Role of Adenylate and Guanylate Cyclases in β1-, β2-, and β3-Adrenoceptor-Mediated Relaxation of Internal Anal Sphincter Smooth Muscle

Journal of Pharmacology and Experimental Therapeutics

Volumn 308, Issue 3, 2004, Pages 1111-1120

  Li, Fangxia ^a   De Godoy, Márcio ^a   Rattan, Satish ^a,b  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 4,4',4'',4''' [CARBONYLBIS[IMINO 5,1,3 BENZENETRIYLBIS(CARBONYLIMINO)]]TETRAKISBENZENE 1,3 DISULFONIC ACID; 5 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL] 1,3 BENZODIOXOLE 2,2 DICARBOXYLIC ACID; 8,8' [CARBONYLBIS(IMINO 3,1 PHENYLENE)]BIS(1,3,5 NAPHTHALENETRISULFONIC ACID); 9 (TETRAHYDRO 2 FURYL)ADENINE; ADENYLATE CYCLASE; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE INHIBITOR; ENZYME INHIBITOR; GUANYLATE CYCLASE; GUANYLATE CYCLASE INHIBITOR; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; KT 5720; KT 5823; PROCATEROL; RECEPTOR SUBTYPE; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG; XAMOTEROL;

ANIMAL TISSUE; ANORECTAL DISEASE; ANUS SPHINCTER; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; GASTROINTESTINAL MOTILITY; MALE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE RELAXATION; WESTERN BLOTTING;

ADENINE; ADENYLATE CYCLASE; ADRENERGIC BETA-AGONISTS; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; BLOTTING, WESTERN; CARBAZOLES; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; GTP-BINDING PROTEINS; GUANYLATE CYCLASE; INDOLES; MALE; MUSCLE RELAXATION; MUSCLE, SMOOTH; OXADIAZOLES; PROCATEROL; PYRROLES; QUINOXALINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, BETA; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, ADRENERGIC, BETA-3; SURAMIN; XAMOTEROL;

EID: 1342287214     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.060145     Document Type: Article

References (56)

