorgenic mycotoxins, J. Nat. Prod. 54, 207.
23. Suarez-Kurtz, G., M.L. Garcia and G.J. Kaczorowski, 1991, Effects of charybdotoxin and iberiotoxm on the spontaneous motility and tonus of different guinea pig smooth muscle tissues, J. Pharmacol. Exp. Ther. 259, 439.
24. + channel, J. Biol. Chem. 265, 18745.
25. Winquist, R.J., L.A. Heaney, D.G. Wallace, E.P. Baskin, R.G. Stein, M.L. Garcia and G.J. Kaczorowski, 1989, Glyburide blocks the relaxation response to BRL-34915 (Cromakalin), minoxidil sulfate and diazoxide in vascular smooth muscle, J. Pharmacol. Exp. Ther. 248, 149.