Alterations in epithelial and mesenchymal intestinal gene expression during doxorubicin-induced mucositis in mice

Digestive Diseases and Sciences

Volumn 52, Issue 8, 2007, Pages 1814-1825

  De Koning, Barbara A E ^a   Lindenbergh Kortleve, Dicky J ^a   Pieters, Rob ^a   Büller, Hans A ^a   Renes, Ingrid B ^a   Einerhand, Alexandra W C ^a  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

Author keywords

Bone morphogenetic proteins; Epithelial homeostasis; Intestinal differentiation; Morphogens; TCF4

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR 4; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN REGULATION; GENE EXPRESSION; HOMEOSTASIS; INTESTINE EPITHELIUM CELL; MESENCHYME; MOUSE; MUCOSA INFLAMMATION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; BONE MORPHOGENETIC PROTEINS; CELL DIVISION; DOXORUBICIN; EPITHELIAL CELLS; GENE EXPRESSION; HOMEOSTASIS; INTESTINAL MUCOSA; MALE; MESODERM; MICE; MICE, INBRED BALB C; MUCOSITIS; RECEPTOR CROSS-TALK;

EID: 34347395368     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-006-9174-5     Document Type: Article

References (49)

1. Barker N, Huls G, Korinek V, et al. (1999) Restricted high-level expression of Tcf-4 protein in intestinal and mammary gland epithelium. Am J Pathol 154:29-35
2. Bitgood MJ, McMahon AP (1995) Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol 172:126-138
3. Blache P, van de Wetering M, Duluc I, et al. (2004) SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes. J Cell Biol 166:37-47
4. Bromley M, Rew D, Becciolini A, et al. (1996) A comparison of proliferation markers (BrdUrd, Ki-67, PCNA) determined at each cell position in the crypts of normal human colonic mucosa. Eur J Histochem 40:89-100
5. de Santa Barbara P, van den Brink GR, Roberts DJ (2003) Development and differentiation of the intestinal epithelium. Cell Mol Life Sci 60:1322-1332
6. Dignass A, Lynch-Devaney K, Kindon H, et al. (1994) Trefoil peptides promote epithelial migration through a transforming growth factor beta-independent pathway. J Clin Invest 94:376-383
7. Duncan M, Grant G (2003) Oral and intestinal mucositis: causes and possible treatments. Aliment Pharmacol Ther 18:853-874
8. Haramis AP, Begthel H, van den Born M, et al. (2004) De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine. Science 303:1684-1686
9. Hardwick JC, Van Den Brink GR, Bleuming SA, et al. (2004) Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon. Gastroenterology 126:111-121
10. He XC, Zhang J, Tong WG, et al. (2004) BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling. Nat Genet 36:1117-1121
11. Hogan BL (1996) Bone morphogenetic proteins in development. Curr Opin Genet Dev 6:432-438
12. Ijiri K, Potten CS (1987) Further studies on the response of intestinal crypt cells of different hierarchical status to eighteen different cytotoxic agents. Br J Cancer 55:113-123
13. Ijiri K, Potten CS (1983) Response of intestinal cells of differing topographical and hierarchical status to ten cytotoxic drugs and five sources of radiation. Br J Cancer 47:175-185
14. Itoh S, Itoh F, Goumans MJ, et al. (2000) Signaling of transforming growth factor-beta family members through Smad proteins. Eur J Biochem 267:6954-6967
15. Kedinger M, Duluc I, Fritsch C, et al. (1998) Intestinal epithelial-mesenchymal cell interactions. Ann NY Acad Sci 859:1-17
16. Kelly KM, Hutchinson RJ, Sposto R, et al. (2002) Feasibility of upfront dose-intensive chemotherapy in children with advanced-stage Hodgkin's lymphoma: preliminary results from the Children's Cancer Group Study CCG-59704. Ann Oncol 13 Suppl 1:107-111
17. Korinek V, Barker N, Moerer P, et al. (1998) Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet 19:379-383
18. Kushner BH, Kramer K, LaQuaglia MP, et al. (2004) Reduction from seven to five cycles of intensive induction chemotherapy in children with high-risk neuroblastoma. J Clin Oncol 22:4888-4892
19. Lee YJ, Swencki B, Shoichet S, et al. (1999) A possible role for the high-mobility group box transcription factor Tcf-4 in vertebrate gut epithelial cell differentiation. J Biol Chem 274:1566- 1572
20. Lockhart PB, Sonis ST (1981) Alterations in the oral mucosa caused by chemotherapeutic agents. A histologic study. J Dermatol Surg Oncol 7:1019-1025
21. Martin M, Garcia-Donas J, Casado A, et al. (2004) Phase II study of pegylated liposomal doxorubicin plus vinorelbine in breast cancer with previous anthracycline exposure. Clin Breast Cancer 5:353-357
22. Mashimo H, Wu DC, Podolsky DK, et al. (1996) Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor. Science 274:262-265
