Tandem regulation of phosphoinositide signaling and acute behavioral effects induced by antidepressant agents in rats

Psychopharmacology

Volumn 193, Issue 2, 2007, Pages 271-282

  Tyeryar, Kimberly R ^a   Undie, Ashiwel S ^a  

^a UNIVERSITY OF MARYLAND   (United States)

Author keywords

Antidepressant agents; CDP diacylglycerol; Depressive disorder; Modified forced swim test; Phosphatidylinositol; Tandem signaling

Indexed keywords

1 ISOPROPYL 6 METHYLERGOLINE 8 CARBOXYLIC ACID 2 HYDROXY 1 METHYLPROPYL ESTER; 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; ALPHA METHYLSEROTONIN; ANTIDEPRESSANT AGENT; DESIPRAMINE; FLUOXETINE; IMIPRAMINE; INOSITOL; INOSITOL PHOSPHATE; MAPROTILINE; NEOMYCIN; PAROXETINE; PHOSPHATIDYLINOSITIDE; SEROTONIN 2 AGONIST; SEROTONIN 2 RECEPTOR; TRITIUM;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN SLICE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FORCED SWIMMING TEST; HIPPOCAMPUS; MALE; NEUROTRANSMISSION; NONHUMAN; PHOSPHOINOSITIDE METABOLISM; PHOSPHOLIPID SYNTHESIS; PRIORITY JOURNAL; RAT; SEROTONINERGIC SYSTEM;

ANALYSIS OF VARIANCE; ANIMALS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; BRAIN; HYDROLYSIS; INOSITOL PHOSPHATES; MALE; NEOMYCIN; PHOSPHATIDYLINOSITOLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN, 5-HT2; SEROTONIN;

EID: 34347397146     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-007-0784-1     Document Type: Article

References (74)

