Functional evidence for the presence of type II 5′-deiodinase in somatotropes and its adaptive role in hypothyroidism

Neuroendocrinology

Volumn 74, Issue 4, 2001, Pages 220-226

  Volpato, Cláudia B ^a   Nunes, Maria Tereza ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

5 Deiodinase; Growth hormone; Somatotropes; Thyroid hormones

Indexed keywords

GROWTH HORMONE; LIOTHYRONINE; MESSENGER RNA; PROPYLTHIOURACIL; THYROXINE; THYROXINE DEIODINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GROWTH HORMONE BLOOD LEVEL; HORMONAL REGULATION; HYPERTHYROIDISM; HYPOTHYROIDISM; LIOTHYRONINE BLOOD LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; THYROXINE BLOOD LEVEL;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; BLOTTING, NORTHERN; HYPOTHYROIDISM; IODIDE PEROXIDASE; MALE; PITUITARY GLAND; RATS; RATS, WISTAR; RNA, MESSENGER; THYROXINE; TRIIODOTHYRONINE;

EID: 0035743456     PISSN: 00283835     EISSN: None     Source Type: Journal    
DOI: 10.1159/000054689     Document Type: Article

References (40)

1. Regulatory influences on iodothyronine deiodination in animal tissues
2. Biochemistry of deiodination
3. Type I iodothyronine deiodinase is a selenocysteine-containing enzyme
4. 3) in vitro
5. Molecular cloning by hybrid arrest of translation in Xenopus laevis oocytes: Identification of a cDNA encoding the type-I iodothyronine 5′-deiodinase from rat liver
6. The contribution of local tissue thyroxine monodeiodination to the nuclear 3,5,3′-triiodothyronine in pituitary, liver and kidney of euthyroid rats
7. Evidence for two pathways of iodothyronine 5′ deiodination in rat pituitary that differ in kinetics, propylthiouracil sensitivity, and response to hypothyroidism
8. Cloning and expression of a cDNA for a mammalian type III iodothyronine deiodinase
9. A thyroid hormone regulated gene in Xenopus laevis encodes a type III iodothyronine 5-deiodinase
10. Contributions of plasma triiodothyronine and local thyroxine monodeiodination to triiodothyronine to nuclear triiodothyronine receptor saturation in pituitary, liver, and kidney of hypothyroid rats: Further evidence relating saturation of pituitary nuclear triiodothyronine receptors and the acute inhibition of thyroid-stimulating hormone release
11. Local activation and inactivation of thyroid hormones: The deiodinase family
12. Pituitary nuclear 3,5,3′-triiodothyronine and thyrotropin secretion: An explanation for the effect of thyroxine
13. The type 2 and type 3 iodothyronine deiodinases play important roles in coordinating development in Rana catesbeiana tadpoles
14. Stereospecific transport of triiodothyronine from plasma to cytosol and from cytosol to nucleus in the rat liver, kidney, brain, and heart
15. Regulation of thyroxine 5′-deiodinase activity by 3,5,3′-triiodothyronine in cultured rat anterior pituitary cells
16. Down-regulation of type II L-thyroxine, 5′-monodeiodinase in cultured GC cells: Different pathways of regulation by L-triiodothyronine and 3,3′,5′-triiodo-L-thyronine
17. 5′-Flanking DNA of the rat growth hormone gene mediates regulated expression by thyroid hormones
18. Regulation of growth hormone messenger RNA synthesis by dexamethasone and triiodothyronine: Transcriptional rate and mRNA stability changes in pituitary tumor cells
19. Thyroid hormone receptor binds to a site in the rat growth hormone promoter required for induction by thyroid hormone
20. Posttranscriptional regulation of rat growth hormone gene expression: Increased stability and nuclear polyadenylation accompany thyroid hormone depletion
21. Hormonal regulation of the growth hormone gene: Relationship of the rate of transcription to the level of nuclear thyroid hormone-receptor complexes
22. The effect of thyroid hormones on growth hormone gene expression in vivo in rats
23. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
24. Evidence for two tissue-specific pathways for in vivo thyroxine 5′-deiodination in the rat
25. Regulation of rat cerebrocortical and adenohypophyseal type II 5′-deiodinase by thyroxine, triiodothyronine and reverse triiodothyronine
26. Functional characterization of the rat growth hormone promoter elements required for induction by thyroid hormone with and without a co-transfected beta type thyroid hormone receptor
27. Binding of thyroid hormone receptors to the thyrotropin β-gene
28. Rapid induction of rat liver S14 gene transcription by thyroid hormone
29. Rapid effects of triiodothyronine on hepatic gene expression: Hybridization analysis of tissue-specific triiodothyronine regulation of mRNA S14
30. Expression of the cardiac ventricular alpha- and beta-myosin heavy chain genes is developmentally and hormonally regulated
31. 2+-ATPase in the rat heart
32. Cis-acting elements of the rat growth hormone gene which mediate basal and regulated expression by thyroid hormone
33. Transcriptional regulation of the thyrotropin subunit genes by thyroid hormone
34. Transcriptional activation and stabilization of malic enzyme RNA precursor by thyroid hormone
35. Thyroid hormone regulation of gene expression
36. Comparison of iodothyronine 5′-deiodinase and other thyroid hormone-dependent enzyme activities in the cerebral cortex of hypothyroid neonatal rat
37. Effects of hypothyroidism on brown adipose tissue adenylyl cyclase activity
38. Conversion of L-thyroxine to triiodo-L-thyronine and biological activity of L-thyroxine, as measured by changes in growth hormone
39. Potential of brown adipose tissue type II thyroxine 5′-deiodinase as a local and systemic source of triiodothyronine in rats