Probing the interface between factor Xa and tissue factor in the quaternary complex tissue factor-factor VIIa-factor Xa-tissue factor pathway inhibitor

European Journal of Biochemistry

Volumn 270, Issue 12, 2003, Pages 2576-2582

  Carlsson, Karin ^a   Freskgård, Per Ola ^b,c   Persson, Egon ^b   Carlsson, Uno ^a   Svensson, Magdalena ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

^b NOVO NORDISK A S   (Denmark)

^c Nuevolution A/S   (Denmark)

Author keywords

Fluorescence; Local probing; Protein protein interactions; Site directed labeling

Indexed keywords

BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 7A; THROMBOPLASTIN; TISSUE FACTOR PATHWAY INHIBITOR;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; COMPARATIVE STUDY; ENZYME ANALYSIS; FLUORESCENCE; LIPID ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; QUATERNARY;

AMINO ACID SUBSTITUTION; BINDING SITES; CLONING, MOLECULAR; ESCHERICHIA COLI; FACTOR VIIA; FACTOR XA; FLUORESCENT DYES; LIPOPROTEINS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PHOSPHATIDYLCHOLINES; PROTEIN STRUCTURE, QUATERNARY; RECOMBINANT PROTEINS; SPECTROMETRY, FLUORESCENCE; VARIATION (GENETICS);

EID: 0038311871     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2003.03625.x     Document Type: Article

References (37)

