Crystal Structure of Tryptophanyl-tRNA Synthetase Complexed with Adenosine-5′ Tetraphosphate: Evidence for Distributed Use of Catalytic Binding Energy in Amino Acid Activation by Class I Aminoacyl-tRNA Synthetases

Journal of Molecular Biology

Volumn 369, Issue 1, 2007, Pages 108-128

  Retailleau, Pascal ^a   Weinreb, Violetta ^b   Hu, Mei ^c   Carter Jr , Charles W ^b  

^a CNRS   (France)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c DUKE UNIVERSITY   (United States)

Author keywords

catalytic use of binding energy; class I aminoacyl tRNA synthetases; induced fit; mechanistic enzymology; phosphoryl transfer

Indexed keywords

ADENOSINE; ADENOSINE TETRAPHOSPHATE; ADENOSINE TRIPHOSPHATE; AMINO ACID; AMINO ACID TRANSFER RNA LIGASE; NUCLEOTIDE; PHOSPHATE; TRYPTOPHAN TRANSFER RNA LIGASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTICODON; ARTICLE; BINDING AFFINITY; BINDING SITE; CALORIMETRY; CATALYSIS; CONFORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENERGY; ENTROPY; ENZYME BINDING; ENZYME LOCALIZATION; ENZYME STRUCTURE; EXPERIMENTAL STUDY; GENE MUTATION; HYDROGEN BOND; MEASUREMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN MODIFICATION; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

GEOBACILLUS STEAROTHERMOPHILUS;

EID: 34247471258     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2007.01.091     Document Type: Article

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