Lipopolysaccharide and cyclic AMP regulation of CB2 cannabinoid receptor levels in rat brain and mouse RAW 264.7 macrophages

Journal of Neuroimmunology

Volumn 181, Issue 1-2, 2006, Pages 82-92

  Mukhopadhyay, Somnath ^a,b   Das, Sucharita ^b   Williams, Evelyn A ^b   Moore, Duane ^b   Jones, Jenelle D ^a   Zahm, Daniel S ^b   Ndengele, Michael M ^b   Lechner, Andrew J ^b   Howlett, Allyn C ^a,b  

^a NORTH CAROLINA CENTRAL UNIVERSITY   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

BV 2 microglia; CB2 cannabinoid receptor; Cyclic AMP; Lipopolysaccharide (LPS); Protein kinase A; RAW 264.7 macrophages

Indexed keywords

BISINDOLYLMALEIMIDE; BUCLADESINE; CANNABINOID 2 RECEPTOR; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; FORSKOLIN; LIPOPOLYSACCHARIDE; MEMBRANE RECEPTOR; N (2 METHYLAMINOETHYL) 5 ISOQUINOLINESULFONAMIDE; NIFLUMIC ACID; POLYMYXIN B; PROTEIN KINASE C INHIBITOR; SULINDAC;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN MEMBRANE; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; IMMUNOCOMPETENT CELL; IMMUNOREACTIVITY; IMMUNOREGULATION; MACROPHAGE; MALE; MICROGLIA; MOUSE; NEUROBLASTOMA CELL; NEUROIMMUNOLOGY; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; REGULATORY MECHANISM; WESTERN BLOTTING;

ANIMALS; CELL LINE; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLOHEXIMIDE; LIPOPOLYSACCHARIDES; MACROPHAGES; MEMBRANE PROTEINS; MICE; MICROGLIA; PROSENCEPHALON; PROTEIN SYNTHESIS INHIBITORS; RATS; RECEPTOR, CANNABINOID, CB2; UP-REGULATION;

EID: 34347393913     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2006.08.002     Document Type: Article

References (66)

