Activation of recombinant human TRPV1 receptors expressed in SH-SY5Y human neuroblastoma cells increases [Ca2+]i, initiates neurotransmitter release and promotes delayed cell death

Journal of Neurochemistry

Volumn 102, Issue 3, 2007, Pages 801-811

  Lam, Patricia M W ^a   Hainsworth, Atticus H ^b,d   Smith, Graham D ^c   Owen, Davina E ^c   Davies, James ^a   Lambert, David G ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b DE MONTFORT UNIVERSITY   (United Kingdom)

^c GLAXOSMITHKLINE   (United Kingdom)

^d ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Cell death; Intracellular Ca2+; Neuronal TRPV1 expression system; Noradrenaline release; Vanilloids

Indexed keywords

ANANDAMIDE; CALCIUM; CAPSAICIN; CAPSAZEPINE; CARBACHOL; DOPAMINE DERIVATIVE; ENDOCANNABINOID; HYGROMYCIN; N (4 HYDROXYPHENYL)ARACHIDONAMIDE; N ARACHIDONOYLDOPAMINE; NEUROTRANSMITTER; OLVANIL; RECEPTOR BLOCKING AGENT; RECOMBINANT RECEPTOR; RESINIFERATOXIN; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1;

ARTICLE; CALCIUM TRANSPORT; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOLECULAR MODEL; NERVE CELL CULTURE; NEUROBLASTOMA CELL; NEUROTRANSMITTER RELEASE; PERFUSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION;

ARACHIDONIC ACIDS; CALCIUM; CALCIUM SIGNALING; CAPSAICIN; CELL CULTURE TECHNIQUES; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; DITERPENES; DOPAMINE; HUMANS; MODELS, BIOLOGICAL; NEUROBLASTOMA; NEURONS; NOREPINEPHRINE; POLYUNSATURATED ALKAMIDES; RECOMBINANT PROTEINS; SYNAPTIC TRANSMISSION; TRANSFECTION; TRPV CATION CHANNELS; UP-REGULATION;

EID: 34447319088     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2007.04569.x     Document Type: Article

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