23. Montgomery RK, Mulberg AE, Grand RJ (1999) Development of the human gastrointestinal tract: twenty years of progress. Gastroenterology 116:702-731
24. Moore JV (1985) Clonogenic response of cells of murine intestinal crypts to 12 cytotoxic drugs. Cancer Chemother Pharmacol 15:11-15
25. Nastos A, Pogge von Strandmann E, Weber H, et al. (1998) The em- bryonic expression of the tissue-specific transcription factor HNF1 alpha in Xenopus: rapid activation by HNF4 and delayed induction by mesoderm inducers. Nucleic Acids Res 26:5602-5608
26. Nicholson DW, Ali A, Thornberry NA, et al. (1995) Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376:37-43
27. Nishanian TG, Kim JS, Foxworth A, et al. (2004) Suppression of tumorigenesis and activation of Wnt signaling by bone morphogenetic protein 4 in human cancer cells. Cancer Biol Ther 3:667-675
28. Patte C, Laplanche A, Bertozzi AI, et al. (2002) Granulocyte colony-stimulating factor in induction treatment of children with non-Hodgkin's lymphoma: a randomized study of the French Society of Pediatric Oncology. J Clin Oncol 20:441-448
29. Pinkerton CR, Cameron CH, Sloan JM, et al. (1982) Jejunal crypt cell abnormalities associated with methotrexate treatment in children with acute lymphoblastic leukaemia. J Clin Pathol 35:1272-1277
30. Playford RJ, Marchbank T, Chinery R, et al. (1995) Human spasmolytic polypeptide is a cytoprotective agent that stimulates cell migration. Gastroenterology 108:108-116
31. Potten CS, Loeffler M (1990) Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. Development 110:1001-1020
32. Potten CS, Owen G, Booth D (2002) Intestinal stem cells protect their genome by selective segregation of template DNA strands. J Cell Sci 115:2381-2388
33. Radtke F, Clevers H (2005) Self-renewal and cancer of the gut: two sides of a coin. Science 307:1904-1909
34. Renes IB, Verburg M, Bulsing NP, et al. (2002) Protection of the Peyer's patch-associated crypt and villus epithelium against methotrexate-induced damage is based on its distinct regulation of proliferation. J Pathol 198:60-68
35. Sonis ST (2004) The pathobiology of mucositis. Nat Rev Cancer 4:277-284
36. Sonis ST, Elting LS, Keefe D, et al. (2004) Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer 100:1995-2025
37. Sukegawa A, Narita T, Kameda T, et al. (2000) The concentric structure of the developing gut is regulated by Sonic hedgehog derived from endodermal epithelium. Development 127:1971-1980
38. Taminiau JA, Gall DG, Hamilton JR (1980) Response of the rat small-intestine epithelium to methotrexate. Gut 21:486-492
39. Taylor JK, Boll W, Levy T, et al. (1997) Comparison of intestinal phospholipase A/lysophospholipase and sucrase-isomaltase genes suggest a common structure for enterocyte-specific promoters. DNA Cell Biol 16:1419-1428
40. Theon AP, Metzger L, Griffey S (1994) In situ analysis of cellular proliferation in canine, feline and equine tumors by immunohistochemistry: a comparison of bromodeoxyuridine, proliferating cell nuclear antigen, and interchromatin-associated antigen immunostaining techniques. J Vet Diagn Invest 6:453-457
41. Trier JS (1962) Morphologic alterations induced by methotrexate in the mucosa of human proximal intestine. I. Serial observations by light microscopy. Gastroenterology 42:295-305
42. Van Beers EH, Buller HA, Grand RJ, et al. (1995) Intestinal brush border glycohydrolases: structure, function, and development. Crit Rev Biochem Mol Biol 30:197-262
43. van de Wetering M, Sancho E, Verweij C, et al. (2002) The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 111:241-250
44. Verburg M, Renes IB, Einerhand AW, et al. (2003) Isolation-stress increases small intestinal sensitivity to chemotherapy in rats. Gastroenterology 124:660-671
45. Verburg M, Renes IB, Meijer HP, et al. (2000) Selective sparing of goblet cells and paneth cells in the intestine of methotrexate-treated rats. Am J Physiol Gastrointest Liver Physiol 279:G1037-1047
46. Verburg M, Renes IB, Van Nispen DJ, et al. (2002) Specific responses in rat small intestinal epithelial mRNA expression and protein levels during chemotherapeutic damage and regeneration. J Histochem Cytochem 50:1525-1536
47. Wright NA, Irwin M (1982) The kinetics of villus cell populations in the mouse small intestine. I. Normal villi: the steady state requirement. Cell Tissue Kinet 15:595-609
48. Xian CJ, Howarth GS, Mardell CE, et al. (1999) Temporal changes in TFF3 expression and jejunal morphology during methotrexate-induced damage and repair. Am J Physiol 277:G785-795
49. Yeh KY, Yeh M, Montgomery RK, et al. (1991) Cortisone and thyroxine modulate intestinal lactase and sucrase mRNA levels and activities in the suckling rat. Biochem Biophys Res Commun 180:174-180