메뉴 건너뛰기




Volumn 50, Issue 2, 2007, Pages 404-413

Exercise training reduces fatty acid availability and improves the insulin sensitivity of glucose metabolism

Author keywords

Endogenous glucose production rate; Euglycaemic hyperinsulinaemic clamp; Exercise; Glucose uptake; Insulin sensitivity; Lipolysis; Stable isotopes

Indexed keywords

FATTY ACID; INSULIN; PALMITIC ACID;

EID: 34447119267     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-006-0498-7     Document Type: Article
Times cited : (161)

References (45)
  • 1
    • 0031944785 scopus 로고    scopus 로고
    • The metabolically obese, normal-weight individual revisited
    • COI: 1:CAS:528:DyaK1cXjs1SgsL8%3D, PID: 9588440
    • Ruderman N, Chisholm D, Pi-Sunyer X, Schneider S (1998) The metabolically obese, normal-weight individual revisited. Diabetes 47:699–713
    • (1998) Diabetes , vol.47 , pp. 699-713
    • Ruderman, N.1    Chisholm, D.2    Pi-Sunyer, X.3    Schneider, S.4
  • 3
    • 0035113719 scopus 로고    scopus 로고
    • Whole-body and adipose tissue glucose metabolism in response to short-term fasting in lean and obese women
    • COI: 1:CAS:528:DC%2BD3MXhs1SgsrY%3D, PID: 11237926
    • Horowitz JF, Coppack SW, Klein S (2001) Whole-body and adipose tissue glucose metabolism in response to short-term fasting in lean and obese women. Am J Clin Nutr 73:517–522
    • (2001) Am J Clin Nutr , vol.73 , pp. 517-522
    • Horowitz, J.F.1    Coppack, S.W.2    Klein, S.3
  • 4
    • 0024602053 scopus 로고
    • Influence of body fat distribution on free fatty acid metabolism in obesity
    • COI: 1:CAS:528:DyaL1MXitFSgsLw%3D, PID: 2649512
    • Jensen MD, Haymond MW, Rizza RA, Cryer PE, Miles JM (1989) Influence of body fat distribution on free fatty acid metabolism in obesity. J Clin Invest 83:1168–1173
    • (1989) J Clin Invest , vol.83 , pp. 1168-1173
    • Jensen, M.D.1    Haymond, M.W.2    Rizza, R.A.3    Cryer, P.E.4    Miles, J.M.5
  • 5
    • 0000246182 scopus 로고    scopus 로고
    • Free fatty acids (FFA), a link between obesity and insulin resistance
    • COI: 1:CAS:528:DyaK1cXjtVaitL8%3D, PID: 9450985
    • Boden G (1998) Free fatty acids (FFA), a link between obesity and insulin resistance. Front Biosci 3:D169–D175
    • (1998) Front Biosci , vol.3 , pp. D169-D175
    • Boden, G.1
  • 6
    • 50549202600 scopus 로고
    • The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
    • COI: 1:STN:280:DyaF387ot1KhsQ%3D%3D, PID: 13990765
    • Randle PJ, Garland PB, Hales CN, Newsholme EA (1963) The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1:785–789
    • (1963) Lancet , vol.1 , pp. 785-789
    • Randle, P.J.1    Garland, P.B.2    Hales, C.N.3    Newsholme, E.A.4
  • 7
    • 0033007561 scopus 로고    scopus 로고
    • Rapid impairment of skeletal muscle glucose transport/phosphorylation by free fatty acids in humans
    • COI: 1:CAS:528:DyaK1MXpsFKmtA%3D%3D, PID: 10334314
    • Roden M, Krssak M, Stingl H et al (1999) Rapid impairment of skeletal muscle glucose transport/phosphorylation by free fatty acids in humans. Diabetes 48:358–364
    • (1999) Diabetes , vol.48 , pp. 358-364
    • Roden, M.1    Krssak, M.2    Stingl, H.3
  • 8
    • 0032954778 scopus 로고    scopus 로고
    • Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity
    • COI: 1:CAS:528:DyaK1MXltFequw%3D%3D, PID: 9916137
    • Dresner A, Laurent D, Marcucci M et al (1999) Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J Clin Invest 103:253–259
    • (1999) J Clin Invest , vol.103 , pp. 253-259
    • Dresner, A.1    Laurent, D.2    Marcucci, M.3
