Relaxation of the isolated human internal anal sphincter by sildenafil

British Journal of Surgery

Volumn 94, Issue 7, 2007, Pages 894-902

  Ballester, C ^a   Sarria B ^a   Garcia Granero E ^b   Morcillo, E J ^a,b   Lledo S ^b   Cortijo, J ^a,c  

^a UNIVERSITY OF VALENCIA   (Spain)

^b HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^c HOSPITAL GENERAL UNIVERSITARIO DE VALENCIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; CYCLIC GMP; CYCLIC NUCLEOTIDE; GLYCERYL TRINITRATE; HISTAMINE; ISOENZYME; NITROPRUSSIDE SODIUM; PHOSPHODIESTERASE V; PHOSPHODIESTERASE V INHIBITOR; PICLAMILAST; SILDENAFIL; ZAPRINAST;

ADULT; AGED; ANUS SPHINCTER; ARTICLE; CALCIUM CELL LEVEL; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; ENZYME IMMUNOASSAY; EPIFLUORESCENCE MICROSCOPY; FEMALE; HUMAN; HUMAN TISSUE; IC 50; ISOLATED ORGAN; MALE; MUSCLE ISOMETRIC CONTRACTION; MUSCLE RELAXATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION;

ADULT; AGED; AGED, 80 AND OVER; ANAL CANAL; CYCLIC GMP; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; MIDDLE AGED; MUSCLE RELAXATION; MUSCLE, SMOOTH; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; PURINES; SULFONES;

EID: 34447325409     PISSN: 00071323     EISSN: 13652168     Source Type: Journal    
DOI: 10.1002/bjs.5724     Document Type: Article

References (42)

