Regulation of Dio2 gene expression by thyroid hormones in normal and type 1 deiodinase-deficient C3H mice

Journal of Endocrinology

Volumn 193, Issue 3, 2007, Pages 435-444

  Wagner, Marcia S ^a   Wajner, Simone M ^a   Dora, José M ^a   Maia, Ana Luiza ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

IODOTHYRONINE; LIOTHYRONINE; MESSENGER RNA; THYROID HORMONE; THYROTROPIN; THYROXINE; THYROXINE DEIODINASE;

ANIMAL TISSUE; ARTICLE; BRAIN REGION; BROWN ADIPOSE TISSUE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME DEGRADATION; ENZYME REGULATION; EUTHYROIDISM; GENE EXPRESSION REGULATION; HYPOPHYSIS; INHERITANCE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRAIN DIFFERENCE; TISSUE SPECIFICITY;

ADIPOSE TISSUE, BROWN; ANIMALS; BLOTTING, NORTHERN; GENE EXPRESSION; GENE EXPRESSION REGULATION; IODIDE PEROXIDASE; MALE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; THYROID HORMONES; THYROXINE; TIME FACTORS; TRIIODOTHYRONINE;

EID: 34447106522     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/JOE-07-0099     Document Type: Article

References (37)

1. Berry MJ, Kates AL & Larsen PR 1990 Thyroid hormone regulates type I deiodinase messenger RNA in rat liver. Molecular Endocrinology 4 743-748.
2. Berry MJ, Grieco D, Taylor BA, Maia AL, Kieffer JD, Beamer W, Glover E, Poland A & Larsen PR 1993 Physiological and genetic analyses of inbred mouse strains with a type I iodothyronine 5′ deiodinase deficiency. Journal of Clinical Investigation 92 1517-1528.
3. 3 as determined by in vivo techniques. Endocrinology 120 55-62.
4. Bianco AC, Salvatore D, Gereben B, Berry MJ & Larsen PR 2002 Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocrine Reviews 23 38-89.
5. Bianco AC, Maia AL, da Silva WS & Christoffolete MA 2005 Adaptive activation of thyroid hormone and energy expenditure. Bioscience Reports 25 191-208.
6. Buchmann A, Bauer-Hofmann R, Mahr J, Drinkwater NR, Luz A & Schwarz M 1991 Mutational activation of the c-Ha-ras gene in liver tumors of different rodent strains: correlation with susceptibility to hepatocarcinogenesis. PNAS 88 911-915.
7. Burmeister LA, Pachucki J & St Germain DL 1997 Thyroid hormones inhibit type 2 iodothyronine deiodinase in the rat cerebral cortex by both pre- and posttranslational mechanisms. Endocrinology 138 5231-5237.
8. Christoffolete MA, Ribeiro R, Singru P, Fekete C, da Silva WS, Gordon DF, Huang SA, Crescenzi A, Harney JW, Ridgway EC et al. 2006 Atypical expression of type 2 iodothyronine deiodinase in thyrotrophs explains the thyroxine-mediated pituitary thyrotropin feedback mechanism. Endocrinology 147 1735-1743.
9. Crantz FR, Silva JE & Larsen PR 1982 An analysis of the sources and quantity of 3,5,3-triiodothyronine specifically bound to nuclear receptors in rat cerebral cortex and cerebellum. Endocrinology 110 367-375.
10. Croteau W, Davey JC, Galton VA & St Germain DL 1996 Cloning of the mammalian type II iodothyronine deiodinase. A selenoprotein differentially expressed and regulated in human and rat brain and other tissues. Journal of Clinical Investigation 98 405-417.
11. Curcio-Morelli C, Zavacki AM, Christofollete M, Gereben B, de Freitas BC, Harney JW, Li Z, Wu G & Bianco AC 2003 Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation. Journal of Clinical Investigation 112 189-196.
12. Escobar-Morreale HF, Obregon MJ, Hernandez A, Escobar del Rey F & Morreale de Escobar G 1997 Regulation of iodothyronine deiodinase activity as studied in thyroidectomized rats infused with thyroxine or triiodothyronine. Endocrinology 138 2559-2569.
13. Gereben B, Goncalves C, Harney JW, Larsen PR & Bianco AC 2000 Selective proteolysis of human type 2 deiodinase: a novel ubiquitin-proteasomal mediated mechanism for regulation of hormone activation. Molecular Endocrinology 14 1697-1708.
14. Gereben B, Kollar A, Harney JW & Larsen PR 2002 The mRNA structure has potent regulatory effects on type 2 iodothyronine deiodinase expression. Molecular Endocrinology 16 1667-1679.
15. St Germain DL 1988 The effects and interactions of substrates, inhibitors, and the cellular thiol-disulfide balance on the regulation of type II iodothyronine 5′-deiodinase. Endocrinology 122 1860-1868.
