Imaging the availability of serotonin transporter in rat brain with I-ADAM and small-animal SPECT

Nuclear Medicine Communications

Volumn 28, Issue 8, 2007, Pages 615-621

  Hwang, Li Chung ^a   Chang, Chia Jung ^a   Liu, Hsueh Hsuan ^a   Kao, Hung Chun ^a   Lee, Shih Ying ^a   Jan, Meei Ling ^a   Chen, Chia Chieh ^a  

^a INSTITUTE OF NUCLEAR ENERGY RESEARCH   (Taiwan)

Author keywords

Serotonin transporter; Small animal SPECT

Indexed keywords

2 [(2 ((DIMETHYLAMINO)PHENYL)THIO)] 5 IODOPHENYLAMINE I 123; CITALOPRAM; RADIOLIGAND; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; AUTORADIOGRAPHY; CEREBELLUM; COLLIMATOR; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIAGNOSTIC IMAGING; IMAGE ANALYSIS; IMAGE QUALITY; MALE; MESENCEPHALON; NONHUMAN; QUANTITATIVE ANALYSIS; RAT; RECEPTOR BINDING; RECEPTOR OCCUPANCY; SEROTONIN UPTAKE; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ANIMALS; CEREBELLUM; CITALOPRAM; FEASIBILITY STUDIES; MALE; MESENCEPHALON; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TOMOGRAPHY, X-RAY COMPUTED;

EID: 34447563770     PISSN: 01433636     EISSN: 14735628     Source Type: Journal    
DOI: 10.1097/MNM.0b013e32825a67cb     Document Type: Article

References (28)

1. Gold PW. The neurobiology of stress and its relevance to psychotherapy. Clin Neurosci Res 2005; 4:315-324.
2. Nelson JC, Mazure CM, Jatlow PI, Bowers MB, Price LH. Combining norepinephrine and serotonin reuptake inhibition mechanisms for treatment of depression: a double-blind, randomized study. Biol Psychiatry 2004; 55:296-300.
3. Nestler EJ. Antidepressant treatments in the 21st century. Biol Psychiatry 1998; 44:526-533.
4. van Pragg HM. Can stress cause depression? Prog Neuro-Psychopharmacol Biol Psychiatry 2004; 28:891-907.
5. White KJ, Walline CC, Barker EL. Serotonin transporters: Implications for antidepressant drug development. AAPS J 2005; 7:E421-E433.
6. 123I]-ADAM. J Neural Transm 2006; 113:659-670.
7. Torres GE, Gainetdinov RR, Caron MG. Plasma membrane monoamine transporters: structure, regulation and function. Neuroscience 2003; 4:13-25.
8. Staley JK, Malison RT, Innis RB. Imaging of the serotonergic system: interactions of neuroanatomical and functional abnormalities of depression. Biol Psychiatry 1998; 44:534-549.
9. Camargo EE. Brain SPECT in neurology and psychiatry. J Nucl Med 2001; 42:611-623.
10. Cselényi Z, Lundberg J, Halldin C, Farde L, Gulyás B. Joint explorative analysis of neuroreceptor subsystems in the human brain: application to receptor-transporter correlation using PET data. Neurochem Int 2004; 45:773-781.
11. Oya S, Choi S, Hou C, Mu M, Kung M, Aton PD, Siciliano M, et al. 2-((2-((dimethylamino)phenyl)thio)-5-iodophenylamine (ADAM): an improved serotonin transporter ligand. Nucl Med Biol 2000; 27:249-254.
12. 123I]ADAM: a SPECT validation study. Eur J Nucl Med Mol Imaging 2005; 32:1229-1336.
13. 123I-ADAM binding to serotonin transporters in patients with major depression and healthy controls: a preliminary study. J Nucl Med 2005; 46:973-977.
14. 123I-ADAM: a serotonin transporter imaging agent. J Nucl Med 2004; 45:834-841.
15. Eckelman WC. The use of PET and knockout mice in the drug discovery process. Drug Discovery Today 2003; 9:404-410.
16. Myers R, Hume S. Small animal PET. Eur Neuropsychopharmacol 2002; 12:545-555.
17. Yadid G, Nakash R, Deri I, Tamar G, Kinor N, Gispan I, et al. Elucidation of the neurobiology of depression: insights from a novel genetic animal model. Progress Neurobiol 2000; 62:353-378.
18. Dremencov E, Gispan-Herman I, Rosenstein M, Mendelman A, Overstreet DH, Zojar J, et al. The serotonin-dopamine interaction is critical for fast-onset action of antidepressant treatment: in vivo studies in an animal model of depression. Progress Neuro-Psychopharmacol Biol Psychiatry 2004; 28:141-147.
19. Schmidt KC, Smith AB. Resolution, sensitivity and precision with autoradiography and small animal position emission tomography: implications for functional brain imaging in animal research. Nucl Med Biol 2005; 32:719-725.
20. Jagoda EM, Vaquero JJ, Seidel J, Green MV, Eckelman WC. Experiment assessment of mass effects in the rat: implications for small animal PET imaging. Nucl Med Biol 2004; 31:771-779.
21. Kung HF, Kung M-P. Mass effect of injected dose in small rodent imaging by SPECT and PET. Nucl Med Biol 2005; 32:673-678.
22. 123I]ADAM - a serotonin transporter radiotracer in healthy human subjects. Nucl Med Biol 2006; 33:193-202.
23. 123I-ADAM and the relationship to the serotonin transporter in rat and mouse brains using quantitative autoradiography. J Nucl Med 2004; 45:673-681.
24. 123I]-ADAM and SPECT. J Nucl Med 2001; 42:1556-1562.
25. 123I]ADAM in healthy subjects administered different doses of escitalopram or citalopram. Psychopharmacology 2006; 188:263-272.
26. 11C]DASB PET imaging study. Am J Psychiatry 2001; 158:1843-1849.
27. Madsen MT. Recent advances in SPECT imaging. J Nucl Med 2007; 48:661-673.
28. Funk T, Despres P, Barber WC, Shah KS, Hasegawa BH. A multipinhole small animal SPECT system with submillimeter resolution. Med Phys 2006; 33:1259-1268.