Methylmercury inhibition of type II 5′-deiodinase activity resulting in a decrease in growth hormone production in GH3 cells

Toxicology

Volumn 237, Issue 1-3, 2007, Pages 203-209

  Mori, Kouki ^a   Yoshida, Katsumi ^b   Nakagawa, Yoshinori ^a   Hoshikawa, Saeko ^a   Ozaki, Hiroshi ^a   Ito, Sadayoshi ^a   Watanabe, Chiho ^c  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Deiodinase; Growth hormone; Methylmercury; Thyroid hormone

Indexed keywords

GENE PRODUCT; GROWTH HORMONE; LIOTHYRONINE; METHYLMERCURY; THYROID HORMONE; THYROXINE; THYROXINE DEIODINASE;

ANALYTIC METHOD; ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GROWTH HORMONE RELEASE; HORMONE SYNTHESIS; HYPOPHYSIS TUMOR; NONHUMAN; PRIORITY JOURNAL; RAT; TUMOR CELL;

ANIMALS; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CULTURE MEDIA; ENZYME INHIBITORS; GROWTH HORMONE; IODIDE PEROXIDASE; METHYLMERCURY COMPOUNDS; RATS; THYROXINE; TRIIODOTHYRONINE;

RATTUS;

EID: 34447106648     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2007.05.012     Document Type: Article

References (39)