1. Arora RC, Meltzer HY (1989) Increased serotonin2 (5-HT2) receptor binding as measured by 3H-lysergic acid diethylamide (3H-LSD) in the blood platelets of depressed patients. Life Sci 44:725-734
2. Berg KA, Stout BD, Maayani S, Clarke WP (2001) Differences in rapid desensitization of 5-hydroxytryptamine(2a) and 5-hydroxytryptamine(2c) receptor-mediated phospholipase C activation. J Pharmacol Exp Ther 299:593-602
3. Beyer CE, Boikess S, Luo B, Dawson LA (2002) Comparison of the effects of antidepressants on norepinephrine and serotonin concentrations in the rat frontal cortex: an in-vivo microdialysis study. J Psychopharmacol 16:297-304
4. Brown E, Kendall DA, Nahorski SR (1984) Inositol phospholipid hydrolysis in rat cerebral cortical slices: I. Receptor characterisation. J Neurochem 42:1379-1387
5. Cesana R, Ceci A, Ciprandi C, Borsini F (1993) Mesulergine antagonism towards the fluoxetine anti-immobility effect in the forced swimming test in mice. J Pharm Pharmacol 45:473-475
6. Choi MJ, Kang RH, Ham BJ, Jeong HY, Lee MS (2005) Serotonin receptor 2A gene polymorphism (-1438A/G) and short-term treatment response to citalopram. Neuropsychobiology 52:155-162
7. Clenet F, De Vos A, Bourin M (2001) Involvement of 5-HT(2C) receptors in the anti-immobility effects of antidepressants in the forced swimming test in mice. Eur Neuropsychopharmacol 11:145-152
8. Coderre TJ (1992) Contribution of protein kinase C to central sensitization and persistent pain following tissue injury. Neurosci Lett 140:181-184
9. Cohen ML, Kurz KD, Mason NR, Fuller RW, Marzoni GP, Garbrecht WL (1985) Pharmacological activity of the isomers of LY53857, potent and selective 5-HT2 receptor antagonists. J Pharmacol Exp Ther 235:319-323
10. Conn PJ, Sanders-Bush E (1986) Regulation of serotonin-stimulated phosphoinositide hydrolysis: relation to the serotonin 5-HT-2 binding site. J Neurosci 6:3669-3675
11. Cowen PJ (1990) A role for 5-HT in the action of antidepressant drugs. Pharmacol Ther 46:43-51
12. Cowen PJ, Charig EM, Fraser S, Elliott JM (1987) Platelet 5-HT receptor binding during depressive illness and tricyclic antidepressant treatment. J Affect Disord 13:45-50
13. Coyle JT, Duman RS (2003) Finding the intracellular signaling pathways affected by mood disorder treatments. Neuron 38:157-160
14. Cryan JF, Lucki I (2000) Antidepressant-like behavioral effects mediated by 5-hydroxytryptamine(2C) receptors. J Pharmacol Exp Ther 295:1120-1126
15. Cusin C, Serretti A, Zanardi R, Lattuada E, Rossini D, Lilli R, Lorenzi C, Smeraldi E (2002) Influence of monoamine oxidase A and serotonin receptor 2A polymorphisms in SSRI antidepressant activity. Int J Neuropsychopharmacol 5:27-35
16. D'Aquila PS, Collu M, Pani L, Gessa GL, Serra G (1994) Antidepressant-like effect of selective dopamine D1 receptor agonists in the behavioural despair animal model of depression. Eur J Pharmacol 262:107-111
17. Delgado PL (2004) How antidepressants help depression: mechanisms of action and clinical response. J Clin Psychiatry 65:25-30
18. Detke MJ, Rickels M, Lucki I (1995) Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants. Psychopharmacology (Berl) 121:66-72
19. Einat H, Clenet F, Shaldubina A, Belmaker RH, Bourin M (2001) The antidepressant activity of inositol in the forced swim test involves 5-HT(2) receptors. Behav Brain Res 118:77-83
20. Engleman EA, Murphy JM, Zhou FC, Hingtgen JN (1992) Response suppression induced with selective 5-HT agonists can be differentially blocked with LY53857 in an animal model of depression. Neurochem Res 17:483-488
21. Feighner JP (1999) Mechanism of action of antidepressant medications. J Clin Psychiatry 60:4-11
22. Frazer A (2000) Norepinephrine involvement in antidepressant action. J Clin Psychiatry 61:25-30
23. Gambarana C, Ghiglieri O, Tagliamonte A, D'Alessandro N, De Montis MG (1995) Crucial role of D1 dopamine receptors in mediating the antidepressant effect of imipramine. Pharmacol Biochem Behav 50:147-151
24. Golding EM, Vink R (1994) Inhibition of phospholipase C with neomycin improves metabolic and neurologic outcome following traumatic brain injury. Brain Res 668:46-53
25. Gould TD, Manji HK (2002) Signaling networks in the pathophysiology and treatment of mood disorders. J Psychosom Res 53:687-697
26. Gurevich I, Tamir H, Arango V, Dwork AJ, Mann JJ, Schmauss C (2002) Altered editing of serotonin 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victims. Neuron 34:349-356
27. Harvey JA (2003) Role of the serotonin 5-HT(2A) receptor in learning. Learn Mem 10:355-362