1. Balzary R.W., and Cocks T.M. Lipopolysaccharide induces epithelium- and prostaglandin E(2)-dependent relaxation of mouse isolated trachea through activation of cyclooxygenase(COX)-1 and COX-2. J. Pharmacol. Exp. Ther. 317 (2006) 806-812
2. Barnett J., Chow J., Ives D., Chiou M., Mackenzie R., Osen E., Nguyen B., Tsing S., Bach C., and Freire J. Purification, characterization and selective inhibition of human prostaglandin G/H synthase expressed in the baculovirus system. Biochim. Biophys. Acta 1209 (1994) 130-139
3. 2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains. J. Neurosci. 23 (2003) 11136-11141
4. Benito C., Kim W.K., Chavarria I., Hillard C.J., Mackie K., Tolon R.M., Williams K., and Romero J. A glial endogenous cannabinoid system is upregulated in the brains of macaques with simian immunodeficiency virus-induced encephalitis. J. Neurosci. 25 (2005) 2530-2536
5. Bruce-Keller A.J. Microglial-neuronal interactions in synaptic damage and recovery. J. Neurosci. Res. 58 (1999) 191-201
6. 2 receptor. Eur. J. Pharmacol. 396 (2000) 141-149
7. Cabral G.A., and Marciano-Cabral F. Cannabinoid receptors in microglia of the central nervous system: immune functional relevance. J. Leukoc. Biol. 78 (2005) 1192-1197
8. 1 receptor participation. Adv. Exp. Med. Biol. 493 (2001) 207-214
9. 2 cannabinoid receptor by rodent macrophages and macrophage-like cells in relation to cell activation. Int. Immunopharmacol. 2 (2002) 69-82
10. 2 receptor-dependent mechanism. Mol. Pharmacol. 65 (2004) 999-1007
11. Casanova M.L., Blazquez C., Martinez-Palacio J., Villanueva C., Fernandez-Acenero M.J., Huffman J.W., Jorcan J.L., and Guzman M. Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. J. Clin. Invest. 111 (2003) 43-50
12. Chao C.C., Hu S., Molitor T.W., Shaskan E.G., and Peterson P.K. Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. J. Immunol. 149 (1992) 2736-2741
13. Chen C.C., and Wang J.K. p38 but not p44/42 mitogen-activated protein kinase is required for nitric oxide synthase induction mediated by lipopolysaccharide in RAW 264.7 macrophages. Mol. Pharmacol. 55 (1999) 481-488
14. Chen C.C., Chiu K.T., Sun Y.T., and Chen W.C. Role of the cyclic AMP-protein kinase A pathway in lipopolysaccharide-induced nitric oxide synthase expression in RAW 264.7 macrophages. Involvement of cyclooxygenase-2. J. Biol. Chem. 274 (1999) 31559-31564
15. Dasgupta S., Jana M., Liu X., and Pahan K. Role of very-late antigen-4 (VLA-4) in myelin basic protein-primed T cell contact-induced expression of proinflammatory cytokines in microglial cells. J. Biol. Chem. 278 (2003) 22424-22431
16. Devane W.A., Dysarz III F.A., Johnson M.R., Melvin L.S., and Howlett A.C. Determination and characterization of a cannabinoid receptor in rat brain. Mol. Pharmacol. 34 (1988) 605-613
17. Dickson D.W., Mattiace L.A., Kure K., Hutchins K., Lyman W.D., and Brosnan C.F. Microglia in human disease, with an emphasis on acquired immune deficiency syndrome. Lab. Invest. 64 (1991) 135-156
18. Dickson D.W., Lee S.C., Mattiace L.A., Yen S.H., and Brosnan C. Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease. Glia 7 (1993) 75-83
19. Dobrovolskaia M.A., and Vogel S.N. Toll receptors, CD14, and macrophage activation and deactivation by LPS. Microbes Infect. 4 (2002) 903-914
20. Fitzgerald K.A., and Chen Z.J. Sorting out Toll signals. Cell 125 (2006) 834-836
21. Galiegue S., Mary S., Marchand J., Dussossoy D., Carriere D., Carayon P., Bouaboula M., Shire D., Le Fur G., and Casellas P. Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur. J. Biochem. 232 (1995) 54-61
22. Giulian D. Ameboid microglia as effectors of inflammation in the central nervous system. J. Neurosci. Res. 18 (1987) 155-171
23. Hagiwara M., Inagaki M., and Hidaka H. Specific binding of a novel compound, N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide (H-8) to the active site of cAMP-dependent protein kinase. Mol. Pharmacol. 31 (1987) 523-528
24. 2 upregulates cyclooxygenase-2 expression in lipopolysaccharide-stimulated RAW 264.7 macrophages. Biochem. Biophys. Res. Commun. 272 (2000) 744-748
25. Howlett A.C., Barth F., Bonner T.I., Cabral G., Casellas P., Devane W.A., Felder C.C., Herkenham M., Mackie K., Martin B.R., Mechoulam R., and Pertwee R.G. International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol. Rev. 54 (2002) 161-202
26. Hubbard N.E., Lee S., Lim D., and Erickson K.L. Differential mRNA expression of prostaglandin receptor subtypes in macrophage activation. Prostaglandins, Leukot. Essent. Fat. Acids 65 (2001) 287-294
27. 9-tetrahydrocannabinol is mediated through the inhibition of nuclear factor-κB/Rel activation. Mol. Pharmacol. 50 (1996) 334-341
28. Johnson J.L., Wimsatt J., Buckel S.D., Dyer R.D., and Maddipati K.R. Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons. Arch. Biochem. Biophys. 324 (1995) 26-34
29. Justement L.B., Aldrich W.A., Wenger G.D., O'Dorisio M.S., and Zwilling B.S. Modulation of cyclic AMP-dependent protein kinase isozyme expression associated with activation of a macrophage cell line. J. Immunol. 136 (1986) 270-277
30. Kaisho T., and Akira S. Toll-like receptor function and signaling. J. Allergy Clin. Immunol. 117 (2006) 979-987
31. Kaminski N.E. Regulation of the cAMP cascade, gene expression and immune function by cannabinoid receptors. J. Neuroimmunol. 83 (1998) 124-132
32. Kishimoto S., Gokoh M., Oka S., Muramatsu M., Kajiwara T., Waku K., and Sugiura T. 2-Arachidonoylglycerol induces the migration of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes through the cannabinoid CB2 receptor-dependent mechanism. J. Biol. Chem. 278 (2003) 24469-24475
33. Klein T.W. Cannabinoid-based drugs as anti-inflammatory therapeutics. Nat. Rev. Immunol. 5 (2005) 400-411