  • 9
    • 0032999369 scopus 로고    scopus 로고
    • Free fatty acids impair hepatic insulin extraction in vivo
    • COI: 1:CAS:528:DyaK1MXitFCqt7g%3D, PID: 10102693
    • Wiesenthal SR, Sandhu H, McCall RH et al (1999) Free fatty acids impair hepatic insulin extraction in vivo. Diabetes 48:766–774
    • (1999) Diabetes , vol.48 , pp. 766-774
    • Wiesenthal, S.R.1    Sandhu, H.2    McCall, R.H.3
  • 10
    • 0345086474 scopus 로고    scopus 로고
    • Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signalling cascade
    • COI: 1:CAS:528:DyaK1MXjsFSgtr8%3D, PID: 10342815
    • Griffin ME, Marcucci MJ, Cline GW et al (1999) Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signalling cascade. Diabetes 48:1270–1274
    • (1999) Diabetes , vol.48 , pp. 1270-1274
    • Griffin, M.E.1    Marcucci, M.J.2    Cline, G.W.3
  • 11
    • 0029888870 scopus 로고    scopus 로고
    • Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat
    • COI: 1:CAS:528:DyaK28XjvVWksrk%3D, PID: 8675683
    • Stein DT, Esser V, Stevenson BE et al (1996) Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat. J Clin Invest 97:2728–2735
    • (1996) J Clin Invest , vol.97 , pp. 2728-2735
    • Stein, D.T.1    Esser, V.2    Stevenson, B.E.3
  • 12
    • 0035487317 scopus 로고    scopus 로고
    • Intramyocellular lipid is associated with resistance to in vivo insulin actions on glucose uptake, antilipolysis, and early insulin signaling pathways in human skeletal muscle
    • COI: 1:CAS:528:DC%2BD3MXntlGhu7k%3D, PID: 11574417
    • Virkamaki A, Korsheninnikova E, Seppala-Lindroos A et al (2001) Intramyocellular lipid is associated with resistance to in vivo insulin actions on glucose uptake, antilipolysis, and early insulin signaling pathways in human skeletal muscle. Diabetes 50:2337–2343
    • (2001) Diabetes , vol.50 , pp. 2337-2343
    • Virkamaki, A.1    Korsheninnikova, E.2    Seppala-Lindroos, A.3
  • 13
    • 0036312905 scopus 로고    scopus 로고
    • Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men
    • COI: 1:CAS:528:DC%2BD38XlsVGjsbs%3D, PID: 12107194
    • Seppala-Lindroos A, Vehkavaara S, Hakkinen AM et al (2002) Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab 87:3023–3028
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 3023-3028
    • Seppala-Lindroos, A.1    Vehkavaara, S.2    Hakkinen, A.M.3
  • 14
    • 0029849462 scopus 로고    scopus 로고
    • Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects
    • COI: 1:STN:280:DyaK2s%2FhtFSnsg%3D%3D, PID: 8857019
    • Perseghin G, Price TB, Petersen KF et al (1996) Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. N Engl J Med 335:1357–1362
    • (1996) N Engl J Med , vol.335 , pp. 1357-1362
    • Perseghin, G.1    Price, T.B.2    Petersen, K.F.3
  • 15
    • 0031014830 scopus 로고    scopus 로고
    • Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
    • COI: 1:CAS:528:DyaK2sXks1aj, PID: 8971073
    • Boden G (1997) Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 46:3–10
    • (1997) Diabetes , vol.46 , pp. 3-10
    • Boden, G.1
  • 16
    • 0032908594 scopus 로고    scopus 로고
    • Insulin regulation of regional free fatty acid metabolism
    • COI: 1:CAS:528:DyaK1MXhvV2rtQ%3D%3D, PID: 9892216
    • Meek SE, Nair KS, Jensen MD (1999) Insulin regulation of regional free fatty acid metabolism. Diabetes 48:10–14
    • (1999) Diabetes , vol.48 , pp. 10-14
    • Meek, S.E.1    Nair, K.S.2    Jensen, M.D.3
  • 17
    • 84982069386 scopus 로고
    • Perceived exertion and pulse rate during graded exercise in various age groups