28. Hingtgen JN, Fuller RW, Mason NR, Aprison MH (1985) Blockade of a 5-hydroxytryptophan-induced animal model of depression with a potent and selective 5-HT2 receptor antagonist (LY53857). Biol Psychiatry 20:592-597
29. Hoyer D, Waeber C, Schoeffter P, Palacios JM, Dravid A (1989) 5-HT1C [5-HT2C] receptor-mediated stimulation of inositol phosphate production in pig choroid plexus. A pharmacological characterization. Naunyn Schmiedebergs Arch Pharmacol 339:252-258
30. Hrdina PD, Demeter E, Vu TB, Sotonyi P, Palkovits M (1993) 5-HT uptake sites and 5-HT2 receptors in brain of antidepressant-free suicide victims/depressives: increase in 5-HT2 sites in cortex and amygdala. Brain Res 614:37-44
31. Labarca R, Janowsky A, Paul SM (1985) Manganese stimulates incorporation of [3H]inositol into an agonist-insensitive pool of phosphatidylinositol in brain membranes. Biochem Biophys Res Commun 132:540-547
32. Leysen JE (2004) 5-HT2 receptors. Curr Drug Targets CNS Neurol Disord 3:11-26
33. Marek GJ, Martin-Ruiz R, Abo A, Artigas F (2005) The selective 5-HT2A receptor antagonist M100907 enhances antidepressant-like behavioral effects of the SSRI fluoxetine. Neuropsychopharmacology 30:2205-2215
34. McKinney WT (1984) Animal models of depression: an overview. Psychiatr Dev 2:77-96
35. Messa C, Colombo C, Moresco RM, Gobbo C, Galli L, Lucignani G, Gilardi MC, Rizzo G, Smeraldi E, Zanardi R, Artigas F, Fazio F (2003) 5-HT(2A) receptor binding is reduced in drug-naive and unchanged in SSRI-responder depressed patients compared to healthy controls: a PET study. Psychopharmacology (Berl) 167:72-78
36. Minov C, Baghai TC, Schule C, Zwanzger P, Schwarz MJ, Zill P, Rupprecht R, Bondy B (2001) Serotonin-2A-receptor and -transporter polymorphisms: lack of association in patients with major depression. Neurosci Lett 303:119-122
37. Mintun MA, Sheline YI, Moerlein SM, Vlassenko AG, Huang Y, Snyder AZ (2004) Decreased hippocampal 5-HT2A receptor binding in major depressive disorder: in vivo measurement with [18F]altanserin positron emission tomography. Biol Psychiatry 55:217-224
38. Navidi M, MacQuarrie RA, Sun GY (1990) Metabolism of phosphatidylinositol in plasma membranes and synaptosomes of rat cerebral cortex: a comparison between endogenous vs exogenous substrate pools. Lipids 25:273-277
39. Nic Dhonnchadha BA, Ripoll N, Clenet F, Hascoet M, Bourin M (2005) Implication of 5-HT2 receptor subtypes in the mechanism of action of antidepressants in the four plates test. Psychopharmacology (Berl) 179:418-429
40. Ossowska G, Nowak G, Klenk-Majewska B, Danilczuk Z, Zebrowska-Lupina I (2002) Effect of imipramine on brain D-1 and 5-HT-2A receptors in a chronic unpredictable stress model in rats. Pol J Pharmacol 54:89-93
41. Pacheco MA, Stockmeier C, Meltzer HY, Overholser JC, Dilley GE, Jope RS (1996) Alterations in phosphoinositide signaling and G-protein levels in depressed suicide brain. Brain Res 723:37-45
42. Pandey GN, Pandey SC, Janicak PG, Marks RC, Davis JM (1990) Platelet serotonin-2 receptor binding sites in depression and suicide. Biol Psychiatry 28:215-222
43. Pandey GN, Pandey SC, Davis JM (1991a) Effect of desipramine on inositol phosphate formation and inositol phospholipids in rat brain and human platelets. Psychopharmacol Bull 27:255-261
44. Pandey SC, Davis JM, Schwertz DW, Pandey GN (1991b) Effect of antidepressants and neuroleptics on phosphoinositide metabolism in human platelets. J Pharmacol Exp Ther 256:1010-1018
45. Pauwels PJ (2000) Diverse signalling by 5-hydroxytryptamine (5-HT) receptors. Biochem Pharmacol 60:1743-1750
46. Popoli M, Brunello N, Perez J, Racagni G (2000) Second messenger-regulated protein kinases in the brain: their functional role and the action of antidepressant drugs. J Neurochem 74:21-33
47. Porsolt RD, Bertin A, Jalfre M (1977) Behavioral despair in mice: a primary screening test for antidepressants. Arch Int Pharmacodyn Ther 229:327-336
48. Porsolt RD, Anton G, Blavet N, Jalfre M (1978) Behavioural despair in rats: a new model sensitive to antidepressant treatments. Eur J Pharmacol 47:379-391
49. Rosel P, Arranz B, Vallejo J, Alvarez P, Menchon JM, Palencia T, Navarro MA (1999) Altered [3H]imipramine and 5-HT2 but not [3H]paroxetine binding sites in platelets from depressed patients. J Affect Disord 52:225-233
50. Rosel P, Arranz B, San L, Vallejo J, Crespo JM, Urretavizcaya M, Navarro MA (2000) Altered 5-HT(2A) binding sites and second messenger inositol trisphosphate (IP(3)) levels in hippocampus but not in frontal cortex from depressed suicide victims. Psychiatry Res 99:173-181
