메뉴 건너뛰기




Volumn 2, Issue 3, 2007, Pages 335-348

Epidermal growth factor receptor inhibitors in non-small-cell lung cancer

Author keywords

Cetuximab; EGFR inhibitors; Epidermal growth factor receptor; Erlotinib; Gefitinib; Monoclonal antibodies; Non small cell lung cancer; Tyrosine kinase inhibitors; Vandetanib

Indexed keywords

4 (4 FLUORO 2 METHYL 5 INDOLYLOXY) 6 METHOXY 7 [3 (1 PYRROLIDINYL)PROPOXY]QUINAZOLINE; BEVACIZUMAB; CANERTINIB; CAPECITABINE; CARBOPLATIN; CETUXIMAB; CISPLATIN; DOCETAXEL; EMD 27000; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; EPIRUBICIN; ERLOTINIB; GEFITINIB; GEMCITABINE; HKI 272; HR 3; IMC 225; LAPATINIB; MATUZUMAB; MEMBRANE RECEPTOR; MONOCLONAL ANTIBODY; NAVELBINE; PACLITAXEL; PANITUMUMAB; PELITINIB; PLACEBO; PLATINUM; PROTEIN TYROSINE KINASE INHIBITOR; SORAFENIB; UNCLASSIFIED DRUG; VANDETANIB;

EID: 34447521416     PISSN: 17460441     EISSN: None     Source Type: Journal    
DOI: 10.1517/17460441.2.3.335     Document Type: Review
Times cited : (7)

References (116)
  • 1
    • 0034722889 scopus 로고    scopus 로고
    • The EGF receptor family as targets for cancer therapy
    • MENDELSOHN J, BASELGA J: The EGF receptor family as targets for cancer therapy. Oncogene (2000) 19:6550-6565.
    • (2000) Oncogene , vol.19 , pp. 6550-6565
    • MENDELSOHN, J.1    BASELGA, J.2
  • 2
    • 0028955388 scopus 로고
    • Epidermal growth factor-related peptides and their receptors in human malignancies: An extensive review on the expression and the functional role of growth factors and receptors of the EGFR family in human cancer
    • SALOMON DS, BRANDT R, CIARDIELLO F, NORMANNO N: Epidermal growth factor-related peptides and their receptors in human malignancies: an extensive review on the expression and the functional role of growth factors and receptors of the EGFR family in human cancer. Crit. Rev. Oncol. Haematol. (1995) 19:183-232.
    • (1995) Crit. Rev. Oncol. Haematol , vol.19 , pp. 183-232
    • SALOMON, D.S.1    BRANDT, R.2    CIARDIELLO, F.3    NORMANNO, N.4
  • 3
    • 0003079827 scopus 로고    scopus 로고
    • The ErbB family of receptors and their ligands: Multiple targets for therapy
    • SALOMON DS, GULLICK W: The ErbB family of receptors and their ligands: multiple targets for therapy. Signal (2001) 2:4-11.
    • (2001) Signal , vol.2 , pp. 4-11
    • SALOMON, D.S.1    GULLICK, W.2
  • 4
    • 0034600849 scopus 로고    scopus 로고
    • The ErbB signaling network: Receptor heterodimerization in development and cancer
    • OLAYIOYE MA, NEVE RM, LANE HA, HYNES NE: The ErbB signaling network: receptor heterodimerization in development and cancer. EMBO J. (2000) 19:3159-3167.
    • (2000) EMBO J , vol.19 , pp. 3159-3167
    • OLAYIOYE, M.A.1    NEVE, R.M.2    LANE, H.A.3    HYNES, N.E.4
  • 5
    • 0033063774 scopus 로고    scopus 로고
    • The epidermal growth factor receptor and its inhibition in cancer therapy
    • WOODBURN JR: The epidermal growth factor receptor and its inhibition in cancer therapy. Pharmacol. Ther. (1999) 82:241-250.
    • (1999) Pharmacol. Ther , vol.82 , pp. 241-250
    • WOODBURN, J.R.1
  • 7
    • 0034799139 scopus 로고    scopus 로고
    • A novel approach in the treatment of cancer: Targeting the epidermal growth factor receptor
    • CIARDIELLO F, TORTORA G: A novel approach in the treatment of cancer: targeting the epidermal growth factor receptor. Clin. Cancer Res. (2001) 7:2958-2970.
    • (2001) Clin. Cancer Res , vol.7 , pp. 2958-2970
    • CIARDIELLO, F.1    TORTORA, G.2
  • 8
    • 0038718522 scopus 로고    scopus 로고
    • Developing inhibitors of the epidermal growth factor receptor for cancer treatment
    • GRUNWALD V, HIDALGO M: Developing inhibitors of the epidermal growth factor receptor for cancer treatment. J. Natl. Cancer Inst. (2003) 95:851-867.
    • (2003) J. Natl. Cancer Inst , vol.95 , pp. 851-867
    • GRUNWALD, V.1    HIDALGO, M.2
  • 9
    • 0041629450 scopus 로고    scopus 로고
    • Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer
    • MENDELSOHN J, BASELGA J: Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer, J. Clin. Oncol. (2003) 21:2787-2799.
    • (2003) J. Clin. Oncol , vol.21 , pp. 2787-2799
    • MENDELSOHN, J.1    BASELGA, J.2
  • 10
    • 0034114769 scopus 로고    scopus 로고
    • Blockade of receptors for growth factors: An anticancer therapy
    • MENDELSOHN J: Blockade of receptors for growth factors: an anticancer therapy. Clin. Cancer Res. (2000) 6:747-753.
    • (2000) Clin. Cancer Res , vol.6 , pp. 747-753
    • MENDELSOHN, J.1
  • 11
    • 1642485133 scopus 로고    scopus 로고
    • Targeting EGFR with mAbs versus TKIs: Different mechanisms, similar endpoints
    • BASELGA J: Targeting EGFR with mAbs versus TKIs: different mechanisms, similar endpoints. Signal (2003) 4:4-6.
    • (2003) Signal , vol.4 , pp. 4-6
    • BASELGA, J.1
  • 12
    • 0037211253 scopus 로고    scopus 로고
    • Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs): Simple drugs with a complex mechanism of action
    • NORMANNO N, MAIELLO MR, DE LUCA A: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs): simple drugs with a complex mechanism of action. J. Cell. Physiol. (2003) 194:13-19.
    • (2003) J. Cell. Physiol , vol.194 , pp. 13-19
    • NORMANNO, N.1    MAIELLO, M.R.2    DE LUCA, A.3
  • 13
    • 0034068319 scopus 로고    scopus 로고
    • Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor
    • CIARDIELLO F, CAPUTO R, BLANCO R et al.: Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor. Clin. Cancer Res. (2000) 6:2053-2063.
    • (2000) Clin. Cancer Res , vol.6 , pp. 2053-2063
    • CIARDIELLO, F.1    CAPUTO, R.2    BLANCO, R.3
  • 14
    • 0034489914 scopus 로고    scopus 로고
    • Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD 1839 (Iressa), an inhibitor of EGFR tyrosine kinase
    • SIROTNAK FM, ZAKOWSKY MF, MILLER VA, SCHER HI, KRIS MG: Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD 1839 (Iressa), an inhibitor of EGFR tyrosine kinase. Clin. Cancer Res. (2000) 6:4885-4892.
    • (2000) Clin. Cancer Res , vol.6 , pp. 4885-4892
    • SIROTNAK, F.M.1    ZAKOWSKY, M.F.2    MILLER, V.A.3    SCHER, H.I.4    KRIS, M.G.5
  • 15
    • 0037109014 scopus 로고    scopus 로고
    • ZD 1839 (Iressa): An orally active inhibitor of epidermal growth factor receptor signaling with potential for cancer therapy
    • WAKELING A, GUY SP, WOODBURN JR et al.: ZD 1839 (Iressa): an orally active inhibitor of epidermal growth factor receptor signaling with potential for cancer therapy. Cancer Res. (2002) 62:5749-5754.