1. Golino, P. (2002) The inhibitors of the tissue factor: factor VII pathway. Thromb. Res. 106, V257-V265.
2. Broze, G.J. Jr, Girard, T.J. & Novotny, W.F. (1990) Regulation of coagulation by a multivalent Kunitz-type inhibitor. Biochemistry 29, 7539-7546.
3. Girard, T.J., Warren, L.A., Novotny, W.F., Likert, K.M., Brown, S.G., Miletich, J.P. & Broze, G.J. Jr (1989) Functional significance of the Kunitz-type inhibitory domains of lipoprotein-associated coagulation inhibitor. Nature 338, 518-520.
4. Sevinsky, J.R., Rao, L.V.M. & Ruf, W. (1996) Ligand-induced protease receptor translocation into caveolae: a mechanism for regulating cell surface proteolysis of the tissue factor-dependent coagulation pathway. J. Cell. Biol. 133, 293-304.
5. Iakhiaev, A., Pendurthi, U.R., Voigt, J., Ezban, M. & Rao, L.V.M. (1999) Catabolism of factor VIIa bound to tissue factor in fibroblasts in the presence and absence of tissue factor pathway inhibitor. J. Biol. Chem. 274, 36995-37003.
6. Hamamoto, T., Yamamoto, M., Nordfang, O., Petersen, J.G.L., Foster, D.C. & Kisiel, W. (1993) Inhibitory properties of full-length and truncated recombinant tissue factor pathway inhibitor (TFPI). Evidence that the third Kunitz-type domain of TFPI is not essential for the inhibition of factor VIIa- tissue factor complexes on cell surfaces. J. Biol. Chem. 268, 8704-8710.
7. Banner, D.W., D'Arcy, A., Chène, C., Winkler, F.K., Guha, A., Konigsberg, W.H., Nemerson, Y. & Kirchhofer, D. (1996) The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor. Nature 380, 41-46.
8. Huang, Q., Neuenschwander, P.F., Rezaie, A.R. & Morrissey, J.H. (1996) Substrate recognition by tissue factor-factor VIIa. Evidence for interaction of residues Lys165 and Lys166 of tissue factor with the 4-carboxyglutamate-rich domain of factor X. J. Biol. Chem. 271, 21752-21757.
9. Ruf, W., Shobe, J., Rao, S.M., Dickinson, C.D., Olson, A. & Edgington, T.S. (1999) Importance of factor VIIa Gla-domain residue Arg-36 for recognition of the macromolecular substrate factor X Gla-domain. Biochemistry 38, 1957-1966.
10. Martin, D.M.A., O'Brien, D.P., Tuddenham, E.G.D. & Byfield, P.G.H. (1993) Synthesis and characterization of wild-type and variant γ-carboxyglutamic acid-containing domains of factor VII. Biochemistry 32, 13949-13955.
11. Ruf, W., Miles, D.J., Rehemtulla, A. & Edgington, T.S. (1992) Tissue factor residues 157-167 are required for efficient proteolytic activation of factor X and factor VII. J. Biol. Chem. 267, 22206-22210.
12. Rehemtulla, A., Ruf, W., Miles, D.J. & Edgington, T.S. (1992) The third Trp-Lys-Ser (WKS) tripeptide motif in tissue factor is associated with a function site. Biochem. J. 282, 737-740.
13. Kirchhofer, D., Lipari, M.T., Moran, P., Eigenbrot, C. & Kelley, R.F. (2000) The tissue factor region that interacts with substrates factor IX and factor X. Biochemistry 39, 7380-7387.
14. Roy, S., Hass, P.E., Bourell, J.H., Henzel, W.J. & Vehar, G.A. (1991) Lysine residues 165 and 166 are essential for the cofactor function of tissue factor. J. Biol. Chem. 266, 22062-22066.
15. Ruf, W., Miles, D.J., Rehemtulla, A. & Edgington, T.S. (1992) Cofactor residues lysine 165 and 166 are critical for protein substrate recognition by the tissue factor-factor VIIa protease complex. J. Biol. Chem. 267, 6375-6381.
16. Dittmar, S., Ruf, W. & Edgington, T.S. (1997) Influence of mutations in tissue factor on the fine specificity of macromolecular substrate activation. Biochem. J. 321, 787-793.
17. Kirchhofer, D., Eigenbrot, C., Lipari, M.T., Moran, P., Peek, M. & Kelley, R.F. (2001) The tissue factor region that interacts with factor Xa in the activation of factor VII. Biochemistry 40, 675-682.
18. Rao, L.V.M. & Ruf, W. (1995) Tissue factor residues Lys165 and Lys166 are essential for rapid formation of the quaternary complex of tissue factor-VIIa with Xa-tissue factor pathway inhibitor. Biochemistry 34, 10867-10871.
19. Girard, T.J., MacPhail, L.A., Likert, K.M., Novotny, W.F., Miletich, J.P. & Broze, G.J. Jr (1990) Inhibition of factor VIIa-tissue factor coagulation activity by a hybrid protein. Science 248, 1421-1424.
20. Warn-Cramer, B.J., Rao, L.V.M., Maki, S.L. & Rapaport, S.I. (1988) Modifications of extrinsic pathway inhibitor (EPI) and FXa that affect their ability to interact and to inhibit factor VIIa/tissue factor: evidence for a two-step model of inhibition. Thromb. Haemost. 60, 453-456.
21. Rao, L.V.M., Williams, T. & Rapaport, S.I. (1996) Studies of the activation of factor VII bound to tissue factor. Blood 87, 3738-3748.
22. Owenius, R., Österlund, M., Lindgren, M., Svensson, M., Olsen, O.H., Persson, E., Freskgård, P.-O. & Carlsson, U. (1999) Properties of spin and fluorescent labels at a receptor-ligand interface. Biophys. J. 77, 2237-2250.
23. Gill, S.C. & von Hippel, P.H. (1989) Calculation of protein extinction coefficients from amino acid sequence data. Anal. Biochem. 182, 319-326.
24. Trim, L., Bjoern, S., Christensen, M., Nicolaisen, E.M., Lund-Hansen, T., Pedersen, A.H. & Hedner, U. (1988) Amino acid sequence and posttranslational modifications of human factor VIIa from plasma and transfected baby hamster kidney cells. Biochemistry 27, 7785-7793.
25. Petersen, J.G.L., Meyn, G., Rasmussen, J.S., Petersen, J., Bjørn, S.E., Jonassen, I., Christiansen, L. & Nordfang, O. (1993) Characterization of human tissue factor pathway inhibitor variants expressed in Saccharomyces cerevisiae. J. Biol. Chem. 268, 13344-13351.
26. 2+ and tissue factor studied using circular dichroism spectroscopy. Protein Sci. 5, 1531-1540.
27. Owenius, R., Österlund, M., Svensson, M., Lindgren, M., Persson, E., Freskgård, P.-O. & Carlsson, U. (2001) Spin and fluorescent probing of the binding interface between tissue factor and factor VIIa at multiple sites. Biophys. J. 81, 2357-2369.
28. Pike, A.C.W., Brzozowski, A.M., Roberts, S.M., Olsen, O.H. & Persson, E. (1999) Structure of human factor VIIa and its implications for the triggering of blood coagulation. Proc. Natl Acad. Sci. USA 96, 8925-8930.
29. Padmanabhan, K., Padmanabhan, K.P., Tulinsky, A., Park, C.H., Bode, W., Huber, R., Blankenship, D.T., Cardin, A.D. & Kisiel, W. (1993) Structure of human des (1-45) factor Xa at 2.2 Å resolution. J. Mol. Biol. 232, 947-966.
30. Brandstetter, H., Kühne, A., Bode, W., Huber, R., von der Saal, W., Wirthensohn, K. & Engh, R.A. (1996) X-ray structure of active site-inhibited clotting factor Xa. Implications for drug design and substrate recognition. J. Biol. Chem. 271, 29988-29992.
31. Husten, E.J., Esmon, C.T. & Johnson, A.E. (1987) The active site of blood coagulation factor Xa. Its distance from the phospholipid surface and its conformational sensitivity to components of the prothrombinase complex. J. Biol. Chem. 262, 12953-12961.
32. McCallum, C.D., Hapak, R.C., Neuenschwander, P.F., Morrissey, J.H. & Johnson, A.E. (1996) The location of the active site of blood coagulation factor VIIa above the membrane surface and its reorientation upon association with tissue factor. A fluorescence energy transfer study. Biol. Chem. 271, 28168-28175.
33. McCallum, C.D., Su, B., Neuenschwander, P.F., Morrissey, J.H. & Johnson, A.E. (1997) Tissue factor positions and maintains the factor VIIa active site far above the membrane surface even in the absence of the factor VIIa Gla domain. A fluorescence resonance energy transfer study. J. Biol. Chem. 272, 30160-30166.
34. Ruf, W., Kalnik, M.W., Lund-Hansen, T. & Edgington, T.S. (1991) Characterization of factor VII association with tissue factor in solution. High and low affinity calcium binding sites in factor VII contribute to functionally distinct interactions. J. Biol. Chem. 266, 15719-15725.
35. Baugh, R.J., Dickinson, C.D., Ruf, W. & Krishnaswamy, S. (2000) Exosite interactions determine the affinity of factor X for the extrinsic Xase complex. J. Biol. Chem. 275, 28826-28833.
36. Zhong, D., Bajaj, M.S., Schmidt, A.E. & Bajaj, S.P. (2002) The N-terminal epidermal growth factor-like domain in factor IX and factor X represents an important recognition motif for binding to tissue factor. J. Biol. Chem. 277, 3622-3631.
37. Österlund, M., Owenius, R., Carlsson, K., Carlsson, U., Persson, E., Lindgren, M., Freskgård, P.-O. & Svensson, M. (2001) Probing inhibitor-induced conformational changes along the interface between tissue factor and factor VIIa. Biochemistry 40, 9324-9328.