1. Abdel-Latif AA (2001) Cross talk between cyclic nucleotides and polyphosphoinositide hydrolysis, protein kinases and contraction in smooth muscle. Exp Biol Med 226:153-163.
2. Andersson K-E (2001) Pharmacology of penile erection. Pharmacol Rev 53:417-450.
3. Azpiroz F and Whitehead WE (2002)Anorectal functional testing: review of collective experience. Am J Gastroenterol 97:232-240.
4. Baird AA and Muir TC (1990) Membrane hyperpolarization, cyclic nucleotide levels and relaxation in the guinea-pig internal anal sphincter. Br J Pharmacol 100:329-335.
5. 3-adrenoceptor activation on basal tone of internal anal sphincter. Am J Physiol 285:G547-G555.
6. Beindl W, Mitterauer T, Hohenegger M, Ijzermann AP, Nanoff C, and Freissmuth M (1996) Inhibition of receptor/G protein coupling by suramin analogues. Mol Pharmacol 50:415-423.
7. Brodde OE (1991) β1- and β2-adrenoceptors in the human heart: properties, function and alterations in chronic heart failure. Br J Pharmacol 43:203-242.
8. Chakder S and Rattan S (1993) Involvement of cAMP and cGMP in relaxation of internal anal sphincter by neural stimulation, VIP and NO. Am J Physiol 264: G702-G707.
9. Chung MK, Gulick TS, Rotondo RE, Schreiner GF, and Lange LG (1990) Mechanism of cytokine inhibition of β-adrenergic agonist stimulation of cyclic AMP in rat cardiac myocytes, impairment of signal transduction. Circ Res 67:753-763.
10. Cirino G, Sorrentino R, di Villa Bianca R, Popolo A, Palmieri A, Imbimbo C, Fusco F, Longo N, Tajana G, Ignarro LJ, et al. (2003) Involvement of β3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function. Proc Natl Acad Sci USA 100:5531-5536.
11. Cook TA, Brading AF, and Mortensen NJ (2001) The pharmacology of the internal anal sphincter and new treatments of ano-rectal disorders. Aliment Pharmacol Ther 15:887-898.
12. Daaka Y, Luttrell LM, and Lefkowitz RJ (1997) Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A. Nature (Lond) 390:88-91.
13. De Ponti F, Giaroni C, Cosentino M, Lecchini S, and Frigo G (1996) Adrenergic mechanisms in the control of gastrointestinal motility: from basic science to clinical applications. Pharmacol Ther 69:59-78.
14. Dhanakoti SN, Gao YS, Nguyen MQ, and Raj JU (2000) Involvement of cGMP-dependent protein kinase in the relaxation of ovine pulmonary arteries to cGMP and cAMP. J Appl Physiol 88:1637-1642.
15. DiMarino M, Banwait K, Rattan S, Cohen S, and DiMarino AJ (2002) β3-adrenergic stimulation inhibits the opossum lower esophageal sphincter. Gastroenterology 123:1508-1515.
16. 3-adrenergic receptor. Science (Wash DC) 245:1118-1121.
17. Fan Y-P, Puri RN, and Rattan S (2002) Animal model for angiotensin II effects in the internal anal sphincter smooth muscle: mechanism of action. Am J Physiol 282: G461-G469.
18. 3-Arenoceptors in the cardiovascular system. Trends Pharmacol Sci 21:426-431.
19. Gilman AG (1987) G protein: transducers of receptor generated signals. Annu Rev Biochem 57:615-649.
20. 3-Adrenergic Agonism: A New Concept in Human Pharmacotherapy, Futura Publishing Co., Inc., Armonk, NY.
21. Grider JR (1993) Interplay of VIP and nitric oxide in regulation of the descending relaxation phase of peristalsis. Am J Physiol 264:G334-G340.
22. Gustafsson ÅB and Brunton LL (2001) Attenuation of cAMP accumulation in adult rat cardiac fibroblasts by IL-1β and NO: role of cGMP-stimulated PDE2. Am J Physiol 283:C463-C471.
23. sα-selective G protein antagonists. Proc Natl Acad Sci USA 95:346-351.
24. Joslyn AF, Barnette MS, Grous M, Fudge M, Price WJ, Manning CD, Thompson WE, Barone FC, and Ormsbee HS (1990) Cyclic nucleotides increase during neurally induced relaxation of sphincteric and nonsphincteric gastrointestinal smooth muscle. J Gastrointest Motil 2:65-72.
25. Kenakin TP (1992) Tissue response as a functional discriminator of receptor heterogeneity: effects of mixed receptor populations on Shild regressions. Mol Pharmacol 41:699-707.
26. i. Circ Res 87:705-709.
27. Kotlikoff MI and Kamm KE (2003) Molecular mechanisms of β-adrenergic relaxation of airway smooth muscle. Annu Rev Physiol 58:115-141.
28. Kotsonis P and Majewski H (1994) Facilitation by procaterol, a β-adrenoceptor agonist, of noradrenaline release in the pithed rat independently of angiotensin II formation. Br J Pharmacol 113:781-788.
