Selective sparing of goblet cells and Paneth cells in the intestine of methotrexate-treated rats

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 279, Issue 5 42-5, 2000, Pages

  Verburg, Melissa ^a   Renes, Ingrid B ^a   Meijer, Helen P ^a   Taminiau, Jan A J M ^b   Büller, Hans A ^a   Einerhand, Alexandra W C ^a   Dekker, Jan ^a,c  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

Chemotherapy; Damage and regeneration; Gene expression; Villus atrophy

Indexed keywords

GLYCOPROTEIN; METHOTREXATE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL REGENERATION; GENE EXPRESSION; GOBLET CELL; IMMUNOHISTOCHEMISTRY; INTESTINE CELL; INTESTINE CRYPT; NONHUMAN; PANETH CELL; PRIORITY JOURNAL; RAT;

EID: 0033667123     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.2000.279.5.g1037     Document Type: Article

References (33)

1. The effect of epidermal growth factor (EGF) on cell proliferation of the gastrointestinal mucosa in rodents
2. Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. IV. Paneth cells
3. Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. III. Entero-endocrine cells
4. Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality
5. Immunohistochemical localization of carbamoyl-phosphate synthetase (ammonia) in adult rat liver; evidence for a heterogeneous distribution
6. Crypt cell production rates at various sites around the colon in Wistar rats and humans
7. Regulation of cell number in the mammalian gastrointestinal tract: The importance of apoptosis
8. Insulin-like growth factor-I (IGF-I) stimulates regrowth of the damaged intestine in rats, when administered following, but not concurrent with, methotrexate
9. Milk growth factors enriched from cheese whey ameliorate intestinal damage by methotrexate when administered orally to rats
10. Light and scanning electron microscopic observations of the effects of sublethal doses of methotrexate on the rat small intestine
11. Preventive effects of germinated barley food-stuff on methotrexate- induced enteritis in rats
12. Transcriptional regulation of intestinal hydrolase biosynthesis during postnatal development in rats
13. Soy-derived antiapoptotic fractions protect gastrointestinal epithelium from damage caused by methotrexate treatment in the rat
14. Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor
15. Ileal epithelial cell migration after 40% small-bowel resection. Autoradiographic studies in the rat
16. The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice
17. Induction of gastric epithelial apoptosis by Helicobacter pylori
18. Vitamin A, a useful biochemical modulator capable of preventing intestinal damage during methotrexate treatment
19. Characterization and derivation of the gene coding for mitochondrial carbamyl phosphate synthetase I of rat
20. Jejunal crypt cell abnormalities associated with methotrexate treatment in children with acute lymphoblastic leukaemia
21. Dephosphorylation of endotoxin by alkaline phosphatase in vivo
22. Identification and characterization of rat intestinal trefoil factor: Tissue- and cell-specific member of the trefoil protein family
23. Response of the rat small-intestine epithelium to methotrexate
24. Regulation of the PepT1 peptide transporter in the rat small intestine in response to 5-fluorouracil-induced injury
25. Biosynthesis of rat MUC2 in colon and its analogy with human MUC2
26. Preparation of anti-mucin polypeptide antisera to study mucin biosynthesis
27. Mucin gene structure and expression: Protection vs. adhesion
28. Differences in expression of homeobox transcription factors in proximal and distal human small intestine
29. Apoptosis and differentiation in the crypt-villus unit of the rat small intestine
30. Temporal changes in TFF3 expression and jejunal morphology during methotrexate-induced damage and repair
31. cDNA for the carboxyl-terminal region of a rat intestinal mucin-like peptide
32. Thyroxine and cortisone cooperate to modulate postnatal intestinal enzyme differentiation in the rat
33. Expression and distribution of surfactant proteins and lysozyme after prolonged hyperpnea