    • (2002) Cancer Res , vol.62 , pp. 5749-5754
    • WAKELING, A.1    GUY, S.P.2    WOODBURN, J.R.3
  • 16
    • 0034084314 scopus 로고    scopus 로고
    • Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: Inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis
    • HUANG S-M, HARARI P: Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis. Clin. Cancer Res. (2000) 6:2166-2174.
    • (2000) Clin. Cancer Res , vol.6 , pp. 2166-2174
    • HUANG, S.-M.1    HARARI, P.2
  • 17
    • 0036795061 scopus 로고    scopus 로고
    • Enhancement of antitumor activity of ionizing radiation by combined treatment with the selective EGFR-tyrosine kinase inhibitor ZD1839 ('Iressa')
    • BIANCO C, TORTORA G, BIANCO R et al.: Enhancement of antitumor activity of ionizing radiation by combined treatment with the selective EGFR-tyrosine kinase inhibitor ZD1839 ('Iressa'). Clin. Cancer Res. (2002) 8:3250-3258.
    • (2002) Clin. Cancer Res , vol.8 , pp. 3250-3258
    • BIANCO, C.1    TORTORA, G.2    BIANCO, R.3
  • 18
    • 0036681995 scopus 로고    scopus 로고
    • Modulation of radiation response and tumor-induced angiogenesis following EGFR blockade by ZD1839 (Iressa) in human squamous cell carcinomas
    • HUANG S, LI J, HARARI PM: Modulation of radiation response and tumor-induced angiogenesis following EGFR blockade by ZD1839 (Iressa) in human squamous cell carcinomas. Cancer Res. (2002) 62:4300-4306.
    • (2002) Cancer Res , vol.62 , pp. 4300-4306
    • HUANG, S.1    LI, J.2    HARARI, P.M.3
  • 19
    • 0034896362 scopus 로고    scopus 로고
    • Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor
    • CIARDIELLO F, CAPUTO R, BIANCO R et al.: Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor. Clin. Cancer Res. (2001) 7:1459-1465.
    • (2001) Clin. Cancer Res , vol.7 , pp. 1459-1465
    • CIARDIELLO, F.1    CAPUTO, R.2    BIANCO, R.3
  • 20
    • 0037388251 scopus 로고    scopus 로고
    • ZD1839, a specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, induces the formation of inactive EGFR/HER2 and EGFR/HER3 heterodimers and prevents heregulin signaling in HER2-overexpressing breast cancer cells
    • ANIDO J, MATAR P, ALBANELL J et al.: ZD1839, a specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, induces the formation of inactive EGFR/HER2 and EGFR/HER3 heterodimers and prevents heregulin signaling in HER2-overexpressing breast cancer cells. Clin. Cancer Res. (2003) 9:1274-1283.
    • (2003) Clin. Cancer Res , vol.9 , pp. 1274-1283
    • ANIDO, J.1    MATAR, P.2    ALBANELL, J.3
  • 21
    • 0037211253 scopus 로고    scopus 로고
    • Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs): Simple drugs with a complex mechanism of action
    • NORMANNO N, MAIELLO MR, DE LUCA A: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs): simple drugs with a complex mechanism of action. J. Cell Phys. (2003) 194:13-19.
    • (2003) J. Cell Phys , vol.194 , pp. 13-19
    • NORMANNO, N.1    MAIELLO, M.R.2    DE LUCA, A.3
  • 22
    • 0036569870 scopus 로고    scopus 로고
    • ZD1839, a selective oral epidermal growth factor receptor-tyrosine kinase inhibitor is well tolerated and active in patients with solid, malignant tumors: Results of a Phase I trial
    • RANSON M, HAMMOND LA, FERRY D et al.: ZD1839, a selective oral epidermal growth factor receptor-tyrosine kinase inhibitor is well tolerated and active in patients with solid, malignant tumors: results of a Phase I trial, J. Clin. Oncol. (2002) 20:2240-2250.
    • (2002) J. Clin. Oncol , vol.20 , pp. 2240-2250
    • RANSON, M.1    HAMMOND, L.A.2    FERRY, D.3
  • 23
    • 0037106377 scopus 로고    scopus 로고
    • Selective oral epidermal growth factor receptor tyrosine inhibitor ZD1839 is generally well-tolerated and has activity in non-small-cell lung cancer and other solid tumors: Results of a Phase I trial
    • HERBST RS, MADDOX A-M, ROTHENBERG ML et al.: Selective oral epidermal growth factor receptor tyrosine inhibitor ZD1839 is generally well-tolerated and has activity in non-small-cell lung cancer and other solid tumors: results of a Phase I trial. J. Clin. Oncol. (2002) 20:3815-3828.
    • (2002) J. Clin. Oncol , vol.20 , pp. 3815-3828
    • HERBST, R.S.1    MADDOX, A.-M.2    ROTHENBERG, M.L.3
  • 24
    • 0036842170 scopus 로고    scopus 로고
    • Phase I safety; pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected tumor types
    • BASELGA J, RISCHIN D, RANSON M et al.: Phase I safety; pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected tumor types. J. Clin. Oncol. (2002) 21:4292-4302.
    • (2002) J. Clin. Oncol , vol.21 , pp. 4292-4302
    • BASELGA, J.1    RISCHIN, D.2    RANSON, M.3
  • 25
    • 0037673681 scopus 로고    scopus 로고
    • Phase I pharmacokinetic trial of the selective oral epidermal growth factor receptor tyrosine kinase inhibitor gefitinib ('Iressa', ZD1839) in Japanese patients with solid malignant tumors
    • NAKAGAWA K, TAMURA T, NEGORO S et al.: Phase I pharmacokinetic trial of the selective oral epidermal growth factor receptor tyrosine kinase inhibitor gefitinib ('Iressa', ZD1839) in Japanese patients with solid malignant tumors. Ann. Oncol. (2003) 14:922-930.
    • (2003) Ann. Oncol , vol.14 , pp. 922-930
    • NAKAGAWA, K.1    TAMURA, T.2    NEGORO, S.3
  • 26
    • 0038276045 scopus 로고    scopus 로고
    • Improvements in quality of life and disease-related symptoms in Phase I trials of the selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD 1839 in non-small-cell lung cancer and other solid tumors
    • LORUSSO P, HERBST RS, RISCHIN D et al.: Improvements in quality of life and disease-related symptoms in Phase I trials of the selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD 1839 in non-small-cell lung cancer and other solid tumors. Clin. Cancer Res. (2003) 9:2040-2048.
    • (2003) Clin. Cancer Res , vol.9 , pp. 2040-2048
    • LORUSSO, P.1    HERBST, R.S.2    RISCHIN, D.3
  • 27
    • 0012381722 scopus 로고    scopus 로고
    • Multi-institutional randomized Phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer
    • FUKUOKA M, YANO S, GIACCONE G et al.: Multi-institutional randomized Phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer. J. Clin. Oncol. (2003) 22:2237-2246.
    • (2003) J. Clin. Oncol , vol.22 , pp. 2237-2246
    • FUKUOKA, M.1    YANO, S.2    GIACCONE, G.3
  • 28
    • 0142055937 scopus 로고    scopus 로고
    • Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine, in symptomatic patients with non-small-cell lung cancer
    • KRIS MG, NATALE RB, HERBST RS et al.: Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine, in symptomatic patients with non-small-cell lung cancer. JAMA (2003) 290:2149-2158.
    • (2003) JAMA , vol.290 , pp. 2149-2158
    • KRIS, M.G.1    NATALE, R.B.2    HERBST, R.S.3
  • 30
    • 0037819319 scopus 로고    scopus 로고
    • A case study documenting the anticancer activity of ZD 1839 in the brain
    • VILLANO JL, MAUER AM, VOKES EE: A case study documenting the anticancer activity of ZD 1839 in the brain. Ann. Oncol. (2003) 14:656-658.