29. 2-adrenergic signaling. J Biol Chem 274:22048-22052.
30. Lennard-Jones JE (2000) Constipation, in Sleisenger & Fordtran's Gastrointestinal and Liver Disease (Feldman M ed) pp 174-197, W. B. Saunders Company, Philadelphia, PA.
31. Lowry OH, Rosebrough NJ, Farr AL, and Randall RJ (1951) Protein measurements with the Folin phenol reagent. J Biol Chem 193:265-275.
32. Malta E, Mian MA, and Raper C (1985) The in vitro pharmacology of xamoterol (ICI 118,587). Br J Pharmacol 85:179-187.
33. 3) β-adrenoceptors. Pharmacol Commun 6:253-258.
34. Morita T, Tsuji T, and Dokita, S (1992) Regional differences in functional roles of cAMP and cGMP in lower urinary tract smooth muscle contractility. Urol Int 49:191-195.
35. Moummi C and Rattan S (1988) Effect of methylene blue and N-ethylmaleimide on internal anal sphincter relaxation. Am J Physiol 255:G571-G578.
36. Murray JA, Du C, Ledlow A, Manternach PL, and Conklin JL (1992) Guanylate cyclase inhibitors: effect on tone, relaxation and cGMP content of lower esophageal sphincter. Am J Physiol 263:G97-G101.
37. Nantel F, Bouvier M, Strosberg AD, and Marullo S (1995) Functional effects of long-term activation on human β2- and β3-adrenoceptor signalling. Br J Pharmacol 114:1045-1051.
38. Ohbayashi HYK, Suzuki R, and Takagi K (1998) Effects of uroguanylin and guanylin against antigen-induced bronchoconstriction and airway microvascular leakage in sensitized guinea-pigs. Life Sci 62:1833-1844.
39. Pérez-Vizcaíno F, Ibarra M, Cogolludo AL, Duarte J, Zaragoza-Arnaez F, Moreno L, López-López G, and Tamargo J (2002) Endothelium-independent vasodilator effects of the flavonoid quercetin and its methylated metabolites in rat conductance and resistance arteries. J Pharmacol Exp Ther 302:66-72.
40. Rathi S, Kazerounian S, Banwait K, Schulz S, Waldman SA, and Rattan S (2003) Functional and molecular characterization of β adrenoceptors in the internal anal sphincter. J Pharmacol Exp Ther 305:615-624.
41. Rattan S and Chakder S (1992) Role of nitric oxide as a mediator of internal anal sphincter relaxation. Am J Physiol 262:G107-G112.
42. Rattan S and Moummi C (1989) Influence of stimulators and inhibitors of cyclic nucleotides on lower esophageal sphincter. J Pharmacol Exp Ther 248:703-709.
43. Rattan S, Moummi C, and Chakder S (1991) CGRP and ANF cause relaxation of opossum internal anal sphincter via different mechanisms. Am J Physiol 260: G764-G769.
44. 3-adrenoceptors in human colon. Br J Pharmacol 120:1527-1535.
45. 3-adrenoceptor agonist in lower esophageal sphincter smooth muscle: in vitro studies. J Pharmacol Exp Ther 304:48-55.
46. Schiller LR (2000) Fecal incontinence, in Sleisenger & Fordtran's Gastrointestinal and Liver Disease (Feldman M ed) pp 160-173, W. B. Saunders Company, Philadelphia, PA.
47. Scott MG, Swan C, Jobson TM, Rees S, and Hall IP (2003) Effects of a range of β2-adrenoceptor agonists on changes in intracellular cyclic AMP and on cyclic AMP driven gene expression in cultured human airway smooth muscle cells. Br J Pharmacol 128:721-729.
48. + channels by cGMP in pulmonary vascular endothelial cells. Am J Physiol 283: L297-L304.
49. 1-like dopamine receptors, involves protein kinase A and protein kinase C. Neuroscience 68:97-106.
50. 1-adrenoceptor partial agonist. Pharmacology and clinical use. Dan Med Bull 40:111-121.
51. Szewczak SM, Behar J, Billett G, Hillemeier C, Rhim BY, and Biancani P (1990) VIP-induced alterations in cAMP and inositol phosphates in the lower esophageal sphincter. Am J Physiol 259:G239-G244.
52. 3-adrenoceptor agonist, CL316,243 and various smooth muscle relaxants. J Pharmacol Exp Ther 293:939-945.
53. Torphy TJ, Fine CF, Burman M, Barnette MS, and Ormsbee HS (1986) Lower esophageal sphincter relaxation is associated with increased cyclic nucleotide content. Am J Physiol 251:G786-G793.
54. 3-Adrenoceptor stimulation induces vasorelaxation mediated essentially by endothelium-derived nitric oxide in rat thoracic aorta. Br J Pharmacol 128:69-76.
55. Tseng C-ML, Tabrizi-Fard MA, and Fung H-L (2000) Differential sensitivity among nitric oxide donors toward ODQ-mediated inhibition of vascular relaxation. J Pharmacol Exp Ther 292:737-742.
56. + current in cat atrial myocytes. J Gen Physiol 119:69-82.