Bioactivation of the proximal food mutagen 2-hydroxyamino-1-methyl-6- phenylimidazo[4,5-b]pyridine (N-OH-PhIP) to DNA-binding species by human mammary gland enzymes

Nutrition

Volumn 14, Issue 9, 1998, Pages 683-686

  Dubuisson, Jeffrey G ^a   Gaubatz, James W ^a  

^a UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

Author keywords

Breast cancer; Dietary carcinogens; DNA damage; Heterocyclic amines; Human mammary gland; Metabolic activation

Indexed keywords

2 HYDROXYAMINO 1 METHYL 6 PHENYL[4,5 B]PYRIDINE; ACYLTRANSFERASE; CARCINOGEN; MUTAGENIC AGENT; PEROXIDASE; PHOSPHOTRANSFERASE; PROSTAGLANDIN; PYRIDINE DERIVATIVE; SULFOTRANSFERASE; SYNTHETASE; TRANSFER RNA; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CHEMICAL CARCINOGENESIS; DIETARY INTAKE; DNA DAMAGE; ENZYME SPECIFICITY; FOOD INTAKE; HUMAN; HUMAN TISSUE; MAMMARY GLAND; MUTAGEN TESTING; PRIORITY JOURNAL;

ACETYLTRANSFERASES; ADULT; AMINO ACYL-TRNA SYNTHETASES; ANIMALS; BIOTRANSFORMATION; CELLS, CULTURED; DNA; DNA ADDUCTS; ENZYME ACTIVATION; EPITHELIAL CELLS; ESTERIFICATION; FEMALE; FOOD; HUMANS; IMIDAZOLES; MAMMARY GLANDS, ANIMAL; MIDDLE AGED; MUTAGENS; PYRIDINES; SULFOTRANSFERASES;

EID: 0031752257     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0899-9007(98)00106-3     Document Type: Article

References (16)

1. Snyderwine E.G. Some perspectives on the nutritional aspects of breast cancer research. Cancer. 74:1994;1070.
2. Gaubatz J.W. Cooked food mutagens and breast cancer. Nutrition. 12:1996;449.
3. Layton D.W., Bogen K.T., Knize M.G., et al. Cancer risk of heterocyclic amines in cooked foods an analysis and implications for research . Carcinogenesis. 16:1995;39.
4. Nagao M., Ushijima T., Wakabayashi K., et al. Dietary carcinogens and mammary carcinogenesis. Cancer. 74:1994;1063.
5. Zhao K., Murray S., Davies D.S., Boobis A.R., Gooderham N.J. Metabolism of the food derived mutagen and carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by human liver microsomes. Carcinogenesis. 15:1994;1285.
6. Kaderlik K.R., Minchin R.F., Mulder G.J., et al. Metabolic activation pathway for the formation of DNA adducts of the carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), in rat extrahepatic tissues. Carcinogenesis. 15:1994;1703.
7. Wild D., Degen G.H. Prostaglandin H synthase-dependent mutagenic activation of heterocyclic aromatic amines of the IQ-type. Carcinogenesis. 8:1987;541.
8. Lin D., Lang N.P., Kadlubar F.F. Species differences in the biotransformation of the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by hepatic microsomes and cytosols from humans, rats, and mice. Drug Metab Dispos. 23:1995;518.
9. 32P-postlabeling analysis of non-radioactive aromatic carcinogen-DNA adducts. Carcinogenesis. 3:1982;1081.
10. Schut H.A.J., Herzog C.R. Formation of DNA adducts of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in male Fischer-344 rats. Cancer Lett. 67:1992;117.
11. Fan L., Schut H.A.J., Snyderwine E.G. Cytotoxicity, DNA adduct formation, and DNA repair induced by 2-hydroxyamino-3-methylimidazo[4,5-f]quinoline and 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine in cultured human mammary epithelial cells. Carcinogenesis. 16:1995;775.
12. Pfau W., O'Hare M.J., Grover P.L., Phillips D.H. Metabolic activation of the food mutagens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) to DNA binding species in human mammary epithelial cells. Carcinogenesis. 13:1992;907.
13. Bell D.A., Badawi A.F., Lang N.P., et al. Polymorphism in the N-acetyltransferase (NAT1) polyadenylation signal association of NAT1*10 allele with higher N-acetylation activity in the bladder and colon tissue . Cancer Res. 55:1995;5226.
14. Sadrieh N., Davis C.D., Snyderwine E.G. N-acetyltransferase expression and metabolic activation of the food-derived heterocyclic amines in the human mammary gland. Cancer Res. 56:1996;2683.
15. Davis C.D., Shut H.A.J., Snyderwine E.G. Enzymatic phase II activation of the H-hydroxylamines of IQ, MeIQx and PhIP by various organs of monkeys and rats. Carcinogenesis. 14:1993;2091.
16. Ghoshal A., Davis C.D., Schut H.A.J., Snyderwine E.G. Possible mechanisms for PhIP-DNA adduct formation in the mammary gland of female Sprague-Dawley rats. Carcinogenesis. 16:1995;2725.