    • (2003) Ann. Oncol , vol.14 , pp. 656-658
    • VILLANO, J.L.1    MAUER, A.M.2    VOKES, E.E.3
  • 31
    • 0038166890 scopus 로고    scopus 로고
    • Epidermal growth factor receptor targeted therapy by ZD 1839 (Iressa) in patients with brain metastases from non-small-cell lung cancer (NSCLC)
    • CAPPUZZO F, ARDIZZONI A, SOTO-PARRA H et al.: Epidermal growth factor receptor targeted therapy by ZD 1839 (Iressa) in patients with brain metastases from non-small-cell lung cancer (NSCLC). Lung Cancer (2003) 41:227-231.
    • (2003) Lung Cancer , vol.41 , pp. 227-231
    • CAPPUZZO, F.1    ARDIZZONI, A.2    SOTO-PARRA, H.3
  • 32
    • 0002806626 scopus 로고    scopus 로고
    • A Phase III clinical trial of ZD 1839 ('Iressa') in combination with gemcitabine and cisplatin in chemotherapy-naïve patients with advanced non-small-cell lung cancer (INTACT 1)
    • Abstract 4
    • GIACCONE G, JOHNSON DH, MANEGOLD C et al.: A Phase III clinical trial of ZD 1839 ('Iressa') in combination with gemcitabine and cisplatin in chemotherapy-naïve patients with advanced non-small-cell lung cancer (INTACT 1). Ann. Oncol. (2002) 13:2 (Abstract 4).
    • (2002) Ann. Oncol , vol.13 , pp. 2
    • GIACCONE, G.1    JOHNSON, D.H.2    MANEGOLD, C.3
  • 33
    • 0000780450 scopus 로고    scopus 로고
    • ZD1839 in combination with paclitaxel and carboplatin in chemotherapy-naïve patients with advanced non-small-cell lung cancer (NSCLC): Results from a Phase III clinical trial (INTACT 2)
    • Abstract 468
    • JOHNSON DH, HERBST R, GIACCONE G et al.: ZD1839 in combination with paclitaxel and carboplatin in chemotherapy-naïve patients with advanced non-small-cell lung cancer (NSCLC): results from a Phase III clinical trial (INTACT 2). Ann. Oncol. (2002) 13:127 (Abstract 468).
    • (2002) Ann. Oncol , vol.13 , pp. 127
    • JOHNSON, D.H.1    HERBST, R.2    GIACCONE, G.3
  • 34
    • 27544503230 scopus 로고    scopus 로고
    • Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer. Results from a randomized, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
    • THATCHER N, CHANG A, PARIKH P et al.: Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer. Results from a randomized, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet (2005) 366:1527-1537.
    • (2005) Lancet , vol.366 , pp. 1527-1537
    • THATCHER, N.1    CHANG, A.2    PARIKH, P.3
  • 35
    • 1642525881 scopus 로고    scopus 로고
    • The characteristics of patients with non-small-cell lung cancer with complete response treated with ZD1839
    • Abstract 2770
    • WU YL, YANG X-N, GU L-J: The characteristics of patients with non-small-cell lung cancer with complete response treated with ZD1839. Proc. Am. Soc. Clin. Oncol. (2003) 22:Abstract 2770.
    • (2003) Proc. Am. Soc. Clin. Oncol , vol.22
    • WU, Y.L.1    YANG, X.-N.2    GU, L.-J.3
  • 36
    • 1642485131 scopus 로고    scopus 로고
    • ZD1839 is more effective in patients with non-small-cell lung cancer (NSCLC) who were lifetime non-tobacco users
    • Abstract 2790
    • WONG N-S, LIM ST, LIM W-T, LEONG S-S, TAN E-H: ZD1839 is more effective in patients with non-small-cell lung cancer (NSCLC) who were lifetime non-tobacco users. Proc. Am. Soc. Clin. Oncol. (2003) 22:Abstract 2790.
    • (2003) Proc. Am. Soc. Clin. Oncol , vol.22
    • WONG, N.-S.1    LIM, S.T.2    LIM, W.-T.3    LEONG, S.-S.4    TAN, E.-H.5
  • 37
    • 0242668495 scopus 로고    scopus 로고
    • Bronchioalveolar histology and smoking history predict response to gefitinib
    • Abstract 2524
    • SHAH NT, MILLER VA, KRIS MG et al.: Bronchioalveolar histology and smoking history predict response to gefitinib. Proc. Am. Soc. Clin. Oncol. (2003) 22:Abstract 2524.
    • (2003) Proc. Am. Soc. Clin. Oncol , vol.22
    • SHAH, N.T.1    MILLER, V.A.2    KRIS, M.G.3
  • 38
    • 0037386774 scopus 로고    scopus 로고
    • Antitumor effects of ZD6474, a small molecole vascular endhotelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase
    • CIARDIELLO F, CAPUTO R, DAMIANO V et al.: Antitumor effects of ZD6474, a small molecole vascular endhotelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase. Clin. Cancer Res. (2003) 9:1546-1556.
    • (2003) Clin. Cancer Res , vol.9 , pp. 1546-1556
    • CIARDIELLO, F.1    CAPUTO, R.2    DAMIANO, V.3
  • 39
    • 0033818695 scopus 로고    scopus 로고
    • Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells
    • CIARDIELLO F, BIANCO R, DAMIANO V et al.: Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells. Clin. Cancer Res. (2000) 6:3739-3747.
    • (2000) Clin. Cancer Res , vol.6 , pp. 3739-3747
    • CIARDIELLO, F.1    BIANCO, R.2    DAMIANO, V.3
  • 40
    • 32044459807 scopus 로고    scopus 로고
    • Phase I clinical evaluation of AZD2171 in combination with gefitinib in patients with advanced tumors
    • 199s
    • VAN CRUIJSEN, VOEST EE, VAN HARPEN CM et al.: Phase I clinical evaluation of AZD2171 in combination with gefitinib in patients with advanced tumors. Proc. Am. Soc. Clin. Oncol. (2005) 23:199s.
    • (2005) Proc. Am. Soc. Clin. Oncol , vol.23
    • CRUIJSEN, V.A.N.1    VOEST, E.E.2    VAN HARPEN, C.M.3
  • 41
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • WILHELM SM, CARTER C, TANG L et al.: BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. (2004) 64:7099-7109.
    • (2004) Cancer Res , vol.64 , pp. 7099-7109
    • WILHELM, S.M.1    CARTER, C.2    TANG, L.3
  • 42
    • 28044434570 scopus 로고    scopus 로고
    • A Phase I study of BAY 43-9006 and gefitinib in patients with refractory or recurrent non-small-cell lung cancer
    • 206s
    • ADJEI AA, MANDREKAR S, MARKS RS et al.: A Phase I study of BAY 43-9006 and gefitinib in patients with refractory or recurrent non-small-cell lung cancer. Proc. Am. Soc. Clin. Oncol. (2005) 23:206s.
    • (2005) Proc. Am. Soc. Clin. Oncol , vol.23
    • ADJEI, A.A.1    MANDREKAR, S.2    MARKS, R.S.3
  • 43
    • 0030774045 scopus 로고    scopus 로고
    • Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase
    • MOYER JD, BARBACCI EG, IWATA KK et al.: Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. (1997) 57:4838-4848.
    • (1997) Cancer Res , vol.57 , pp. 4838-4848
    • MOYER, J.D.1    BARBACCI, E.G.2    IWATA, K.K.3
  • 44
    • 0032695910 scopus 로고    scopus 로고
    • Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: Dynamics of receptor inhibition in situ and antitumor effects in athymic mice
    • POLLACK VA, SAVAGE DM, BAKER DA et al.: Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: dynamics of receptor inhibition in situ and antitumor effects in athymic mice. J. Pharmacol. Exp. Ther. (1999) 291:739-748.
    • (1999) J. Pharmacol. Exp. Ther , vol.291 , pp. 739-748
    • POLLACK, V.A.1    SAVAGE, D.M.2    BAKER, D.A.3
  • 45
    • 0035398631 scopus 로고    scopus 로고
    • Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies
    • HIDALGO M, SIU LL, NEMUNAITIS J et al.: Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies. J. Clin. Oncol. (2001) 19:3267-3279.