51. Rosel P, Arranz B, Urretavizcaya M, Oros M, San L, Navarro MA (2004) Altered 5-HT2A and 5-HT4 postsynaptic receptors and their intracellular signalling systems IP3 and cAMP in brains from depressed violent suicide victims. Neuropsychobiology 49:189-195
52. Saarelainen T, Hendolin P, Lucas G, Koponen E, Sairanen M, MacDonald E, Agerman K, Haapasalo A, Nawa H, Aloyz R, Ernfors P, Castren E (2003) Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects. J Neurosci 23:349-357
53. Schmauss C (2003) Serotonin 2C receptors: suicide, serotonin, and runaway RNA editing. Neuroscientist 9:237-242
54. Serretti A, Artioli P, De Ronchi D (2004) The 5-HT2C receptor as a target for mood disorders. Expert Opin Ther Targets 8:15-23
55. Sharma A, Kulkarni SK (1994) Dopamine receptor mediated antidepressant action of B-HT 920 in mice. Indian J Exp Biol 32:172-175
56. Sheline YI, Mintun MA, Barch DM, Wilkins C, Snyder AZ, Moerlein SM (2004) Decreased hippocampal 5-HT(2A) receptor binding in older depressed patients using [18F]altanserin positron emission tomography. Neuropsychopharmacology 29:2235-2241
57. Sibille E, Sarnyai Z, Benjamin D, Gal J, Baker H, Toth M (1997) Antisense inhibition of 5-hydroxytryptamine2a receptor induces an antidepressant-like effect in mice. Mol Pharmacol 52:1056-1063
58. Strome EM, Jivan S, Doudet DJ (2005) Quantitative in vitro phosphor imaging using [3H] and [18F] radioligands: the effects of chronic desipramine treatment on serotonin 5-HT2 receptors. J Neurosci Methods 141:143-154
59. Sugimoto Y, Yamada S, Yamada J (2002) The 5-HT2 receptor antagonist reduces immobility of mice treated with the atypical antidepressant mianserin in the forced swimming test. Biol Pharm Bull 25:1479-1481
60. Taylor C, Fricker AD, Devi LA, Gomes I (2005) Mechanisms of action of antidepressants: from neurotransmitter systems to signaling pathways. Cell Signal 17:549-557
61. Tiraboschi E, Tardito D, Kasahara J, Moraschi S, Pruneri P, Gennarelli M, Racagni G, Popoli M (2004) Selective phosphorylation of nuclear CREB by fluoxetine is linked to activation of CaM kinase IV and MAP kinase cascades. Neuropsychopharmacology 29:1831-1840
62. Todd KG, McManus DJ, Baker GB (1995) Chronic administration of the antidepressants phenelzine, desipramine, clomipramine, or maprotiline decreases binding to 5-hydroxytryptamine2A receptors without affecting benzodiazepine binding sites in rat brain. Cell Mol Neurobiol 15:361-370
63. Tohda M, Watanabe H (1998) Enhancement of serotonin 2C receptor mRNA expression by antidepressants possessing the receptor-blocking activity in the rat brain. Jpn J Pharmacol 78:515-517
64. Tyeryar KR, Undie AS (2003) Chemically diverse antidepressants regulate phosphoinositide-derived diacylglycerol formation in depression-relevant regions of the rat brain. FASEB J 17:244
65. Undie AS (1999) Relationship between dopamine agonist stimulation of inositol phosphate formation and cytidine diphosphate-diacylglycerol accumulation in brain slices. Brain Res 816:286-294
66. Undie AS, Friedman E (1990) Stimulation of a dopamine D1 receptor enhances inositol phosphates formation in rat brain. J Pharmacol Exp Ther 253:987-992
67. Undie AS, Friedman E (1992) Selective dopaminergic mechanism of dopamine and SKF38393 stimulation of inositol phosphate formation in rat brain. Eur J Pharmacol 226:297-302
68. Van Oekelen D, Luyten WH, Leysen JE (2003) 5-HT2A and 5-HT2C receptors and their atypical regulation properties. Life Sci 72:2429-2449
69. West CH, Weiss JM (1998) Effects of antidepressant drugs on rats bred for low activity in the swim test. Pharmacol Biochem Behav 61:67-79
70. Yamada J, Sugimoto Y (2001) Effects of 5-HT(2) receptor antagonists on the anti-immobility effects of imipramine in the forced swimming test with mice. Eur J Pharmacol 427:221-225
71. Yamada J, Sugimoto Y (2002) Differential effects of the 5-HT2 receptor antagonist on the anti-immobility effects of noradrenaline and serotonin reuptake inhibitors in the forced swimming test. Brain Res 958:161-165
72. Yates M, Leake A, Candy JM, Fairbairn AF, McKeith IG, Ferrier IN (1990) 5HT2 receptor changes in major depression. Biol Psychiatry 27:489-496
73. Yau JL, Olsson T, Noble J, Seckl JR (1999) Serotonin receptor subtype gene expression in the hippocampus of aged rats following chronic amitriptyline treatment. Brain Res Mol Brain Res 70:282-287
74. Zanardi R, Artigas F, Moresco R, Colombo C, Messa C, Gobbo C, Smeraldi E, Fazio F (2001) Increased 5-hydroxytryptamine-2 receptor binding in the frontal cortex of depressed patients responding to paroxetine treatment: a positron emission tomography scan study. J Clin Psychopharmacol 21:53-58