Glucocorticoids suppress β-cell development and induce hepatic metaplasia in embryonic pancreas

Biochemical Journal

Volumn 375, Issue 1, 2003, Pages 41-50

  Shen, Chia Ning ^a   Seckl, Jonathan R ^b   Slack, Jonathan M W ^a   Tosh, David ^a  

^a University of Bath   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

CCAAT enhancer binding protein (C EBP ); Fetal programming; Glucocorticoids; Hepatic transdifferentiation; Insulin; Pancreatic duodenal homeobox 1 (Pdx 1)

Indexed keywords

DRUG PRODUCTS; GLUCOSE; METABOLISM;

GESTATION;

BIOCHEMISTRY;

ALBUMIN; ALPHA 1 ANTITRYPSIN; BIOLOGICAL MARKER; CCAAT ENHANCER BINDING PROTEIN BETA; DEXAMETHASONE; GLUCOCORTICOID; INSULIN; PREALBUMIN; TRANSCRIPTION FACTOR PDX 1; HOMEODOMAIN PROTEIN; INSULIN PROMOTER FACTOR 1; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL MATURATION; CONTROLLED STUDY; DOWN REGULATION; EMBRYONAL TISSUE; FETUS; GENETIC TRANSFECTION; LIVER; LIVER TOXICITY; METAPLASIA; NONHUMAN; PANCREAS; PANCREAS ISLET BETA CELL; PREGNANCY; PRIORITY JOURNAL; RAT; ANIMAL; CELL LINE; DRUG EFFECT; FEMALE; IN VITRO STUDY; METABOLISM; MOUSE; ORGAN CULTURE TECHNIQUE; PANCREAS ISLET; PATHOLOGY; PRENATAL DEVELOPMENT;

ANIMALIA;

ANIMALS; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CELL DIFFERENTIATION; CELL LINE; DEXAMETHASONE; FEMALE; GLUCOCORTICOIDS; HOMEODOMAIN PROTEINS; INSULIN; ISLETS OF LANGERHANS; LIVER; METAPLASIA; MICE; ORGAN CULTURE TECHNIQUES; PANCREAS; RATS; TRANS-ACTIVATORS;

EID: 0141940249     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20030140     Document Type: Article

References (32)