    • (2001) J. Clin. Oncol , vol.19 , pp. 3267-3279
    • HIDALGO, M.1    SIU, L.L.2    NEMUNAITIS, J.3
  • 46
    • 0038545803 scopus 로고    scopus 로고
    • Erlotinib (Tarceva): A promising drug targeting epidermal growth factor receptor tyrosine kinase
    • BULGARU AM, MANI S, GOEL S, PEREZ-SOLER R: Erlotinib (Tarceva): a promising drug targeting epidermal growth factor receptor tyrosine kinase. Expert Rev. Anticancer Ther. (2003) 3:269-279.
    • (2003) Expert Rev. Anticancer Ther , vol.3 , pp. 269-279
    • BULGARU, A.M.1    MANI, S.2    GOEL, S.3    PEREZ-SOLER, R.4
  • 47
    • 1842772526 scopus 로고    scopus 로고
    • Multicenter Phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell carcinoma of the head and neck
    • SOULIERES D, SENZER NN, VOKES EE et al.: Multicenter Phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell carcinoma of the head and neck. J. Clin. Oncol. (2001) 22:77-85.
    • (2001) J. Clin. Oncol , vol.22 , pp. 77-85
    • SOULIERES, D.1    SENZER, N.N.2    VOKES, E.E.3
  • 48
    • 0001069404 scopus 로고    scopus 로고
    • Phase II evaluation of OSI-774, a potent oral antagonist of the EGFR-TK in patients with advanced ovarian carcinoma
    • Abstact
    • FINKLER N, GORDON A, CROZIER M et al.: Phase II evaluation of OSI-774, a potent oral antagonist of the EGFR-TK in patients with advanced ovarian carcinoma. Proc Am. Soc. Clin. Oncol. (2001) 20:Abstact 831.
    • (2001) Proc Am. Soc. Clin. Oncol , vol.20 , pp. 831
    • FINKLER, N.1    GORDON, A.2    CROZIER, M.3
  • 49
    • 4344646459 scopus 로고    scopus 로고
    • Determinants of tumor response and survival with erlotinib in patients with non-small-cell lung cancer
    • PEREZ-SOLER R, CHACHOUA A, HAMMOND LA et al.: Determinants of tumor response and survival with erlotinib in patients with non-small-cell lung cancer. J. Clin. Oncol. (2004) 22:3238-3247.
    • (2004) J. Clin. Oncol , vol.22 , pp. 3238-3247
    • PEREZ-SOLER, R.1    CHACHOUA, A.2    HAMMOND, L.A.3
  • 50
    • 5644303684 scopus 로고    scopus 로고
    • A randomized placebo-controlled trial of erlotinib in patients with advanced non-small-cell lung cancer (NSCLC) following failure of first line or second line chemotherapy. A National Cancer Institute of Canada Clinical Trial Group (NCIC CTG) trial
    • Abstract 7022
    • SHEPHERD FA, PEREIRA J, CIULEANU TE et al.: A randomized placebo-controlled trial of erlotinib in patients with advanced non-small-cell lung cancer (NSCLC) following failure of first line or second line chemotherapy. A National Cancer Institute of Canada Clinical Trial Group (NCIC CTG) trial. Proc. Am. Soc. Clin. Oncol. (2004) 23:Abstract 7022.
    • (2004) Proc. Am. Soc. Clin. Oncol , vol.23
    • SHEPHERD, F.A.1    PEREIRA, J.2    CIULEANU, T.E.3
  • 51
    • 4444238981 scopus 로고    scopus 로고
    • Results of a Phase III trial of erlotinib (OSI-774) combined with cisplatin and gemcitabine chemotehrapy in advanced non-small-cell lung cancer (NSCLC)
    • Abstract 7010
    • GATZEMEIER U, PLUZANSKA A, SZCZESNA A et al.: Results of a Phase III trial of erlotinib (OSI-774) combined with cisplatin and gemcitabine chemotehrapy in advanced non-small-cell lung cancer (NSCLC). Proc. Am. Soc. Clin. Oncol. (2004) 23:Abstract 7010.
    • (2004) Proc. Am. Soc. Clin. Oncol , vol.23
    • GATZEMEIER, U.1    PLUZANSKA, A.2    SZCZESNA, A.3
  • 52
    • 24944440830 scopus 로고    scopus 로고
    • TRIBUTE - a Phase III trial of erlotinib HCl (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer (NSCLC)
    • Abstract 7011
    • HERBST RS, PRAGER D, HERMANN R et al.: TRIBUTE - a Phase III trial of erlotinib HCl (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer (NSCLC). Proc. Am. Soc. Clin. Oncol. (2004) 23:Abstract 7011.
    • (2004) Proc. Am. Soc. Clin. Oncol , vol.23
    • HERBST, R.S.1    PRAGER, D.2    HERMANN, R.3
  • 53
    • 20244381389 scopus 로고    scopus 로고
    • Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combntion with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer
    • HERBST RS, JOHNSON DH, MININBERG E et al.: Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combntion with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer. J. Clin. Oncol. (2005) 23:2544-2555.
    • (2005) J. Clin. Oncol , vol.23 , pp. 2544-2555
    • HERBST, R.S.1    JOHNSON, D.H.2    MININBERG, E.3
  • 54
    • 0035553174 scopus 로고    scopus 로고
    • The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW572016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo
    • RUSNAK DW, LACKEY K, AFFLECK et al.: The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW572016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol. Cancer Ther. (2001) 1:85-94.
    • (2001) Mol. Cancer Ther , vol.1 , pp. 85-94
    • RUSNAK, D.W.1    LACKEY, K.2    AFFLECK3
  • 55
    • 27844454552 scopus 로고    scopus 로고
    • Preliminary safty results of a Phase II trial comparing two schedules of lapatinib ( GW572016) as first line therapy for advanced or metastatic non small cell lung cancer
    • ROSS H, BLUMENCLEIN G-R, DOWLATI A et al.: Preliminary safty results of a Phase II trial comparing two schedules of lapatinib ( GW572016) as first line therapy for advanced or metastatic non small cell lung cancer. Proc. Am. Soc. Clin. Oncol. (2005).
    • (2005) Proc. Am. Soc. Clin. Oncol
    • ROSS, H.1    BLUMENCLEIN, G.-R.2    DOWLATI, A.3
  • 56
    • 21044439024 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetics evaluation of oral CI-1033 in patients with refractory cancer
    • NEMUNITIS J, EISEMAN I, CUNNINGHAM C et al.: Phase I clinical and pharmacokinetics evaluation of oral CI-1033 in patients with refractory cancer. Clin. Cancer Res. (2005) 11:3846-3853.
    • (2005) Clin. Cancer Res , vol.11 , pp. 3846-3853
    • NEMUNITIS, J.1    EISEMAN, I.2    CUNNINGHAM, C.3
  • 57
    • 15344339405 scopus 로고    scopus 로고
    • A Phase II, single agent study of CI-1033 administered at two doses in ovarian cancer patients who failed platinum therapy
    • CAMPOS SM, SEIDEN MV, OZA A et al.: A Phase II, single agent study of CI-1033 administered at two doses in ovarian cancer patients who failed platinum therapy. Proc. Am. Soc. Clin. Oncol. (2004)22:5054.
    • (2004) Proc. Am. Soc. Clin. Oncol , vol.22 , pp. 5054
    • CAMPOS, S.M.1    SEIDEN, M.V.2    OZA, A.3
  • 58
    • 13844317894 scopus 로고    scopus 로고
    • EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
    • KOBAYASHI S, BOGGON TJ, DAYARAM et al.: EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. (2005) 352:786-792.
    • (2005) N. Engl. J. Med , vol.352 , pp. 786-792
    • KOBAYASHI, S.1    BOGGON, T.J.2    DAYARAM3
  • 59
    • 21144439000 scopus 로고    scopus 로고
    • Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib
    • KWAK EL, SORDELLA R, BELL DW et al.: Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib. Proc. Natl. Acad. Sci. USA (2005) 102:7665-7670.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 7665-7670
    • KWAK, E.L.1    SORDELLA, R.2    BELL, D.W.3
  • 60
    • 2542582261 scopus 로고    scopus 로고
    • Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase
    • RABINDRAN SK, DISCAFANI CM, ROSFJORD EC et al.: Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase. Cancer Res. (2004) 64:3958-3965.
