A novel CYBA variant, the -675A/T polymorphism, is associated with essential hypertension

Journal of Hypertension

Volumn 25, Issue 8, 2007, Pages 1620-1626

  Moreno, María U ^a   José, Gorka San ^a   Fortuño, Ana ^a   Beloqui, Oscar ^b   Redón, Josep ^c   Chaves, Felipe J ^c   Corella, Dolores ^d   Díez, Javier ^a,b   Zalba, Guillermo ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UNIVERSITY CLINIC OF NAVARRA   (Spain)

^c HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^d UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Essential hypertension; NADPH oxidase; Polymorphism; Superoxide

Indexed keywords

REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ADULT; ARTERY INTIMA PROLIFERATION; ARTICLE; ATHEROSCLEROSIS; CHEMOLUMINESCENCE; CODON; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENE ACTIVITY; GENE FREQUENCY; GENETIC IDENTIFICATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MUTAGENESIS; OXIDATIVE STRESS; PHAGOCYTE; PREVALENCE; PRIORITY JOURNAL; RANDOM SAMPLE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SYSTOLIC BLOOD PRESSURE;

EID: 34447309993     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/HJH.0b013e3281ac211d     Document Type: Article

References (37)

1. Taniyama Y, Griendling KK. Reactive oxygen species in the vasculature: molecular and cellular mechanisms. Hypertension 2003; 42:1075-1081.
2. Redón J, Oliva MR, Tormos C, Giner V, Chaves J, Iradi A, Sáez GT. Antioxidant activities and oxidative stress byproducts in human hypertension. Hypertension 2003; 41:1096-1101.
3. Alexander RW. Theodore Cooper Memorial Lecture. Hypertension and the pathogenesis of atherosclerosis. Oxidative stress and the mediation of arterial inflammatory response: a new perspective. Hypertension 1995; 25:155-161.
4. Harrison DG. Cellular and molecular mechanisms of endothelial cell dysfunction. J Clin Invest 1997; 100:2153-2157.
5. Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 2000; 87:840-844.
6. Griendling KK, Sorescu D, Ushio-Fukai M. NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res 2000; 86:494-501.
7. Zalba G, Beaumont FJ, San José G, Fortuño A, Fortuño MA, Etayo JC, DÍez J. Vascular NADH/NADPH oxidase is involved in enhanced superoxide production in spontaneously hypertensive rats. Hypertension 2000; 35:1055-1061.
8. Fukui T, Ishizaka N, Rajagopalan S, Laursen JB, Capers Qt, Taylor WR, et al. p22phox mRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats. Circ Res 1997; 80:45-51.
9. Beswick RA, Dorrance AM, Leite R, Webb RC. NADH/NADPH oxidase and enhanced superoxide production in the mineralocorticoid hypertensive rat. Hypertension 2001; 38:1107-1111.
10. Zalba G, San José G, Moreno MU, Fortuño MA, Fortuño A, Beaumont FJ, DÍez. Oxidative stress in arterial hypertension: role of NAD(P)H oxidase. Hypertension 2001; 38:1395-1399.
11. Touyz RM, Schiffrin EL. Increased generation of superoxide by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients: role of phospholipase D-dependent NAD(P)H oxidase-sensitive pathways. J Hypertens 2001; 19:1245-1254.
12. Pettit AI, Wong RK, Lee V, Jennings S, Quinn PA, Ng LL. Increased free radical production in hypertension due to increased expression of the NADPH oxidase subunit p22 (phox) in lymphoblast cell lines. J Hypertens 2002; 20:677-683.
13. Fortuño A, Oliván S, Beloqui O, San José G, Moreno MU, Díez J, Zalba G. Association of increased phagocytic NADPH oxidase-dependent superoxide production with diminished nitric oxide generation in essential hypertension. J Hypertens 2004; 22:2169-2175.
14. Ushio-Fukai M, Zafari AM, Fukui T, Ishizaka N, Griendling KK. p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells. J Biol Chem 1996; 271:23317-23321.
15. Zalba G, San José G, Beaumont FJ, Fortuño MA, Fortuño A, Díez J. Polymorphisms and promoter overactivity of the p22 (phox) gene in vascular smooth muscle cells from spontaneously hypertensive rats. Circ Res 2001; 88:217-222.
16. Zalba G, San José G, Moreno MU, Fortuño A, Díez J. NADPH oxidase-mediated oxidative stress: genetic studies of the p22 (phox) gene in hypertension. Antioxid Redox Signal 2005; 7:1327-1336.