    • Borg G, Linderholm H (1967) Perceived exertion and pulse rate during graded exercise in various age groups. Acta Med Scand (Suppl) 472:194–206
    • (1967) Acta Med Scand (Suppl) , vol.472 , pp. 194-206
    • Borg, G.1    Linderholm, H.2
  • 18
    • 0031038158 scopus 로고    scopus 로고
    • Exercise and the metabolic syndrome
    • COI: 1:STN:280:DyaK2s3gtF2gug%3D%3D, PID: 9049471
    • Eriksson J, Taimela S, Koivisto VA (1997) Exercise and the metabolic syndrome. Diabetologia 40:125–135
    • (1997) Diabetologia , vol.40 , pp. 125-135
    • Eriksson, J.1    Taimela, S.2    Koivisto, V.A.3
  • 19
    • 0027378025 scopus 로고
    • Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration
    • COI: 1:CAS:528:DyaK2cXls1eg, PID: 8214047
    • Romijn JA, Coyle EF, Sidossis LS et al (1993) Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. Am J Physiol 265:E380–E391
    • (1993) Am J Physiol , vol.265 , pp. E380-E391
    • Romijn, J.A.1    Coyle, E.F.2    Sidossis, L.S.3
  • 20
    • 0037683663 scopus 로고    scopus 로고
    • Effect of growth hormone (GH) on glycerol and free fatty acid metabolism during exhaustive exercise in GH-deficient adults
    • COI: 1:CAS:528:DC%2BD3sXjtFClt7s%3D, PID: 12679475
    • Gibney J, Healy ML, Stolinski M et al (2003) Effect of growth hormone (GH) on glycerol and free fatty acid metabolism during exhaustive exercise in GH-deficient adults. J Clin Endocrinol Metab 88:1792–1797
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 1792-1797
    • Gibney, J.1    Healy, M.L.2    Stolinski, M.3
  • 21
    • 33644776570 scopus 로고    scopus 로고
    • Contrasting insulin sensitivity of endogenous glucose production rate in subjects with hepatocyte nuclear factor-1beta and-1alpha mutations
    • COI: 1:CAS:528:DC%2BD28XhsFajs7s%3D, PID: 16443774
    • Brackenridge A, Pearson ER, Shojaee-Moradie F, Hattersley AT, Russell-Jones D, Umpleby AM (2006) Contrasting insulin sensitivity of endogenous glucose production rate in subjects with hepatocyte nuclear factor-1beta and-1alpha mutations. Diabetes 55:405–411
    • (2006) Diabetes , vol.55 , pp. 405-411
    • Brackenridge, A.1    Pearson, E.R.2    Shojaee-Moradie, F.3    Hattersley, A.T.4    Russell-Jones, D.5    Umpleby, A.M.6
  • 22
    • 0032527974 scopus 로고    scopus 로고
    • Intracellular and extracellular skeletal muscle triglyceride metabolism during alternating intensity exercise in humans
    • COI: 1:CAS:528:DyaK1cXltlCgurY%3D, PID: 9706008
    • Rico-Sanz J, Hajnal JV, Thomas EL, Mierisova S, Ala-Korpela M, Bell JD (1998) Intracellular and extracellular skeletal muscle triglyceride metabolism during alternating intensity exercise in humans. J Physiol 510:615–622
    • (1998) J Physiol , vol.510 , pp. 615-622
    • Rico-Sanz, J.1    Hajnal, J.V.2    Thomas, E.L.3    Mierisova, S.4    Ala-Korpela, M.5    Bell, J.D.6
  • 23
    • 0345533861 scopus 로고    scopus 로고
    • Diversity in levels of intracellular total creatine and triglycerides in human skeletal muscles observed by (1)H-MRS
    • COI: 1:CAS:528:DC%2BD3cXlslemug%3D%3D, PID: 10601151
    • Rico-Sanz J, Thomas EL, Jenkinson G, Mierisova S, Iles R, Bell JD (1999) Diversity in levels of intracellular total creatine and triglycerides in human skeletal muscles observed by (1)H-MRS. J Appl Physiol 87:2068–2072
    • (1999) J Appl Physiol , vol.87 , pp. 2068-2072
    • Rico-Sanz, J.1    Thomas, E.L.2    Jenkinson, G.3    Mierisova, S.4    Iles, R.5    Bell, J.D.6
  • 24
    • 12144259379 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population