    • (2004) Cancer Res , vol.64 , pp. 3958-3965
    • RABINDRAN, S.K.1    DISCAFANI, C.M.2    ROSFJORD, E.C.3
  • 61
    • 0037102369 scopus 로고    scopus 로고
    • ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration
    • WEDGE SR, OGILVIE DJ, DUKES M et al.: ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res. (2002) 62:4646-4655.
    • (2002) Cancer Res , vol.62 , pp. 4646-4655
    • WEDGE, S.R.1    OGILVIE, D.J.2    DUKES, M.3
  • 62
    • 0037115405 scopus 로고    scopus 로고
    • ZD6474, an orallyavailable inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases
    • CARLOMAGNO F, VITAGLIANO D, GUIDA T et al.: ZD6474, an orallyavailable inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases. Cancer Res. (2002) 62:7284-7290.
    • (2002) Cancer Res , vol.62 , pp. 7284-7290
    • CARLOMAGNO, F.1    VITAGLIANO, D.2    GUIDA, T.3
  • 63
    • 0842289982 scopus 로고    scopus 로고
    • Antitumor activity of ZD6474, a VEGFR tyrosine kinase inhibitor, in human cancer cells with acquired resistance to anti-EGFR therapy
    • CIARDIELLO F, BIANCO R, CAPUTO R et al.: Antitumor activity of ZD6474, a VEGFR tyrosine kinase inhibitor, in human cancer cells with acquired resistance to anti-EGFR therapy. Clin. Cancer Res. (2004) 10:784-793.
    • (2004) Clin. Cancer Res , vol.10 , pp. 784-793
    • CIARDIELLO, F.1    BIANCO, R.2    CAPUTO, R.3
  • 64
    • 33645065322 scopus 로고    scopus 로고
    • Schedule-dependent effects of ZD6474, a potent inhbitor of VEGFR signaling, combined with radiotherapy in a lung tumor xenograft model
    • WILLIAMS KJ, TELFER BA, STRATFORD IJ et al.: Schedule-dependent effects of ZD6474, a potent inhbitor of VEGFR signaling, combined with radiotherapy in a lung tumor xenograft model. Clin. Cancer Res. (2003) 9:6141S.
    • (2003) Clin. Cancer Res , vol.9
    • WILLIAMS, K.J.1    TELFER, B.A.2    STRATFORD, I.J.3
  • 65
    • 0001410793 scopus 로고    scopus 로고
    • Clinical evaluation of ZD6474, an orally active inhibitor of VEGF signaling, in patients with solid tumors
    • HURWITZ H, HOLDEN SN, ECKHARDT SG et al.: Clinical evaluation of ZD6474, an orally active inhibitor of VEGF signaling, in patients with solid tumors. Proc. Am. Soc. Clin. Oncol. (2002) 21:82a.
    • (2002) Proc. Am. Soc. Clin. Oncol , vol.21
    • HURWITZ, H.1    HOLDEN, S.N.2    ECKHARDT, S.G.3
  • 66
    • 0141542201 scopus 로고    scopus 로고
    • A Phase I study of an oral VEGF receptor tyrosine kinase inhibitor ZD6474, in Japanese patients with solid tumors
    • MINAMI H, EBI H, TAHARA M et al.: A Phase I study of an oral VEGF receptor tyrosine kinase inhibitor ZD6474, in Japanese patients with solid tumors. Proc. Am. Soc. Clin. Oncol. (2003) 22:194a.
    • (2003) Proc. Am. Soc. Clin. Oncol , vol.22
    • MINAMI, H.1    EBI, H.2    TAHARA, M.3
  • 67
    • 28444488046 scopus 로고    scopus 로고
    • A comparison of the antitumor efficacy of ZD6474 and gefitinib (Iressa) in patients with NSCLC:results of a randomised, double bind, Phase II study
    • NATALE R, BODKIN D, GOVINDAN R et al.: A comparison of the antitumor efficacy of ZD6474 and gefitinib (Iressa) in patients with NSCLC:results of a randomised, double bind, Phase II study. Lung Cancer (2005) 49(Suppl. 2):s37.
    • (2005) Lung Cancer , vol.49 , Issue.SUPPL. 2
    • NATALE, R.1    BODKIN, D.2    GOVINDAN, R.3
  • 68
    • 28444452328 scopus 로고    scopus 로고
    • ZD6474 in combination with carboplatin and paclitaxel as first-line treatment in patients with NSCLC: Results of the run-in phase of a two-part randomized Phase II study
    • Abstract P-497
    • HEYMACH JV, WEST H, KERR et al.: ZD6474 in combination with carboplatin and paclitaxel as first-line treatment in patients with NSCLC: results of the run-in phase of a two-part randomized Phase II study. Lung Cancer (2005) 49(Suppl. 2):S247 (Abstract P-497).
    • (2005) Lung Cancer , vol.49 , Issue.SUPPL. 2
    • HEYMACH, J.V.1    WEST, H.2    KERR3
  • 69
    • 33750938418 scopus 로고    scopus 로고
    • A Phase II trial of ZD6474 plus docetaxel in patients with previously treated NSCLC: Follow-up results
    • 368s Abstract 7016
    • HEYMACH JV, JOHNSON BE, PRAGER D et al.: A Phase II trial of ZD6474 plus docetaxel in patients with previously treated NSCLC: Follow-up results. J. Clin. Oncol. (2006) 24:368s (Abstract 7016).
    • (2006) J. Clin. Oncol , vol.24
    • HEYMACH, J.V.1    JOHNSON, B.E.2    PRAGER, D.3
  • 70
    • 0028819660 scopus 로고
    • Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model
    • GOLDSTEIN NI, PREWETT M, ZUKLYS K, ROCKWELL P, MENDELSOHN J: Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model. Clin. Cancer Res. (1995) 1:1311-1318.
    • (1995) Clin. Cancer Res , vol.1 , pp. 1311-1318
    • GOLDSTEIN, N.I.1    PREWETT, M.2    ZUKLYS, K.3    ROCKWELL, P.4    MENDELSOHN, J.5
  • 71
    • 0029670014 scopus 로고    scopus 로고
    • Involvement of p27kip 1 in G 1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody
    • WU X, RUBIN M, FAN Z et al.: Involvement of p27kip 1 in G 1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody. Oncogene (1996) 12:1397-1403.
    • (1996) Oncogene , vol.12 , pp. 1397-1403
    • WU, X.1    RUBIN, M.2    FAN, Z.3
  • 72
    • 0029776415 scopus 로고    scopus 로고
    • Anti-epidermal growth factor receptor monoclonal antibody C225 upregulates p27kip1 and induces G 1 arrest in prostatic cancer cell line DU145
    • PENG D, FAN Z, LU Y, DEBLASIO T, SCHER H, MENDELSOHN J: Anti-epidermal growth factor receptor monoclonal antibody C225 upregulates p27kip1 and induces G 1 arrest in prostatic cancer cell line DU145. Cancer Res. (1996) 56:3666-3669.
    • (1996) Cancer Res , vol.56 , pp. 3666-3669
    • PENG, D.1    FAN, Z.2    LU, Y.3    DEBLASIO, T.4    SCHER, H.5    MENDELSOHN, J.6
  • 73
    • 16144362509 scopus 로고    scopus 로고
    • Antitumor activity of combined blockade of epidermal growth factor receptor and protein kinase A
    • CIARDIELLO F, DAMIANO V, BIANCO R et al.: Antitumor activity of combined blockade of epidermal growth factor receptor and protein kinase A. J. NatL Cancer Inst. (1996) 88:1770-1776.