1. Barker, D. J. P., Gluckman, P. D., Godfrey, K. M., Harding, J. E., Owens, J. A. and Robinson, J. S. (1993) Fetal nutrition and cardiovascular disease in adult life. Lancet 341, 938-941
2. Edwards, C. R. W., Benediktsson, R., Lindsay, R. S. and Seckl, J. R. (1993) Dysfunction of placental glucocorticoid barrier - link between fetal environment and hypertension. Lancet 341, 355-357
3. Holness, M. J., Langdown, M. L. and Sugden, M. C. (2000) Early-life programming of susceptibility to dysregulation of glucose metabolism and the development of Type 2 diabetes mellitus. Biochem. J. 349, 657-665
4. Campbell, A. L. and Murphy, B. E. P. (1977) The maternal-fetal cortisol gradient during pregnancy and at delivery. J. Clin. Endocrinol. Metab. 45, 435-440
5. Benediktsson, R., Calder, A. A., Edwards, C. R. and Seckl, J. R. (1997) Placental 11 β-hydroxysteroid dehydrogenase: a key regulator of fetal glucocorticoid exposure. Clin. Endocrinol. 46, 161-166
6. Reinisch, J. M., Simon, N. G., Karwo, W. G. and Gandleman, R. (1978) Prenatal exposure to prednisone in humans and animals retards intra-uterine growth. Science 202, 436-438
7. Seckl, J. R., Cleasby, M. and Nyirenda, M. J. (2000) Glucocorticoids, 11β hydroxysteroid dehydrogenase, and fetal programming. Kidney Int. 57, 1412-1417
8. Benediktsson, R., Lindsay, R., Noble, J., Seckl, J. R. and Edwards, C. R. W. (1993) Glucocorticoids exposure in utero: a new model for adult hypertension. Lancet 341, 339-341
9. Levitt, N. S., Lambert, E. V., Woods, D., Hales, D., Andrew, R. and Seckl, J. R. (1996) Dexamethasone in the last week of pregnancy attenuates hippocampal glucocorticoid receptor gene expression and elevates blood pressure in the adult offspring in the rat. Neuroendocrinology 64, 412-418
10. Lindsay, R. S., Lindsay, R. M., Edwards, C. R. and Seckl, J. R. (1996) Inhibition of 11-β-hydroxysteroid dehydrogenase in pregnant rats and the programming of blood pressure in the offspring. Hypertension 27, 1200-1204
11. Lindsay, R. S., Lindsay, R. M., Edwards, Waddell, B. and Seckl, J. R. (1996) Programming of glucose tolerance in the rat: role of placental 11β-hydroxysteroid dehydrogenase. Diabetologia 39, 1299-1305
12. Ryffel, G. U. (2001) Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: functional and pathological consequences J. Mol. Endocrinol. 27, 11-29
13. Slack, J. M. W. and Tosh, D. (2001) Transdifferentiation and metaplasia - switching cell types. Curr. Opin. Genetics Dev. 11, 581-586
14. Tosh, D. and Slack, J. M. W. (2002) How cells change their phenotype. Nat. Rev. Mol. Cell Biol. 3, 187-194
15. Shen, C.-N., Slack, J. M. W. and Tosh, D. (2000) Molecular basis of transdifferentiation of pancreas to liver. Nat. Cell Biol. 2, 879-887
16. Tosh, D., Shen, C.-N. and Slack, J. M. W. (2002) Differentiated properties of hepatocytes induced from pancreatic cells. Hepatology 36, 535-543
17. Tosh, D., Shen, C.-N. and Slack, J. M. W. (2002) Conversion of pancreatic cells to hepatocytes. Biochem. Soc. Trans. 30, 51-54
18. Percival, A. C. and Slack, J. M. W. (1999) Analysis of pancreatic development using a cell lineage label. Exp. Cell Res. 247, 123-132
19. Horb, L. D. and Slack, J. M. W. (2000) Role of cell division in branching morphogenesis and differentiation of the embryonic pancreas. Int. J. Dev. Biol. 44, 791-796
20. Nyirenda, M. J., Lindsay, R. S., Kenyon, C. J., Burchell, A. and Seckl, J. R. (1998) Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring. J. Clin. Invest. 101, 2174-2181
21. Slack, J. M. W. (1995) Developmental biology of the pancreas. Development 121, 1569-1580
22. Seckl, J. R. (2001) Glucocorticoids, programming of the fetus; adult phenotypes and molecular mechanisms. Mol. Cell. Endocrinol. 185, 61-71
23. Blondeau, B., Lesage, J., Czernichow, P., Dupouy, J. P. and Breant, B. (2001) Glucocorticoids impair fetal β-cell development in rats. Am. J. Physiol. Endocrinol. Metab. 281, E592-E599
24. Blondeau, B., Avril, I., Duchene, B. and Breant, B. (2002) Endocrine pancreas development is altered in foetuses from rats previously showing intra-uterine growth retardation in response to malnutrition. Diabetologia 45, 394-401
25. Langley-Evans, S. C., Phillips, G. J., Benediktsson, R., Gardner, D. S., Edwards, C. R., Jackson, A. A. and Seckl, J. R. (1996) Protein intake in pregnancy, placental glucocorticoid metabolism and the programming of hypertension in the rat. Placenta 17, 169-172
26. Jonsson, J., Carlsson, L., Edlund, T. and Edlund, H. (1994) Insulin-promoter-factor 1 is required for pancreas development in mice. Nature (London) 371, 606-609
27. Ohlsson, H., Karlsson, K. and Edlund, T. (1993) IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J. 12, 4251-4259
28. Ahlgren, U., Jonsson, J., Jonsson, L., Simu, K. and Edlund, H. (1998) Beta-cell-specific inactivation of the mouse lpf1/Pdx-1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Genes Dev. 12, 1763-1768
29. Sharma, S., Jhala, U. S., Johnson, T., Ferreri, K., Leonard, J. and Montminy, M. (1997) Hormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1. Mol. Cell Biol. 17, 2598-2604
30. Lu, M. Seufert, J. and Habener, J. F. (1997) Pancreatic β-cell-specific repression of insulin gene transcription by CCAAT/Enhancer-binding protein β J. Biol. Chem. 272, 28349-28359
31. Philippe, J. and Missotten, M. (1990) Dexamethasone inhibits insulin biosynthesis by destabilizing insulin messenger ribonucleic acid in hamster insulinoma cells. Endocrinology 127, 164-1645
32. Cleasby, M. E., Kelly, P. A., Walker, B. R. and Seckl, J. R. (2003) Programming of rat muscle and fat metabolism by in utero overexposure to glucocorticoids. Endocrinology 144, 999-1007