Substitution of the gla domain in factor X with that of protein C impairs its interaction with factor VIIa/tissue factor: Lack of comparable effect by similar substitution in factor IX

Journal of Biological Chemistry

Volumn 282, Issue 21, 2007, Pages 15632-15644

  Ndonwi, Matthew ^a,b   Broze Jr , George J ^b   Agah, Sayeh ^c   Schmidt, Amy E ^c   Bajaj, S Paul ^c,d  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BARNES JEWISH HOSPITAL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d JOINT REPLACEMENT INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYGLUTAMIC ACID (GLA); EPIDERMAL GROWTH FACTOR-LIKE (EGF1); REPLACEMENT MUTANTS;

COAGULATION; MOLECULAR INTERACTIONS; MUTAGENESIS; SUBSTITUTION REACTIONS; TISSUE;

ENZYME ACTIVITY;

4 CARBOXYGLUTAMIC ACID; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 7A; BUTYRATE RESPONSE FACTOR 1; PROTEIN C; THROMBOPLASTIN; BLOOD CLOTTING FACTOR 9; HYBRID PROTEIN;

ARTICLE; BLOOD CLOTTING; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; GENETICS; HUMAN; METABOLISM; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE;

ANIMALS; FACTOR IX; FACTOR VIIA; FACTOR X; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN C; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; THROMBOPLASTIN;

EID: 34447524033     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M701908200     Document Type: Article

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