    • (1996) J. NatL Cancer Inst , vol.88 , pp. 1770-1776
    • CIARDIELLO, F.1    DAMIANO, V.2    BIANCO, R.3
  • 74
    • 0032904485 scopus 로고    scopus 로고
    • Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor monoclonal antibody C225
    • CIARDIELLO F, BIANCO R, DAMIANO V et al.: Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor monoclonal antibody C225. Clin. Cancer Res. (1999) 5:909-916.
    • (1999) Clin. Cancer Res , vol.5 , pp. 909-916
    • CIARDIELLO, F.1    BIANCO, R.2    DAMIANO, V.3
  • 75
    • 0032407024 scopus 로고    scopus 로고
    • Mouse-human chimeric anti-epidermal growth factor receptor antibody C225 inhibits the growth of human renal cell carcinoma xenografts in nude mice
    • PREWETT M, ROTHMAN M, WAKSAL H, FELDMAN M, BANDER NH, HICKLIN DJ: Mouse-human chimeric anti-epidermal growth factor receptor antibody C225 inhibits the growth of human renal cell carcinoma xenografts in nude mice. Clin. Cancer Res. (1998) 4:2957-2966.
    • (1998) Clin. Cancer Res , vol.4 , pp. 2957-2966
    • PREWETT, M.1    ROTHMAN, M.2    WAKSAL, H.3    FELDMAN, M.4    BANDER, N.H.5    HICKLIN, D.J.6
  • 76
    • 0032972944 scopus 로고    scopus 로고
    • Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice
    • PERROTTE P, MATSUMOTO T, INOUE K et al.: Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice. Clin. Cancer Res. (1999) 5:257-265.
    • (1999) Clin. Cancer Res , vol.5 , pp. 257-265
    • PERROTTE, P.1    MATSUMOTO, T.2    INOUE, K.3
  • 77
    • 18844473781 scopus 로고    scopus 로고
    • Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms
    • BRUNS CJ HARBISON MT, DAVIS DW et al.: Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms. Clin. Cancer Res. (2000) 6:1936-1948.
    • (2000) Clin. Cancer Res , vol.6 , pp. 1936-1948
    • BRUNS, C.J.1    HARBISON, M.T.2    DAVIS, D.W.3
  • 78
    • 0033818695 scopus 로고    scopus 로고
    • Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells
    • CIARDIELLO F, BIANCO R, DAMIANO V et al.: Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells. Clin. Cancer Res. (2000) 6:3739-3747.
    • (2000) Clin. Cancer Res , vol.6 , pp. 3739-3747
    • CIARDIELLO, F.1    BIANCO, R.2    DAMIANO, V.3
  • 79
    • 0034489116 scopus 로고    scopus 로고
    • Paclitaxel enhances the effects of the anti-epidermal growth factor receptor monoclonal antibody ImClone C225 in mice with metastatic human bladder transitional cell carcinoma
    • INOUE K, SLATON JW, PERROTTE P et al.: Paclitaxel enhances the effects of the anti-epidermal growth factor receptor monoclonal antibody ImClone C225 in mice with metastatic human bladder transitional cell carcinoma. Clin. Cancer Res. (2000) 6:4874-4884.
    • (2000) Clin. Cancer Res , vol.6 , pp. 4874-4884
    • INOUE, K.1    SLATON, J.W.2    PERROTTE, P.3
  • 80
    • 17344382185 scopus 로고    scopus 로고
    • Combined modality therapy of A431 human epidermoid cancer using anti-EGFR antibody C225 and radiation
    • SALEH MH, RAISCH KP, STACKHOUSE MA et al.: Combined modality therapy of A431 human epidermoid cancer using anti-EGFR antibody C225 and radiation. Cancer Biother. Radiopharm. (1999) 14:451-463.
    • (1999) Cancer Biother. Radiopharm , vol.14 , pp. 451-463
    • SALEH, M.H.1    RAISCH, K.P.2    STACKHOUSE, M.A.3
  • 81
    • 0033966576 scopus 로고    scopus 로고
    • In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody
    • MILAS L, MASON K, HUNTER N et al.: In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody. Clin. Cancer Res. (2000) 6:701-708.
    • (2000) Clin. Cancer Res , vol.6 , pp. 701-708
    • MILAS, L.1    MASON, K.2    HUNTER, N.3
  • 82
    • 0033561522 scopus 로고    scopus 로고
    • Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck
    • HUANG SM, BOCK JM, HARARI PM: Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck. Cancer Res. (1999) 15:1935-1940.
    • (1999) Cancer Res , vol.15 , pp. 1935-1940
    • HUANG, S.M.1    BOCK, J.M.2    HARARI, P.M.3
  • 83
    • 0033748391 scopus 로고    scopus 로고
    • Antitumor activity of combined treatment of human cancer cells with ionizing radiations and anti-epidermal growth factor receptor monoclonal antibody C225 plus type I protein kinase A antisense oligonucleotide
    • BIANCO C, BIANCO R, TORTORA G et al.: Antitumor activity of combined treatment of human cancer cells with ionizing radiations and anti-epidermal growth factor receptor monoclonal antibody C225 plus type I protein kinase A antisense oligonucleotide. Clin. Cancer Res. (2000) 6:4343-4350.
    • (2000) Clin. Cancer Res , vol.6 , pp. 4343-4350
    • BIANCO, C.1    BIANCO, R.2    TORTORA, G.3
  • 84
    • 0034084314 scopus 로고    scopus 로고
    • Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: Inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis
    • HUANG S-M, HARARI P: Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis. Clin. Cancer Res. (2000) 6:2166-2174.
    • (2000) Clin. Cancer Res , vol.6 , pp. 2166-2174
    • HUANG, S.-M.1    HARARI, P.2
  • 85
    • 19244366949 scopus 로고    scopus 로고
    • Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin
    • BASELGA J, PFISTER D, COOPER MR et al.: Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin. J. Clin. Oncol. (2000) 18:904-914.
    • (2000) J. Clin. Oncol , vol.18 , pp. 904-914
    • BASELGA, J.1    PFISTER, D.2    COOPER, M.R.3
  • 86
    • 0038816710 scopus 로고    scopus 로고
    • Phase IB/IIA study of anti-epidermal growth factor receptor antibody, cetuximab, in combination with gemcitabine/carboplatin in patients with advanced stage IV non-small-cell lung cancer
    • Abstract 2587
    • ROBERT F, BLUMENSCHEIN G, DICKE K et al.: Phase IB/IIA study of anti-epidermal growth factor receptor antibody, cetuximab, in combination with gemcitabine/carboplatin in patients with advanced stage IV non-small-cell lung cancer. Proc. Am. Soc. Clin. Oncol. (2003) 23:Abstract 2587.
    • (2003) Proc. Am. Soc. Clin. Oncol , vol.23
    • ROBERT, F.1    BLUMENSCHEIN, G.2    DICKE, K.3
  • 87
    • 0038140036 scopus 로고    scopus 로고
    • A multicenter Phase I/II study of cetuximab in combination with paclitaxel and carboplatin in untreated patients with stage IV non-small-cell lung cancer
    • Abstract 2592
    • KELLY K, HANNA N, ROSENBERG A et al.: A multicenter Phase I/II study of cetuximab in combination with paclitaxel and carboplatin in untreated patients with stage IV non-small-cell lung cancer. Proc. Am. Soc. Clin. Oncol. (2003) 23:Abstract 2592.
    • (2003) Proc. Am. Soc. Clin. Oncol , vol.23
    • KELLY, K.1    HANNA, N.2    ROSENBERG, A.3
  • 88
    • 34447572055 scopus 로고    scopus 로고
    • KIM ES, MAUER AM, TRAN HT et al.: A Phase II study of Cetuximab, an IgG1 epidermal growth factor receptor-blocking antibody, in combination with docetaxel in chemotherapy-refractory/resistant patients with advanced non-small-cell lung cancer: final report. Proc. Am. Soc. Clin. Oncol. (2003) 23:Abstract 2581.
    • KIM ES, MAUER AM, TRAN HT et al.: A Phase II study of Cetuximab, an IgG1 epidermal growth factor receptor-blocking antibody, in combination with docetaxel in chemotherapy-refractory/resistant patients with advanced non-small-cell lung cancer: final report. Proc. Am. Soc. Clin. Oncol. (2003) 23:Abstract 2581.
