Raising the active site of factor VIIa above the membrane surface reduces its procoagulant activity but not factor VII autoactivation

Journal of Biological Chemistry

Volumn 281, Issue 36, 2006, Pages 26062-26068

  Waters, Emily K ^a,c   Yegneswaran, Subramanian ^b   Morrissey, James H ^a,d  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c CENTER FOR BLOOD RESEARCH   (United States)

^d UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING; MEMBRANE-BOUND ENZYMES; PLASMA SERINE PROTEASE; PROCOAGULANT ACTIVITY;

BLOOD; CELL MEMBRANES; ENZYME KINETICS; RESONANCE; SURFACE PLASMON RESONANCE; TISSUE;

PHYSIOLOGY;

AMIDE; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 7; BLOOD CLOTTING FACTOR 7A; ENZYME; FLUORESCENT DYE; MEMBRANE PROTEIN; PADGEM PROTEIN; PROCOAGULANT; THROMBOPLASTIN; TRIPEPTIDE DERIVATIVE;

ARTICLE; BINDING AFFINITY; BINDING SITE; BLOOD CLOTTING; CHIMERA; FLUORESCENCE RESONANCE ENERGY TRANSFER; NONHUMAN; PLASMA; PRIORITY JOURNAL;

ANIMALS; BINDING SITES; BLOOD COAGULATION; CELL MEMBRANE; FACTOR VII; FACTOR VIIA; FACTOR X; FLUORESCENCE RESONANCE ENERGY TRANSFER; FLUORESCENT DYES; HUMANS; P-SELECTIN; PROTEIN BINDING; PROTEIN CONFORMATION; RECOMBINANT FUSION PROTEINS; THROMBOPLASTIN;

EID: 33748747497     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M604915200     Document Type: Article

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