    • COI: 1:CAS:528:DC%2BD2MXhsVCktLg%3D, PID: 15339742
    • Szczepaniak LS, Nurenberg P, Leonard D et al (2005) Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. Am J Physiol Endocrinol Metab 288:E462–E468
    • (2005) Am J Physiol Endocrinol Metab , vol.288 , pp. E462-E468
    • Szczepaniak, L.S.1    Nurenberg, P.2    Leonard, D.3
  • 25
    • 0035090380 scopus 로고    scopus 로고
    • Relationship between abdominal fat compartments and glucose and lipid metabolism in early postmenopausal women
    • COI: 1:CAS:528:DC%2BD3MXht1KntL4%3D, PID: 11158040
    • Rendell M, Hulthen UL, Tornquist C, Groop L, Mattiasson I (2001) Relationship between abdominal fat compartments and glucose and lipid metabolism in early postmenopausal women. J Clin Endocrinol Metab 86:744–749
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 744-749
    • Rendell, M.1    Hulthen, U.L.2    Tornquist, C.3    Groop, L.4    Mattiasson, I.5
  • 26
    • 0029788141 scopus 로고    scopus 로고
    • Quantitative measurement of 3-O-methyl-d-glucose by gas chromatography-mass spectrometry as a measure of glucose transport in vivo
    • COI: 1:CAS:528:DyaK28XlvFCgurc%3D, PID: 8831149
    • Shojaee-Moradie F, Jackson NC, Jones RH, Mallet AI, Hovorka R, Umpleby AM (1996) Quantitative measurement of 3-O-methyl-d-glucose by gas chromatography-mass spectrometry as a measure of glucose transport in vivo. J Mass Spectrom 31:961–966
    • (1996) J Mass Spectrom , vol.31 , pp. 961-966
    • Shojaee-Moradie, F.1    Jackson, N.C.2    Jones, R.H.3    Mallet, A.I.4    Hovorka, R.5    Umpleby, A.M.6
  • 27
    • 0002185862 scopus 로고
    • Double antibody technique for the simultaneous assay of insulin and growth hormone
    • Antoniades HN, (ed), Harvard University Press, Cambridge, MA
    • Sonksen PH (1976) Double antibody technique for the simultaneous assay of insulin and growth hormone. In: Antoniades HN (ed) Hormones in human blood: detection and assay. Harvard University Press, Cambridge, MA, pp 176–199
    • (1976) Hormones in human blood: detection and assay , pp. 176-199
    • Sonksen, P.H.1
  • 28
    • 0000331917 scopus 로고
    • Inhjbition by insulin of hepatic glucose production in the normal dog
    • COI: 1:CAS:528:DyaF2MXlt12ltA%3D%3D, PID: 14259965
    • Steele R, Bishop JS, Dunn A, Altszuler N, Rathbeb I, Debodo RC (1965) Inhjbition by insulin of hepatic glucose production in the normal dog. Am J Physiol 208:301–306
    • (1965) Am J Physiol , vol.208 , pp. 301-306
    • Steele, R.1    Bishop, J.S.2    Dunn, A.3    Altszuler, N.4    Rathbeb, I.5    Debodo, R.C.6
  • 29
    • 0023245416 scopus 로고
    • Estimation of endogenous glucose production during hyperinsulinemic–euglycemic glucose clamps. Comparison of unlabeled and labeled exogenous glucose infusates
    • COI: 1:CAS:528:DyaL2sXlslWrt7g%3D, PID: 3297886
    • Finegood DT, Bergman RN, Vranic M (1987) Estimation of endogenous glucose production during hyperinsulinemic–euglycemic glucose clamps. Comparison of unlabeled and labeled exogenous glucose infusates. Diabetes 36:914–924
    • (1987) Diabetes , vol.36 , pp. 914-924
    • Finegood, D.T.1    Bergman, R.N.2    Vranic, M.3
  • 30
    • 0020757484 scopus 로고
    • Optimal segments: a method for smoothing tracer data to calculate metabolic fluxes
    • COI: 1:CAS:528:DyaL3sXktF2iuro%3D, PID: 6846533
    • Finegood DT, Bergman RN (1983) Optimal segments: a method for smoothing tracer data to calculate metabolic fluxes. Am J Physiol 244:E472–E479
    • (1983) Am J Physiol , vol.244 , pp. E472-E479
