GFAT as a target molecule of methylmercury toxicity in Saccharomyces cerevisiae

FASEB Journal

Volumn 14, Issue 7, 2000, Pages 968-972

  Naganuma, Akira ^a   Miura, Nobuhiko ^a   Kaneko, Satoshi ^a   Mishina, Tetsuya ^a   Hosoya, Shinji ^a   Miyairi, Shinichi ^a   Furuchi, Takemitsu ^a   Kuge, Shusuke ^b  

^a TOHOKU UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Gene screening; Glucosamine; Glucosamine 6 phosphate; P chloromercuribenzoate; Resistance

Indexed keywords

4 CHLOROMERCURIBENZOIC ACID; GLUTAMINE FRUCTOSE 6 PHOSPHATE AMINOTRANSFERASE; METHYLMERCURY;

ARTICLE; BINDING AFFINITY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME BINDING; GENETIC SCREENING; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

EUKARYOTA; FUNGI; MYXOGASTRIA; SACCHAROMYCES CEREVISIAE;

EID: 0034012498     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.14.7.968     Document Type: Article

References (27)

1. Atchinson, W. D., and Hare, M. F. (1994) Mechanisms of methylmercury-induced neurotoxicity. FASEB J. 8, 622-629
2. Clarkson, T. W. (1997) The toxicology of mercury. Crit. Rev. Clin. Lab. Sci. 34, 369-403
3. Harada, M. (1995) Minamata disease: methylmercury poisoning in Japan caused by environmental pollution. Crit. Rev. Toxicol. 25, 1-24
4. Duffy, L. K., Rodgers, T., and Patton, M. (1998) Regional health assessment relating to mercury content of fish caught in the Yukon-Kuskokwim Delta rivers system. Alaska Med. 40, 75-77
5. Holsbeek, L., Das, H. K., and Joiris, C. R. (1997) Mercury speciation and accumulation in Bangladesh freshwater and anadromous fish. Sci. Total Environ. 198, 201-210
6. Jaffe, R., Cai, Y., West-Thomas, J., Morales, M., and Jones, R. D. (1997) Occurrence of methylmercury in Lake Valencia. Venezuela. Bull. Environ. Contain. Toxicol. 59, 99-105
7. Malm, O. (1998) Gold mining as a source of mercury exposure in the Brazilian Amazon. Environ. Res. 77, 73-78
8. Akagi, H., Malm, O., and Branches, F. J. P. (1996) Human exposure to mercury due to gold mining in the Amazon. Brazil. Environ. Sci. 4, 199-211
9. Grandjean, P., White, R. F., Nielsen, A., Cleary, D., and Santos, E. C. (1999) Methylmercury neurotoxicity in Amazonian children downstream from gold mining. Environ. Health Perspect. 107, 587-591
10. Lebel, J., Mergler, D., Branches, F., Lucotte, M., Amorim, M., Larribe, F., and Dolbec, J. (1998) Neurotoxic effects of low-level methylmercury contamination in the Amazonian Basin. Environ. Res. 79, 20-32
11. Nierenberg, D. W., Nordgren, R. E., Chang, M. B., Siegler, R. W., Blayney, M. B., Hochherg, F., Toribara, T. Y., Cernichiari, E., and Clarkson, T. W. (1998) Delayed cerebellar disease and death after accidental exposure to dimethylmercury. New Engl. J. Med. 338, 1672-1676
12. Freemantle, S. J., Jackman, A. L., Kelland, L. R., Calvert, A. H., and Lunec, J. (1995) Molecular characterisation of two cell lines selected for resistance to the folate-based thymidylate synthase inhibitor, ZD1694. Br. J. Cancer 71, 925-930
13. Jenh, C. H., Geyer, P. K., Baskin, F., and Johnson, L. F. (1985) Thymidylate synthase gene amplification in fluorodeoxyuridine-resistant mouse cell lines. Mol. Pharmacol. 28, 80-85
14. Srimatkandada, S., Medina, W. D., Cashmore, A. R., Whyte, W., Engel, D., Moroson, B. A., Franco, C. T., Dube, S. K., and Bertino, J. R. (1983) Amplification and organization of dihydrofolate reductase genes in a human leukemic cell line. K-562, resistant to methotrexate. Biochemistry 22, 5774-5781
15. Yen, Y., Grill, S. P., Dutschman, G. E., Chang, C. N., Zhou, B. S., and Cheng, Y. C. (1994) Characterization of a hydroxyurea-resistant human KB cell line with supersensitivity to 6-thioguanine. Cancer Res. 54, 3686-3691
16. \16. Ghosh, S., Blumenthal, H. J., Davidson, E., and Roseman, S. (1960) Enzymatic synthesis of glucosamine-6-phosphate. J. Biol. Chem. 235, 1265-1273
17. Qulali, M., Ross, R. A., and Crabb, D. W. (1991) Estradiol induces class I alcohol dehydrogenase activity and mRNA in kidney of female rats. Arch Biochem. Biophys. 288, 406-413
18. Carlberg, I., and Mannervik, B. (1975) Purification and characterization of the flavoenzyme glutathione reductase from rat liver. J. biol. Chem. 250, 5475-5480
19. Morton, R. K., and Sturtevant, J. M. (1964) Kinetic investigations of yeast L-Lactate dehydrogenase. J. Biol. Chem. 239, 1614-1620
20. Watzele, G., and Tanner, W. (1989) Cloning of the glutamine: fructose-6-phosphate amidotransferase gene from yeast. Pheromonal regulation of its transcription. J. Biol. Chem. 264, 8753-8758
21. Zalkin, H. (1985) Glucosamine-6-phosphate synthase. Methods Enzymol. 113, 278-281
22. Dixon, M. (1953) The determination of enzyme inhibitor constants. Biochem. J. 55, 170-171
23. Badet, B., Vermoote, P., Haumont, P. Y., Lederer, F., and LeGoffic, F. (1987) Glucosamine synthetase from Escherichia coli: purification, properties, and glutamine-utilizing site location. Biochemistry 26, 1940-1948
24. Winterburn, P. J., and Phelps, C. F. (1971) Binding of substrates and modifiers to glucosamine synthetase. Biochem. J. 121, 721-730
25. Mochizuki, Y., and Hori, S. H. (1977) Purification and properties of hexokinase from the starfish. Asterias amurensis. J. Biochem. 81, 1849-1855
26. Paterson, A. J., and Kudlow, J. E. (1995) Regulation of glutamine:fructose-6-phosphate amidotransferase gene transcription by epidermal growth factor and glucose. Endocrinology 136, 2809-2816
27. McKnight, G. L., Mudri, S. L., Mathewes, S. L., Traxinger, R. R., Marshall, S., Sheppard, P. O., and O'Hara, P. J. (1992) Molecular cloning, cDNA sequence, and bacterial expression of human glutamine:fructose-6-phosphate amidotransferase. J. Biol. Chem. 267, 25208-25212