16. de Jesus LA, Carvalho SD, Ribeiro MO, Schneider M, Kim SW, Harney JW, Larsen PR & Bianco AC 2001 The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue. Journal of Clinical Investigation 108 1379-1385.
17. Kim SW, Harney JW & Larsen PR, 1998 Studies of the hormonal regulation of type 2 5′-iodothyronine deiodinase messenger ribonucleic acid in pituitary tumor cells using semiquantitative reverse transcription-polymerase chain reaction. Endocrinology 139 4895-4905.
18. Kuiper GG, Klootwijk W & Visser TJ 2002 Substitution of cysteine for a conserved alanine residue in the catalytic center of type II iodothyronine deiodinase alters interaction with reducing cofactor. Endocrinology 143 1190-1198.
19. Larsen PR, Silva JE & Kaplan MM 1981 Relationships between circulating and intracellular thyroid hormones: physiological and clinical implications. Endocrine Reviews 2 87-102.
20. Leonard JL, Silva JE, Kaplan MM, Mellen SA, Visser TJ & Larsen PR 1984 Acute posttranscriptional regulation of cerebrocortical and pituitary iodothyronine 5′-deiodinases by thyroid hormone. Endocrinology 114 998-1004.
21. Maia AL, Harney JW & Larsen PR 1995a Pituitary cells respond to thyroid hormone by discrete, gene-specific pathways. Endocrinology 136 1488-1494.
22. Maia AL, Berry MJ, Sabbag R, Harney JW & Larsen PR 1995 b Structural and functional differences in the diol gene in mice with inherited type 1 deiodinase deficiency. Molecular Endocrinology 9 969-980.
23. 3 in euthyroid humans. Journal of Clinical Investigation 115 2524-2533.
24. Manning KL & McDonald TP 1997 C3H mice have larger spleens, lower platelet counts, and shorter platelet lifespans than C57BL mice: an animal model for the study of hypersplenism. Experimental Hematology 25 1019-1024.
25. Martinez-deMena R, Hernandez A & Obregon MJ 2002 Triiodothyronine is required for the stimulation of type II 5′-deiodinase mRNA in rat brown adipocytes. American Journal of Physiology. Endocrinology and Metabolism 282 E1119-E1127.
26. Paigen B, Albee D, Holmes PA & Mitchell D 1987 Genetic analysis of routine strains C57BL/6J and C3H/HeJ to confirm the map position of Ath-1, a gene determining atherosclerosis susceptibility. Biochemical Genetics 25 501-511.
27. 4. Molecular Endocrinology 15 2137-2148.
28. Schneider MJ, Fiering SN, Thai B, Wu SY, St Germain E, Parlow AF, St Germain DL & Galton VA 2006 Targeted disruption of the type 1 selenodeiodinase gene (Diol) results in marked changes in thyroid hormone economy in mice. Endocrinology 147 580-589.
29. Schoenmakers CH, Pigmans IG, Poland A & Visser TJ 1993 Impairment of the selenoenzyme type I iodothyronine deiodinase in C3H/He mice. Endocrinology 132 357-361.
30. Silva JE & Larsen PR 1985 Potential of brown adipose tissue type II thyroxine 5′-deiodinase as a local and systemic source of triiodothyronine in rats. Journal of Clinical Investigation 76 2296-2305.
31. Silva JE & Leonard JL, 1985 Regulation of rat cerebrocortical and adenohypophyseal type II 5′-deiodinase by thyroxine, triiodothyronine, and reverse triiodothyronine. Endocrinology 116 1627-1635.
32. Silva JE, Dick TE & Larsen PR 1978 The contribution of local tissue thyroxin monodeiodination to the nuclear 3,5,3-triiodothyronine in pituitary, liver, and kidney of euthyroid rats. Endocrinology 103 1196-1207.
33. Steinsapir J, Harney J & Larsen PR 1998 Type 2 iodothyronine deiodinase in rat pituitary tumor cells is inactivated in proteasomes. Journal of Clinical Investigation 102 1895-1899.
34. Steinsapir J, Bianco AC, Buettner C, Harney J & Larsen PR 2000 Substrate-induced downregulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center. Endocrinology 141 1127-1135.
35. Streckfuss F, Hamann I, Schomburg L, Michaelis M, Sapin R, Klein MO, Kohrle J & Schweizer U 2005 Hepatic deiodinase activity is dispensable for the maintenance of normal circulating thyroid hormone levels in mice. Biochemical and Biophysical Research Communications 337 739-745.
36. Visser TJ 1996 Pathways of thyroid hormone metabolism. Acta Medica Austriaca 23 10-16.
37. Wagner MS, Morimoto R, Dora JM, Benneman A, Pavan R & Maia AL 2003 Hypothyroidism induces type 2 iodothyronine deiodinase expression in mouse heart and testis. Journal of Molecular Endocrinology 31 541-550.