Altered [3H]imipramine and 5-HT2 but not [3H]paroxetine binding sites in platelets from depressed patients

Journal of Affective Disorders

Volumn 52, Issue 1-3, 1999, Pages 225-233

  Rosel, P ^a   Arranz, B ^a,c   Vallejo, J ^b   Alvarez, P ^b   Menchon, J M ^b   Palencia, T ^a   Navarro, M A ^a  

^a Universitari Vall d'Hebron   (Spain)

^b Dept Psychiat Hosp Princeps d'E ^*  (Spain)

^c CASM   (Spain)

Author keywords

5HT2; 3H Imipramine; 3H Ketanserin; 3H Paroxetine; Endogenous depression

Indexed keywords

IMIPRAMINE; KETANSERIN; MIANSERIN; PAROXETINE; SEROTONIN; SEROTONIN 2 RECEPTOR; SEROTONIN CREATININE SULFATE; TRITIUM; ANTIDEPRESSANT AGENT; BIOLOGICAL MARKER; SEROTONIN RECEPTOR; TRICYCLIC ANTIDEPRESSANT AGENT;

ADULT; AGED; ARTICLE; BINDING SITE; CONTROLLED STUDY; DEPRESSION; DRUG RECEPTOR BINDING; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MELANCHOLIA; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM; THROMBOCYTE; BLOOD; CELL MEMBRANE; COMPARATIVE STUDY; DRUG EFFECT; MAJOR DEPRESSION; METABOLISM; MIDDLE AGED; PSYCHOLOGICAL ASPECT;

ADULT; AGED; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; ANTIDEPRESSIVE AGENTS, TRICYCLIC; BINDING SITES; BIOLOGICAL MARKERS; CELL MEMBRANE; DEPRESSIVE DISORDER, MAJOR; FEMALE; HUMANS; IMIPRAMINE; MALE; MIDDLE AGED; PAROXETINE; RECEPTORS, SEROTONIN;

EID: 0032586706     PISSN: 01650327     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0327(98)00030-5     Document Type: Article

References (55)

