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34447128359
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A series of oligomers (dimer, trimer, tetramer, pentamer) up to the hexamer level was prepared for the heterochiral series
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A series of oligomers (dimer, trimer, tetramer, pentamer) up to the hexamer level was prepared for the heterochiral series
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30
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34447114677
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1H NMR spectrum of hexamer 7 is complicated by resonance overlap and unambiguous assignment of every resonance was not possible. However, a pentameric derivative was completely assigned and demonstrated an analogous pattern to tetramer 4
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Residues are labelled alphabetically from the N- to the C-terminus, with protons within each residue being numbered from the highest ranking carbon according to IUPAC recommendations
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32
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34447129804
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i+1 hydrogen bonds would produce the same pattern of shielded and deshielded amide protons but would require a hydrogen bond to the C-terminal ester (and is inconsistent with the patterns of NOE enhancements observed)
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i+1 hydrogen bonds would produce the same pattern of shielded and deshielded amide protons but would require a hydrogen bond to the C-terminal ester (and is inconsistent with the patterns of NOE enhancements observed)
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