1. Lindsey I, Jones OM, Cunningham G Mortensen NJ. Chronic anal fissure. Br J Surg 2004; 91: 270-279.
2. Garcia-Granero E, Munoz-Eorner E, Minguez, M, Ballester C, Garcia-Botello S, Lledo S. Treatment of chronic anal fissure. Cir Esp 2005; 78(Suppl 3): 24-27.
3. Cook TA, Brading AF, Mortensen NJ. The pharmacology of the internal anal sphincter and new treatments of ano-rectal disorders. Aliment Pharmacol Ther 2001; 15: 887-898.
4. Minguez M, Herreros B, Espi A, Garcia-Granero E, Sanchiz V, Mora F et al. Long-term follow-up (42 months) of chronic anal fissure after healing with botulinum toxin. Gastroenterology 2002; 123: 112-117.
5. Carvajal JA, Germain AM, Huidobro-Toro JP, Weiner CP. Molecular mechanism of cGMP-mediated smooth muscle relaxation. J Cell Physiol 2000; 184: 409-420.
6. Sanz MJ, Cortijo J, Morcillo FJ. PDE4 inhibitors as new anti-inflammatory drugs: effects on cell trafficking and cell adhesion molecules expression. Pharmacol Ther 2005; 106: 269-297.
7. Turko IV, Ballard SA, Francis SH, Corbin JD. Inhibition of cyclic GMP-binding cyclic GMP-specific phosphodiesterase (type 5) by sildenafil and related compounds. Mol Pharmacol 1999; 56: 124-130.
8. Cirino G, Fusco F, Imbimbo C, Mirone V. Pharmacology of erectile dysfunction in man. Pharmacol Ther 2006; 111: 400-423.'
9. Galie N, Ghofrani HA, Torbicki A, Barst RJ, Rubin LJ, Badesch D et al. Sildenafil citrate therapy for pulmonary arterial hypertension. N Engl J Med 2005; 353: 2148-2157.
10. Aygen E, Camci C, Durmus AS, Dogru O, Topuz O, Ayten R et al. Inhibitory effects of sildenafil citrate on the tonus of isolated dog internal anal sphincter. Dis Colon Rectum 2005; 48: 1615-1619.
11. Torrabadella L, Salgado G, Burns RW, Berman IR. Manometric study of topical sildenafil (Viagra) in patients with chronic anal fissure: sildenafil reduces anal resting tone. Dis Colon Rectum 2004; 47: 733-738.
12. Tomita R, Tanjoh K, Fujisaki S, Fukuzawa M. The role of nitric oxide (NO) in the human internal anal sphincter. J Gastroenterol 2001; 36: 386-391.
13. Bujko K, Nowacki MP, Nasierowska-Guttmejer A, Michalski W, Bebenek M, Pudelko M et al. Sphincter preservation following preoperative radiotherapy for rectal cancer: report of a randomised trial comparing short-term radiotherapy vs. conventionally fractionated radiochemotherapy. Radiother Oncol 2004; 72: 15-24.
14. Acheson AG, Griffin N, Scholefield JH, Wilson VG. L-Arginine- induced relaxation of the internal anal sphincter is not mediated by nitric oxide. Br J Surg 2003; 90: 1155-1162.
15. Jonas-Obichere M, Scholefield J H, Acheson A, Mundey M, Tyler H, Wilson VG. Comparison of the effects of nitric oxide donors and calcium channel blockers on the intrinsic myogenic tone of sheep isolated internal anal sphincter. Br J Surg 2005; 92: 1263-1269.
16. Jones OM, Brading AF, Mortensen NJ. Phosphodiesterase inhibitors cause relaxation of the internal anal sphincter in vitro. Dis Colon Rectum 2002; 45: 530-536.
17. Sarria B, Naline E, Cortijo J, Moreau J, Cerda JM, Morcillo EJ et al. Functional, biochemical and morphological studies on human bronchi after cryopreservation. Br J Pharmacol 1995; 116: 2569-2574.
18. Cortijo J, Sarria B, Mata M, Naline E, Advenier C, Morcillo EJ. Effects of ouabain on human bronchial muscle in vitro. Naunyn Schmiedebergs Arch Pharmacol 2003; 368: 393-403.
19. 2 receptors in acetylcholine-isoproterenol functional antagonism in human isolated bronchus. Am J Physiol Lung Cell Mol Physiol 2002; 283: T1125-L1132.
20. Jeremy JY, Ballard SA, Naylor AM, Miller MA, Angelini GD. Effects of sildenafil, a type-5 cGMP phosphodiesterase inhibitor, and papaverine on cyclic GMP and cyclic AMP levels in the rabbit corpus cavernosum in vitro. Br J Urol 1997; 79: 958-963.
21. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-254.
22. Mata M, Sarria B, Buenestado A, Cortijo J, Cerda M, Morcillo FJ. Phosphodiesterase 4 inhibition decreases MUC5AC expression induced by epidermal growth factor in human airway epithelial cells. Thorax 2005; 60: 144-152.
23. Lin RJ, Wu BN, Lo YC, Shen KP, Lin YT, Huang CH et al. KMUP-1 relaxes rabbit corpus cavernosum smooth muscle in vitro and in vivo: involvement of cyclic GMP and K channels. Br J Pharmacol 2002; 135: 1159-1166.
24. Kruuse C, Khurana TS, Rybalkin SD, Birk S, Engel U, Fdvinsson L et al. Phosphodiesterase 5 and effects of sildenafil on cerebral arteries of man and guinea pig. Eur J Pharmacol 2005; 521: 105-114.
25. Boolell M, Allen MJ, Ballard SA, Gepi-Attee S, Muirhead GJ, Naylor AM et al. Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. Int J Impot Res 1996; 8: 47-52.
26. Boolell M, Gepi-Attee S, Gingell JC, Allen MJ. Sildenafil, a novel effective oral therapy for male erectile dysfunction. Br J Urol 1996; 78: 257-261.
27. Pollack J, Holm T, Cedermark B, Holmstrom B, Mellgren A. Long-term effect of preoperative radiation therapy on anorectal function. Dis Colon Rectum 2006; 49: 345-352.
28. Da Silva GM, Berho M, Wexner SD, Efron J, Weiss EG, Nogueras JJ et al. Histologic analysis of the irradiated anal sphincter. Dis Colon Rectum 2003; 46: 1492-1497.
29. Levesque L, Lam MH, Allaire P, Mondat M, Houle S, Beaudoin G et al. Effects of radiation therapy on vascular responsiveness. J Cardiovasc Pharmacol 2001; 37: 381-393.
30. Mundey MK, Jonas M, Worthley T, Scholefield JH, Wilson VG. Pharmacological characterization of neurogenic responses of the sheep isolated internal anal sphincter. Br J Pharmacol 2000; 130: 489-494.
31. de Saram K, McNeill KL, Khokher S, Ritter JM, Chowienczyk PJ. Divergent effects of vitamin C on relaxations of rabbit aortic rings to acetylcholine and NO-donors. Br J Pharmacol 2002; 135: 1044-1050.
32. Karimi G, Khoshbaten A, Abdollahi M, Sharifzadeh M, Namiranian K, Dehpour AR. Effects of subacute lead acetate administration on nitric oxide and cyclooxygenase pathways in rat isolated aortic ring. Pharmacol Res 2002; 46: 31-37.
33. Ijioma SC, Challiss RA, Boyle JP. Comparative effects of activation of soluble and particulate guanylyl cyclase on cyclic GMP elevation and relaxation of bovine tracheal smooth muscle. Br J Pharmacol 1995; 115: 723-732.
34. Chakder S, Rattan S. Involvement of cAMP and cGMP in relaxation of internal anal sphincter by neural stimulation, VIP, and NO. Am J Physiol 1993; 264: G702-G707.
35. Li F, De Godoy M, Rattan S. Role of adenylate and guanylate cyclases in beta1-, beta2-, and beta3-adrenoceptor-mediated relaxation of internal anal sphincter smooth muscle. J Pharmacol Exp Ther 2004; 308: 1111-1120.
36. VanderWall KJ, Bealer JF, Adzick NS, Harrison MR. Cyclic GMP relaxes the internal anal sphincter in Hirschsprung's disease. J Pediatr Surg 1995; 30: 1013-1015.
37. Lin CS, Chow S, Lau A, Tu R, Lue TF. Identification and regulation of human PDE5A gene promoter. Biochem Biophys Res Commun 2001; 280: 684-692.
38. Lin CS, Chow S, Lau A, Tu R, Lue TF. Human PDE5A gene encodes three PDE5 isoforms from two alternate promoters. Int J Impot Res 2002; 14: 15-24.
39. Murray F, MacLean MR, Pyne NJ. Increased expression of the cGMP-inhibited cAMP-specific (PDE3) and cGMP binding cGMP-specific (PDE5) phosphodiesterases in models of pulmonary hypertension. Br J Pharmacol 2002; 137: 1187-1194.
40. Pauvert O, Lugnier C, Keravis T, Marthan R, Rousseau E, Savineau JP. Effect of sildenafil on cyclic nucleotide phosphodiesterase activity, vascular tone and calcium signaling in rat pulmonary artery. Br J Pharmacol 2003; 139: 513-522.
41. Lund JN. Nitric oxide deficiency in the internal anal sphincter of patients with chronic anal fissure. Int J Colorectal Dis 2006; 21: 673-675.
42. Schouten WR, Briel JW, Auwerda JJ, De Graaf EJ. Ischaemic nature of anal fissure. Br J Surg 1996; 83: 63-65.