34. Kloss C.U., Bohatschek M., Kreutzberg G.W., and Raivich G. Effect of lipopolysaccharide on the morphology and integrin immunoreactivity of ramified microglia in the mouse brain and in cell culture. Exp. Neurol. 168 (2001) 32-46
35. 2 production by lipopolysaccharide-stimulated macrophages is not dependent on nuclear factor κB. J. Surg. Res. 113 (2003) 189-194
36. Lo C.J., Cryer H.G., Fu M., and Lo F.R. Regulation of macrophage eicosanoid generation is dependent on nuclear factor κB. J. Trauma 45 (1998) 19-23
37. Marciano-Cabral F., Ludwick C., Puffenbarger R.A., and Cabral G.A. Differential stimulation of microglial pro-inflammatory cytokines by Acanthamoeba culbertsoni versus Acanthamoeba castellanii. J. Eukaryot. Microbiol. 51 (2004) 472-479
38. 2 receptor in microglial cells in response to inflammatory stimuli. J. Neurochem. 95 (2005) 437-445
39. Matsuda L.A., Lolait S.J., Brownstein M.J., Young A.C., and Bonner T.I. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346 (1990) 561-564
40. 2 receptor participation. J. Pharmacol. Exp. Ther. 289 (1999) 1620-1625
41. Munro S., Thomas K.L., and Abu-Shaar M. Molecular characterization of a peripheral receptor for cannabinoids. Nature 365 (1993) 61-65
42. Ndengele M.M., Bellone C.J., Lechner A.J., and Matuschak G.M. Brief hypoxia differentially regulates LPS-induced IL-1beta and TNF-alpha gene transcription in RAW 264.7 cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 278 (2000) L1289-L1296
43. 2 receptors are expressed by perivascular microglial cells in the human brain: an immunohistochemical study. Synapse 53 (2004) 208-213
44. 2 cannabinoid receptor using a recombinant Semliki Forest virus. Biochem. Pharmacol. 65 (2003) 1931-1942
45. Parolaro D. Presence and functional regulation of cannabinoid receptors in immune cells. Life Sci. 65 (1999) 637-644
46. Puffenbarger R.A., Boothe A.C., and Cabral G.A. Cannabinoids inhibit LPS-inducible cytokine mRNA expression in rat microglial cells. Glia 29 (2000) 58-69
47. Rademacher D.J., Kearn C.S., Carrier E.J., Patel S., Delgado M.A., Barkmeier A., Klick D.E., Breese N.M., Pfister S.L., Nithipatikom K., Campbell W.B., and Hillard C.J. Production of hydroxyeicosatetraenoic acids and prostaglandins by a novel rat microglial cell line. J. Neuroimmunol. 149 (2004) 130-141
48. Ramirez B.G., Blazquez C., Gomez D.P., Guzman M., and de Ceballos M.L. Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation. J. Neurosci. 25 (2005) 1904-1913
49. Ross R.A., Brockie H.C., and Pertwee R.G. Inhibition of nitric oxide production in RAW 264.7 macrophages by cannabinoids and palmitoylethanolamide. Eur. J. Pharmacol. 401 (2000) 121-130
50. 9-tetrahydrocannabinol on human immune function and host defense. Chem. Phys. Lipids 121 (2002) 229-239
51. 2 receptors. J. Neuroimmunol. 109 (2000) 155-163
52. 1 cannabinoid receptor in macrophage-like cells from brain tissue: immunochemical characterization by fusion protein antibodies. J. Neuroimmunol. 82 (1998) 13-21
53. Siren A.L., McCarron R., Wang L., Garcia-Pinto P., Ruetzler C., Martin D., and Hallenbeck J.M. Proinflammatory cytokine expression contributes to brain injury provoked by chronic monocyte activation. Mol. Med. 7 (2001) 219-229
54. Skaper S.D., Buriani A., Dal Toso R., Petrelli L., Romanello S., Facci L., and Leon A. The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 3984-3989
55. Steiner A.A., Dogan M.D., Ivanov A.I., Patel S., Rudaya A.Y., Jennings D.H., Orchinik M., Pace T.W., O'Connor K.A., Watkins L.R., and Romanovsky A.A. A new function of the leptin receptor: mediation of the recovery from lipopolysaccharide-induced hypothermia. FASEB J. 18 (2004) 1949-1951
56. Uribe R.M., Lee S., and Rivier C. Endotoxin stimulates nitric oxide production in the paraventricular nucleus of the hypothalamus through nitric oxide synthase I: correlation with hypothalamic-pituitary-adrenal axis activation. Endocrinology 140 (1999) 5971-5981
57. 2 receptors. Science 310 (2005) 329-332
58. Wadleigh D.J., Reddy S.T., Kopp E., Ghosh S., and Herschman H.R. Transcriptional activation of the cyclooxygenase-2 gene in endotoxin-treated RAW 264.7 macrophages. J. Biol. Chem. 275 (2000) 6259-6266
59. Waksman Y., Olson J.M., Carlisle S.J., and Cabral G.A. The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cells. J. Pharmacol. Exp. Ther. 288 (1999) 1357-1366
60. Walter L., and Stella N. Cannabinoids and neuroinflammation. Br. J. Pharmacol. 141 (2004) 775-785
61. Walter L., Franklin A., Witting A., Wade C., Xie Y., Kunos G., Mackie K., and Stella N. Nonpsychotropic cannabinoid receptors regulate microglial cell migration. J. Neurosci. 23 (2003) 1398-1405
62. Walter L., Dinh T., and Stella N. ATP induces a rapid and pronounced increase in 2-arachidonoylglycerol production by astrocytes, a response limited by monoacylglycerol lipase. J. Neurosci. 24 (2004) 8068-8074
63. Weinstein S.L., Gold M.R., and DeFranco A.L. Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages. Proc. Natl. Acad. Sci. U. S. A. 88 (1991) 4148-4152
64. Williams K.C., and Hickey W.F. Central nervous system damage, monocytes and macrophages, and neurological disorders in AIDS. Annu. Rev. Neurosci. 25 (2002) 537-562
65. Witting A., Walter L., Wacker J., Moller T., and Stella N. P2X7 receptors control 2-arachidonoylglycerol production by microglial cells. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 3214-3219
66. Woo M.S., Jung S.H., Hyun J.W., and Kim H.S. Differential regulation of inducible nitric oxide synthase and cytokine gene expression by forskolin and dibutyryl-cAMP in lipopolysaccharide-stimulated mouse BV2 microglial cells. Neurosci. Lett. 356 (2004) 187-190