    • Finegood, D.T.1    Bergman, R.N.2
  • 31
    • 0023604784 scopus 로고
    • Effect of physical training on insulin action in obesity
    • COI: 1:STN:280:DyaL1c%2FlsFyqtQ%3D%3D, PID: 3315786
    • DeFronzo RA, Sherwin RS, Kraemer N (1987) Effect of physical training on insulin action in obesity. Diabetes 36:1379–1385
    • (1987) Diabetes , vol.36 , pp. 1379-1385
    • DeFronzo, R.A.1    Sherwin, R.S.2    Kraemer, N.3
  • 32
    • 0031038158 scopus 로고    scopus 로고
    • Exercise and the metabolic syndrome
    • COI: 1:STN:280:DyaK2s3gtF2gug%3D%3D, PID: 9049471
    • Eriksson J, Taimela S, Koivisto VA (1997) Exercise and the metabolic syndrome. Diabetologia 40:125–135
    • (1997) Diabetologia , vol.40 , pp. 125-135
    • Eriksson, J.1    Taimela, S.2    Koivisto, V.A.3
  • 33
    • 33644824890 scopus 로고    scopus 로고
    • Exercise and improved insulin sensitivity in older women: evidence of the enduring benefits of higher intensity training
    • COI: 1:CAS:528:DC%2BD28XosVKksg%3D%3D, PID: 16141382
    • DiPietro L, Dziura J, Yeckel CW, Neufer PD (2006) Exercise and improved insulin sensitivity in older women: evidence of the enduring benefits of higher intensity training. J Appl Physiol 100:142–149
    • (2006) J Appl Physiol , vol.100 , pp. 142-149
    • DiPietro, L.1    Dziura, J.2    Yeckel, C.W.3    Neufer, P.D.4
  • 34
    • 0027212601 scopus 로고
    • Exercise increases muscle GLUT-4 levels and insulin action in subjects with impaired glucose tolerance
    • COI: 1:CAS:528:DyaK3sXlslylt78%3D, PID: 8333511
    • Hughes VA, Fiatarone MA, Fielding RA et al (1993) Exercise increases muscle GLUT-4 levels and insulin action in subjects with impaired glucose tolerance. Am J Physiol 264:E855–E862
    • (1993) Am J Physiol , vol.264 , pp. E855-E862
    • Hughes, V.A.1    Fiatarone, M.A.2    Fielding, R.A.3
  • 35
    • 0029043408 scopus 로고
    • Alterations in lipoprotein lipase in insulin resistance
    • PID: 7550532
    • Eckel RH, Yost TJ, Jensen DR (1995) Alterations in lipoprotein lipase in insulin resistance. Int J Obes Relat Metab Disord 19(Suppl 1):S16–S21
    • (1995) Int J Obes Relat Metab Disord , vol.19 , pp. S16-S21
    • Eckel, R.H.1    Yost, T.J.2    Jensen, D.R.3
  • 36
    • 33645286503 scopus 로고    scopus 로고
    • Enhancement of serum lipoprotein lipase mass levels by intensive insulin therapy
    • COI: 1:CAS:528:DC%2BD28XivVCmurw%3D, PID: 16446009
    • Miyashita Y, Ebisuno M, Ohhira M et al (2006) Enhancement of serum lipoprotein lipase mass levels by intensive insulin therapy. Diabetes Res Clin Pract 72:61–67
    • (2006) Diabetes Res Clin Pract , vol.72 , pp. 61-67
    • Miyashita, Y.1    Ebisuno, M.2    Ohhira, M.3
  • 37
    • 0032426930 scopus 로고    scopus 로고
    • Endurance training changes in lipolytic responsiveness of obese adipose tissue
    • PID: 9843736
    • De Glisezinski I, Crampes F, Harant I et al (1998) Endurance training changes in lipolytic responsiveness of obese adipose tissue. Am J Physiol 275:E951–E956
    • (1998) Am J Physiol , vol.275 , pp. E951-E956
    • De Glisezinski, I.1    Crampes, F.2    Harant, I.3
  • 38
    • 0023237834 scopus 로고
    • Acute elevation of free fatty acid levels leads to hepatic insulin resistance in obese subjects
    • COI: 1:STN:280:DyaL2s3gtFSlsw%3D%3D, PID: 3553852
    • Bevilacqua S, Bonadonna R, Buzzigoli G et al (1987) Acute elevation of free fatty acid levels leads to hepatic insulin resistance in obese subjects. Metabolism 36:502–506
    • (1987) Metabolism , vol.36 , pp. 502-506