1. 3H]Paroxetine binding in human platelets in relation to age and sex. Neurobiol. Aging. 11:1990;615-618.
2. Arango V., Ernsberger P., Marzuk M., Chen J., Tierney H., Stanley M., Reis D.J., Mann J.J. Autoradiographic demonstration of increased serotonin 5-HT2 and β-adrenergic receptor binding sites in the brain of suicide victims. Arch. Gen. Psychiatry. 47:1990;1038-1044.
3. Arora R.C., Meltzer H.Y. Serotonergic measures in the brains.of suicide victims: 5-HT2 binding sites in the frontal cortex of suicide victims and control subjects. Am. J. Psychiatry. 146:1989;730-736.
4. 3H]citalopram as markers of the human brain 5-HT uptake site: a comparison study. J. Neural Transm. 97:1994;27-40.
5. Arranz B., Eriksson A., Mellerup E., Plenge P., Marcusson J. Brain 5-HT1A, 5-HT1D and 5-HT2 receptors in suicide victims. Biol. Psychiatry. 35:1994;457-463.
6. 3H]imipramine binding in depressed males and females. Commun. Psychopharmacol. 4:1980;425-432.
7. Asberg M., Thoren P., Traskman L. Serotonin depression a biochemical subgroup within the affective disorders. Science. 191:1976;478-480.
8. Asberg M., Bertilsson L., Martensson B., Scalia-Tomba G.P., Thoren P., Traskman-Bendz Z. CSF monoamine metabolites in melancholia. Acta Psychiatry Scand. 69:1984;201-219.
9. Biegon A., Weizman A., Karp L., Ram A., Tiamo S., Wolff M. Serotonin 5-HT2 receptor binding on blood platelets a peripheral marker for depression. Life Sci. 41:1987;2485-2492.
10. Cheetham S.C., Crompton M.R., Katona C.L.E., Horton R.W. Brain 5-HT2 receptor binding sites in depressed suicide victims. Brain Res. 443:1988;272-280.
11. 3H]paroxetine binding in depressed patients. Psychiatry Res. 26:1988;11-17.
12. D'Haenen H., Bossuyt A., Mertens J., Bossuyt-Piron C., Gijsemans M., Kaufman L. SPECT Imaging of serotonin 2 receptors in depression. Psychiatry Res. Neuroimaging. 45:1992;227-237.
13. 3H]paroxetine binding in blood platelets of psychiatric patients and healthy volunteers. J. Psychopharmacol. 3:1989;78-81.
14. 3H]imipramine binding in psychiatric disorders. Biol. Psychiatry. 22:1987;278-286.
15. Kendall D.A., Nahorski S.R. 5-HT-stimulated inositol phospholipid hydrolysis in rat cerebral cortex slices: pharmacological characterization and effects of antidepressants. J. Pharmacol. Exp. Ther. 233:1985;473-479.
16. 3H-paroxetine to blood platelets in healthy volunteers: indications for a gender difference. Biol. Psychiatry. 28:1990;509-517.
17. 3H]paroxetine binding with the 5-HT transporter in brain and platelets: relevance to studies in depression. J. Recept. Res. 7:1987;499-521.
18. Lowther S., De Parmentier F., Cromptom M.R., Katona C.L.E., Horton R.W. Brain 5-HT2 receptors in suicide victims: violence of death depression and effects of antidepressant treatment. Brain Res. 642:1994;281-289.
19. Mann J.J., Stanley M., McBride P.A., McEwen B.S. Increased serotonin 2 and β-adrenergic receptor binding in the frontal cortex of suicide victims. Arch. Gen. Psychiatry. 43:1986;954-959.
20. 3H]paroxetine binding in rat brain. J. Neurochem. 50:1988;1783-1790.
21. Markwell M.A., Haas S.M., Bieber L.L., Tolbert N.E. A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Anal. Biochem. 87:1987;202-225.
22. McBride P.A., Brown R.P., De Meo M., Keilp J., Mieczkowski T., Mann J.J. The relationship of platelet 5-HT2 receptor indices to major depressive disorder, personality traits and suicidal behavior. Biol. Psychiatry. 35:1994;295-308.
23. McKeith I.G., Marshall E.F., Ferrier I.N., Armstrong M.M., Kennedy W.N., Perry E.K., Eccleston D. 5-HT receptor binding in postmorten brain from patients with affective disorder. J. Affect. Disorders. 13:1987;67-74.
24. 3H]imipramine binding. Acta Psychiatry Scand. 82:1990;330-334.
25. Murphy D.L., Campbell I.C., Costa J.L. The brain serotonergic system in the affective disorders. Neuropsychopharmacology. 2:1978;1-31.
26. 3H]imipramine binding in depressed patients and its circadian variations in healthy controls. J. Affect. Disorders. 11:1986;207-212.
27. 3H-paroxetine binding in controls and depressed patients: relationship to serotonin uptake and age. Psychiatry Res. 51:1993;147-155.
28. 3H-imipramine binding in major depression, Soc. Neurosci. USA, abstract 586.4.
29. Owen F., Chambers D.R., Cooper S.J., Crow T.J., Johnson J.A., Lofthouse R., Poulter M. Serotonergic mechanisms in brain of suicide victims. Brain Res. 362:1986;185-188.
30. Owens M.J., Nemeroff C.B. Role of serotonin in the pathophysiology of depression: forms on the serotonin transporter. Clin. Chem. 40:1994;288-295.
31. Pandey G.N., Pandey S.C., Janicak P.G., Marks R.C., Davis J.M. Platelet serotonin-2 receptor binding sites in depression and suicide. Biol. Psychiatry. 28:1990;215-222.
32. Pandey G.N., Pandey S.C., Dwivedi Y., Sharna R.P., Janicak P.G., Davis J.M. Platelet serotonin-2A receptors: A potential biological marker for suicidal behaviour. Am. J. Psychiatry. 152:1995;850-855.
33. Paul S.M., Rehavi M., Skolnick P., Ballenger P.C., Goowin F.K. Depressed patients have decrease binding of tritiated imipramine to platelet serotonin transporter. Arch. Gen. Psychiatry. 38:1981;1315-1317.
34. 3H]citalopram binding to the 5-HT transporter from brain and platelets. Eur. J. Pharmacol. 206:1991;243-250.
35. 3H]imipramine binding to platelets of depressed patients free of previous medication with 5-HT uptake inhibitors. Psychopharmacology. 89:1986;456-461.
36. 3H]imipramine binding in rat cerebral cortex. Eur. J. Pharmacol. 58:1979;347-348.
37. 3H]imipramine binding and serotonin uptake in platelets from untreated depressed and control volunteers. Psychopharmacology. 77:1982;332-335.
38. Risch S.C., Nemeroff C.B. Neurochemical alterations of serotonergic neuronal system in depression. J. Clin. Psychiatry. 53:1992;3-7.
39. 3H]imipramine binding: influences of protein concentration of varying proportions of cytosol or intact platelets and displacing agents used. Biol. Psychiatry. 38:1995;464-470.
40. 3H]imipramine binding in healthy controls; Age and gender effects. Biol. Psychiatry. 40:1996;981-985.
41. 3H]paroxetine in human brain. J. Neural Transm. 104:1997;89-96.
42. 3H]paroxetine binding in depressed patients. J. Affect. Disorders. 44:1997;79-85.
43. 3H]paroxetine binding sites in suicide brains. J. Neural Transm. 104:1997;921-929.
44. 3H]paroxetine binding sites in human brain: studies in suicide victims, Psychiatry Res., (1998) in press.
45. Sneddon J.M. Blood platelets as a model for monoamine containing neurones. Prog. Neurobiol. 1:1973;151-198.
46. 3H] imipramine binding in primary major depression compared with depression secondary to medical illness in elderly outpatients. J. Affect. Disorders. 15:1988;195-200.
47. Stanley M., Virgilio S., Gershon S. Tritiated imipramine binding sites are decreased in the frontal cortex of suicides. Science. 216:1982;1337-1339.
48. Stanley M., Mann J.J. Increased serotonin-2 binding sites in frontal cortex of suicide victims. Lancet. i:1983;214-216.
49. Steckler T., Ruggeberg-Schmicht K., Muller-Oerlinghausen B. Human platelet 5-HT2 receptor binding site re-evaluated: a criticism of recurrent techniques. J. Neural Transm. 92:1993;11-24.
50. 3H]imipramine binding: A state-dependent marker in depression. Neur. Psychopharmacol. 8:1984;737-741.
51. 3H]paroxetine binding sites in major depression, Soc. Neurosci., 15: 673 (1989) Abstract 274.4.
52. 3H]imipramine binding and plasma cortisol level in depression. Biol. Psychiatry. 26:1989;52-60.
53. 3H-imipramine binding. Psychiatry Res. 16:1985;141-146.
54. 3H]imipramine binding in platelets from untreated depressed patients compared to healthy controls. Psychiatry Res. 16:1985;131-139.
55. Yates M., Leake A., Candy J.M., Fairbairn A.F., McKeith I.G., Ferrier I.N. 5-HT2 receptor changes in major depression. Biol. Psychiatry. 27:1990;489-496.