1. Bianco A.C., Salvatore D., Gereben B., Berry M.J., and Larsen P.R. Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinase. Endocr. Rev. 23 (2002) 38-89
2. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 162 (1976) 248-254
3. Burmeister L.A., Pachucki J., and St. Germain D.L. Thyroid hormones inhibit type 2 iodothyronine deiodinase in the rat cerebral cortex by both pre- and post-translational mechanisms. Endocrinology 138 (1997) 5231-5237
4. Burton G.V., and Meikle A.W. Acute and chronic methyl mercury poisoning impairs rat adrenal and testicular function. J. Toxicol. Environ. Health 6 (1980) 597-606
5. Castoldi A.F., Coccini T., Ceccatelli S., and Manzo L. Neurotoxicity and molecular effects of methylmercury. Brain Res. Bull. 55 (2001) 197-203
6. Choi B.H. The effects of methylmercury on the developing brain. Prog. Neurobiol. 32 (1989) 447-470
7. Choi B.H., Lapham L.W., Amin-Zaki L., and Saleem T. Abnormal neuronal migration, deranged cerebral cortical organization, and diffuse white matter astrocytosis of human fetal brain: a major effect of methylmercury poisoning in utero. J. Neuropathol. Exp. Neurol. 37 (1978) 719-733
8. Crantz F.R., Silva J.E., and Larsen P.R. An analysis of the sources and quantity of 3,5 3′-triiodothyronine specifically bound to nuclear receptors in rat cerebral cortex and cerebellum. Endocrinology 110 (1982) 367-375
9. Croteau W., Davey J.C., Galton V.A., and St. Germain D.L. Cloning of the mammalian type II iodothyronine deiodinase: a selenoprotein differentially expressed and regulated in human and rat brain and other tissues. J. Clin. Invest. 98 (1996) 405-417
10. Curcio-Morelli C., Zavacki A.M., Christofollete M., Gereben B., de Freitas B.C.G., Harney J.W., Li Z., Wu G., and Bianco A.C. Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation. J. Clin. Invest. 112 (2003) 189-196
11. Dieguez-Acuna F.J., and Woods J.S. Inhibition of NF-κB-DNA binding by mercuric ion: utility of the non-thiol reductant, tris(2-carboxyethyl)phosphine hydrochloride (TCEP), on detection of impaired NF-κB-DNA binding by thiol-directed agents. Toxicol. In Vitro 14 (2000) 7-16
12. Friberg L., and Mottet N.K. Accumulation of methylmercury and inorganic mercury in the brain. Biol. Trace Elem. Res. 21 (1989) 201-206
13. Harvey C.B., and Williams G.R. Mechanism of thyroid hormone action. Thyroid 12 (2002) 441-446
14. Hughes W.L. A physicochemical rationale for the biological activity of mercury and its compounds. Ann. N.Y. Acad. Sci. 65 (1957) 454-460
15. Kabuto M. Acute endocrine effects of a single administration of methylmercury chloride (MMC) in rats. Endocr. Jpn. 33 (1986) 683-690
16. Kitamura S., Jinno N., Ohta S., Kuroki H., and Fujimoto N. Thyroid hormonal activity of the flame retardants tetrabromobisphenol A and tetrachlorobisphenol A. Biochem. Biophys. Res. Commun. 293 (2002) 554-559
17. Kojima K., and Fujita M. Summary of recent studies in Japan on methyl mercury poisoning. Toxicology 1 (1973) 43-62
18. Kosta L., Byrne A.R., and Zelenko V. Correlation between selenium and mercury in man following exposure to inorganic mercury. Nature 254 (1975) 238-239
19. Kromidas L., Trombetta L.D., and Jamall I.S. The protective effects of glutathione against methylmercury cytotoxicity. Toxicol. Lett. 51 (1990) 67-80
20. Kunimoto M., and Suzuki T. Migration of granule neurons in cerebellar organotypic cultures is impaired by methylmercury. Neurosci. Lett. 226 (1997) 183-186
21. Lewis P.D., Patel A.J., Johnson A.L., and Balazs R. Effect of thyroid deficiency on cell acquisition in the postnatal rat brain: a quantitative histological study. Brain Res. 104 (1976) 49-62
22. Moller-Madsen B., and Thorlacius-Ussing O. Accumulation of mercury in the anterior pituitary of rats following oral or intraperitoneal administration of methylmercury. Virchows Archiv. B 51 (1986) 303-311
23. Mori K., Stone S., Braverman L.E., and DeVito W.J. Involvement of tyrosine phosphorylation in the regulation of 5′-deiodinases in FRTL-5 rat thyroid cells and rat astrocytes. Endocrinology 137 (1996) 1313-1318
24. Mori K., Yoshida K., Tani J.-I., Hoshikawa S., Ito S., and Watanabe C. Methylmercury inhibits type II 5′-deiodinase activity in NB41A3 neuroblastoma cells. Toxicol. Lett. 161 (2006) 96-101
25. Naganuma A., Miura N., Kaneko S., Mishina T., Hosoya S., Miyairi S., Furuchi T., and Kuge S. GFAT as a target molecule of methylmercury toxicity in saccharomyces cerevisiae. FASEB J. 14 (2000) 968-972
26. Nagashima K. A review of experimental methylmercury toxicity in rats: neuropathology and evidence for apoptosis. Toxicol. Pathol. 25 (1997) 624-631
27. Nylander M., Friberg L., Eggleston D., and Bjorkman L. Mercury accumulation in tissues from dental stuff and controls in relation to exposure. Swed. Dent. J. 13 (1989) 235-243
28. Porterfield S.P., and Hendrich C.E. The role of thyroid hormones in prenatal and neonatal neurological development-current perspectives. Endocr. Rev. 14 (1993) 94-106
29. Rabie A., Favre C., Clavel M.C., and Legrand J. Effects of thyroid dysfunction on the development of the rat cerebellum, with special reference to cell death within the internal granular layer. Brain Res. 120 (1977) 521-531
30. Samuels H.H., and Shapiro L.E. Thyroid hormone stimulates de novo growth hormone synthesis in cultured GH1 cells: evidence for the accumulation of a rate limiting RNA species in the induction process. Proc. Natl. Acad. Sci. U.S.A. 73 (1976) 3369-3373
31. Samuels H.H., Stanley H.F., and Casanova J. Depletion of l-3,5,3′-triiodothyronine and l-thyroxine in euthyroid calf serum for use in cell culture studies of the action of thyroid hormone. Endocrinology 105 (1979) 80-85
32. Schimmel M., and Utiger R.D. Thyroidal and peripheral production of thyroid hormones. Ann. Intern. Med. 87 (1977) 760-768
33. Seo H., Vassart G., Brocas H., and Refetoff S. Triiodothyronine stimulates specifically growth hormone mRNA in rat pituitary tumor cells. Proc. Natl. Acad. Sci. U.S.A. 74 (1977) 2054-2058
34. Silva J.E., and Leonard J.L. Regulation of rat cerebrocortical and adenohypophyseal type II 5′-deiodinase by thyroxine, triiodothyronine, and reverse triiodothyronine. Endocrinology 116 (1985) 1627-1635
35. Silva J.E., Dick T.E., and Larsen P.R. The contribution of local tissue thyroxine monodeiodination to the nuclear 3,5,3′-triiodothyronine in pituitary, liver and kidney of euthyroid rats. Endocrinology 103 (1978) 1196-1207
36. St. Germain D.L. Metabolic effect of 3,3′,5′-triiodothyronine in cultured growth hormone-producing rat pituitary tumor cells. J. Clin. Invest. 76 (1985) 890-893
37. Steinsapir J., Harney J., and Larsen P.R. Type 2 iodothyronine deiodinase in rat pituitary tumor cells is inactivated in proteasomes. J. Clin. Invest. 102 (1998) 1895-1899
38. Volpato C.B., and Nunes M.T. Functional evidence for the presence of type II 5′-deiodinase in somatotropes and its adaptive role in hypothyroidism. Neuroendocrinology 74 (2001) 220-226
39. Watanabe C., Yoshida K., Kasanuma Y., Kun Y., and Satoh H. In utero methylmercury exposure differentially affects the activities of selenoenzymes in the fetal mouse brain. Environ. Res. 80 (1999) 208-214