    • Bevilacqua, S.1    Bonadonna, R.2    Buzzigoli, G.3
  • 39
    • 0025764186 scopus 로고
    • Modulation of hepatic glucose production by non-esterified fatty acids in type 2 (non-insulin-dependent) diabetes mellitus
    • COI: 1:STN:280:DyaK3MzlslaktA%3D%3D, PID: 1884899
    • Saloranta C, Franssila-Kallunki A, Ekstrand A, Taskinen MR, Groop L (1991) Modulation of hepatic glucose production by non-esterified fatty acids in type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 34:409–415
    • (1991) Diabetologia , vol.34 , pp. 409-415
    • Saloranta, C.1    Franssila-Kallunki, A.2    Ekstrand, A.3    Taskinen, M.R.4    Groop, L.5
  • 40
    • 0025296906 scopus 로고
    • Free-fatty acid inhibition of insulin binding, degradation, and action in isolated rat hepatocytes
    • COI: 1:CAS:528:DyaK3cXktVSrsbw%3D, PID: 2185108
    • Svedberg J, Bjorntorp P, Smith U, Lonnroth P (1990) Free-fatty acid inhibition of insulin binding, degradation, and action in isolated rat hepatocytes. Diabetes 39:570–574
    • (1990) Diabetes , vol.39 , pp. 570-574
    • Svedberg, J.1    Bjorntorp, P.2    Smith, U.3    Lonnroth, P.4
  • 41
    • 17744383753 scopus 로고    scopus 로고
    • Free fatty acids inhibit the glucose-stimulated increase of intramuscular glucose-6-phosphate concentration in humans
    • COI: 1:CAS:528:DC%2BD3MXjs1OmtL4%3D, PID: 11344220
    • Krebs M, Krssak M, Nowotny P et al (2001) Free fatty acids inhibit the glucose-stimulated increase of intramuscular glucose-6-phosphate concentration in humans. J Clin Endocrinol Metab 86:2153–2160
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 2153-2160
    • Krebs, M.1    Krssak, M.2    Nowotny, P.3
  • 42
    • 0032829745 scopus 로고    scopus 로고
    • Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects
    • COI: 1:CAS:528:DyaK1MXmtVaitb0%3D, PID: 10480616
    • Santomauro AT, Boden G, Silva ME et al (1999) Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects. Diabetes 48:1836–1841
    • (1999) Diabetes , vol.48 , pp. 1836-1841
    • Santomauro, A.T.1    Boden, G.2    Silva, M.E.3
  • 43
    • 0342314436 scopus 로고    scopus 로고
    • Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients
    • COI: 1:CAS:528:DC%2BD3cXjsF2ms74%3D, PID: 10905483
    • Ryysy L, Hakkinen AM, Goto T et al (2000) Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients. Diabetes 49:749–758
    • (2000) Diabetes , vol.49 , pp. 749-758
    • Ryysy, L.1    Hakkinen, A.M.2    Goto, T.3
  • 44
    • 0141615879 scopus 로고    scopus 로고
    • Fatty liver in type 2 diabetes mellitus: relation to regional adiposity, fatty acids, and insulin resistance
    • COI: 1:CAS:528:DC%2BD3sXosV2qsrg%3D, PID: 12959938
    • Kelley DE, McKolanis TM, Hegazi RA, Kuller LH, Kalhan SC (2003) Fatty liver in type 2 diabetes mellitus: relation to regional adiposity, fatty acids, and insulin resistance. Am J Physiol Endocrinol Metab 285:E906–E916
    • (2003) Am J Physiol Endocrinol Metab , vol.285 , pp. E906-E916
    • Kelley, D.E.1    McKolanis, T.M.2    Hegazi, R.A.3    Kuller, L.H.4    Kalhan, S.C.5
  • 45
    • 0037357399 scopus 로고    scopus 로고
    • Carbohydrate-induced manipulation of insulin sensitivity independently of intramyocellular lipids
    • PID: 12628032
    • Frost GS, Goff LM, Hamilton G et al (2003) Carbohydrate-induced manipulation of insulin sensitivity independently of intramyocellular lipids. Br J Nutr 89:365–375
    • (2003) Br J Nutr , vol.89 , pp. 365-375
    • Frost, G.S.1    Goff, L.M.2    Hamilton, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.