Discovery of cyclopentane- and cyclohexane-trans-1,3-diamines as potent melanin-concentrating hormone receptor 1 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 15, 2007, Pages 4232-4241

  Giordanetto, Fabrizio ^a   Karlsson, Olle ^a   Lindberg, Jan ^a   Larsson, Lars Olof ^a   Linusson, Anna ^b   Evertsson, Emma ^a   Morgan, David G A ^c   Inghardt, Tord ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b UMEÅ UNIVERSITY   (Sweden)

^c ASTRAZENECA   (United Kingdom)

Author keywords

MCH; MCH R1 antagonists; Melanin concentrating hormone receptor; Obesity

Indexed keywords

2 AMINOQUINOLINE; CYCLOHEXANE; CYCLOPENTANE; DIAMINE DERIVATIVE; HORMONE RECEPTOR BLOCKING AGENT; MELANIN; THIOPHENE DERIVATIVE;

ARTICLE; IN VITRO STUDY; SUBSTITUTION REACTION;

CYCLOHEXANES; CYCLOPENTANES; DIAMINES; HUMANS; MODELS, MOLECULAR; RECEPTORS, SOMATOSTATIN;

EID: 34447096407     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.05.034     Document Type: Article

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