  • 89
    • 0038140033 scopus 로고    scopus 로고
    • Cetuximab (C225) in combination with cisplatin/vinorelbin versus cisplatin/vinorelbin alone in the first-line treatment of patients (pts) with epidermal growth factor receptor (EGFR) positive advanced non-small-cell lung cancer (NSCLC)
    • Abstract 2582
    • GATZEMEIER U, ROSELL R, RAMLAU R et al.: Cetuximab (C225) in combination with cisplatin/vinorelbin versus cisplatin/vinorelbin alone in the first-line treatment of patients (pts) with epidermal growth factor receptor (EGFR) positive advanced non-small-cell lung cancer (NSCLC). Proc. Am. Soc. Clin. Oncol. (2003) 23:Abstract 2582.
    • (2003) Proc. Am. Soc. Clin. Oncol , vol.23
    • GATZEMEIER, U.1    ROSELL, R.2    RAMLAU, R.3
  • 90
    • 33846661208 scopus 로고    scopus 로고
    • Concurrent chemotherapy plus cetuximab or chemotherapy followed by cetuximab in advanced non-small-cell lung cancer (NSCLC): A randomized Phase II selectional trial SWOG 0342
    • Abstract 7015
    • KELLY K, HERBST RS, CROWLEY JJ et al.: Concurrent chemotherapy plus cetuximab or chemotherapy followed by cetuximab in advanced non-small-cell lung cancer (NSCLC): a randomized Phase II selectional trial SWOG 0342. Proc. Am. Soc. Clin. Oncol. (2006) 24:Abstract 7015.
    • (2006) Proc. Am. Soc. Clin. Oncol , vol.24
    • KELLY, K.1    HERBST, R.S.2    CROWLEY, J.J.3
  • 91
    • 33244488713 scopus 로고    scopus 로고
    • Updated results from a dose and schedule study of panitumumab (ABX-EGF) monotherapy, in patients with advanced solid maligmancies
    • WEINER LM, BELLDEGRUN A, ROWINSKY E et al.: Updated results from a dose and schedule study of panitumumab (ABX-EGF) monotherapy, in patients with advanced solid maligmancies. Proc. Am. Soc. Clin. Oncol. (2005) 23:3059.
    • (2005) Proc. Am. Soc. Clin. Oncol , vol.23 , pp. 3059
    • WEINER, L.M.1    BELLDEGRUN, A.2    ROWINSKY, E.3
  • 92
    • 34447547010 scopus 로고    scopus 로고
    • DOI T, OHTSU A, SAIJO N et al.: A Phase I study of humanized monclonalanti-epidermal growth factor receptor (EGFR) antibody 'EM72000 (Matuzumab)' administered weekly in Japanese patients with advanced solid tumors; safety, PK, and PD results of kin biopsies. Proc. Am. Soc. Clin. Oncol. (2005) 23:3077.
    • DOI T, OHTSU A, SAIJO N et al.: A Phase I study of humanized monclonalanti-epidermal growth factor receptor (EGFR) antibody 'EM72000 (Matuzumab)' administered weekly in Japanese patients with advanced solid tumors; safety, PK, and PD results of kin biopsies. Proc. Am. Soc. Clin. Oncol. (2005) 23:3077.
  • 93
    • 21644457565 scopus 로고    scopus 로고
    • Phase I stdy of the humanized epidermal growth factor receptor (EGFR) antibody EMD72000 (matuzumab) in combination with ECX (epirubicin, cisplatin and capecitabine) as first line treatment for advanced oesophagogastric (OG) adenocarcinoma
    • RAO S, STARLING N, BENSON A et al.: Phase I stdy of the humanized epidermal growth factor receptor (EGFR) antibody EMD72000 (matuzumab) in combination with ECX (epirubicin, cisplatin and capecitabine) as first line treatment for advanced oesophagogastric (OG) adenocarcinoma. Proc. Am. Soc. Clin. Oncol. (2005) 24.
    • (2005) Proc. Am. Soc. Clin. Oncol , vol.24
    • RAO, S.1    STARLING, N.2    BENSON, A.3
  • 94
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • LYNCH TJ, BELL DW, SORDELLA R et al.: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. (2004) 350:2129-2139.
    • (2004) N. Engl. J. Med , vol.350 , pp. 2129-2139
    • LYNCH, T.J.1    BELL, D.W.2    SORDELLA, R.3
  • 95
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • PAEZ JG, JANNE PA, LEE JC et al.: EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science (2004) 304:1497-1500.
    • (2004) Science , vol.304 , pp. 1497-1500
    • PAEZ, J.G.1    JANNE, P.A.2    LEE, J.C.3
  • 96
    • 4444344330 scopus 로고    scopus 로고
    • EGF receptor gene mutations are common in lung cancers from 'never smokers' and are associated with sensitivity of tumors to gefitinib and erlotinib
    • PAO W, MILLER V, ZAKOWSKI M et al.: EGF receptor gene mutations are common in lung cancers from 'never smokers' and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc. Natl. Acad. Sci. USA (2004) 101:13306-13311.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 13306-13311
    • PAO, W.1    MILLER, V.2    ZAKOWSKI, M.3
  • 97
    • 28444478439 scopus 로고    scopus 로고
    • Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants
    • GREULICH H, CHEN TH, FENG W et al.: Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants. PloS Med. (2005) 2:e313.
    • (2005) PloS Med , vol.2
    • GREULICH, H.1    CHEN, T.H.2    FENG, W.3
  • 98
    • 24944497744 scopus 로고    scopus 로고
    • Mutatuons in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
    • EBERHARD DA, JOHNSON BE, AMLER LC et al.: Mutatuons in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. J. Clin. Oncol. (2005) 23:5900-5909.
    • (2005) J. Clin. Oncol , vol.23 , pp. 5900-5909
    • EBERHARD, D.A.1    JOHNSON, B.E.2    AMLER, L.C.3
  • 99
    • 28844501639 scopus 로고    scopus 로고
    • Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancer
    • SHIGEMATSU H, GAZDAR AF: Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancer. Int. J. Cancer (2006) 118:257-262.
    • (2006) Int. J. Cancer , vol.118 , pp. 257-262
    • SHIGEMATSU, H.1    GAZDAR, A.F.2
  • 100
    • 28844449401 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: Molecular analysis of the IDEAL/INTACT gefitinib trials
    • BELL DW, LYNCH TJ, HASERLAT SM et al.: Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: molecular analysis of the IDEAL/INTACT gefitinib trials. J. Clin. Oncol. (2005) 23:8081-8092.
    • (2005) J. Clin. Oncol , vol.23 , pp. 8081-8092
    • BELL, D.W.1    LYNCH, T.J.2    HASERLAT, S.M.3
  • 101
    • 20244388126 scopus 로고    scopus 로고
    • Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence
    • MITSUDOMI T, KOSAKA T, ENDOH H et al.: Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence, J. Clin. Oncol. (2005) 23:2513-2520.
    • (2005) J. Clin. Oncol , vol.23 , pp. 2513-2520
    • MITSUDOMI, T.1    KOSAKA, T.2    ENDOH, H.3
  • 102
    • 32944466837 scopus 로고    scopus 로고
    • Evaluation of epidermal growth factor receptor mutations and gene copy numbers as predictors of clinical outcomes in Japanese patients with recurrent non-small-cell lung cancer (NSCLC) receiving gefitinib
    • TAKANO T, OHE Y, YOSHIDA H et al.: Evaluation of epidermal growth factor receptor mutations and gene copy numbers as predictors of clinical outcomes in Japanese patients with recurrent non-small-cell lung cancer (NSCLC) receiving gefitinib. ASCO (2005):7032.
    • (2005) ASCO , pp. 7032
    • TAKANO, T.1    OHE, Y.2    YOSHIDA, H.3
  • 103
    • 31544440171 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutations in needle biopsy/aspiration samples predict response to gefitinib therapy and survival of patients with advanced non small cell lung cancer
    • SHIH JY, GOW CH, YU CJ et al.: Epidermal growth factor receptor mutations in needle biopsy/aspiration samples predict response to gefitinib therapy and survival of patients with advanced non small cell lung cancer. Int. J. Cancer (2006) 118:963-969.