17. Guzik TJ, West NE, Black E, McDonald D, Ratnatunga C, Pillai R, Channon KM. Functional effect of the C242T polymorphism in the NAD(P)H oxidase p22phox gene on vascular superoxide production in atherosclerosis. Circulation 2000; 102:1744-1747.
18. Moreno MU, San José G, Fortuño A, Beloqui O, Díez J, Zalba G. The C242T CYBA polymorphism of the NADPH oxidase is associated with essential hypertension. J Hypertens 2006; 24:1299-1306.
19. Moreno MU, San José G, Orbe J, Páramo JA, Beloqui O, Díez J, Zalba G. Preliminary characterisation of the promoter of the human p22 (phox) gene: identification of a new polymorphism associated with hypertension. FEBS Lett 2003; 542:27-31.
20. San José G, Moreno MU, Oliván S, Beloqui O, Fortuño A, Díez J, Zalba G. Functional effect of the p22phox-930A/G polymorphism on p22phox expression and NADPH oxidase activity in hypertension. Hypertension 2004; 44:163-169.
21. Kokubo Y, Iwai N, Tago N, Inamoto N, Okayama A, Yamawaki H, et al. Association analysis between hypertension and CYBA, CLCNKB, and KCNMB1 functional polymorphisms in the Japanese population - the Suita Study. Circ J 2005; 69:138-142.
22. Zalba G, Beloqui O, San José G, Moreno MU, Fortuño A, Díez J. NADPH oxidase-dependent superoxide production is associated with carotid intima-media thickness in subjects free of clinical atherosclerotic disease. Arterioscler Thromb Vasc Biol 2005; 25:1452-1457.
23. Inoue N, Kawashima S, Kanazawa K, Yamada S, Akita H, Yokoyama M. Polymorphism of the NADH/NADPH oxidase p22 phox gene in patients with coronary artery disease. Circulation 1998; 97:135-137.
24. Terwilliger J, Ott J. Handbook of human genetic linkage. Baltimore, Maryland: Johns Hopkins University Press; 1994.
25. Rueckschloss U, Quinn MT, Holtz J, Morawietz H. Dose-dependent regulation of NAD(P)H oxidase expression by angiotensin II in human endothelial cells: protective effect of angiotensin II type 1 receptor blockade in patients with coronary artery disease. Arterioscler Thromb Vasc Biol 2002; 22:1845-1851.
26. Lee VM, Quinn PA, Jennings SC, Ng LL. NADPH oxidase activity in preeclampsia with immortalized lymphoblasts used as models. Hypertension 2003; 41:925-931.
27. Ungvari Z, Csiszar A, Huang A, Kaminski PM, Wolin MS, Koller A. High pressure induces superoxide production in isolated arteries via protein kinase C-dependent activation of NAD(P)H oxidase. Circulation 2003; 108:1253-1258.
28. Semenza GL, Agani F, Feldser D, Iyer N, Kotch L, Laughner E, Yu A. Hypoxia, HIF-1, and the pathophysiology of common human diseases. Adv Exp Med Biol 2000; 475:123-130.
29. Dery M-AC, Michaud MD, Richard DE. Hypoxia-inducible factor 1: regulation by hypoxic and non-hypoxic activators. Int J Biochem Cell Biol 2005; 37:535-540.
30. Richard DE, Berra E, Pouyssegur J. Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells. J Biol Chem 2000; 275:26765-26771.
31. Sánchez-López E, López AF, Esteban V, Yague S, Egido J, Ruiz-Ortega M, Alvarez-Arroyo MV. Angiotensin II regulates vascular endothelial growth factor via hypoxia-inducible factor-1alpha induction and redox mechanisms in the kidney. Antioxid Redox Signal 2005; 7:1275-1284.
32. Jones RD, Hancock JT, Morice AH. NADPH oxidase: a universal oxygen sensor? Free Radic Biol Med 2000; 29:416-424.
33. Zhan G, Serrano F, Fenik P, Hsu R, Kong L, Pratico D, et al. NADPH oxidase mediates hypersomnolence and brain oxidative injury in a murine model of sleep apnea. Am J Respir Crit Care Med 2005; 172:921-929.
34. Liu JQ, Zelko IN, Erbynn EM, Sham JS, Folz RJ. Hypoxic pulmonary hypertension: role of superoxide and NADPH oxidase (gp91phox). Am J Physiol Lung Cell Mol Physiol 2006; 290:L2-L10.
35. Goyal P, Weissmann N, Grimminger F, Hegel C, Bader L, Rose F, et al. Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxia-inducible factor 1 via increase in reactive oxygen species. Free Radical Bio Med 2004; 36:1279-1288.
36. Azumi H, Inoue N, Takeshita S, Rikitake Y, Kawashima S, Hayashi Y, et al. Expression of NADH/NADPH oxidase p22phox in human coronary arteries. Circulation 1999; 100:1494-1498.
37. Sorescu D, Weiss D, Lassegue B, Clempus RE, Szocs K, Sorescu GP, et al. Superoxide production and expression of nox family proteins in human atherosclerosis. Circulation 2002; 105:1429-1435.