    • (2006) Int. J. Cancer , vol.118 , pp. 963-969
    • SHIH, J.Y.1    GOW, C.H.2    YU, C.J.3
  • 104
    • 21044445279 scopus 로고    scopus 로고
    • Mutation in the tyrosine kinase domain of epidermal growth factor receptor is a predictive and progostic factor for gefitinib treatment in patients with non-small-cell lung cancer
    • CHOU TY, CHIU CH, LI LH et al.: Mutation in the tyrosine kinase domain of epidermal growth factor receptor is a predictive and progostic factor for gefitinib treatment in patients with non-small-cell lung cancer. Clin. Cancer Res. (2005) 11:3750-3757.
    • (2005) Clin. Cancer Res , vol.11 , pp. 3750-3757
    • CHOU, T.Y.1    CHIU, C.H.2    LI, L.H.3
  • 105
    • 20244389188 scopus 로고    scopus 로고
    • Predictive and prognostic impact of epidermal growth factor receptor mutation in non-small-cell lung cancer patients treated with gefitinib
    • HAN SW, KIM TY, HWANG PG et al.: Predictive and prognostic impact of epidermal growth factor receptor mutation in non-small-cell lung cancer patients treated with gefitinib. J. Clin. Oncol. (2005) 23:2493-2501.
    • (2005) J. Clin. Oncol , vol.23 , pp. 2493-2501
    • HAN, S.W.1    KIM, T.Y.2    HWANG, P.G.3
  • 106
    • 23844490782 scopus 로고    scopus 로고
    • Activating mutations in the tyrosine kinasedomain of epidermal growth factor receptor are associated with improved survival in gefitinib-treated chemorefractory lung adenocarcinomas
    • TARON M, ICHINOSE Y, ROSELL E et al.: Activating mutations in the tyrosine kinasedomain of epidermal growth factor receptor are associated with improved survival in gefitinib-treated chemorefractory lung adenocarcinomas. Clin. Cancer Res. (2005) 11:5878-5885.
    • (2005) Clin. Cancer Res , vol.11 , pp. 5878-5885
    • TARON, M.1    ICHINOSE, Y.2    ROSELL, E.3
  • 107
    • 20444498630 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer
    • CAPPUZZO F, HIRSCH FR, ROSSI E et al.: Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer. J. Natl. Cancer Inst. (2005) 97:643-655.
    • (2005) J. Natl. Cancer Inst , vol.97 , pp. 643-655
    • CAPPUZZO, F.1    HIRSCH, F.R.2    ROSSI, E.3
  • 108
    • 19944433797 scopus 로고    scopus 로고
    • The relationship between epidermal growth factor receptor mutations and clinicopathologic features in non-small-cell lung cancers
    • TOKUMO M, TOYOOKA S, KIURA K et al.: The relationship between epidermal growth factor receptor mutations and clinicopathologic features in non-small-cell lung cancers. Clin. Cancer Res. (2005) 11:1167-1173.
    • (2005) Clin. Cancer Res , vol.11 , pp. 1167-1173
    • TOKUMO, M.1    TOYOOKA, S.2    KIURA, K.3
  • 109
    • 24344459713 scopus 로고    scopus 로고
    • Epidermal growth factor receptor activiting mutations in Spanish gefitinib-treated non-small-cell lung cancer patients
    • CORTES-FUNES H, GOMEZ C, ROSELL R et al.: Epidermal growth factor receptor activiting mutations in Spanish gefitinib-treated non-small-cell lung cancer patients. Ann. Oncol. (2005) 16:1081-1086.
    • (2005) Ann. Oncol , vol.16 , pp. 1081-1086
    • CORTES-FUNES, H.1    GOMEZ, C.2    ROSELL, R.3
  • 110
    • 22044453790 scopus 로고    scopus 로고
    • Erlotinib in lung cancer-molecular and clinical predictors of outcomes
    • TSAO MS, SAKURADA A, CUTZ JC et al.: Erlotinib in lung cancer-molecular and clinical predictors of outcomes. N. Engl. J. Med. (2005) 353:133-144.
    • (2005) N. Engl. J. Med , vol.353 , pp. 133-144
    • TSAO, M.S.1    SAKURADA, A.2    CUTZ, J.C.3
  • 111
    • 33746789922 scopus 로고    scopus 로고
    • Prospective Phase II study of gefitinib for chemotherapy-naive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations
    • INOUE A, SUZUKI T, FUKUHARA T et al.: Prospective Phase II study of gefitinib for chemotherapy-naive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations. J. Clin. Oncol. (2006) 24:3340-3346.
    • (2006) J. Clin. Oncol , vol.24 , pp. 3340-3346
    • INOUE, A.1    SUZUKI, T.2    FUKUHARA, T.3
  • 112
    • 33846702438 scopus 로고    scopus 로고
    • Prospective analysis of the epidermal growth factor receptor gene mutations in non-small-cell lung cancer in Japan
    • 18s Abstract 7077
    • MORIKAWA A, INOUE A, SUZUKI T et al.: Prospective analysis of the epidermal growth factor receptor gene mutations in non-small-cell lung cancer in Japan. J. Clin. Oncol. (2006) 24:18s (Abstract 7077).
    • (2006) J. Clin. Oncol , vol.24
    • MORIKAWA, A.1    INOUE, A.2    SUZUKI, T.3
  • 113
    • 34250009465 scopus 로고    scopus 로고
    • Phase II study of the efficacy of gefitinib in patients with non-small-cell lung cancer with the EGFR mutations
    • 18s Abstract 77183
    • SUNAGA N, YANAGITANI N, KAIRA K et al.: Phase II study of the efficacy of gefitinib in patients with non-small-cell lung cancer with the EGFR mutations. J. Clin. Oncol. (2006)24:18s (Abstract 77183).
    • (2006) J. Clin. Oncol , vol.24
    • SUNAGA, N.1    YANAGITANI, N.2    KAIRA, K.3
  • 114
    • 34249986515 scopus 로고    scopus 로고
    • Phase II study of gefiitinib for non-small-cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) gene mutations detected by PNA-LNA PCR clamp
    • 18s Abstract 77183
    • SUTANI A, NAGAI Y, UDAGAWA K et al.: Phase II study of gefiitinib for non-small-cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) gene mutations detected by PNA-LNA PCR clamp. J. Clin. Oncol. (2006) 24:18s (Abstract 77183).
    • (2006) J. Clin. Oncol , vol.24
    • SUTANI, A.1    NAGAI, Y.2    UDAGAWA, K.3
  • 115
    • 33845434121 scopus 로고    scopus 로고
    • A prospective Phase II trial of erlotinib in advanced non-small-cell lung cancer (NSCLC) patients (p) with mutations in the tyrosine kinase domain of the epidermal growth factor receptor (EGFR)
    • PAZ-ARES L, SANCHEZ JM, GARCIA-VALESCO A et al.: A prospective Phase II trial of erlotinib in advanced non-small-cell lung cancer (NSCLC) patients (p) with mutations in the tyrosine kinase domain of the epidermal growth factor receptor (EGFR). J. Clin. Oncol. (2006) 24:7020.
    • (2006) J. Clin. Oncol , vol.24 , pp. 7020
    • PAZ-ARES, L.1    SANCHEZ, J.M.2    GARCIA-VALESCO, A.3
  • 116
    • 18344386101 scopus 로고    scopus 로고
    • A curious link between epidermal growth factor receptor amplification and survival: Effect of 'allele dilution' on gefitinib sensitivity?
    • KAYE FJ: A curious link between epidermal growth factor receptor amplification and survival: effect of 'allele dilution' on gefitinib sensitivity? J. Natl. Cancer Inst. (2005) 97:621-623.
    • (2005) J. Natl. Cancer Inst , vol.97 , pp. 621-623
    • KAYE, F.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.